{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:13:14Z","timestamp":1789913594221,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.meegid.2008.02.011","type":"journal-article","created":{"date-parts":[[2008,3,5]],"date-time":"2008-03-05T19:57:56Z","timestamp":1204747076000},"page":"344-350","source":"Crossref","is-referenced-by-count":18,"title":["An in silico immunological approach for prediction of CD8+ T cell epitopes of Leishmania major proteins in susceptible BALB\/c and resistant C57BL\/6 murine models of infection"],"prefix":"10.1016","volume":"9","author":[{"given":"F.Z.","family":"Guerfali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ben-Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Sghaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ben-Aissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mkannez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Laouini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2008.02.011_bib1","first-page":"33","article-title":"A strategy for the identification of T-cell epitopes on Leishmania cysteine proteinases","volume":"104","author":"Alves","year":"2001","journal-title":"Cytobios"},{"key":"10.1016\/j.meegid.2008.02.011_bib2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.imlet.2005.06.004","article-title":"Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis","volume":"101","author":"Antonelli","year":"2005","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.meegid.2008.02.011_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-3083.2007.01909.x","article-title":"The cross-priming pathway: a portrait of an intricate immune system","volume":"65","author":"Basta","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib4","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.4049\/jimmunol.168.8.3992","article-title":"CD8+ T cells are required for primary immunity in C57BL\/6 mice following low-dose, intradermal challenge with Leishmania major","volume":"168","author":"Belkaid","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"Bendtsen","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.meegid.2008.02.011_bib6","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.177.6.3525","article-title":"Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo","volume":"177","author":"Bertholet","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib7","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.143.5.1283","article-title":"Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay","volume":"143","author":"Bevan","year":"1976","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.meegid.2008.02.011_bib8","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1128\/IAI.69.5.3232-3239.2001","article-title":"Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis","volume":"69","author":"Bottrel","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2008.02.011_bib9","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.4049\/jimmunol.159.9.4467","article-title":"Parasite-driven in vitro human lymphocyte cytotoxicity against autologous infected macrophages from mucosal leishmaniasis","volume":"159","author":"Brodskyn","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib10","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/eji.1830241135","article-title":"Leishmania major infection in mice primes for specific major histocompatibility complex class I-restricted cytotoxic T cell responses","volume":"24","author":"Da Conceicao-Silva","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib11","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/IAI.55.11.2802-2806.1987","article-title":"Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation","volume":"55","author":"da Silva","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2008.02.011_bib12","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0264-410X(98)00338-7","article-title":"Evaluation of the stability and immunogenicity of autoclaved and nonautoclaved preparations of a vaccine against American tegumentary leishmaniasis","volume":"17","author":"De Luca","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2008.02.011_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0952-7915(00)00238-7","article-title":"Antigen presentation to CD8+ T cells: cross-priming in infectious diseases","volume":"13","author":"den Haan","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cimid.2004.03.004","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Desjeux","year":"2004","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.meegid.2008.02.011_bib15","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1016\/j.vaccine.2005.12.053","article-title":"Leishmania donovani: identification of stimulatory soluble antigenic proteins using cured human and hamster lymphocytes for their prophylactic potential against visceral leishmaniasis","volume":"24","author":"Garg","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2008.02.011_bib16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature02240","article-title":"Immune recognition of a human renal cancer antigen through post-translational protein splicing","volume":"427","author":"Hanada","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.meegid.2008.02.011_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0952-7915(99)80050-8","article-title":"Cytotoxic T lymphocyte activation by cross-priming","volume":"11","author":"Heath","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib18","first-page":"138","article-title":"Leishmanial excreted factors and their possible biological role","volume":"99","author":"Hernandez","year":"1983","journal-title":"Ciba Found. Symp."