{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:50:33Z","timestamp":1769309433188,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":278,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.meegid.2018.11.014","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T21:32:29Z","timestamp":1542403949000},"page":"10-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prediction of HIV integrase resistance mutation using in silico approaches"],"prefix":"10.1016","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-4537","authenticated-orcid":false,"given":"Heitor Horlando Sampaio Araujo","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9112-7167","authenticated-orcid":false,"given":"Ronald","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2018.11.014_bb0005","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00302-14","article-title":"Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication","author":"Abram","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2018.11.014_bb0010","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1128\/JVI.01725-15","article-title":"Dolutegravir-selected HIV-1 containing the N155H and R263K resistance substitutions does not acquire additional compensatory mutations under drug pressure that lead to higher-level Resistance and increased replicative capacity","volume":"89","author":"Anstett","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2018.11.014_bb0015","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrmicro3132","article-title":"Past, present and future: 30\u202fyears of HIV research","volume":"11","author":"Barr\u00e9-Sinoussi","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.meegid.2018.11.014_bb0020","doi-asserted-by":"crossref","first-page":"W510","DOI":"10.1093\/nar\/gkp322","article-title":"QMEAN server for protein model quality estimation","volume":"37","author":"Benkert","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2018.11.014_bb0025","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2105-9-S2-S6","article-title":"A three-state prediction of single point mutations on protein stability changes","volume":"9","author":"Capriotti","year":"2008","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.meegid.2018.11.014_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/science.6601823","article-title":"Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Gallo","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.meegid.2018.11.014_bb0035","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.meegid.2018.11.014_bb0040","doi-asserted-by":"crossref","first-page":"W294","DOI":"10.1093\/nar\/gks493","article-title":"GalaxyWEB server for protein structure prediction and refinement","volume":"40","author":"Ko","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2018.11.014_bb0045","doi-asserted-by":"crossref","first-page":"15910","DOI":"10.1073\/pnas.1002346107","article-title":"Structure-based modeling of the functional HIV-1 intasome and its inhibition","volume":"107","author":"Krishnan","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2018.11.014_bb0050","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/ci500020m","article-title":"g_mmpbsa \u2014a GROMACS tool for high-throughput MM-PBSA calculations","volume":"54","author":"Kumari","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.meegid.2018.11.014_bb0055","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/bioinformatics\/btv769","article-title":"MAESTROweb: a web server for structure-based protein stability prediction","volume":"32","author":"Laimer","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.meegid.2018.11.014_bb0060","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand\u2013protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.meegid.2018.11.014_bb0065","doi-asserted-by":"crossref","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.meegid.2018.11.014_bb0070","doi-asserted-by":"crossref","first-page":"W569","DOI":"10.1093\/nar\/gkq369","article-title":"RosettaBackrub\u2014a web server for flexible backbone protein structure modeling and design","volume":"38","author":"Lauck","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2018.11.014_bb0075","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1086\/503914","article-title":"Web resources for HIV Type 1 genotypic-resistance test interpretation","volume":"42","author":"Liu","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.meegid.2018.11.014_bb0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by C\u03b1 geometry: \u03d5,\u03c8 and C\u03b2 deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.meegid.2018.11.014_bb0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1124\/pr.111.005553","article-title":"The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition","volume":"64","author":"Michaud","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.meegid.2018.11.014_bb0090","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.antiviral.2009.09.001","article-title":"Pharmacogenetics of antiretrovirals","volume":"85","author":"Tozzi","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.meegid.2018.11.014_bb0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.meegid.2018.11.014_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134818306361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134818306361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:35:53Z","timestamp":1761575753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134818306361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":20,"alternative-id":["S1567134818306361"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2018.11.014","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of HIV integrase resistance mutation using in silico approaches","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2018.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}