{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:07:57Z","timestamp":1762297677946},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.meegid.2010.10.006","type":"journal-article","created":{"date-parts":[[2010,11,4]],"date-time":"2010-11-04T08:41:55Z","timestamp":1288860115000},"page":"740-745","source":"Crossref","is-referenced-by-count":7,"title":["Evolutionary genomics of Glossina morsitans immune-related CLIP domain serine proteases and serine protease inhibitors"],"prefix":"10.1016","volume":"11","author":[{"given":"Sarah","family":"Mwangi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Murungi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Christoffels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2010.10.006_bib0005","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0010","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1371\/journal.pbio.0060305","article-title":"A signalling protease required for melanization in Drosophila affects resistance and tolerance of infections","volume":"6","author":"Ayres","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0965-1748(02)00029-2","article-title":"Immunopeptides in the defense reactions of Glossina morsitans to bacterial and Trypanosoma brucei brucei infections","volume":"32","author":"Boulanger","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0020","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20060648","article-title":"The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families","volume":"401","author":"Br\u00fcning","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.meegid.2010.10.006_bib0025","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.0105-2896.2004.00116.x","article-title":"The prophenoloxidase-activating system in invertebrates","volume":"198","author":"Cerenius","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.meegid.2010.10.006_bib0030","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/nar\/29.1.234","article-title":"STACK: sequence tag alignment and consensus knowledgebase","volume":"29","author":"Christoffels","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2010.10.006_bib0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1126\/science.1077136","article-title":"Immunity-related genes and gene families in Anopheles gambiae","volume":"298","author":"Christophides","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.meegid.2010.10.006_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.0105-2896.2004.0127.x","article-title":"Comparative and functional genomics of the immune system in the malaria vector Anopheles Gambiae","volume":"198","author":"Christophides","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.meegid.2010.10.006_bib0045","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1534-5807(02)00267-8","article-title":"An immune-responsive Serpin regulates the melanization cascade in Drosophila","volume":"4","author":"De Gregorio","year":"2002","journal-title":"Dev. Cell."},{"key":"10.1016\/j.meegid.2010.10.006_bib0050","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2583.2006.00682.x","article-title":"Immune pathways and defence mechanisms in honey bees Apis mellifera","volume":"15","author":"Evans","year":"2006","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0055","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri2194","article-title":"The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections","volume":"7","author":"Ferrandon","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0060","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/1471-2164-10-489","article-title":"Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes","volume":"10","author":"Garrett","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.meegid.2010.10.006_bib0065","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","article-title":"A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood","volume":"52","author":"Guindon","year":"2003","journal-title":"Syst. Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0070","doi-asserted-by":"crossref","first-page":"12648","DOI":"10.1073\/pnas.221363798","article-title":"Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis","volume":"98","author":"Hao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2010.10.006_bib0075","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1021\/bi00081a008","article-title":"Effects of mutations in the hinge region of serpins","volume":"32","author":"Hopkins","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.meegid.2010.10.006_bib0080","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/j.1365-2958.2006.05180.x","article-title":"Innate immune responses regulate trypanosome parasite infection of the tsetse fly Glossina morsitans morsitans","volume":"60","author":"Hu","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0085","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bioinformatics\/17.8.754","article-title":"MRBAYES: Bayesian inference of phylogeny","volume":"17","author":"Huelsenbeck","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2010.10.006_bib0090","doi-asserted-by":"crossref","first-page":"15119","DOI":"10.1073\/pnas.261573998","article-title":"A genome-wide analysis of immune responses in Drosophila","volume":"98","author":"Irving","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.meegid.2010.10.006_bib0095","doi-asserted-by":"crossref","first-page":"102","DOI":"10.5483\/BMBRep.2008.41.2.102","article-title":"CLIP-domain serine proteases in Drosophila innate immunity","volume":"41","author":"Jang","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.meegid.2010.10.006_bib0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0965-1748(99)00113-7","article-title":"The clip-domain family