{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:54:39Z","timestamp":1791424479469,"version":"4.3.3"},"reference-count":126,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.meegid.2014.10.020","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T01:01:35Z","timestamp":1415062895000},"page":"371-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"special_numbering":"C","title":["Natural transformation and genome evolution in Streptococcus pneumoniae"],"prefix":"10.1016","volume":"33","author":[{"given":"Daniel","family":"Straume","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro Anita","family":"Stams\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiv Sigve","family":"H\u00e5varstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2014.10.020_b0005","doi-asserted-by":"crossref","first-page":"e1002156","DOI":"10.1371\/journal.pgen.1002156","article-title":"Role of the single-stranded DNA-binding protein SsbB in pneumococcal transformation: maintenance of a reservoir for genetic plasticity","volume":"7","author":"Attaiech","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.79.2.137","article-title":"Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III","volume":"79","author":"Avery","year":"1944","journal-title":"J. Exp. Med."},{"issue":"234","key":"10.1016\/j.meegid.2014.10.020_b0015","first-page":"237","article-title":"The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases","volume":"28","author":"Bateman","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.meegid.2014.10.020_b0020","doi-asserted-by":"crossref","first-page":"E905","DOI":"10.1073\/pnas.1119172109","article-title":"Control of cell division in Streptococcus pneumoniae by the conserved Ser\/Thr kinase StkP","volume":"109","author":"Beilharz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0025","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/IAI.01511-07","article-title":"Population diversity and dynamics of Streptococcus mitis, Streptococcus oralis, and Streptococcus infantis in the upper respiratory tracts of adults, determined by a nonculture strategy","volume":"76","author":"Bek-Thomsen","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2014.10.020_b0030","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pgen.0020031","article-title":"Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes","volume":"2","author":"Bentley","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0035","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1128\/AEM.00098-12","article-title":"Properties and biological role of streptococcal fratricins","volume":"78","author":"Berg","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0040","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1128\/JB.06273-11","article-title":"LytF, a novel competence-regulated murein hydrolase in the genus Streptococcus","volume":"194","author":"Berg","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0045","doi-asserted-by":"crossref","first-page":"e1003596","DOI":"10.1371\/journal.ppat.1003596","article-title":"Midcell recruitment of the DNA uptake and virulence nuclease, EndA, for pneumococcal transformation","volume":"9","author":"Berg\u00e9","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.meegid.2014.10.020_b0050","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1098\/rspb.2009.1679","article-title":"Horizontal gene transfer in evolution: facts and challenges","volume":"277","author":"Boto","year":"2010","journal-title":"Proc. R. Soc. B"},{"key":"10.1016\/j.meegid.2014.10.020_b0055","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1093\/nar\/gku110","article-title":"Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae","volume":"42","author":"Boudes","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2014.10.020_b0060","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1365-2958.2011.07730.x","article-title":"The secretion ATPase ComGA is required for the binding and transport of transforming DNA","volume":"81","author":"Briley","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0065","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1371\/journal.ppat.0030168","article-title":"Vaccine escape recombinants emerge after pneumococcal vaccination in the United States","volume":"3","author":"Brueggemann","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.meegid.2014.10.020_b0070","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1128\/JB.00573-07","article-title":"Search for genes essential for pneumococcal transformation: the RadA DNA repair protein plays a role in genomic recombination of donor DNA","volume":"189","author":"Burghout","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0075","doi-asserted-by":"crossref","first-page":"a000406","DOI":"10.1101\/cshperspect.a000406","article-title":"Membrane-associated DNA transport machines","volume":"2","author":"Burton","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.meegid.2014.10.020_b0080","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-2958.1998.00737.x","article-title":"A competence regulon in Streptococcus pneumoniae revealed by genomic analysis","volume":"27","author":"Campbell","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0085","doi-asserted-by":"crossref","first-page":"38449","DOI":"10.1074\/jbc.M112.391482","article-title":"The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide","volume":"287","author":"Cassone","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2014.10.020_b0090","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1073\/pnas.1218832110","article-title":"Specific DNA recognition mediated by a type IV pilin","volume":"110","author":"Cehovin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/ng.2895","article-title":"Dense genomic sampling identifies highways of pneumococcal recombination","volume":"46","author":"Chewapreecha","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0100","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ijmm.2007.02.009","article-title":"Crossing