{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:50:42Z","timestamp":1775901042485,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005288","name":"Fapespa","doi-asserted-by":"publisher","award":["006\/2014"],"award-info":[{"award-number":["006\/2014"]}],"id":[{"id":"10.13039\/501100005288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.meegid.2016.07.037","type":"journal-article","created":{"date-parts":[[2016,7,30]],"date-time":"2016-07-30T05:31:46Z","timestamp":1469856706000},"page":"361-366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Characterization of novel intragenotype recombination events among norovirus pandemic GII.4 variants"],"prefix":"10.1016","volume":"44","author":[{"given":"Jones Anderson Monteiro","family":"Siqueira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato da Silva","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cleonice Aguiar","family":"Justino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre da Costa","family":"Linhares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvone Benchimol","family":"Gabbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2016.07.037_bb0005","series-title":"24th International Congress of Pediatrics","article-title":"Results of a hospital-based study on rotavirus gastroenteritis in Latin American children","author":"Abate","year":"2004"},{"key":"10.1016\/j.meegid.2016.07.037_bb0010","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/aje\/154.11.1013","article-title":"Multistate outbreak of Norwalk-like virus gastroenteritis associated with a common caterer","volume":"11","author":"Anderson","year":"2001","journal-title":"Am. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.meegid.2016.07.037_bb0015","first-page":"149","article-title":"Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Bel\u00e9m, Par\u00e1, Brazil","volume":"1","author":"Arag\u00e3o","year":"2010","journal-title":"Rev. Pan-Amaz. Sa\u00fade"},{"key":"10.1016\/j.meegid.2016.07.037_bb0020","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1086\/499315","article-title":"Molecular and epidemiologic trends of caliciviruses associated with outbreaks of acute gastroenteritis in the United States, 2000\u20132004","volume":"193","author":"Blanton","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.07.037_bb0025","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1128\/JCM.43.9.4659-4664.2005","article-title":"Molecular epidemiology of caliciviruses detected in sporadic and outbreak cases of gastroenteritis in France from December 1998 to February 2004","volume":"43","author":"Bon","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0030","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1099\/vir.0.83321-0","article-title":"Norovirus recombination","volume":"88","author":"Bull","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1128\/JCM.44.2.327-333.2006","article-title":"Emergence of a new norovirus genotype II.4 variant associated with global outbreaks of gastroenteritis","volume":"44","author":"Bull","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2016.07.037_bb2000","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3201\/eid1107.041273","article-title":"Norovirus recombination in ORF1\/ORF2 overlap","volume":"11","author":"Bull","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.07.037_bb0045","doi-asserted-by":"crossref","DOI":"10.1097\/INF.0000000000001077","article-title":"Temporal Changes in Pediatric Gastroenteritis Following Rotavirus Vaccination in Quebec","author":"Doll","year":"2016","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.meegid.2016.07.037_bb0050","series-title":"Computational and Molecular Biology Approaches to Viral Replication and Pathogenesis","author":"Donaldson","year":"2008"},{"issue":"5","key":"10.1016\/j.meegid.2016.07.037_bb0055","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1017\/S0950268808000630","article-title":"Outbreaks of noroviral gastroenteritis in Florida, 2006\u20132007","volume":"137","author":"Doyle","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.meegid.2016.07.037_bb0060","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1128\/JVI.03464-12","article-title":"Recombination within the pandemic norovirus GII.4 lineage","volume":"87","author":"Eden","year":"2013","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.meegid.2016.07.037_bb0065","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1086\/314525","article-title":"Molecular epidemiology of \u201cNorwalk-like viruses\u201d in outbreaks of gastroenteritis in the United States","volume":"178","author":"Fankhauser","year":"1998","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.meegid.2016.07.037_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092988","article-title":"Temporal dynamics of norovirus GII.4 variants in Brazil between 2004 and 2012","volume":"9","author":"Fioretti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2016.07.037_bb0075","series-title":"Field's Virology","first-page":"582","article-title":"Caliciviridae: the noroviruses","author":"Green","year":"2013"},{"key":"10.1016\/j.meegid.2016.07.037_bb0080","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3201\/eid1410.080188","article-title":"Deaths from Norovirus among the elderly, England and Wales","volume":"14","author":"Harris","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.07.037_bb0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.meegid.2016.02.007","article-title":"Analysis of uncommon norovirus recombinants from Manaus, Amazon region, Brazil: GII.P22\/GII.5, GII.P7\/GII.6 and GII.Pg\/GII.1","volume":"39","author":"Hernandez","year":"2016","journal-title":"Infect. Gen. Evol."