{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:09:08Z","timestamp":1771538948774,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Francisco Jos\u00e9 de Caldas \u2013 COLCIENCIAS"},{"name":"Uni\u00f3n Temporal Programa Nacional de Investigaci\u00f3n para la prevenci\u00f3n, control y tratamiento integral de la enfermedad de Chagas en Colombia","award":["380-2011"],"award-info":[{"award-number":["380-2011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.meegid.2014.11.012","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T18:18:36Z","timestamp":1416507516000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Comparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental model"],"prefix":"10.1016","volume":"29","author":[{"given":"Lissa","family":"Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angie","family":"Vivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleny","family":"Montilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Fl\u00f3rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan David","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2014.11.012_b0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0166-6851(99)90035-X","article-title":"Differential tissue distribution of diverse clones of Trypanosoma cruzi in infected mice","author":"Andrade","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0010","first-page":"269","article-title":"Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations","author":"Andrade","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.recesp.2012.07.006","article-title":"Estratificaci\u00f3n del riesgo en la enfermedad de Chagas","volume":"65","author":"Barbosa","year":"2012","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.meegid.2014.11.012_b0020","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4269\/ajtmh.2008.78.294","article-title":"Molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS","volume":"78","author":"Burgos","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2014.11.012_b0025","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1086\/655680","article-title":"Molecular identification of Trypanosoma cruzi discrete typing units in end-stage chronic Chagas heart disease and reactivation after heart transplantation","volume":"51","author":"Burgos","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0030","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ijpara.2010.06.006","article-title":"Trypanosoma cruzi I genotypes in different geographical regions and transmission cycles based on a microsatellite motif of the intergenic spacer of spliced-leader genes","volume":"40","author":"Cura","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1084\/jem.20011433","article-title":"A Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas disease is due to a single parasite lineage","volume":"195","author":"Di Noia","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.meegid.2014.11.012_b0040","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.exppara.2012.02.016","article-title":"Biological behaviour in mice of Trypanosoma cruzi isolates from Amazonas and Paran\u00e1, Brazil","volume":"130","author":"Dos Reis","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0045","doi-asserted-by":"crossref","first-page":"e2000","DOI":"10.1371\/journal.pntd.0002000","article-title":"Analytical performance of a multiplex Real-Time PCR assay using TaqMan probes for quantification of Trypanosoma cruzi satellite ADN in blood samples","volume":"7","author":"Duffy","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0050","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0123-9392(11)70736-6","article-title":"Evaluaci\u00f3n de la variabilidad gen\u00e9tica de aislamientos colombianos de Trypanosoma cruzi mediante marcadores microsat\u00e9lites","volume":"15","author":"Duque","year":"2011","journal-title":"Infection"},{"issue":"12\u201313","key":"10.1016\/j.meegid.2014.11.012_b0055","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.micinf.2011.06.002","article-title":"Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease","volume":"13","author":"Ferreira","year":"2011","journal-title":"Microb. Infect."},{"key":"10.1016\/j.meegid.2014.11.012_b0060","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00436-010-1874-2","article-title":"Chagasic megacolon associated with Trypanosoma cruzi I in a Colombian patient","volume":"107","author":"Fl\u00f3rez","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.meegid.2014.11.012_b0065","doi-asserted-by":"crossref","first-page":"e5113","DOI":"10.1371\/journal.pone.0005113","article-title":"The MHC gene region of murine hosts influences the differential tissue tropism of infecting Trypanosoma cruzi strains","author":"Freitas","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2014.11.012_b0070","first-page":"228","article-title":"Enfermedad de Chagas: Realidad y perspectivas","volume":"20","author":"Guhl","year":"2009","journal-title":"Rev. Biomed."