{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:42:41Z","timestamp":1784767361102,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Tokyo Metropolitan Government","award":["H28"],"award-info":[{"award-number":["H28"]}]},{"name":"Ministry of Health and Welfare of Japan","award":["H24B-14"],"award-info":[{"award-number":["H24B-14"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.meegid.2017.04.003","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:03:28Z","timestamp":1491523408000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection"],"prefix":"10.1016","volume":"51","author":[{"given":"Mohammad Enamul Hoque","family":"Kayesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Kitab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hayasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Kohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Tsukiyama-Kohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2017.04.003_bb0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/JVI.01448-09","article-title":"Pathogenesis of hepatitis C virus infection in Tupaia belangeri","volume":"84","author":"Amako","year":"2010","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.meegid.2017.04.003_bb0015","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/jb\/mvj067","article-title":"Identification and characterization of carbohydrate molecules in mammalian cells recognized by dengue virus type 2","volume":"139","author":"Aoki","year":"2006","journal-title":"J. Biochem."},{"issue":"3","key":"10.1016\/j.meegid.2017.04.003_bb0020","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4269\/ajtmh.2009.80.416","article-title":"Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining","volume":"80","author":"Balsitis","year":"2009","journal-title":"Am.J.Trop. Med. Hyg."},{"key":"10.1016\/j.meegid.2017.04.003_bb0025","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappa B - a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"7446","key":"10.1016\/j.meegid.2017.04.003_bb0030","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.meegid.2017.04.003_bb0035","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.immuni.2010.03.012","article-title":"Intracellular Toll-like receptors","volume":"32","author":"Blasius","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.meegid.2017.04.003_bb0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0166-0934(97)00211-5","article-title":"Endothelial cell monolayers as a model system to investigate dengue shock syndrome","volume":"71","author":"Bonner","year":"1998","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.meegid.2017.04.003_bb0045","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/0022034510381264","article-title":"TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk","volume":"90","author":"Brown","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.meegid.2017.04.003_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001420","article-title":"Activation of the innate immune response against DENV in normal non-transformed human fibroblasts","volume":"5","author":"Bustos-Arriaga","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"4","key":"10.1016\/j.meegid.2017.04.003_bb0055","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1165\/ajrcmb.20.4.3420","article-title":"Both Erk and p38 kinases are necessary for cytokine gene transcription","volume":"20","author":"Carter","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.meegid.2017.04.003_bb0060","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.antiviral.2015.08.013","article-title":"Animal models for studying dengue pathogenesis and therapy","volume":"123","author":"Chan","year":"2015","journal-title":"Antivir. Res."},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jinf.2009.10.003","article-title":"Gene expression analysis during dengue virus infection in HepG2 cells reveals virus control of innate immune response","volume":"60","author":"Concei\u00e7\u00e3o","year":"2010","journal-title":"J. Infect."},{"issue":"6","key":"10.1016\/j.meegid.2017.04.003_bb0070","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.ajpath.2013.02.027","article-title":"Inflammatory and innate immune responses in dengue infection: protection versus disease induction","volume":"182","author":"Costa","year":"2013","journal-title":"Am. J. Pathol."},{"issue":"17","key":"10.1016\/j.meegid.2017.04.003_bb0075","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.1128\/JVI.74.17.7814-7823.2000","article-title":"Infection of human cells by dengue virus is modulated by different cell types and viral strains","volume":"74","author":"Diamond","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2017.04.003_bb0080","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/ncomms2416","article-title":"Genome of the Chinese tree shrew","volume":"4","author":"Fan","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.meegid.2017.04.003_bb0085","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.meegid.2017.04.003_bb0090","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tig.2007.02.002","article-title":"Evolutionary history of 7SL RNA-derived SINEs in Supraprimates","volume":"23","author":"Kriegs","year":"2007","journal-title":"Trends Genet."},{"key":"10.1016\/j.meegid.2017.04.003_bb0095","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF01310705","article-title":"Dengue-2 virus infection of human mononuclear cell lines and establishment of persistent infections","volume":"110","author":"Kurane","year":"1990","journal-title":"Arch. Virol."},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01314622","article-title":"Dengue virus infection of human skin fibroblasts in vitro production of IFN-beta, IL-6 and GM-CSF","volume":"124","author":"Kurane","year":"1992","journal-title":"Arch. Virol."},{"issue":"2","key":"10.1016\/j.meegid.2017.04.003_bb0110","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/JVI.02258-15","article-title":"Herpes simplex virus 1 infection of tree shrews differs from that of mice in the severity of acute infection and viral transcription in the peripheral nervous system","volume":"90","author":"Li","year":"2016","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.meegid.2017.04.003_bb0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0023346","article-title":"Activation of Toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-\u03b2 in cultured hepatoma cells","volume":"6","author":"Liang","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.meegid.2017.04.003_bb0120","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1099\/0022-1317-77-10-2547","article-title":"Dengue 1 virus binding to human hepatoma HepG2 and simian Vero cell surfaces differs","volume":"77","author":"Marianneau","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.meegid.2017.04.003_bb0125","series-title":"Molecular Evolution and Phylogenetics","author":"Nei","year":"2000"},{"key":"10.1016\/j.meegid.2017.04.003_bb0130","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jviromet.2006.01.003","article-title":"Quantitation of flaviviruses by fluorescent focus assay","volume":"134","author":"Payne","year":"2006","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.meegid.2017.04.003_bb0135","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol. Biol. Evol."