},{"key":"10.1016\/j.meegid.2008.02.011_bib19","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1084\/jem.169.5.1819","article-title":"Elimination of CD4+ suppressor T cell from susceptible BALB\/c mice release CD8+ T lymphocytes to mediate protective immunity against Leishmania","volume":"169","author":"Hill","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.meegid.2008.02.011_bib20","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1128\/IAI.66.8.3968-3970.1998","article-title":"Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice","volume":"66","author":"Huber","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2008.02.011_bib21","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1128\/IAI.69.8.4906-4915.2001","article-title":"Heterogeneity of wild Leishmania major isolates in experimental murine pathogenicity and specific immune response","volume":"69","author":"Kebaier","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2008.02.011_bib22","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.vaccine.2004.11.061","article-title":"Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes","volume":"23","author":"Lemesre","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2008.02.011_bib23","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1016\/j.vaccine.2007.02.083","article-title":"Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial","volume":"25","author":"Lemesre","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2008.02.011_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(88)91043-4","article-title":"Introduction of soluble protein into the class I pathway of antigen processing and presentation","volume":"54","author":"Moore","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.meegid.2008.02.011_bib25","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2008.02.011_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-2478(93)90126-M","article-title":"Course of Leishmania infection in beta2-microglobulin-deficient mice","volume":"37","author":"Overath","year":"1993","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.meegid.2008.02.011_bib27","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1371\/journal.pcbi.0020065","article-title":"A community resource benchmarking predictions of peptide binding to MHC-I molecules","volume":"2","author":"Peters","year":"2006","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.meegid.2008.02.011_bib28","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1128\/IAI.69.12.7453-7460.2001","article-title":"Differences in gamma interferon production in vitro predict the pace of the in vivo response to Leishmania amazonensis in healthy volunteers","volume":"69","author":"Pompeu","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2008.02.011_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002510050595","article-title":"SYFPEITHI: database for MHC ligands and peptide motifs","volume":"50","author":"Rammensee","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/j.meegid.2008.02.011_bib30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0198-8859(02)00432-9","article-title":"Prediction of MHC class I binding peptides using profile motifs","volume":"63","author":"Reche","year":"2002","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(02)80012-8","article-title":"Protein degradation and the generation of MHC class I-presented peptides","volume":"80","author":"Rock","year":"2002","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib32","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ni1089","article-title":"Post-proteasomal antigen processing for major histocompatibility complex class I presentation","volume":"5","author":"Rock","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib33","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1016\/j.vaccine.2007.04.003","article-title":"Immunization with Leishmania infantum released proteins confers partial protection against parasite infection with a predominant Th1 specific immune response","volume":"6","author":"Rosa","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2008.02.011_bib34","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice","volume":"2","author":"Sacks","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib35","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/eji.1830240338","article-title":"Leishmania major-specific CD8+ T cells are inducers and targets of nitric oxide produced by parasitized macrophages","volume":"24","author":"Stefani","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib36","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/eji.1830171007","article-title":"Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis","volume":"17","author":"Titus","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib37","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1128\/IAI.72.10.5654-5661.2004","article-title":"Immunization with Leishmania major exogenous antigens protects susceptible BALB\/c mice against challenge infection with L. major","volume":"72","author":"Tonui","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2008.02.011_bib38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.4269\/ajtmh.2007.76.579","article-title":"Cross-protection against Leishmania donovani but not L. braziliensis caused by vaccination with L. major soluble promastigote exogenous antigens in BALB\/c mice","volume":"76","author":"Tonui","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2008.02.011_bib39","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.4049\/jimmunol.167.12.6967","article-title":"Immune elimination of Leishmania major in mice: implications for immune memory, vaccination, and reactivation disease","volume":"167","author":"Uzonna","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib40","first-page":"115","article-title":"Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity","volume":"17","author":"Von Stebut","year":"2007","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.meegid.2008.02.011_bib41","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.4049\/jimmunol.151.4.2077","article-title":"Targeted activation of CD8+ T cells and infection of b-2 microglobulin deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis","volume":"151","author":"Wang","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.meegid.2008.02.011_bib42","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1126\/science.3257585","article-title":"Cells process exogenous proteins for recognition by cytotoxic T lymphocytes","volume":"239","author":"Yewdell","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.meegid.2008.02.011_bib43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0962-8924(01)02030-X","article-title":"Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing","volume":"11","author":"Yewdell","year":"2001","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.meegid.2008.02.011_bib44","doi-asserted-by":"crossref","first-page":"W180","DOI":"10.1093\/nar\/gki479","article-title":"PREDBALB\/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB\/c mouse","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134808000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134808000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T21:22:40Z","timestamp":1684272160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134808000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S1567134808000440"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2008.02.011","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}