{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:24:45Z","timestamp":1791296685368,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/08075-4"],"award-info":[{"award-number":["2011\/08075-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/19439-7"],"award-info":[{"award-number":["2011\/19439-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/05580-2"],"award-info":[{"award-number":["2012\/05580-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/20735-2"],"award-info":[{"award-number":["2012\/20735-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/06580-9"],"award-info":[{"award-number":["2013\/06580-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006366","name":"Minist\u00e9rio da Educa\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.meegid.2016.08.012","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T16:40:42Z","timestamp":1471279242000},"page":"132-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["The role of CCR5 in Chagas disease - a systematic review"],"prefix":"10.1016","volume":"45","author":[{"given":"Amanda P.","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane M.","family":"Ayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo B.","family":"Bestetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4836-3113","authenticated-orcid":false,"given":"Cinara C.","family":"Brand\u00e3o de Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Cavasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-8177","authenticated-orcid":false,"given":"Luiz C.","family":"de Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2016.08.012_bb0005","unstructured":"Andrade, A., Pinto, SC., Oliveira, RS., orgs. Animais de Laborat\u00f3rio: cria\u00e7\u00e3o e experimenta\u00e7\u00e3o [online]. Rio de Janeiro: Editora FIOCRUZ, 2002. (388 p. ISBN: 85-7541-015-6. Available from SciELO Books<http:\/\/books.scielo.org>)."},{"issue":"e8246","key":"10.1016\/j.meegid.2016.08.012_bb0010","first-page":"1","article-title":"Inhibition of HIV-1 replication in human monocyte-derived macrophages by parasite Trypanosoma cruzi","volume":"4","author":"Andreani","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2016.08.012_bb0015","doi-asserted-by":"crossref","first-page":"284729","DOI":"10.1155\/2013\/284729","article-title":"Genetic susceptibility to Chagas disease: an overview about the infection and about the association between disease and the immune response genes","volume":"2013","author":"Ayo","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.meegid.2016.08.012_bb0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2796.2001.00867.x","article-title":"Chemokines in pathology and medicine","volume":"250","author":"Baggiolini","year":"2001","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.meegid.2016.08.012_bb0025","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1146\/annurev.immunol.15.1.675","article-title":"Human chemokines: an update","volume":"15","author":"Baggiolini","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.atg.2013.05.004","article-title":"C-C chemokine receptor type five (CCR5): an emerging target for the control of HIV infection","volume":"2","author":"Barmania","year":"2013","journal-title":"Appl. Transl. Genomics"},{"key":"10.1016\/j.meegid.2016.08.012_bb0035","doi-asserted-by":"crossref","first-page":"357948","DOI":"10.1155\/2012\/357948","article-title":"Biologic and genetics aspects of chagas disease at endemic areas","volume":"2012","author":"Bellini","year":"2012","journal-title":"J. Trop. Med."},{"key":"10.1016\/j.meegid.2016.08.012_bb0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijcard.2008.05.024","article-title":"Sudden cardiac death in Chagas' heart disease in the contemporary era","volume":"131","author":"Bestetti","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijcard.2014.07.112","article-title":"Precordial chest pain in patients with chronic Chagas disease","volume":"176","author":"Bestetti","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0050","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijcard.2010.05.033","article-title":"Effects of beta-blockers on the outcome of patients with Chagas cardiomyopathy with chronic heart failure","volume":"151","author":"Bestetti","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0055","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.pcad.2009.11.008","article-title":"Chagas cardiomyopathy\u2014where do we stand after a hundred years?","volume":"52","author":"Biolo","year":"2010","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.meegid.2016.08.012_bb0060","series-title":"Immune Response and Immunopathology in Trypanosoma cruzi Infection Chagas Disease (American Trypanosomiasis): Its Impact on Transfusion and Clinical Medicine, ISBT Brazil'92, S\u00e3o Paulo","first-page":"31","author":"Brener","year":"1992"},{"key":"10.1016\/j.meegid.2016.08.012_bb0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cyto.2012.01.007","article-title":"Chemotactic cytokine receptor 5 gene polymorphism: relevance to microvascular complications in type 2 diabetes","volume":"58","author":"Buraczynska","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.meegid.2016.08.012_bb0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1034\/j.1399-0039.2001.580302.x","article-title":"Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy","volume":"58","author":"Calzada","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.meegid.2016.08.012_bb0075","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.STR.0000163104.92943.50","article-title":"Chagasic cardiomyopathy is independently associated with ischemic stroke in Chagas' disease","volume":"36","author":"Carod-Artal","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.meegid.2016.08.012_bb0080","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/hmg\/8.10.1939","article-title":"Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences","volume":"8","author":"Carrington","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.meegid.2016.08.012_bb0085","first-page":"11","article-title":"Animais de laborat\u00f3rio: o camundongo","volume":"28","author":"Chorilli","year":"2007","journal-title":"Rev. Ci\u00eanc. Farm. B\u00e1sica Apl."