},{"key":"10.1016\/j.meegid.2014.11.012_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2011.04.002","article-title":"Trypanosoma cruzi I diversity: towards the need of genetic subdivision?","volume":"119","author":"Guhl","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.meegid.2014.11.012_b0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.meegid.2006.12.003","article-title":"Infection Identifying four Trypanosoma cruzi I isolate haplotypes from different geographic regions in Colombia","volume":"7","author":"Herrera","year":"2007","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2014.11.012_b0085","doi-asserted-by":"crossref","unstructured":"Herrera, C., Guhl, F., Falla, A., Fajardo, A., Montilla, M. et al., 2009. Genetic Variability and phylogenetic relationships within Trypanosoma cruzi I isolated in colombia based on miniexon gene sequences. J. Parasitol. Res., pii: 897364.","DOI":"10.1155\/2009\/897364"},{"issue":"3","key":"10.1016\/j.meegid.2014.11.012_b0090","first-page":"210","article-title":"Trypanosoma cruzi: parasitismo del tejido conectivo adiposo","volume":"15","author":"Herrera","year":"2005","journal-title":"Rev. Cient."},{"key":"10.1016\/j.meegid.2014.11.012_b0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/B978-0-12-385863-4.00009-5","article-title":"Advances in imaging of animal models of Chagas disease","volume":"75","author":"Jelicks","year":"2011","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0100","doi-asserted-by":"crossref","first-page":"e510","DOI":"10.1371\/journal.pntd.0000510","article-title":"Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent chagas disease","volume":"3","author":"Llewellyn","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0105","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ijpara.2010.12.004","article-title":"Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection","volume":"41","author":"Llewellyn","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0110","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.humpath.2009.11.005","article-title":"Mixed infection of Trypanosoma cruzi I and II in a Colombian cardiomyopathic patient","volume":"41","author":"Mantilla","year":"2010","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.meegid.2014.11.012_b0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1017\/S0031182009005861","article-title":"A new genotype of Trypanosoma cruzi associated with bats evidenced by phylogenetic analyses using SSU rADN, cytochrome b and Histone H2B genes and genotyping based on ITS1 rADN","volume":"136","author":"Marcili","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.meegid.2014.11.012_b0120","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1645\/GE-212R","article-title":"Challenge of Trypanosoma cruzi chronically infected mice with trypomastigotes activates the immune system and reduces subpatent parasitemia levels","author":"Marinho","year":"2004","journal-title":"J. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0125","doi-asserted-by":"crossref","first-page":"e1584","DOI":"10.1371\/journal.pntd.0001584","article-title":"Multiple mitochondrial introgression events and heteroplasmy in Trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing","volume":"6","author":"Messenger","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0130","doi-asserted-by":"crossref","first-page":"e41284","DOI":"10.1371\/journal.pone.0041284","article-title":"Trypanosoma cruzi IV causing outbreaks of acute Chagas disease and infections by different haplotypes in the Western Brazilian Amazonia","volume":"7","author":"Monteiro","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2014.11.012_b0135","doi-asserted-by":"crossref","first-page":"e915","DOI":"10.1371\/journal.pntd.0000915","article-title":"Sex, subdivision, and domestic dispersal of Trypanosoma cruzi lineage I in southern Ecuador","volume":"4","author":"Oca\u00f1a","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0140","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.meegid.2012.04.013","article-title":"TcBat a bat-exclusive lineage of Trypanosoma cruzi in the Panama Canal Zone, with comments on its classification and the use of the 18S rRNA gene for lineage identification","volume":"12","author":"Pinto","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2014.11.012_b0145","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actatropica.2012.05.003","article-title":"Biological behavior of different Trypanosoma cruzi isolates circulating in an endemic area for Chagas disease in the Gran Chaco region of Argentina","volume":"123","author":"Ragone","year":"2012","journal-title":"Acta Trop."},{"key":"10.1016\/j.meegid.2014.11.012_b0150","unstructured":"Ram\u00edrez, C., Jaramillo, A., Becerra, A., Monsalve, E., Villareal, W. et al., 2007. Lesi\u00f3n cerebral como presentaci\u00f3n de la enfermedad de Chagas. Primer caso reportado en Colombia. Acta Neurol. Colomb. 23, 15\u201318."},{"key":"10.1016\/j.meegid.2014.11.012_b0155","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1128\/JCM.01601-09","article-title":"Evaluation of adult chronic chagas heart disease diagnosis by molecular and serological methods","volume":"47","author":"Ram\u00edrez","year":"2009","journal-title":"J. Clin. Microbiol."