},{"issue":"2","key":"10.1016\/j.meegid.2017.04.003_bb0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bbrc.2015.11.121","article-title":"Property of hepatitis B virus replication in Tupaia belangeri hepatocytes","volume":"469","author":"Sanada","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.meegid.2017.04.003_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019323","article-title":"Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7\/8 agonists in macaques","volume":"6","author":"Sariol","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2017.04.003_bb0150","first-page":"469","article-title":"Effect of IL-6 and TNF-alpha on dengue virus infection of human dendritic cells","volume":"22","author":"Shi","year":"2006","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.meegid.2017.04.003_bb0155","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"Simmons","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.meegid.2017.04.003_bb0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jmv.20798","article-title":"Infection of human primary hepatocytes with dengue virus serotype 2","volume":"79","author":"Suksanpaisan","year":"2007","journal-title":"J. Med. Virol."},{"issue":"2","key":"10.1016\/j.meegid.2017.04.003_bb0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.virol.2008.10.022","article-title":"Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus","volume":"383","author":"Sun","year":"2009","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.meegid.2017.04.003_bb0170","first-page":"818","article-title":"Detection of dengue virus by simple RT-PCR using universal degenerate primers observations from a preliminary study","volume":"27","author":"Suwanwong","year":"2010","journal-title":"Arch. Hell. Med."},{"issue":"5","key":"10.1016\/j.meegid.2017.04.003_bb0175","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/mutage\/1.5.359","article-title":"Establishment of lung fibroblastic cell lines from non-human primate Tupaia belangeri and their use in a forward gene mutation assay at the hypoxanthine-guanine phosphoribolsyl transferase locus","volume":"1","author":"Taketomi","year":"1986","journal-title":"Mutagenesis"},{"issue":"4","key":"10.1016\/j.meegid.2017.04.003_bb0180","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1462-5822.2008.01277.x","article-title":"Human TLR3 recognizes dengue virus and modulates viral replication in vitro","volume":"11","author":"Tsai","year":"2009","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.meegid.2017.04.003_bb0185","series-title":"Tupaia belangeri as an Experimental Animal Model for Viral Infection","first-page":"367","volume":"63(4)","author":"Tsukiyama-Kohara","year":"2014"},{"key":"10.1016\/j.meegid.2017.04.003_bb0190","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.04.003_bb0195","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12879-016-1668-y","article-title":"Serotype influences on dengue severity: a cross-sectional study on 485 confirmed dengue cases in Vit\u00f3ria, Brazil","volume":"16","author":"Vicente","year":"2016","journal-title":"BMC Infect. Dis."},{"issue":"9","key":"10.1016\/j.meegid.2017.04.003_bb0200","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1099\/vir.0.82878-0","article-title":"Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma","volume":"88","author":"Xu","year":"2007","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0205","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.dci.2015.04.014","article-title":"Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis)","volume":"52","author":"Xu","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"39","key":"10.1016\/j.meegid.2017.04.003_bb0210","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1073\/pnas.1604939113","article-title":"Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew","volume":"113","author":"Xu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2017.04.003_bb0215","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/QCO.0b013e32835fb938","article-title":"The pathogenesis of dengue","volume":"26","author":"Yacoub","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0220","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12985-015-0256-x","article-title":"Chronic hepatitis B virus infection and occurrence of hepatocellular carcinoma in tree shrews (Tupaia belangeri chinensis)","volume":"12","author":"Yang","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.meegid.2017.04.003_bb0225","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4149\/av_2014_01_20","article-title":"Growth characteristics and cytokine\/chemokine induction profiles of dengue viruses in various cell lines","volume":"58","author":"Yohan","year":"2014","journal-title":"Acta Virol."},{"issue":"1","key":"10.1016\/j.meegid.2017.04.003_bb0230","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12879-016-1418-1","article-title":"Characterization of hepatitis E virus infection in tree shrew (Tupaia belangeri chinensis)","volume":"16","author":"Yu","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2017.04.003_bb0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.dci.2016.02.025","article-title":"Identification and characterization of Toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)","volume":"60","author":"Yu","year":"2016","journal-title":"Dev. Comp. Immunol."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134817301168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134817301168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T15:10:11Z","timestamp":1568992211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134817301168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":47,"alternative-id":["S1567134817301168"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2017.04.003","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2017.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}