the barrier: evolution and spread of a major class of mosaic pbp2x in Streptococcus pneumoniae, S. mitis and S. oralis","volume":"297","author":"Chi","year":"2007","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1089\/mdr.1998.4.325","article-title":"Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates causing respiratory disease in the United States","volume":"4","author":"Corso","year":"1998","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.meegid.2014.10.020_b0110","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.1198545","article-title":"Rapid pneumococcal evolution in response to clinical interventions","volume":"331","author":"Croucher","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.meegid.2014.10.020_b0115","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1473-3099(08)70281-0","article-title":"Impact of conjugate pneumococcal vaccines on antibiotic resistance","volume":"8","author":"Dagan","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.meegid.2014.10.020_b0120","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1365-2958.2003.03892.x","article-title":"Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of CiaR mutant cells","volume":"51","author":"Dagkessamanskaia","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00035-13","article-title":"Bacterial genome instability","volume":"78","author":"Darmon","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.meegid.2014.10.020_b0130","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1365-2958.2006.05150.x","article-title":"Evolution of mutation rates in bacteria","volume":"60","author":"Denamur","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0135","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1365-2958.2006.05558.x","article-title":"Transformation in Streptococcus pneumoniae: formation of eclipse complex in a coiA mutant implicates CoiA in genetic recombination","volume":"63","author":"Desai","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tim.2010.04.002","article-title":"Impact of recombination on bacterial evolution","volume":"18","author":"Didelot","year":"2010","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0145","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2010-11-10-r107","article-title":"Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species","volume":"11","author":"Donati","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.meegid.2014.10.020_b0150","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1365-2958.1993.tb01723.x","article-title":"Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2b in S. pneumoniae","volume":"9","author":"Dowson","year":"1993","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0155","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1128\/IAI.72.4.2434-2437.2004","article-title":"Protein serine\/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae","volume":"72","author":"Echenique","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2014.10.020_b0160","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1099\/mic.0.026328-0","article-title":"Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC","volume":"155","author":"Eldholm","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.meegid.2014.10.020_b0165","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1365-2958.2010.07143.x","article-title":"Pneumococcal CbpD is a murein hydrolase that requires a dual cell envelope binding specificity to kill target cells during fratricide","volume":"76","author":"Eldholm","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0170","doi-asserted-by":"crossref","first-page":"e1003758","DOI":"10.1371\/journal.ppat.1003758","article-title":"Conservative sex and the benefits of transformation in Streptococcus pneumoniae","volume":"9","author":"Engelmoer","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.meegid.2014.10.020_b0175","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0180","doi-asserted-by":"crossref","first-page":"e1004275","DOI":"10.1371\/journal.pgen.1004275","article-title":"Interplay of the Serine\/Threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division","volume":"10","author":"Fleurie","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0185","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000332748","article-title":"Stress-induced modulators of repeat instability and genome evolution","volume":"21","author":"Fonville","year":"2011","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.meegid.2014.10.020_b0190","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/10409230701648494","article-title":"Stress-induced mutagenesis in bacteria","volume":"42","author":"Foster","year":"2007","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.meegid.2014.10.020_b0195","doi-asserted-by":"crossref","first-page":"e1003458","DOI":"10.1371\/journal.pgen.1003458","article-title":"Dialects of the DNA uptake sequence in Neisseriaceae","volume":"9","author":"Frye","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0200","doi-asserted-by":"crossref","first-page":"e72613","DOI":"10.1371\/journal.pone.0072613","article-title":"Competence in Streptococcus pneumoniae is a response to an increasing mutational burden","volume":"8","author":"Gagne","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2014.10.020_b0205","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1099\/mic.0.036335-0","article-title":"The pneumococcal eukaryotic-type serine\/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro","volume":"156","author":"Giefing","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.meegid.2014.10.020_b0210","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.1072","article-title":"Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event","volume":"3","author":"Golubchik","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0215","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1128\/AAC.00336-07","article-title":"Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis","volume":"51","author":"Gould","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2014.10.020_b0220","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1017\/S0022172400031879","article-title":"The significance of pneumococcal types","volume":"27","author":"Griffith","year":"1928","journal-title":"J. Hyg."