of serine proteinases in arthropods","volume":"30","author":"Jiang","year":"2000","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0105","series-title":"Insect Immunology","first-page":"69","article-title":"Phenoloxidases in insect immunity","author":"Kanost","year":"2008"},{"key":"10.1016\/j.meegid.2010.10.006_bib0110","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/molbev\/msn067","article-title":"An improved general amino acid replacement matrix","volume":"25","author":"Le","year":"2008","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpara.2007.06.004","article-title":"Differential expression of fat body genes in Glossina morsitans morsitans following infection with Trypanosoma brucei brucei","volume":"38","author":"Lehane","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0120","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.285.5435.1917","article-title":"Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila","volume":"285","author":"Levashina","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.meegid.2010.10.006_bib0125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.embor.7400478","article-title":"Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei","volume":"6","author":"Michel","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.meegid.2010.10.006_bib0130","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1101\/gr.9.11.1143","article-title":"A comprehensive approach to clustering of expressed human gene sequence: the sequence tag alignment and consensus knowledge base","volume":"9","author":"Miller","year":"1999","journal-title":"Genome Res."},{"key":"10.1016\/j.meegid.2010.10.006_bib0135","doi-asserted-by":"crossref","first-page":"21384","DOI":"10.1016\/S0021-9258(19)36934-0","article-title":"Horseshoe crab coagulation factor B. A unique serine protease zymogen activated by cleavage of an Ile\u2013Ile bond","volume":"268","author":"Muta","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2010.10.006_bib0140","doi-asserted-by":"crossref","first-page":"15957","DOI":"10.1016\/S0021-9258(17)33954-6","article-title":"The serpin superfamily of proteinase inhibitors: structure, function, and regulation","volume":"269","author":"Potempa","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2010.10.006_bib0145","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tcb.2005.10.001","article-title":"Tip of another iceberg: Drosophila serpins","volume":"15","author":"Reichhart","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0150","doi-asserted-by":"crossref","first-page":"10560","DOI":"10.1073\/pnas.0401406101","article-title":"The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin","volume":"101","author":"Richer","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2010.10.006_bib0155","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.ibmb.2008.09.001","article-title":"A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori","volume":"38","author":"Tanaka","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0160","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.it.2005.02.006","article-title":"Regulators of the Toll and Imd pathways in the Drosophila innate immune response","volume":"26","author":"Tanji","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0165","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2010.10.006_bib0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.abb.2008.04.030","article-title":"Mutagenesis of the cysteine-rich clip domain in the Drosophila patterning protease, Snake","volume":"475","author":"Tian","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.meegid.2010.10.006_bib0175","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1126\/science.1139862","article-title":"Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes","volume":"316","author":"Waterhouse","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.meegid.2010.10.006_bib0180","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2\u2014a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2010.10.006_bib0185","doi-asserted-by":"crossref","unstructured":"WHO, 2006. Weekly epidemiological record No 8. 81, 69\u201380.","DOI":"10.21608\/jfnile.2006.117038"},{"key":"10.1016\/j.meegid.2010.10.006_bib0190","doi-asserted-by":"crossref","first-page":"14341","DOI":"10.1074\/jbc.M500570200","article-title":"Manduca sexta Serpin-6 regulates immune serine proteinases PAP-3 and HP8","volume":"280","author":"Zou","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2010.10.006_bib0195","doi-asserted-by":"crossref","first-page":"R177","DOI":"10.1186\/gb-2007-8-8-r177","article-title":"Comparative genomic analysis of the Tribolium immune system","volume":"8","author":"Zou","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.meegid.2010.10.006_bib0200","doi-asserted-by":"crossref","first-page":"18454","DOI":"10.1073\/pnas.0804658105","article-title":"Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection","volume":"105","author":"Zou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2010.10.006_bib0205","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ygeno.2008.12.010","article-title":"A comparative analysis of serpin genes in the silkworm genome","volume":"93","author":"Zou","year":"2009","journal-title":"Genomics"}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156713481000287X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156713481000287X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T02:14:36Z","timestamp":1636769676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156713481000287X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S156713481000287X"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2010.10.006","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}