{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:23:55Z","timestamp":1789590235862,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273133"],"award-info":[{"award-number":["81273133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.meegid.2015.09.008","type":"journal-article","created":{"date-parts":[[2015,9,13]],"date-time":"2015-09-13T01:55:20Z","timestamp":1442109320000},"page":"126-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Genotype diversity and distribution of Orientia tsutsugamushi in scrub typhus patients and rodents in Shandong, northern China"],"prefix":"10.1016","volume":"36","author":[{"given":"Li","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2015.09.008_bb0005","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1086\/503680","article-title":"Clinical features of scrub typhus","volume":"42","author":"Basnyat","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4161\/hv.3.3.4009","article-title":"Scrub typhus vaccines: past history and recent developments","volume":"3","author":"Chattopadhyay","year":"2007","journal-title":"Hum. Vaccin."},{"key":"10.1016\/j.meegid.2015.09.008_bb0015","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.4014\/jmb.1407.07048","article-title":"Protective immunity of 56-kDa type-specific antigen of Orientia tsutsugamushi causing scrub typhus","volume":"24","author":"Choi","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0020","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1708-8305.1995.tb00662.x","article-title":"Current epidemiology and treatment of Tsutsugamushi disease in Japan","volume":"2","author":"Ebisawa","year":"1995","journal-title":"J. Travel Med."},{"key":"10.1016\/j.meegid.2015.09.008_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1574-6968.1999.tb08791.x","article-title":"Phylogenetic analysis of Orientia tsutsugamushi strains based on the sequence homologies of 56-kDa type-specific antigen genes","volume":"180","author":"Enatsu","year":"1999","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.meegid.2015.09.008_bb0030","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1128\/JCM.31.6.1637-1640.1993","article-title":"Serotype-specific amplification of Rickettsia tsutsugamushi DNA by nested polymerase chain reaction","volume":"31","author":"Furuya","year":"1993","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0035","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1086\/339908","article-title":"The past and present threat of rickettsial diseases to military medicine and international public health","volume":"34","author":"Kelly","year":"2002","journal-title":"Clin. Infect. Dis."},{"issue":"Suppl. 3","key":"10.1016\/j.meegid.2015.09.008_bb0040","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1086\/596576","article-title":"Scrub typhus: the geographic distribution of phenotypic and genotypic variants of Orientia tsutsugamushi","volume":"48","author":"Kelly","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0045","article-title":"Differences in clinical features according to Boryoung and Karp genotypes of Orientia tsutsugamushi","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2015.09.008_bb0050","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijid.2008.07.020","article-title":"The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan","volume":"13","author":"Lai","year":"2009","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0055","series-title":"Zhonghua Liu Xing Bing Xue Za Zhi=Zhonghua Liuxingbingxue Zazhi","first-page":"698","article-title":"Amplification and typing of Sta56 gene of Orientia tsutsugamushi from Shandong province","volume":"25","author":"Liu","year":"2004"},{"key":"10.1016\/j.meegid.2015.09.008_bb0060","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1471-2334-9-82","article-title":"Clinical characteristics of the autumn\u2013winter type scrub typhus cases in south of Shandong province, northern China","volume":"9","author":"Liu","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0065","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s12013-013-9646-0","article-title":"Consistency of the key genotypes of Orientia tsutsugamushi in scrub typhus patients, rodents, and chiggers from a new endemic focus of northern China","volume":"67","author":"Liu","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.meegid.2015.09.008_bb0070","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1348-0421.1996.tb01135.x","article-title":"Virulence in mice of Orientia tsutsugamushi isolated from patients in a new endemic area in Japan","volume":"40","author":"Nagano","year":"1996","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0075","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4269\/ajtmh.2005.73.936","article-title":"Protection against scrub typhus by a plasmid vaccine encoding the 56-KD outer membrane protein antigen gene","volume":"73","author":"Ni","year":"2005","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2015.09.008_bb0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.13-0064","article-title":"Unresolved problems related to scrub typhus: a seriously neglected life-threatening