},{"key":"10.1016\/j.meegid.2014.10.020_b0225","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2958.1994.tb01038.x","article-title":"A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae","volume":"12","author":"Guenzi","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0230","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1073\/pnas.0500879102","article-title":"Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements","volume":"102","author":"Guiral","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0235","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/elps.1150190423","article-title":"Mosaic genes and their role in penicillin-resistant Streptococcus pneumoniae","volume":"19","author":"Hakenbeck","year":"1998","journal-title":"Electrophoresis"},{"key":"10.1016\/j.meegid.2014.10.020_b0240","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2217\/fmb.12.2","article-title":"Molecular mechanisms of \u03b2-lactam resistance in Streptococcus pneumoniae","volume":"7","author":"Hakenbeck","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0245","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2958.2007.05900.x","article-title":"Identification of the genes directly controlled by the response regulator CiaR in Streptococcus pneumoniae: five out of 15 promoters drive expression of small non-coding RNAs","volume":"66","author":"Halfmann","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0250","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1126\/science.1171908","article-title":"Hyper-recombination, diversity, and antibiotic resistance in pneumococcus","volume":"324","author":"Hanage","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.meegid.2014.10.020_b0255","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0140-6736(67)92346-X","article-title":"A resistant pneumococcus","volume":"2","author":"Hansman","year":"1967","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2014.10.020_b0260","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1073\/pnas.92.24.11140","article-title":"An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae","volume":"92","author":"H\u00e5varstein","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0265","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2958.1995.tb02295.x","article-title":"A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export","volume":"16","author":"H\u00e5varstein","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0270","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1046\/j.1365-2958.1996.521416.x","article-title":"Identification of the streptococcal competence-pheromone receptor","volume":"21","author":"H\u00e5varstein","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0275","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1365-2958.2005.05021.x","article-title":"New insights into the pneumococcal fratricide: relationship to clumping and identification of a novel immunity factor","volume":"59","author":"H\u00e5varstein","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0280","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1128\/JB.00690-07","article-title":"Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome","volume":"189","author":"Hiller","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1399-302X.1995.tb00113.x","article-title":"Clonal diversity of the Streptococcus mitis biovar 1 population in the human oral cavity and pharynx","volume":"10","author":"Hohwy","year":"1995","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.meegid.2014.10.020_b0290","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.2008-3099","article-title":"Continued impact of pneumococcal conjugate vaccine on carriage in young children","volume":"124","author":"Huang","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.meegid.2014.10.020_b0295","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1128\/jb.173.1.372-381.1991","article-title":"Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family","volume":"173","author":"Hui","year":"1991","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0300","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1056\/NEJM197810052991402","article-title":"Emergence of multiply resistant pneumococci","volume":"299","author":"Jacobs","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2014.10.020_b0305","series-title":"Molecular Biology of Streptococci","first-page":"25","article-title":"Biologically active peptides in streptococci","author":"Johnsborg","year":"2007"},{"key":"10.1016\/j.meegid.2014.10.020_b0310","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2958.2008.06288.x","article-title":"A predatory mechanism dramatically increases the efficiency of lateral gene transfer in Streptococcus pneumoniae and related commensal species","volume":"69","author":"Johnsborg","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0315","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrmicro3199","article-title":"Bacterial transformation: distribution, shared mechanisms and divergent control","volume":"12","author":"Johnston","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0320","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tim.2014.01.002","article-title":"Streptococcus pneumoniae, le transformiste","volume":"22","author":"Johnston","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0325","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1128\/JB.187.13.4338-4345.2005","article-title":"Choline-binding protein D (CbpD) in Streptococcus pneumoniae is essential for competence-induced cell