{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:51:10Z","timestamp":1793746270339,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Colciencias","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005278","name":"University of Antioquia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Banco de la Rep\u00fablica"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.meegid.2014.07.003","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T15:17:37Z","timestamp":1405005457000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["African genetic ancestry is associated with a protective effect on Dengue severity in colombian populations"],"prefix":"10.1016","volume":"27","author":[{"given":"Juan Camilo","family":"Chac\u00f3n-Duque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaustubh","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efren","family":"Avenda\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Ruiz-Linares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta Nelly","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Bedoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2014.07.003_b0005","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrg1916","article-title":"A tutorial on statistical methods for population association studies","volume":"7","author":"Balding","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0010","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1365-3156.2006.01678.x","article-title":"Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever","volume":"11","author":"Bandyopadhyay","year":"2006","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.meegid.2014.07.003_b0015","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1073\/pnas.0508716103","article-title":"Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate","volume":"103","author":"Bedoya","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.meegid.2014.07.003_b0020","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ejhg.2008.4","article-title":"Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population","volume":"16","author":"Blanton","year":"2008","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0025","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.emboj.7601558","article-title":"Human genetics of infectious diseases: a unified theory","volume":"26","author":"Casanova","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.meegid.2014.07.003_b0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrg3114","article-title":"Human genetic susceptibility to infectious disease","volume":"13","author":"Chapman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.micinf.2008.12.006","article-title":"Human genetic determinants of dengue virus susceptibility","volume":"11","author":"Coffey","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.meegid.2014.07.003_b0040","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1469-1809.2009.00510.x","article-title":"Genetic admixture in Brazilians exposed to infection with Leishmania chagasi","volume":"73","author":"Ettinger","year":"2009","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0045","doi-asserted-by":"crossref","first-page":"e1002554","DOI":"10.1371\/journal.pgen.1002554","article-title":"Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas","volume":"8","author":"Galanter","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0050","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3109\/03014460903433810","article-title":"Genetic admixture estimates by Alu elements in Afro-Colombian and Mestizo populations from Antioquia, Colombia","volume":"37","author":"Gomez-Perez","year":"2010","journal-title":"Ann. Hum. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.meegid.2014.07.003_b0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1179\/2046904712Z.00000000045","article-title":"Controversies in dengue pathogenesis","volume":"32","author":"Halstead","year":"2012","journal-title":"Paediatr. Int. Child Health"},{"key":"10.1016\/j.meegid.2014.07.003_b0060","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4269\/ajtmh.2001.65.180","article-title":"Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission","volume":"65","author":"Halstead","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2014.07.003_b0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pharmthera.2012.10.007","article-title":"Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis","volume":"137","author":"Herrero","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.meegid.2014.07.003_b0070","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/(SICI)1097-0258(19980730)17:14<1623::AID-SIM871>3.0.CO;2-S","article-title":"A simple method of sample size calculation for linear and logistic regression","volume":"17","author":"Hsieh","year":"1998","journal-title":"Stat. Med."},{"key":"10.1016\/j.meegid.2014.07.003_b0075","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/ng.960","article-title":"Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1","volume":"43","author":"Khor","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0080","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/infdis\/jis351","article-title":"Dengue research opportunities in the Americas","volume":"206","author":"Laughlin","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.07.003_b0085","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1086\/596507","article-title":"Patterns of gene transcript abundance in the blood of children with severe or uncomplicated dengue highlight differences in disease evolution and host response to dengue virus infection","volume":"199","author":"Long","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.07.003_b0090","first-page":"188","article-title":"Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations","volume":"60","author":"McKeigue","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1469-1809.2000.6420171.x","article-title":"Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African-American