{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:36:53Z","timestamp":1761129413282},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Cedars-Sinai Medical Center's Institutional Research Award"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["PO1 CA177322"],"award-info":[{"award-number":["PO1 CA177322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.meegid.2017.03.012","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T10:30:15Z","timestamp":1489487415000},"page":"74-85","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Comparative analysis of protein evolution in the genome of pre-epidemic and epidemic Zika virus"],"prefix":"10.1016","volume":"51","author":[{"given":"Arunachalam","family":"Ramaiah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deisy","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaithilingaraja","family":"Arumugaswami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2017.03.012_bb0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2017.03.012_bb0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10709-013-9713-x","article-title":"Detection of site-specific positive Darwinian selection on pandemic influenza A\/H1N1 virus genome: integrative approaches","volume":"141","author":"Arunachalam","year":"2013","journal-title":"Genetica"},{"key":"10.1016\/j.meegid.2017.03.012_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ygeno.2014.10.012","article-title":"Adaptive evolution of a novel avian-origin influenza A\/H7N9 virus","volume":"104","author":"Arunachalam","year":"2014","journal-title":"Genomics"},{"issue":"3","key":"10.1016\/j.meegid.2017.03.012_bb0020","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00500-14","article-title":"Complete coding sequence of zika virus from a French polynesia outbreak in 2013","volume":"2","author":"Baronti","year":"2014","journal-title":"Genome Announc."},{"key":"10.1016\/j.meegid.2017.03.012_bb0025","doi-asserted-by":"crossref","first-page":"8339","DOI":"10.1128\/JVI.79.13.8339-8347.2005","article-title":"Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains","volume":"79","author":"Beasley","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0030","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/bioinformatics\/btq662","article-title":"Toward the estimation of the absolute quality of individual protein structure models","volume":"27","author":"Benkert","year":"2011","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.meegid.2017.03.012_bb0035","doi-asserted-by":"crossref","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2017.03.012_bb0040","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro - preliminary report","volume":"375","author":"Brasil","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.meegid.2017.03.012_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003266","article-title":"Properties of MHC class I presented peptides that enhance immunogenicity","volume":"9","author":"Calis","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0050","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/ng.590","article-title":"Human T cell epitopes of mycobacterium tuberculosis are evolutionarily hyperconserved","volume":"42","author":"Comas","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.meegid.2017.03.012_bb0055","doi-asserted-by":"crossref","first-page":"11530","DOI":"10.1073\/pnas.1105315108","article-title":"Coordinate linkage of HIV evolution reveals regions of immunological vulnerability","volume":"108","author":"Dahirel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2017.03.012_bb0060","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1093\/bioinformatics\/btq429","article-title":"Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology","volume":"26","author":"Delport","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2017.03.012_bb0065","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2017.03.012_bb0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-5-113","article-title":"MUSCLE: a multiple sequence alignment method with reduced time and space complexity","volume":"5","author":"Edgar","year":"2004","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.meegid.2017.03.012_bb0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(16)00003-9","article-title":"Zika virus genome from the Americas","volume":"387","author":"Enfissi","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2017.03.012_bb0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.288.5464.339","article-title":"The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies","volume":"288","author":"Farci","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.meegid.2017.03.012_bb0085","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.aaf5036","article-title":"Zika virus in the Americas: early epidemiological and genetic findings","volume":"352","author":"Faria","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.meegid.2017.03.012_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002636","article-title":"Molecular evolution of Zika virus during its emergence in the 20(th) century","volume":"8","author":"Faye","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2017.03.012_bb0095","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.03.012_bb0100","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.meegid.2017.03.012_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001477","article-title":"Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage","volume":"6","author":"Haddow","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.meegid.2017.03.012_bb0110","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3201\/eid1509.090442","article-title":"Zika virus outside Africa","volume":"15","author":"Hayes","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.03.012_bb0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12985-016-0551-1","article-title":"Nucleotide composition of the Zika virus RNA genome and its codon usage","volume":"13","author":"van Hemert","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.meegid.2017.03.012_bb0120","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nsmb.3258","article-title":"Structure of the NS3 helicase from Zika virus","volume":"23","author":"Jain","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0125","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nature07746","article-title":"Adaptation of HIV-1 to human leukocyte antigen class I","volume":"458","author":"Kawashima","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.meegid.2017.03.012_bb0130","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(02)00660-8","article-title":"Structure of dengue virus: implications for flavivirus organization, maturation, and fusion","volume":"108","author":"Kuhn","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.meegid.2017.03.012_bb0135","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00705-006-0903-z","article-title":"Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses","volume":"152","author":"Kuno","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0140","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"Lanciotti","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.03.012_bb0145","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid2205.160065","article-title":"Phylogeny of Zika virus in Western Hemisphere, 2015","volume":"22","author":"Lanciotti","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.03.012_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.meegid.2017.03.012_bb0155","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3201\/eid1605.100164","article-title":"The evolution and emergence of RNA viruses","volume":"16","author":"Mahy","year":"2010","journal-title":"Emerg. Infect. Dis."