lysis","volume":"187","author":"Kausmally","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0330","doi-asserted-by":"crossref","first-page":"e2683","DOI":"10.1371\/journal.pone.0002683","article-title":"Evolution of Streptococcus pneumoniae and its close commensal relatives","volume":"3","author":"Kilian","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2014.10.020_b0335","doi-asserted-by":"crossref","first-page":"e01490","DOI":"10.1128\/mBio.01490-14","article-title":"Parallel evolution of Streptococcus pneumoniae and Streptococcus mitis to pathogenic and mutualistic lifestyles","volume":"5","author":"Kilian","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.meegid.2014.10.020_b0340","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0006-3002(60)90205-5","article-title":"A study of the genetic material determining an enzyme in pneumococcus","volume":"39","author":"Lacks","year":"1960","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.meegid.2014.10.020_b0345","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1128\/JB.123.1.222-232.1975","article-title":"Identification of a deoxyribonuclease implicated in genetic transformation of Diplococcus pneumoniae","volume":"123","author":"Lacks","year":"1975","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0350","doi-asserted-by":"crossref","first-page":"e1003473","DOI":"10.1371\/journal.ppat.1003473","article-title":"A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae","volume":"9","author":"Laurenceau","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.meegid.2014.10.020_b0355","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000106080","article-title":"Characterization of proteins belonging to the CHAP-related superfamily within the Firmicutes","volume":"14","author":"Layec","year":"2008","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.meegid.2014.10.020_b0360","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1128\/JB.181.16.5004-5016.1999","article-title":"Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation","volume":"181","author":"Lee","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0365","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1469-0691.2010.03182.x","article-title":"Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period","volume":"16","author":"Li\u00f1ares","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.meegid.2014.10.020_b0370","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1093\/nar\/gku349","article-title":"Molecular determinants of the DprA-RecA interaction for nucleation on ssDNA","volume":"42","author":"Lisboa","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2014.10.020_b0375","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1128\/IAI.00020-06","article-title":"Lysogeny of Streptococcus pneumoniae with MM1 phage: improved adherence and other phenotypic changes","volume":"74","author":"Loeffler","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2014.10.020_b0380","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.febslet.2010.12.016","article-title":"Recognition of peptidoglycan and \u03b2-lactam antibiotics by the extracellular domain of the Ser\/Thr protein kinase StkP from Streptococcus pneumoniae","volume":"585","author":"Maestro","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.meegid.2014.10.020_b0385","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1093\/molbev\/msl115","article-title":"Gene gain and gene loss in Streptococcus: is it driven by habitat?","volume":"23","author":"Marri","year":"2006","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2014.10.020_b0390","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/j.1365-2958.2010.07071.x","article-title":"Expression and maintenance of ComD\u2013ComE, the two-component signal-transduction system that controls competence of Streptococcus pneumoniae","volume":"75","author":"Martin","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0395","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/mmi.12104","article-title":"ComE\/ComE\u223cP interplay dictates activation or extinction status of pneumococcal X-state (competence)","volume":"87","author":"Martin","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0400","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1016\/S0021-9258(18)53362-7","article-title":"DNA processing during entry in transformation of Streptococcus pneumoniae","volume":"268","author":"Mejean","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2014.10.020_b0405","first-page":"1","article-title":"Serotype distribution and antimicrobial susceptibility of USA Streptococcus pneumoniae isolates collected prior to and post introduction of 13-valent pneumococcal conjugate vaccine","author":"Mendes","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.10.020_b0410","doi-asserted-by":"crossref","first-page":"E1035","DOI":"10.1073\/pnas.1219868110","article-title":"Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence","volume":"110","author":"Mirouze","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0415","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1128\/AAC.47.7.2236-2241.2003","article-title":"Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae","volume":"47","author":"Montanari","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2014.10.020_b0420","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1093\/nar\/gkq1152","article-title":"Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae","volume":"39","author":"Moon","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2014.10.020_b0425","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1086\/528996","article-title":"Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005","volume":"197","author":"Moore","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.10.020_b0430","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/AAC.47.4.1464-1467.2003","article-title":"Frequency of mutation to rifampin resistance in Streptococcus pneumoniae clinical strains: hexA and hexB polymorphisms do not account for