populations","volume":"64","author":"McKeigue","year":"2000","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0100","doi-asserted-by":"crossref","first-page":"e1003096","DOI":"10.1371\/journal.pgen.1003096","article-title":"The covariate\u2019s dilemma","volume":"8","author":"Mefford","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0105","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1038\/ng1440","article-title":"Implications of correlations between skin color and genetic ancestry for biomedical research","volume":"36","author":"Parra","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0110","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1086\/302148","article-title":"Estimating African American admixture proportions by use of population-specific alleles","volume":"63","author":"Parra","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2014.05.054","article-title":"The color of health: skin color, ethnoracial classification, and discrimination in the health of Latin Americans","author":"Perreira","year":"2014","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.meegid.2014.07.003_b0155","series-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2008"},{"key":"10.1016\/j.meegid.2014.07.003_b0120","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4269\/ajtmh.2008.79.673","article-title":"Serum levels of cytokines in two ethnic groups with dengue virus infection","volume":"79","author":"Restrepo","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2014.07.003_b0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ajpa.21270","article-title":"Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers","volume":"143","author":"Rojas","year":"2010","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.meegid.2014.07.003_b0130","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1471-8286.2007.01931.x","article-title":"Genepop\u2019007: a complete re-implementation of the genepop software for Windows and Linux","volume":"8","author":"Rousset","year":"2008","journal-title":"Mol. Ecol. Resour."},{"key":"10.1016\/j.meegid.2014.07.003_b0135","article-title":"Purification of nucleic acids by extraction with phenol:chloroform","author":"Sambrook","year":"2006","journal-title":"CSH Protoc."},{"key":"10.1016\/j.meegid.2014.07.003_b0140","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00705-006-0869-x","article-title":"Race. a risk factor for dengue hemorrhagic fever","volume":"152","author":"Sierra","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.meegid.2014.07.003_b0145","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.humimm.2007.03.001","article-title":"HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection","volume":"68","author":"Sierra","year":"2007","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.meegid.2014.07.003_b0150","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"Simmons","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2014.07.003_b0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.soc.34.040507.134657","article-title":"Race mixture: boundary crossing in comparative perspective","volume":"35","author":"Telles","year":"2009","journal-title":"Annu. Rev. Sociol."},{"key":"10.1016\/j.meegid.2014.07.003_b0165","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0065-308X(06)64004-9","article-title":"Human genetic diversity and the epidemiology of parasitic and other transmissible diseases","volume":"64","author":"Tibayrenc","year":"2007","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.meegid.2014.07.003_b0170","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/gepi.21702","article-title":"African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations","volume":"37","author":"Vergara","year":"2013","journal-title":"Genet. Epidemiol."},{"key":"10.1016\/j.meegid.2014.07.003_b0175","doi-asserted-by":"crossref","first-page":"e1000037","DOI":"10.1371\/journal.pgen.1000037","article-title":"Geographic patterns of genome admixture in Latin American Mestizos","volume":"4","author":"Wang","year":"2008","journal-title":"PLoS Genet."},{"issue":"Suppl. 1","key":"10.1016\/j.meegid.2014.07.003_b0180","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1179\/2046904712Z.00000000048","article-title":"The dengue situation in Africa","volume":"32","author":"Were","year":"2012","journal-title":"Paediatr. Int. Child Health"},{"key":"10.1016\/j.meegid.2014.07.003_b0185","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1016\/j.vaccine.2011.07.022","article-title":"The pathogenesis of dengue","volume":"29","author":"Whitehorn","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.meegid.2014.07.003_b0190","unstructured":"WHO, 1997. Dengue Haemorragic Fever: Diagnosis, Treatment, Prevention and Control, Geneva, Switzerland."},{"key":"10.1016\/j.meegid.2014.07.003_b0195","unstructured":"WHO, 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. In: W.H. (Ed.), Organization, Geneva, Switzerland."},{"key":"10.1016\/j.meegid.2014.07.003_b0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-genom-082509-141523","article-title":"Admixture mapping comes of age","volume":"11","author":"Winkler","year":"2010","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.meegid.2014.07.003_b0205","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1517\/phgs.4.4.431.22758","article-title":"Human population structure and genetic association studies","volume":"4","author":"Ziv","year":"2003","journal-title":"Pharmacogenomics"}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814002329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814002329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T06:13:47Z","timestamp":1572761627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134814002329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":41,"alternative-id":["S1567134814002329"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2014.07.003","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"African genetic ancestry is associated with a protective effect on Dengue severity in colombian populations","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2014.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}