{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:05:24Z","timestamp":1761581124465},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["R01 GM080586"],"award-info":[{"award-number":["R01 GM080586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.meegid.2013.09.011","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T16:00:34Z","timestamp":1379174434000},"page":"239-248","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The evolution and diversity of a low complexity vaccine candidate, merozoite surface protein 9 (MSP-9), in Plasmodium vivax and closely related species"],"prefix":"10.1016","volume":"20","author":[{"given":"Stella M.","family":"Chenet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Andre\u00edna","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Barnwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananias A.","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2013.09.011_b0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/jsbi.2001.4392","article-title":"Protein repeats: structures, functions, and evolution","volume":"134","author":"Andrade","year":"2001","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.meegid.2013.09.011_b0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/expr.1998.4372","article-title":"Plasmodium vivax, P. cynomolgi, and P. knowlesi: identification of homologue proteins associated with the surface of merozoites","volume":"91","author":"Barnwell","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.meegid.2013.09.011_b0015","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/genetics\/163.4.1327","article-title":"Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax","volume":"163","author":"Baum","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.meegid.2013.09.011_b0020","series-title":"The Primate Malaria","author":"Coatney","year":"1971"},{"key":"10.1016\/j.meegid.2013.09.011_b0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0166-6851(02)00327-4","article-title":"Diversity and natural selection in Plasmodium vivax Duffy binding protein gene","volume":"127","author":"Cole-Tobian","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.meegid.2013.09.011_b0030","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cell.2006.02.006","article-title":"Invasion of red blood cells by malaria parasites","volume":"124","author":"Cowman","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.meegid.2013.09.011_b0035","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1016\/S0264-410X(01)00202-X","article-title":"Plasmodium falciparum acid basic repeat antigen (ABRA) peptides: erythrocyte binding and biological activity","volume":"19","author":"Curtidor","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2013.09.011_b0040","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/genetics\/149.1.189","article-title":"Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum","volume":"149","author":"Escalante","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.meegid.2013.09.011_b0045","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pt.2004.06.002","article-title":"Assessing the effect of natural selection in malaria parasites","volume":"20","author":"Escalante","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.meegid.2013.09.011_b0050","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1073\/pnas.0409652102","article-title":"A monkey\u2019s tale: the origin of Plasmodium vivax as a human malaria parasite","volume":"102","author":"Escalante","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.meegid.2013.09.011_b0055","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.bbrc.2005.10.154","article-title":"Two Plasmodium falciparum merozoite proteins binding to erythrocyte band 3 form a direct complex","volume":"338","author":"Kariuki","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.meegid.2013.09.011_b0060","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/bioinformatics\/bti079","article-title":"HyPhy: hypothesis testing using phylogenies","volume":"21","author":"Kosakovsky Pond","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2013.09.011_b0065","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msr125","article-title":"A random effects branch-site model for detecting episodic diversifying selection","author":"Kosakovsky Pond","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2013.09.011_b0070","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1365-3024.2001.00390.x","article-title":"Immunogenicity of recombinant fragments of Plasmodium falciparum acidic basic repeat antigen produced in Escherichia coli","volume":"23","author":"Kushwaha","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.meegid.2013.09.011_b0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0166-6851(02)00077-4","article-title":"Amino terminus of Plasmodium falciparum acidic basic repeat antigen interacts with the erythrocyte membrane through band 3 protein","volume":"122","author":"Kushwaha","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.meegid.2013.09.011_b0080","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1074\/jbc.M308716200","article-title":"A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3","volume":"13","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2013.09.011_b0085","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/bioinformatics\/btp187","article-title":"DnaSP v5: a software for comprehensive analysis of DNA polymorphism data","volume":"25","author":"Librado","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2013.09.011_b0090","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1016\/j.vaccine.2008.09.029","article-title":"Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals","volume":"26","author":"Lima-Junior","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2013.09.011_b0095","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1016\/j.vaccine.2010.02.046","article-title":"Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP-9) induces IFN-gamma and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon","volume":"28","author":"Lima-Junior","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2013.09.011_b0100","doi-asserted-by":"crossref","first-page":"e36419","DOI":"10.1371\/journal.pone.0036419","article-title":"Influence of HLA-DRB1 and HLA-DQB1 alleles on IgG antibody response to the P. vivax MSP-1, MSP-3a and MSP-9 in individuals from Brazilian endemic area","volume":"7","author":"Lima-Junior","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2013.09.011_b0105","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.vaccine.2007.12.042","article-title":"Plasmodium berghei merozoite surface protein-9: immunogenicity and protective efficacy using a homologous challenge model","volume":"26","author":"Lopera-Mesa","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2013.09.011_b0110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/S0031182003004773","article-title":"Plasmodium vivax Duffy binding protein: a modular evolutionary proposal","volume":"128","author":"Martinez","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.meegid.2013.09.011_b0115","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/351652a0","article-title":"Adaptive protein evolution at the Adh locus in Drosophila","volume":"351","author":"McDonald","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.meegid.2013.09.011_b0120","series-title":"Molecular Evolution and Phylogenetics","author":"Nei","year":"2000"},{"key":"10.1016\/j.meegid.2013.09.011_b0125","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0065-2776(08)60695-1","article-title":"Rationale for the development of an engineered sporozoite malaria vaccine","volume":"45","author":"Nussenzweig","year":"1989","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.meegid.2013.09.011_b0130","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0014-4894(92)90253-7","article-title":"Plasmodium