hypermutation","volume":"47","author":"Morosini","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2014.10.020_b0435","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0923-2508(00)00171-6","article-title":"Regulation of competence for genetic transformation in Streptococcus pneumoniae: a link between quorum sensing and DNA processing genes","volume":"151","author":"Morrison","year":"2000","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0440","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2958.1998.00668.x","article-title":"Competence-specific induction of recA is required for full recombination proficiency during transformation in Streptococcus pneumoniae","volume":"27","author":"Mortiere-Barri\u00e8re","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0445","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2007.07.038","article-title":"A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA","volume":"130","author":"Mortier-Barri\u00e8re","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.meegid.2014.10.020_b0450","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.2041-1014.2012.00655.x","article-title":"Pneumococcal surface proteins: when the whole is greater than the sum of its parts","volume":"27","author":"P\u00e9rez-Dorado","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0455","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1046\/j.1365-2958.1996.501417.x","article-title":"Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system","volume":"21","author":"Pestova","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0460","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1128\/JB.182.21.6192-6202.2000","article-title":"Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays","volume":"182","author":"Peterson","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0465","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1046\/j.1365-2958.2003.03907.x","article-title":"Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays","volume":"51","author":"Peterson","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0470","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1186\/1471-2164-10-642","article-title":"Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae","volume":"10","author":"Pillai","year":"2009","journal-title":"BMC Genet."},{"key":"10.1016\/j.meegid.2014.10.020_b0475","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1128\/JB.01750-08","article-title":"Competence for genetic transformation in Streptococcus pneumoniae: termination of activity of the alternative sigma factor ComX is independent of proteolysis of ComX and ComW","volume":"191","author":"Piotrowski","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0480","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1127912","article-title":"Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae","volume":"313","author":"Prudhomme","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.meegid.2014.10.020_b0485","doi-asserted-by":"crossref","first-page":"E2466","DOI":"10.1073\/pnas.1205638109","article-title":"Structure-function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation","volume":"109","author":"Quevillon-Cheruel","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0490","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1128\/JB.181.12.3618-3625.1999","article-title":"A high incidence of prophage carriage among natural isolates of Streptococcus pneumoniae","volume":"181","author":"Ramirez","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0495","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.tim.2009.03.002","article-title":"A modular master on the move: the Tn916 family of mobile genetic elements","volume":"17","author":"Roberts","year":"2009","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0500","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1574-6976.2011.00283.x","article-title":"Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance","volume":"35","author":"Roberts","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.meegid.2014.10.020_b0505","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1128\/JB.01272-08","article-title":"Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages","volume":"191","author":"Romero","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0510","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.2041-1014.2011.00635.x","article-title":"Identification of a functional capsule locus in Streptococcus mitis","volume":"27","author":"Rukke","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0515","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1128\/JCM.03280-13","article-title":"Nasopharyngeal microbiota in healthy children and pneumonia patients","volume":"52","author":"Sakwinska","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0520","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1574-6968.2008.01408.x","article-title":"Conjugal mobilization of the mega element carrying mef (E) from Streptococcus salivarius to Streptococcus pneumoniae","volume":"290","author":"Santagati","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.meegid.2014.10.020_b0525","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1128\/JB.01616-06","article-title":"Eukaryotic-type serine\/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae","volume":"189","author":"Saskov\u00e1","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0530","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/mmi.12009","article-title":"Streptococcus pneumoniae R6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome-wide recombination events","volume":"86","author":"Sauerbier","year":"2012","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0535","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/mmi.12277","article-title":"Target evaluation of the non-coding csRNAs reveals a link of the two-component regulatory system CiaRH to competence control in Streptococcus pneumoniae