{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:43:33Z","timestamp":1768567413236,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.meegid.2014.09.032","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T18:27:31Z","timestamp":1412360851000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-1721","authenticated-orcid":false,"given":"Xiaowei","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2014.09.032_b0005","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.3748\/wjg.15.5761","article-title":"Clinical relevance and public health significance of hepatitis B virus genomic variations","volume":"15","author":"Cao","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.meegid.2014.09.032_b0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jcv.2006.12.007","article-title":"Improved multiplex-PCR to identify hepatitis B virus genotypes A-F and subgenotypes B1, B2, C1 and C2","volume":"38","author":"Chen","year":"2007","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.meegid.2014.09.032_b0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.2006.114066","article-title":"Temporal relationship between hepatitis B virus enhancer II\/basal core promoter sequence variation and risk of hepatocellular carcinoma","volume":"57","author":"Chou","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.meegid.2014.09.032_b0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.canlet.2013.09.041","article-title":"Human cytidine deaminases facilitate hepatitis B virus evolution and link inflammation and hepatocellular carcinoma","volume":"343","author":"Deng","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.meegid.2014.09.032_b0025","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/08820130802111605","article-title":"HLA-class II alleles in Egyptian patients with hepatocellular carcinoma","volume":"37","author":"El-Chennawi","year":"2008","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.meegid.2014.09.032_b0030","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/hep.24799","article-title":"Genetic variants in human leukocyte antigen\/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development","volume":"55","author":"Hu","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.meegid.2014.09.032_b0035","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1200\/JCO.2011.36.2335","article-title":"Lifetime risk and sex difference of hepatocellular carcinoma among patients with chronic hepatitis B and C","volume":"29","author":"Huang","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.meegid.2014.09.032_b0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ng.2483","article-title":"Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma","volume":"45","author":"Jiang","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2014.09.032_b0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ng.348","article-title":"A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians","volume":"41","author":"Kamatani","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2014.09.032_b0050","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2893.2003.00487.x","article-title":"Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures","volume":"11","author":"Lavanchy","year":"2004","journal-title":"J. Viral Hepat."},{"issue":"12","key":"10.1016\/j.meegid.2014.09.032_b0055","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1128\/JCM.01505-13","article-title":"Male-specific W4P\/R mutation in the pre-S1 region of hepatitis B virus, increasing the risk of progression of liver diseases in chronic patients","volume":"51","author":"Lee","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2014.09.032_b0060","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jmv.21829","article-title":"A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma","volume":"83","author":"Liu","year":"2011","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2014.09.032_b0065","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/jnci\/djp180","article-title":"Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis","volume":"101","author":"Liu","year":"2009","journal-title":"J. Natl Cancer Inst."},{"issue":"1","key":"10.1016\/j.meegid.2014.09.032_b0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jcv.2014.06.010","article-title":"Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era","volume":"61","author":"Li","year":"2014","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.meegid.2014.09.032_b0075","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1128\/JVI.02142-10","article-title":"Immune-induced evolutionary selection focused on a single reading frame in overlapping hepatitis B virus proteins","volume":"85","author":"Maman","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2014.09.032_b0080","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1093\/hmg\/ddr301","article-title":"A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population","volume":"20","author":"Mbarek","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.meegid.2014.09.032_b0085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.meegid.2013.08.013","article-title":"Genotyping and molecular characterization of hepatitis B virus in liver disease patients in Kenya","volume":"20","author":"Ochwoto","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2014.09.032_b0090","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.meegid.2014.09.032_b0095","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJM199504203321604","article-title":"Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia","volume":"332","author":"Thursz","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2014.09.032_b0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ajg.2010.399","article-title":"Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma","volume":"106","author":"Yin","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.meegid.2014.09.032_b0105","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00535-010-0253-1","article-title":"Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma","volume":"45","author":"Yin","year":"2010","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.meegid.2014.09.032_b0110","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/carcin\/bgm301","article-title":"Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area","volume":"29","author":"Yin","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.meegid.2014.09.032_b0115","doi-asserted-by":"crossref","first-page":"12176","DOI":"10.1128\/JVI.02073-13","article-title":"HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations","volume":"87","author":"Zhang","year":"2013","journal-title":"J. Virol."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814003669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814003669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T17:23:40Z","timestamp":1538155420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134814003669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":23,"alternative-id":["S1567134814003669"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2014.09.032","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2014.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}