disease","volume":"89","author":"Paris","year":"2013","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2015.09.008_bb0085","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3201\/eid1905.121445","article-title":"Scrub typhus outbreak, Northern Thailand, 2006\u20132007","volume":"19","author":"Rodkvamtook","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0090","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7883\/yoken1952.35.255","article-title":"Serologic analysis of scrub typhus isolates from the Pescadores and Philippine Islands","volume":"35","author":"Shirai","year":"1982","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0095","first-page":"794","article-title":"Scrub typhus in the Western Pacific region","volume":"26","author":"Silpapojakul","year":"1997","journal-title":"Ann. Acad. Med. Singap."},{"key":"10.1016\/j.meegid.2015.09.008_bb0100","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1128\/IAI.58.7.2076-2084.1990","article-title":"The 56-kilodalton major protein antigen of Rickettsia tsutsugamushi: molecular cloning and sequence analysis of the sta56 gene and precise identification of a strain-specific epitope","volume":"58","author":"Stover","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2015.09.008_bb0105","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1099\/00207713-45-3-589","article-title":"Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov","volume":"45","author":"Tamura","year":"1995","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0110","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/jmedent\/11.3.237","article-title":"The ecology of chigger-borne rickettsiosis (scrub typhus)","volume":"11","author":"Traub","year":"1974","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.1975.tb35091.x","article-title":"The acquisition of Rickettsia tsutsugamushi by chiggers (trombiculid mites) during the feeding process","volume":"266","author":"Traub","year":"1975","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.meegid.2015.09.008_bb0125","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/infdis\/146.6.811","article-title":"Doxycycline propylaxis for human scrub typhus","volume":"146","author":"Twartz","year":"1982","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0130","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00001432-200310000-00009","article-title":"Scrub typhus and tropical rickettsioses","volume":"16","author":"Watt","year":"2003","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.meegid.2015.09.008_bb0135","series-title":"Parasites & Vectors","first-page":"513","article-title":"A city park as a potential epidemic site of scrub typhus: a case\u2013control study of an outbreak in Guangzhou, China","volume":"7","author":"Wei","year":"2014"},{"key":"10.1016\/j.meegid.2015.09.008_bb0140","first-page":"777","article-title":"The epidemiological characteristics and prevention and cure of scrub typhus in China","volume":"16","author":"WU","year":"2000","journal-title":"Chin. J. Public Health"},{"key":"10.1016\/j.meegid.2015.09.008_bb0145","first-page":"280","article-title":"Preliminary investigation of scrub typhus in Shandong Province","volume":"8","author":"Yang","year":"1987","journal-title":"Chin. J. Epidemiol."},{"key":"10.1016\/j.meegid.2015.09.008_bb0150","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4269\/ajtmh.2008.78.968","article-title":"Comparative analysis of nucleotide sequences of Orientia tsutsugamushi in different epidemic areas of scrub typhus in Shandong, China","volume":"78","author":"Yang","year":"2008","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2015.09.008_bb0155","series-title":"Zhonghua Liu Xing Bing Xue Za Zhi=Zhonghua Liuxingbingxue Zazhi","first-page":"419","article-title":"Current epidemic status and issues on prevention and control of scrub typhus [in Chinese]","volume":"32","author":"Zhang","year":"2011"},{"key":"10.1016\/j.meegid.2015.09.008_bb0160","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.4269\/ajtmh.2012.12-0306","article-title":"Scrub typhus: surveillance, clinical profile and diagnostic issues in Shandong, China","volume":"87","author":"Zhang","year":"2012","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2015.09.008_bb0165","series-title":"Parasites and Vectors","first-page":"312","article-title":"Molecular epidemiology of Orientia tsutsugamushi in chiggers and ticks from domestic rodents in Shandong, northern China","volume":"6","author":"Zhang","year":"2013"}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134815003755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134815003755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T07:36:55Z","timestamp":1599550615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134815003755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":33,"alternative-id":["S1567134815003755"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2015.09.008","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotype diversity and distribution of Orientia tsutsugamushi in scrub typhus patients and rodents in Shandong, northern China","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2015.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}