{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:39:47Z","timestamp":1771922387808,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.meegid.2019.01.003","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T02:26:05Z","timestamp":1546568765000},"page":"253-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["1H nuclear magnetic resonance-based metabolic profiling of cerebrospinal fluid to identify metabolic features and markers for tuberculosis meningitis"],"prefix":"10.1016","volume":"68","author":[{"given":"Peixu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguanliu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2019.01.003_bb0005","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/jnr.24048","article-title":"Metabolomic-guided discovery of Alzheimer's disease biomarkers from body fluid","volume":"95","author":"Ady Enche","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.meegid.2019.01.003_bb0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/ane.12590","article-title":"Cerebrospinal fluid biomarkers for Parkinson's disease-a systematic review","volume":"135","author":"Andersen","year":"2017","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.meegid.2019.01.003_bb0015","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2217\/bmm.14.67","article-title":"Methods of rapid diagnosis for the etiology of meningitis in adults","volume":"8","author":"Bahr","year":"2014","journal-title":"Biomark. Med"},{"issue":"573","key":"10.1016\/j.meegid.2019.01.003_bb0020","article-title":"Clinical presentations, diagnosis, mortality and prognostic markers of tuberculous meningitis in Vietnamese children: a prospective descriptive study","volume":"16","author":"Bang","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/1352458515622827","article-title":"Metabolomics in multiple sclerosis","volume":"22","author":"Bhargava","year":"2016","journal-title":"Mult. Scler."},{"key":"10.1016\/j.meegid.2019.01.003_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0032-1333468","article-title":"The changing landscape of diagnostic services for tuberculosis","volume":"34","author":"Boehme","year":"2013","journal-title":"Semin. Respir. Crit. Care. Med."},{"key":"10.1016\/j.meegid.2019.01.003_bb0035","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5588\/ijtld.14.0805","article-title":"Appropriate use of the Xpert MTB\/RIF assay in suspected tuberculous meningitis","volume":"19","author":"Boyles","year":"2015","journal-title":"Int. J. Tuberc. Lung Dis."},{"issue":"130","key":"10.1016\/j.meegid.2019.01.003_bb0040","article-title":"Comprehensive 1H NMR metabolic profiling of body fluids for differentiation of meningitis in adults","volume":"12","author":"Chatterji","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.meegid.2019.01.003_bb0045","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1128\/JCM.05756-11","article-title":"A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Mycobacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid","volume":"50","author":"Chen","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2019.01.003_bb0050","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.cca.2012.06.018","article-title":"The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis","volume":"413","author":"Chen","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.meegid.2019.01.003_bb0055","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1473-3099(14)70852-7","article-title":"Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis","volume":"14","author":"Chiang","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0060","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/jnnp.44.9.791","article-title":"Cerebrospinal fluid amino acid concentrations in patients with viral and tuberculous meningitis","volume":"44","author":"Corston","year":"1981","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.meegid.2019.01.003_bb0065","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.biochi.2013.05.011","article-title":"Potential role and therapeutic interests of myo-inositol in metabolic diseases","volume":"95","author":"Croze","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.meegid.2019.01.003_bb0070","doi-asserted-by":"crossref","first-page":"100095","DOI":"10.18632\/oncotarget.21942","article-title":"Identification of potential metabolic biomarkers of cerebrospinal fluids that differentiate tuberculous meningitis from other types of meningitis by a metabolomics study","volume":"8","author":"Dai","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.meegid.2019.01.003_bb0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1183\/09031936.00007814","article-title":"Xpert MTB\/RIF assay for the diagnosis of extrapulmonary tuberculosis: a systematic review and meta-analysis","volume":"44","author":"Denkinger","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.meegid.2019.01.003_bb0080","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jmoldx.2016.07.007","article-title":"Emerging and future applications of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry in the clinical microbiology laboratory: A Report of the Association for Molecular Pathology","volume":"18","author":"Doern","year":"2016","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.meegid.2019.01.003_bb0085","first-page":"19","article-title":"Cerebrospinal fluid lactate and lactate dehydrogenase levels as diagnostic aids in tuberculous meningitis","volume":"67","author":"Donald","year":"1985","journal-title":"S. Afr. Med. J."