},{"issue":"1","key":"10.1016\/j.meegid.2016.07.037_bb0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jcv.2013.06.018","article-title":"New norovirus classified as a recombinant GII.g\/GII.1 causes an extended foodborne outbreak at a university hospital in Munich","volume":"58","author":"Hoffmann","year":"2013","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0095","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0166-0934(99)00114-7","article-title":"Design and evaluation of a primer pair that detects both Norwalk- and Sapporo-like caliciviruses by RT-PCR","volume":"83","author":"Jiang","year":"1999","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.meegid.2016.07.037_bb0100","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-0934(01)00404-9","article-title":"Genogroup-specific PCR primers for detection of Norwalk-like viruses","volume":"100","author":"Kojima","year":"2002","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.meegid.2016.07.037_bb0110","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00705-013-1708-5","article-title":"Proposal for a unified norovirus nomenclature and genotyping","volume":"158","author":"Kroneman","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0115","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1099\/vir.0.039057-0","article-title":"The recombinant origin of emerging human norovirus GII.4\/2008: intragenotypic exchange of the capsid P2 domain","volume":"93","author":"Lam","year":"2012","journal-title":"J. Gen. Virol."},{"issue":"22","key":"10.1016\/j.meegid.2016.07.037_bb0120","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1093\/bioinformatics\/btu531","article-title":"AliView: a fast and lightweight alignment viewer and editor for large datasets","volume":"30","author":"Larsson","year":"2014","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.meegid.2016.07.037_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050031","article-title":"Mechanisms of GII.4 norovirus persistence in human populations","volume":"5","author":"Lindesmith","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.meegid.2016.07.037_bb0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/JVI.73.1.152-160.1999","article-title":"Full-length human immunodeficiency virus type 1 genomes from subtype coinfected seroconverters in India, with evidence of intersubtype recombination","volume":"n. 1","author":"Lole","year":"1999","journal-title":"J. Virol."},{"issue":"168","key":"10.1016\/j.meegid.2016.07.037_bb0135","first-page":"1","article-title":"Novel norovirus recombinants detected in South Africa","volume":"11","author":"Mans","year":"2014","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.meegid.2016.07.037_bb0140","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jmv.23784","article-title":"Human caliciviruses detected in HIV-seropositive children in Kenya","volume":"86","author":"Mans","year":"2014","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0145","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1089\/aid.2005.21.98","article-title":"A modified Bootscan algorithm for automated identification of recombinant sequences and recombination breakpoints","volume":"21","author":"Martin","year":"2005","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.meegid.2016.07.037_bb0150","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vev003","article-title":"RDP4: detection and analysis of recombination patterns in virus genomes","volume":"1","author":"Martin","year":"2015","journal-title":"Virus Evol."},{"issue":"1","key":"10.1016\/j.meegid.2016.07.037_bb0155","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4269\/ajtmh.15-0203","article-title":"Burden of norovirus and rotavirus in children after rotavirus vaccine introduction, Cochabamba, Bolivia","volume":"94","author":"McAtee","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"7","key":"10.1016\/j.meegid.2016.07.037_bb0160","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jmv.23774","article-title":"Norovirus infection in immunocompromised children and children with hospital-acquired acute gastroenteritis","volume":"86","author":"Munir","year":"2014","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0165","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1128\/JVI.02125-09","article-title":"Divergent evolution of norovirus GII\/4 by genome recombination from May 2006 to February 2009 in Japan","volume":"84","author":"Motomura","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcv.2009.04.018","article-title":"A new variant of norovirus GII.4\/2007 and inter-genotype recombinant strains of NVGII causing acute watery diarrhoea among children in Kolkata, India","volume":"45","author":"Nayak","year":"2009","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0175","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0180","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s00705-006-0739-6","article-title":"Genetic analysis of noroviruses associated with fatalities in healthcare facilities","volume":"151","author":"Okada","year":"2006","journal-title":"Arch. Virol."},{"issue":"12","key":"10.1016\/j.meegid.2016.07.037_bb0185","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s00705-007-1028-8","article-title":"Genetic variation of the norovirus GII-4 genotype associated with a large number of outbreaks in Chiba prefecture, Japan","volume":"152","author":"Okada","year":"2007","journal-title":"Arch. Virol."