{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:12:56Z","timestamp":1773443576392,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":301,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100015096","name":"Canadian Dairy Commission","doi-asserted-by":"publisher","award":["AMD-18"],"award-info":[{"award-number":["AMD-18"]}],"id":[{"id":"10.13039\/100015096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.meegid.2017.12.003","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T12:02:10Z","timestamp":1512648130000},"page":"157-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil"],"prefix":"10.1016","volume":"58","author":[{"given":"Ana Paula Ramalho da","family":"Costa-Louren\u00e7o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Jeanine","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e9sia Tha\u00eds Barros","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Campelo Vilardi","family":"Argentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talita","family":"Coelho-Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina Albuquerque","family":"Canin\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana L\u00facia Pires","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Meurer","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Eduardo Longo","family":"Fracalanzza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Trees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-5458","authenticated-orcid":false,"given":"Raquel Regina","family":"Bonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2017.12.003_bb0005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/S1517-83822007000200020","article-title":"Emergence of fluoroquinolone-resistant Neisseria gonorrhoeae in S\u00e3o Paulo, Brazil","volume":"38","author":"Belda Junior","year":"2007","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.meegid.2017.12.003_bb0010","article-title":"High-level azithromycin-resistant Neisseria gonorrhoeae clinical isolate in France, March 2014","volume":"19","author":"Bercot","year":"2014","journal-title":"Euro Surveill. Bull. Eur. Sur Mal. Transm. Eur. Commun. Dis. Bull."},{"key":"10.1016\/j.meegid.2017.12.003_bb0015","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1128\/AAC.00309-10","article-title":"High-level azithromycin resistance occurs in Neisseria gonorrhoeae as a result of a single point mutation in the 23S rRNA genes","volume":"54","author":"Chisholm","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0020","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/sextrans-2015-052312","article-title":"An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England","volume":"92","author":"Chisholm","year":"2016","journal-title":"Sex. Transm. Infect."},{"key":"10.1016\/j.meegid.2017.12.003_bb0025","author":"CLC Genomics Workbench [WWW Document]"},{"key":"10.1016\/j.meegid.2017.12.003_bb0030","series-title":"M100 Performance Standards for Antimicrobial Susceptibility Testing","author":"CLSI","year":"2017"},{"key":"10.1016\/j.meegid.2017.12.003_bb0035","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1258\/0956462991913835","article-title":"Characterization of an outbreak of tetM-containing Neisseria gonorrhoeae in Argentina","volume":"10","author":"Cobo","year":"1999","journal-title":"Int. J. STD AIDS"},{"key":"10.1016\/j.meegid.2017.12.003_bb0040","author":"CONITEC"},{"key":"10.1016\/j.meegid.2017.12.003_bb0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1590\/0037-8682-0009-2013","article-title":"Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from patients attending a public referral center for sexually transmitted diseases in Belo Horizonte, state of Minas Gerais, Brazil","volume":"46","author":"Costa","year":"2013","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.meegid.2017.12.003_bb0050","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ijantimicag.2017.02.003","article-title":"Reduced susceptibility to cefixime but not ceftriaxone: an uncertain perspective for the treatment of gonorrhoea in Brazil","volume":"49","author":"Costa-Louren\u00e7o","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.meegid.2017.12.003_bb0055","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/JCM.03195-15","article-title":"Genomic epidemiology and molecular resistance mechanisms of azithromycin-resistant Neisseria gonorrhoeae in Canada from 1997 to 2014","volume":"54","author":"Demczuk","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2017.12.003_bb0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00007435-200406000-00007","article-title":"High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinolone-resistant Neisseria gonorrhoeae","volume":"31","author":"Dewi","year":"2004","journal-title":"Sex. Transm. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/mcpr.1998.0216","article-title":"A PCR assay for discriminating Neisseria gonorrhoeaebeta-lactamase-producing plasmids","volume":"13","author":"Dillon","year":"1999","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.meegid.2017.12.003_bb0070","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00007435-200109000-00008","article-title":"Reduced susceptibility to azithromycin and high percentages of penicillin and tetracycline resistance in Neisseria gonorrhoeae isolates from Manaus, Brazil, 1998","volume":"28","author":"Dillon","year":"2001","journal-title":"Sex. Transm. Dis."},{"issue":"Suppl. 4","key":"10.1016\/j.meegid.2017.12.003_bb0075","article-title":"Two decades of the gonococcal antimicrobial surveillance program in South America and the Caribbean: challenges and opportunities","volume":"89","author":"Dillon","year":"2013","journal-title":"Sex. Transm. Infect."},{"key":"10.1016\/j.meegid.2017.12.003_bb0080","author":"FigTree [WWW Document]"},{"key":"10.1016\/j.meegid.2017.12.003_bb0085","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/OLQ.0b013e3181b61bb1","article-title":"Emergence of high level azithromycin-resistant Neisseria gonorrhoeae strain isolated in Argentina","volume":"36","author":"Galarza","year":"2009","journal-title":"Sex. Transm. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-015-1294-0","article-title":"Prevalence of bla TEM-220 gene in penicillinase-producing Neisseria gonorrhoeae strains carrying Toronto\/Rio plasmid in Argentina, 2002\u20132011","volume":"15","author":"Gianecini","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0095","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1128\/AAC.03838-14","article-title":"Identification of TEM-135 \u03b2-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina","volume":"59","author":"Gianecini","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0100","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1086\/386312","article-title":"Quinolone resistance-determining region mutations and por type of Neisseria gonorrhoeae isolates: resistance surveillance and typing by molecular methodologies","volume":"189","author":"Giles","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S1473-3099(13)70693-5","article-title":"Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study","volume":"14","author":"Grad","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0110","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/infdis\/jiw420","article-title":"Genomic epidemiology of gonococcal resistance to extended-Spectrum Cephalosporins, macrolides, and fluoroquinolones in the United States, 2000-2013","volume":"214","author":"Grad","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0115","article-title":"Phandango: an interactive viewer for bacterial population genomics","author":"Hadfield","year":"2017","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.meegid.2017.12.003_bb0120","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1128\/AAC.49.10.4327-4334.2005","article-title":"High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants","volume":"49","author":"Hu","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0125","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1093\/jac\/dkw279","article-title":"WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2mg\/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014","volume":"71","author":"Jacobsson","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0130","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijantimicag.2016.10.023","article-title":"Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance","volume":"49","author":"Johnson","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.meegid.2017.12.003_bb0135","author":"Minist\u00e9rio da S\u00e1ude, B. da S., Blog, Sa\u00fade, Minist\u00e9rio"},{"key":"10.1016\/j.meegid.2017.12.003_bb0140","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/AAC.30.5.664","article-title":"High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant","volume":"30","author":"Morse","year":"1986","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0145","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1128\/AAC.46.9.3020-3025.2002","article-title":"Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae","volume":"46","author":"Ng","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0150","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1128\/AAC.46.9.2811-2820.2002","article-title":"Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae","volume":"46","author":"Olesky","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0160","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3201\/eid2305.170088","article-title":"Azithromycin resistance and decreased ceftriaxone susceptibility in Neisseria gonorrhoeae, Hawaii, USA","volume":"23","author":"Papp","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0165","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0140-6736(76)92466-1","article-title":"Beta-lactamase-producing, penicillin-resistant gonococcus","volume":"2","author":"Phillips","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2017.12.003_bb0170","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/bioinformatics\/btp051","article-title":"RAMI: a tool for identification and characterization of phylogenetic clusters in microbial communities","volume":"25","author":"Pommier","year":"2009","journal-title":"Bioinforma. Oxf. Engl."},{"key":"10.1016\/j.meegid.2017.12.003_bb0175","author":"PubMLST"},{"key":"10.1016\/j.meegid.2017.12.003_bb0180","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.46.3.769-777.2002","article-title":"Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae","volume":"46","author":"Ropp","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0185","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/OLQ.0b013e3182631c9f","volume":"39","author":"Starnino","year":"2012","journal-title":"Sex. Transm. Dis."},{"key":"10.1016\/j.meegid.2017.12.003_bb0190","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1128\/AAC.45.1.117-123.2001","article-title":"Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains isolated in Denmark from 1995 to 1998","volume":"45","author":"Su","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0195","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1128\/AAC.02993-14","article-title":"Characterization of a novel Neisseria gonorrhoeae penicillinase-producing plasmid isolated in Australia in 2012","volume":"58","author":"Trembizki","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2017.12.003_bb0200","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/sti.75.1.60","article-title":"Molecular epidemiology of tetM genes in Neisseria gonorrhoeae","volume":"75","author":"Turner","year":"1999","journal-title":"Sex. Transm. Infect."},{"key":"10.1016\/j.meegid.2017.12.003_bb0205","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1128\/JCM.01175-11","article-title":"Molecular characterization of quinolone-resistant Neisseria gonorrhoeae isolates from Brazil","volume":"49","author":"Uehara","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2017.12.003_bb0210","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2217\/fmb.12.117","article-title":"Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea","volume":"7","author":"Unemo","year":"2012","journal-title":"Future Microbiol"},{"key":"10.1016\/j.meegid.2017.12.003_bb0215","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1111\/j.1749-6632.2011.06215.x","article-title":"Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future","volume":"1230","author":"Unemo","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156713481730429X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156713481730429X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:32:21Z","timestamp":1761575541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156713481730429X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":42,"alternative-id":["S156713481730429X"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2017.12.003","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2017.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}