R6","volume":"89","author":"Schnorpfeil","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0540","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1128\/JB.187.12.3969-3979.2005","article-title":"Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system","volume":"187","author":"Sebert","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0545","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2958.1994.tb01089.x","article-title":"Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis","volume":"12","author":"Sibold","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0550","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cell.2014.01.068","article-title":"Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin","volume":"157","author":"Slager","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.meegid.2014.10.020_b0555","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1073\/pnas.112464599","article-title":"Induction of natural competence in Streptococcus pneumoniae triggers lysis and DNA release from a subfraction of the cell population","volume":"99","author":"Steinmoen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.meegid.2014.10.020_b0560","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1128\/JB.185.24.7176-7183.2003","article-title":"Competence-induced cells of Streptococcus pneumoniae lyse competence-deficient cells of the same strain during cocultivation","volume":"185","author":"Steinmoen","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0565","doi-asserted-by":"crossref","first-page":"e00071","DOI":"10.1128\/mBio.00071-11","article-title":"Competence in Streptococcus pneumoniae is regulated by the rate of ribosomal decoding errors","volume":"2","author":"Stevens","year":"2011","journal-title":"mBio"},{"key":"10.1016\/j.meegid.2014.10.020_b0570","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1128\/JB.187.9.3052-3061.2005","article-title":"Two distinct functions of ComW in stabilization and activation of the alternative sigma factor ComX in Streptococcus pneumoniae","volume":"187","author":"Sung","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0575","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jbiosc.2011.02.006","article-title":"Role of ComFA in controlling the DNA uptake rate during transformation of competent Bacillus subtilis","volume":"111","author":"Takeno","year":"2011","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.meegid.2014.10.020_b0580","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrmicro1234","article-title":"Mechanisms of, and barriers to, horizontal gene transfer between bacteria","volume":"3","author":"Thomas","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0585","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1128\/JB.01933-14","article-title":"Competence for genetic transformation in Streptococcus pneumoniae: mutations in \u03c3A bypass the comW requirement","volume":"196","author":"Tovpeko","year":"2014","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2014.10.020_b0590","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1365-2958.1999.01528.x","article-title":"Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniae","volume":"33","author":"Ween","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0595","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1128\/AEM.01343-12","article-title":"Fratricide is essential for efficient gene transfer between pneumococci in biofilms","volume":"78","author":"Wei","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.meegid.2014.10.020_b0600","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/S0140-6736(10)62225-8","article-title":"Serotype replacement in disease after pneumococcal vaccination","volume":"378","author":"Weinberger","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2014.10.020_b0605","doi-asserted-by":"crossref","first-page":"e64197","DOI":"10.1371\/journal.pone.0064197","article-title":"Exit from competence for genetic transformation in Streptococcus pneumoniae is regulated at multiple levels","volume":"8","author":"Weng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2014.10.020_b0610","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1056\/NEJM200012283432603","article-title":"Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States","volume":"343","author":"Whitney","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2014.10.020_b0615","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa022823","article-title":"Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine","volume":"348","author":"Whitney","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2014.10.020_b0620","doi-asserted-by":"crossref","first-page":"e102045","DOI":"10.1371\/journal.pone.0102045","article-title":"Streptococcus pneumoniae in saliva of Dutch primary school children","volume":"9","author":"Wyllie","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2014.10.020_b0625","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/infdis\/jis703","article-title":"Pneumococcal capsular switching: a historical perspective","volume":"207","author":"Wyres","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.10.020_b0630","first-page":"211","article-title":"The ciaR\/ciaH regulatory network of Streptococcus pneumoniae","volume":"4","author":"Z\u00e4hner","year":"2002","journal-title":"J. Mol. Microbiol. Biotechnol."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814003918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814003918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T03:52:36Z","timestamp":1650513156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134814003918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":126,"alternative-id":["S1567134814003918"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2014.10.020","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural transformation and genome evolution in Streptococcus pneumoniae","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2014.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}