falciparum: chymotryptic-like proteolysis associated with a 101-kDa acidic\u2013basic repeat antigen","volume":"75","author":"Nwagwu","year":"1992","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.meegid.2013.09.011_b0135","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.vaccine.2003.07.021","article-title":"Immunogenicity of Plasmodium vivax merozoite surface protein-9 recombinant proteins expressed in E. coli","volume":"22","author":"Oliveira-Ferreira","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2013.09.011_b0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.meegid.2006.08.002","article-title":"A comparative study of the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax","volume":"7","author":"Pacheco","year":"2007","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2013.09.011_b0145","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.meegid.2010.03.013","article-title":"Evidence for negative selection on the gene encoding rhoptry-associated protein 1 (RAP-1) in Plasmodium spp","volume":"10","author":"Pacheco","year":"2010","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2013.09.011_b0150","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/1471-2148-11-299","article-title":"Timing the origin of human malarias: the lemur puzzle","volume":"11","author":"Pacheco","year":"2011","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.meegid.2013.09.011_b0155","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.meegid.2012.02.009","article-title":"Evidence of purifying selection on merozoite surface protein 8 (MSP8) and 10 (MSP10) in Plasmodium spp","volume":"12","author":"Pacheco","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2013.09.011_b0160","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1128\/IAI.68.3.1366-1373.2000","article-title":"Assessing the binding of four Plasmodium falciparum T helper cell epitopes to HLA-DQ and induction of T-cell responses in HLA-DQ transgenic mice","volume":"68","author":"Pimtanothai","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2013.09.011_b0165","doi-asserted-by":"crossref","first-page":"666","DOI":"10.4269\/ajtmh.2005.72.666","article-title":"Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes","volume":"72","author":"Rayner","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2013.09.011_b0170","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.94.24.13040","article-title":"Plasmodium falciparum antigenic diversity: evidence of clonal population structure","volume":"94","author":"Rich","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.meegid.2013.09.011_b0175","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1021\/cr068407v","article-title":"Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design","volume":"108","author":"Rodriguez","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.meegid.2013.09.011_b0180","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btg180","article-title":"MrBayes 3: Bayesian phylogenetic inference under mixed models","volume":"19","author":"Ronquist","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2013.09.011_b0185","doi-asserted-by":"crossref","first-page":"W321","DOI":"10.1093\/nar\/gkh377","article-title":"The predictprotein server","volume":"32","author":"Rost","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2013.09.011_b0190","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.meegid.2013.09.011_b0195","doi-asserted-by":"crossref","first-page":"W471","DOI":"10.1093\/nar\/gks372","article-title":"COFACTOR: An accurate comparative algorithm for structure-based protein function annotation","volume":"40","author":"Roy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2013.09.011_b0200","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol. Biol. Evol."},{"issue":"12","key":"10.1016\/j.meegid.2013.09.011_b0205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1475-2875-12-15","article-title":"Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax?","volume":"11","author":"Schneider","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.meegid.2013.09.011_b0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0169-4758(91)90166-L","article-title":"On the function of repetitive domains in protein antigens of Plasmodium and other eukaryotic parasites","volume":"5","author":"Schofield","year":"1991","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.meegid.2013.09.011_b0215","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1128\/IAI.66.6.2895-2904.1998","article-title":"Characterization of protective epitopes in a highly conserved Plasmodium falciparum antigenic protein containing repeats of acidic and basic residues","volume":"6","author":"Sharma","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2013.09.011_b0220","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2013.09.011_b0225","doi-asserted-by":"crossref","first-page":"e5568","DOI":"10.1371\/journal.pone.0005568","article-title":"Prospective identification of malaria parasite genes under balancing selection","volume":"4","author":"Tetteh","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2013.09.011_b0230","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1086\/424852","article-title":"Antigenic drift in the ligand domain of Plasmodium vivax Duffy binding protein confers resistance to inhibitory antibodies","volume":"190","author":"VanBuskirk","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2013.09.011_b0235","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0166-6851(01)00433-9","article-title":"Merozoite surface protein-9 of Plasmodium vivax and related simian malaria parasites is orthologous to p101\/ABRA of P. falciparum","volume":"120","author":"Vargas-Serrato","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.meegid.2013.09.011_b0240","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1567-1348(03)00007-8","article-title":"Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi","volume":"3","author":"Vargas-Serrato","year":"2003","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2013.09.011_b0245","doi-asserted-by":"crossref","first-page":"11421","DOI":"10.1016\/S0021-9258(18)37973-0","article-title":"Primary structure of a Plasmodium falciparum malaria antigen located at the merozoite surface and within the parasitophorous vacuole","volume":"263","author":"Weber","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2013.09.011_b0250","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0097-8485(94)85023-2","article-title":"Non-globular domains in protein sequences: automated segmentation using complexity measures","volume":"18","author":"Wootton","year":"1994","journal-title":"Comput. Chem."},{"key":"10.1016\/j.meegid.2013.09.011_b0255","unstructured":"World Health Organization (WHO), 2011. World Malaria Report 2011. <http:\/\/www.who.int\/malaria\/world_malaria_report_2011\/en> (accessed July 24, 2012)."},{"key":"10.1016\/j.meegid.2013.09.011_b0260","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134813003523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134813003523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T06:18:07Z","timestamp":1646547487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134813003523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":52,"alternative-id":["S1567134813003523"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2013.09.011","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The evolution and diversity of a low complexity vaccine candidate, merozoite surface protein 9 (MSP-9), in Plasmodium vivax and closely related species","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2013.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}