},{"issue":"4","key":"10.1016\/j.meegid.2014.11.012_b0160","doi-asserted-by":"crossref","first-page":"e899","DOI":"10.1371\/journal.pntd.0000899","article-title":"Chagas cardiomyopathy manifestations and Trypanosoma cruzi genotypes circulating in chronic Chagasic patients","volume":"30","author":"Ram\u00edrez","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0165","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1111\/j.1365-294X.2012.05699.x","article-title":"Contemporary cryptic sexuality in Trypanosoma Cruzi","volume":"21","author":"Ram\u00edrez","year":"2012","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.meegid.2014.11.012_b0170","unstructured":"Ram\u00edrez, J.D., Guhl, F., 2012. Molecular epidemiology of parasitic diseases: the chagas disease model. Epidemiol. Curr. Perspect. Res. Pract. 6."},{"key":"10.1016\/j.meegid.2014.11.012_b0175","unstructured":"Ram\u00edrez, J.D., Tapia, G., Mu\u00f1oz, G., Poveda, C., Rend\u00f3n, L.M. et al., 2013. Trypanosome species in neo-tropical bats: biological, evolutionary and epidemiological implications. Infect. Genet. Evol., pii: S1567-1348(13)00247-5."},{"key":"10.1016\/j.meegid.2014.11.012_b0180","doi-asserted-by":"crossref","first-page":"e2041","DOI":"10.1371\/journal.pntd.0002041","article-title":"Molecular epidemiology of human oral Chagas disease outbreaks in Colombia","volume":"7","author":"Ram\u00edrez","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0185","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.idc.2012.03.002","article-title":"American trypanosomiasis (Chagas disease)","volume":"26","author":"Rassi","year":"2012","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.meegid.2014.11.012_b0190","first-page":"3","article-title":"Caracterizaci\u00f3n biol\u00f3gica de asilados de Trypanosoma cruzi del occidente de Venezuela","volume":"7","author":"Rivera","year":"2000","journal-title":"Rev. Ecol. Lat. Am."},{"key":"10.1016\/j.meegid.2014.11.012_b0195","first-page":"123","article-title":"Trypanosomiasis cerebral en VIH\/Sida. Reporte de un caso y revisi\u00f3n de la literatura","volume":"26","author":"Salcedo J Moreno","year":"2006","journal-title":"Enf. Inf. Microbiol."},{"key":"10.1016\/j.meegid.2014.11.012_b0200","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3201\/eid1907.121576","article-title":"Molecular epidemiologic source tracking of orally transmitted Chagas disease, Venezuela","volume":"19","author":"Segovia","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2014.11.012_b0205","first-page":"187","article-title":"Characteristic biological of a strain of Trypanosoma cruzi in a murine model and analysis of survival","volume":"26","author":"Suarez","year":"2009","journal-title":"Rev. Peru. Med. Exp. Salud P\u00fablica"},{"key":"10.1016\/j.meegid.2014.11.012_b0210","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/B978-0-12-385895-5.00010-4","article-title":"Adipose tissue, diabetes and chagas disease","volume":"76","author":"Tanowitz","year":"2011","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.meegid.2014.11.012_b0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.actatropica.2008.08.006","article-title":"Biological characterization of Trypanosoma cruzi stocks from domestic and sylvatic vectors in Sierra Nevada of Santa Marta, Colombia","volume":"108","author":"T\u00e9llez","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.meegid.2014.11.012_b0220","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1590\/0074-0276130201","article-title":"The identification of two Trypanosoma cruzi I genotypes from domestic and sylvatic transmission cycles in Colombia based on a single polymerase chain reaction amplification of the spliced-leader intergenic region","volume":"108","author":"Villa","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2014.11.012_b0225","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1590\/S0074-02762009000700021","article-title":"A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI","volume":"104","author":"Zingales","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2014.11.012_b0230","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1756-3305-5-226","article-title":"North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype","volume":"5","author":"Zumaya","year":"2012","journal-title":"Parasit. Vect."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814004158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134814004158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T12:42:43Z","timestamp":1566045763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134814004158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":46,"alternative-id":["S1567134814004158"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2014.11.012","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental model","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2014.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}