},{"issue":"3","key":"10.1016\/j.meegid.2017.03.012_bb0160","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4269\/ajtmh.1969.18.411","article-title":"Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia","volume":"18","author":"Marchette","year":"1969","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2017.03.012_bb0165","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2017.03.012_bb0170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.1089316","article-title":"Structure of West Nile virus","volume":"302","author":"Mukhopadhyay","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.meegid.2017.03.012_bb0175","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/molbev\/mst030","article-title":"FUBAR: a fast, unconstrained Bayesian AppRoximation for inferring selection","volume":"30","author":"Murrell","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0180","doi-asserted-by":"crossref","first-page":"O595","DOI":"10.1111\/1469-0691.12707","article-title":"Rapid spread of emerging Zika virus in the Pacific area","volume":"20","author":"Musso","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.meegid.2017.03.012_bb0185","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1573409912666160401115812","article-title":"Characterizing the Zika virus genome \u2013 a bioinformatics study","volume":"12","author":"Nandy","year":"2016","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"9","key":"10.1016\/j.meegid.2017.03.012_bb0190","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome - case report, French Polynesia, December 2013","volume":"19","author":"Oehler","year":"2014","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.meegid.2017.03.012_bb0195","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/molbev\/msi105","article-title":"Not so different after all: a comparison of methods for detecting amino acid sited under selection","volume":"22","author":"Pond","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0200","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/bioinformatics\/bti079","article-title":"HyPhy: hypothesis testing using phylogenies","volume":"21","author":"Pond","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2017.03.012_bb0205","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1371\/journal.pcbi.0020062","article-title":"Adaptation to different human populations by HIV-1 revealed by codon-based analyses","volume":"2","author":"Pond","year":"2006","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0210","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1093\/molbev\/msr125","article-title":"A random effects branch-site model for detecting episodic diversifying selection","volume":"28","author":"Pond","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0215","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1128\/JVI.03812-13","article-title":"Statistical linkage analysis of substitutions in patient-derived sequences of genotype 1a hepatitis C virus nonstructural protein 3 exposes targets for immunogen design","volume":"88","author":"Quadeer","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0220","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s13337-016-0305-0","article-title":"Ebola virus evolves in human to minimize the detection by immune cells by accumulating adaptive mutations","volume":"27","author":"Ramaiah","year":"2016","journal-title":"VirusDisease"},{"key":"10.1016\/j.meegid.2017.03.012_bb0225","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sysbio\/sys029","article-title":"MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space","volume":"61","author":"Ronquist","year":"2012","journal-title":"Syst. Biol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0230","first-page":"183","article-title":"TreeBASE: a prototype database of phylogenetic analyses and an interactive tool for browsing the phylogeny of life","volume":"81","author":"Sanderson","year":"1994","journal-title":"Am. J. Bot."},{"key":"10.1016\/j.meegid.2017.03.012_bb0235","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1534\/genetics.105.040741","article-title":"Epistasis and the adaptability of an RNA virus","volume":"170","author":"Sanjuan","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.meegid.2017.03.012_bb0240","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00705-013-1855-8","article-title":"Genome analysis of pandemic and post-pandemic influenza A pH1N1 viruses isolated in Rio Grande do Sul, Brazil","volume":"159","author":"Sant'Anna","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0245","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.meegid.2017.03.012_bb0250","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8\u00c5 resolution cryo-EM structure of Zika virus","author":"Sirohi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.meegid.2017.03.012_bb0255","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1126\/science.1097211","article-title":"Mapping the antigenic and genetic evolution of influenza virus","volume":"305","author":"Smith","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.meegid.2017.03.012_bb0260","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.gene.2003.11.020","article-title":"Negative selection on neutralization epitopes of poliovirus surface proteins: implications for prediction of candidate epitopes for immunization","volume":"328","author":"Suzuki","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.meegid.2017.03.012_bb0265","first-page":"715","article-title":"Estimation of the number of nucleotide substituions in the control region of mitochondrial DNA in humans and chimpanzees","volume":"11","author":"Tamura","year":"1993","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0270","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0275","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s13238-016-0275-4","article-title":"The crystal structure of Zika virus helicase: basis for antiviral drug design","volume":"7","author":"Tian","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.meegid.2017.03.012_bb0280","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(16)00273-7","article-title":"Microcephaly in Brazil: how to interpret reported numbers?","volume":"387","author":"Victora","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2017.03.012_bb0285","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.tim.2016.01.002","article-title":"RNA Structure Duplications and Flavivirus Host Adaptation","volume":"24","author":"Villordo","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0290","doi-asserted-by":"crossref","first-page":"D405","DOI":"10.1093\/nar\/gku938","article-title":"The immune epitope database (IEDB) 3.0","volume":"43","author":"Vita","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2017.03.012_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000048","article-title":"A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach","volume":"4","author":"Wang","year":"2008","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0300","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.chom.2016.04.006","article-title":"From mosquitos to humans: genetic evolution of Zika virus","volume":"19","author":"Wang","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.meegid.2017.03.012_bb0305","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02063-16","article-title":"Emergence of epidemic Zika virus transmission and congenital Zika syndrome: are recently evolved traits to blame?","volume":"8","author":"Weaver","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.meegid.2017.03.012_bb0310","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/molbev\/mst064","article-title":"DAMBE5: a comprehensive software package for data analysis in molecular biology and evolution","volume":"30","author":"Xia","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.meegid.2016.05.004","article-title":"Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas","volume":"43","author":"Ye","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0320","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nsmb.2463","article-title":"Cryo-EM structure of the mature dengue virus at 3.5-\u00c5 resolution","volume":"20","author":"Zhang","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.meegid.2017.03.012_bb0325","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2016.48","article-title":"Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic","volume":"5","author":"Zhu","year":"2016","journal-title":"Emerg. Microbes Infect."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134817300837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134817300837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T15:24:10Z","timestamp":1535988250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134817300837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":65,"alternative-id":["S1567134817300837"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2017.03.012","relation":{},"ISSN":["1567-1348"],"issn-type":[{"type":"print","value":"1567-1348"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of protein evolution in the genome of pre-epidemic and epidemic Zika virus","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2017.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}