},{"key":"10.1016\/j.meegid.2016.08.012_bb0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1590\/0074-0276140362","article-title":"The main sceneries of Chagas disease transmission. The vectors, blood and oral transmissions - a comprehensive review","volume":"110","author":"Coura","year":"2015","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2016.08.012_bb0095","doi-asserted-by":"crossref","first-page":"683230","DOI":"10.1155\/2014\/683230","article-title":"Chagas disease cardiomyopathy: immunopathology and genetics","volume":"2014","author":"Cunha-Neto","year":"2014","journal-title":"Mediat. Inflamm."},{"issue":"Suppl I","key":"10.1016\/j.meegid.2016.08.012_bb0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1590\/S0074-02762009000900032","article-title":"Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy","volume":"104","author":"Cunha-Neto","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2016.08.012_bb0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000218333","article-title":"Timing of expression of inflammatory mediators in skeletal muscles from mice acutely infected with the RAstrain of Trypanosoma cruzi","volume":"76","author":"Cutrullis","year":"2009","journal-title":"Pathobiology"},{"key":"10.1016\/j.meegid.2016.08.012_bb0110","doi-asserted-by":"crossref","first-page":"126954","DOI":"10.1155\/2014\/126954","article-title":"CC chemokine receptor 5: the interface of host immunity and cancer","volume":"2014","author":"de Oliveira","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.meegid.2016.08.012_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141847","article-title":"Genetic susceptibility to cardiac and digestive clinical forms of chronic chagas disease: involvement of the CCR5 59029 A\/G polymorphism","volume":"10","author":"de Oliveira","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2016.08.012_bb0120","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.molimm.2013.11.007","article-title":"Dogs infected with the blood trypomastigote form of Trypanosoma cruzi display an increase expression of cytokines and chemokines plus an intense cardiac parasitism during acute infection","volume":"58","author":"de Souza","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0167-5273(85)90262-1","article-title":"Life expectancy analysis in patients with Chagas disease: prognosis after one decade (1973\u20131983)","volume":"8","author":"Espinosa","year":"1985","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0130","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.humimm.2004.05.002","article-title":"Is the CCR5-59029-G\/G genotype a protective factor for cardiomyopathy in Chagas disease?","volume":"65","author":"Fern\u00e1ndez-Mestre","year":"2004","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0135","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.humimm.2012.04.005","article-title":"Genetic variants in the chemokines and chemokine receptors in Chagas disease","volume":"73","author":"Fl\u00f3rez","year":"2012","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0140","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2334-13-587","article-title":"Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways","volume":"13","author":"Frade","year":"2013","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2016.08.012_bb0145","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1128\/IAI.73.12.7960-7966.2005","article-title":"Type 1 chemokine receptor expression in Chagas' disease correlates with morbidity in cardiac patients","volume":"73","author":"Gomes","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2016.08.012_bb0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vetimm.2010.06.010","article-title":"Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in beagle dogs","volume":"138","author":"Guedes","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/IAI.74.1.135-143.2006","article-title":"The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi","volume":"74","author":"Hardison","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2016.08.012_bb0160","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1590\/S0074-02762008000400011","article-title":"TNF\/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-alpha blockade","volume":"103","author":"Kroll-Palhares","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2016.08.012_bb0165","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.cyto.2013.08.008","article-title":"Genetic diversity and linkage disequilibrium in the chemokine receptor CCR2-CCR5 region among individuals and populations","volume":"64","author":"Lawhorn","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.meegid.2016.08.012_bb0170","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(00)80110-5","article-title":"Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.meegid.2016.08.012_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0074-02762004000100001","article-title":"Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease","volume":"99","author":"Macedo","year":"2004","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2016.08.012_bb0180","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/427515","article-title":"CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi","volume":"191","author":"Machado","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.08.012_bb0185","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.humimm.2014.09.023","article-title":"SNP\/haplotype associations of CCR2 and CCR5 genes with severity of chagasic cardiomyopathy","volume":"75","author":"Machuca","year":"2014","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0190","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/infdis\/jir145","article-title":"Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population","volume":"203","author":"Mamtani","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.08.012_bb0195","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.micinf.2008.04.009","article-title":"The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection","volume":"10","author":"Mariano","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.meegid.2016.08.012_bb0200","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/01.CIR.0000141561.15939.EC","article-title":"Regulated on activation, normal T cell expressed and secreted (RANTES) antagonist (Met-RANTES) controls the early phase of Trypanosoma cruzi-elicited myocarditis","volume":"110","author":"Marino","year":"2004","journal-title":"Circulation"},{"issue":"Suppl. 