},{"issue":"8","key":"10.1016\/j.meegid.2016.07.037_bb0190","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.3201\/eid1408.071114","article-title":"Systematic literature review of role of noroviruses in sporadic gastroenteritis","volume":"14","author":"Patel","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.07.037_bb0195","author":"Rambaut"},{"issue":"1","key":"10.1016\/j.meegid.2016.07.037_bb0200","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bjm.2015.11.011","article-title":"The role of human adenoviruses type 41 in acute diarrheal disease in Minas Gerais after rotavirus vaccination","volume":"47","author":"Reis","year":"2016","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0205","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1128\/JVI.79.8.4977-4990.2005","article-title":"Evidence of recombination in the norovirus capsid gene","volume":"79","author":"Rohayem","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne illness acquired in the United States\u2013major pathogens","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerg. Infect. Dis."},{"issue":"3","key":"10.1016\/j.meegid.2016.07.037_bb0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1348-0421.2005.tb03718.x","article-title":"Genotyping of norovirus strains detected in outbreaks between april 2002 and march 2003 in Osaka City, Japan","volume":"49","author":"Seto","year":"2005","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0220","first-page":"1181","article-title":"Rapid and efficient detection method of Norwalk virus","volume":"60","author":"Shinohara","year":"2002","journal-title":"Nippon Rinsho"},{"key":"10.1016\/j.meegid.2016.07.037_bb0225","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1128\/JVI.00674-07","article-title":"Epochal evolution of GGII.4 norovirus capsid proteins from 1995 to 2006","volume":"81","author":"Siebenga","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0230","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1086\/605127","article-title":"Norovirus illness is a global problem: emergence and spread of norovirus GII.4 variants, 2001\u20132007","volume":"200","author":"Siebenga","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.07.037_bb0235","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF00182389","article-title":"Analyzing the mosaic structure of genes","volume":"34","author":"Smith","year":"1992","journal-title":"J. Mol. Evol."},{"issue":"4","key":"10.1016\/j.meegid.2016.07.037_bb0240","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/jmv.23506","article-title":"Norovirus infection in children admitted to hospital for acute gastroenteritis in Bel\u00e9m, Par\u00e1, Northern Brazil","volume":"85","author":"Siqueira","year":"2013","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0245","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ajic.2012.08.002","article-title":"Clinical characteristics of norovirus associated deaths: a systematic literature review","volume":"41","author":"Trivedi","year":"2013","journal-title":"Am. J. Infect. Control"},{"key":"10.1016\/j.meegid.2016.07.037_bb0250","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1086\/525259","article-title":"Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b","volume":"46","author":"Tu","year":"2008","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.meegid.2016.07.037_bb0255","first-page":"1389","article-title":"Novel surveillance network for norovirus gastroenteritis outbreaks, United States","volume":"17","author":"Vega","year":"2011","journal-title":"Emerg. Infect. Dis."},{"issue":"24","key":"10.1016\/j.meegid.2016.07.037_bb0260","doi-asserted-by":"crossref","first-page":"14184","DOI":"10.1128\/JVI.02494-14","article-title":"RNA populations in immunocompromised patients as reservoirs for novel norovirus variants","volume":"88","author":"Vega","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0265","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/JCM.01535-14","article-title":"Advances in laboratory methods for detection and typing of norovirus","volume":"53","author":"Vinj\u00e9","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0270","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virol.2007.03.012","article-title":"Characterisation of a novel recombination event in the norovirus polymerase gene","volume":"363","author":"Waters","year":"2007","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.meegid.2016.07.037_bb0275","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1096-9071(199808)55:4<312::AID-JMV10>3.0.CO;2-G","article-title":"Small round structured (Norwalk-like) viruses and classical human caliciviruses in southeastern Australia, 1980\u20131996","volume":"55","author":"Wright","year":"1998","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2016.07.037_bb0280","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/cid\/cir478","article-title":"Impact of an emergent norovirus variant in 2009 on norovirus outbreak activity in the United States","volume":"53","author":"Yen","year":"2011","journal-title":"Clin. Infect. Dis."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134816303276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134816303276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T15:40:52Z","timestamp":1600962052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134816303276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":56,"alternative-id":["S1567134816303276"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2016.07.037","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of novel intragenotype recombination events among norovirus pandemic GII.4 variants","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2016.07.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}