1","key":"10.1016\/j.meegid.2016.08.012_bb0205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1590\/S0074-02762005000900015","article-title":"CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis","volume":"100","author":"Marino","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2016.08.012_bb0210","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.micinf.2008.11.012","article-title":"Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1\/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage","volume":"11","author":"Medeiros","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.meegid.2016.08.012_bb0215","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/eji.200535629","article-title":"Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role offibronectin and the chemokines CXCL12 and CCL4","volume":"36","author":"Mendes-da-Cruz","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0220","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/08958370050123225","article-title":"Animal models of cardiac disease: potential usefulness for studying health effects of inhaled particles","volume":"12","author":"Muggenburg","year":"2000","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001867","article-title":"Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10","volume":"6","author":"Nogueira","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2016.08.012_bb0230","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ijcard.2014.07.043","article-title":"CCR5 chemokine receptor gene variants in chronic Chagas' disease","volume":"176","author":"Oliveira","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0235","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCHEARTFAILURE.108.839761","article-title":"Small animal models of heart failure: development of novel therapies, past and present","volume":"2","author":"Patten","year":"2009","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.meegid.2016.08.012_bb0240","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2016.08.012_bb0245","doi-asserted-by":"crossref","first-page":"637","DOI":"10.4269\/ajtmh.1993.48.637","article-title":"Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes","volume":"48","author":"Reis","year":"1993","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2016.08.012_bb0250","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.micinf.2010.04.011","article-title":"Role of CCL3\/MIP-1alpha and CCL5\/RANTES during acute Trypanosoma cruzi infection in rats","volume":"12","author":"Roff\u00ea","year":"2010","journal-title":"Microbes Infect."},{"key":"10.1016\/j.meegid.2016.08.012_bb0255","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors","volume":"18","author":"Rossi","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0260","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.18.1.593","article-title":"The role of chemokine receptors in primary, effector, and memory immune responses","volume":"18","author":"Sallusto","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.meegid.2016.08.012_bb0265","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1590\/S0074-02762006000900054","article-title":"The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models","volume":"101","author":"Souza","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.meegid.2016.08.012_bb0270","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actatropica.2008.04.016","article-title":"The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection","volume":"108","author":"Souza","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.meegid.2016.08.012_bb0275","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1128\/IAI.00502-10","article-title":"Experimental infection with Schistosoma mansoni in CCR5-deficient mice is associated with increased disease severity, as CCR5 plays a role in controlling granulomatous inflammation","volume":"79","author":"Souza","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2016.08.012_bb0280","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.4049\/jimmunol.1100033","article-title":"Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation","volume":"187","author":"Sullivan","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0285","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.bcp.2012.08.008","article-title":"Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors","volume":"84","author":"Szpakowska","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.meegid.2016.08.012_bb0290","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/380803","article-title":"Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease","volume":"189","author":"Talvani","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2016.08.012_bb0295","first-page":"2063","article-title":"Chagas disease and its toll on the heart","volume":"30","author":"Taylor","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.meegid.2016.08.012_bb0300","series-title":"Chagas Disease (American Trypanosomiasis): Fact Sheet","author":"World Health Organization","year":"2016"}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134816303495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134816303495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T23:38:36Z","timestamp":1657755516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134816303495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":60,"alternative-id":["S1567134816303495"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2016.08.012","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of CCR5 in Chagas disease - a systematic review","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2016.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}