},{"key":"10.1016\/j.meegid.2019.01.003_bb0090","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1128\/JCM.00572-12","article-title":"The small membrane filter method of microscopy to diagnose pulmonary tuberculosis","volume":"50","author":"Fennely","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2019.01.003_bb0095","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s10096-015-2450-6","article-title":"CSF lactate for accurate diagnosis of community-acquired bacterial meningitis","volume":"34","author":"Giulieri","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"9","key":"10.1016\/j.meegid.2019.01.003_bb0100","article-title":"Epidemiology of extrapulmonary tuberculosis in Brazil: a hierarchical model","volume":"14","author":"Gomes","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0105","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S1473-3099(14)70872-2","article-title":"Death and disability: the outcomes of tuberculous meningitis","volume":"14","author":"Graham","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0115","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5588\/ijtld.11.0687","article-title":"Clinical prediction rule for differentiating tuberculous from viral meningitis","volume":"16","author":"Hristea","year":"2012","journal-title":"Int. J. Tuberc. Lung Dis."},{"issue":"67","key":"10.1016\/j.meegid.2019.01.003_bb0120","article-title":"Diagnostic accuracy, incremental yield and prognostic value of Determine TB-LAM for routine diagnostic testing for tuberculosis in HIV-infected patients requiring acute hospital admission in South Africa: a prospective cohort","volume":"15","author":"Lawn","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.meegid.2019.01.003_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tube.2016.05.016","article-title":"Evaluation of multiplex PCR using MPB64 and IS6110 primers for rapid diagnosis of tuberculous meningitis","volume":"100","author":"Lekhak","year":"2016","journal-title":"Tuberculosis (Edinb)."},{"key":"10.1016\/j.meegid.2019.01.003_bb0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cca.2017.01.002","article-title":"Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis","volume":"466","author":"Li","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.meegid.2019.01.003_bb0135","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1039\/c4mb00090k","article-title":"NMR- and MS-based metabolomics: various organ responses following naphthalene intervention","volume":"10","author":"Ling","year":"2014","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.meegid.2019.01.003_bb0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/QCO.0000000000000331","article-title":"Recent advances in the diagnosis and management of tuberculous meningitis","volume":"30","author":"Mai","year":"2017","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0145","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1473-3099(10)70138-9","article-title":"Tuberculous meningitis: a uniform case definition for use in clinical research","volume":"10","author":"Marais","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0150","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s11306-014-0741-z","article-title":"A hypothetical astrocyte-microglia lactate shuttle derived from a 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis","volume":"11","author":"Mason","year":"2015","journal-title":"Metabolomics"},{"issue":"251","key":"10.1016\/j.meegid.2019.01.003_bb0155","article-title":"Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid","volume":"16","author":"Mason","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0160","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11306-016-1053-2","article-title":"A putative urinary biosignature for diagnosis and follow-up of tuberculous meningitis in children: outcome of a metabolomics study disclosing host-pathogen responses","volume":"12","author":"Mason","year":"2016","journal-title":"Metabolomics"},{"issue":"534","key":"10.1016\/j.meegid.2019.01.003_bb0165","article-title":"Cerebrospinal fluid amino acid profiling of pediatric cases with tuberculous meningitis","volume":"11","author":"Mason","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.meegid.2019.01.003_bb0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3855\/jidc.3295","article-title":"Cost-effectiveness in the diagnosis of tuberculosis: choices in developing countries","volume":"8","author":"Molicotti","year":"2014","journal-title":"J. Infect. Dev. Ctries."},{"key":"10.1016\/j.meegid.2019.01.003_bb0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Innovation: metabolomics: the apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.meegid.2019.01.003_bb0180","first-page":"545","article-title":"Diagnostic test accuracy of adenosine deaminase for tuberculous meningitis: a systematic review and meta-analysis","volume":"74","author":"Pormohammad","year":"2017","journal-title":"J. Inf. Secur."},{"key":"10.1016\/j.meegid.2019.01.003_bb0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-0186(97)00061-2","article-title":"The neurochemical markers in cerebrospinal fluid to differentiate between aseptic and tuberculous meningitis","volume":"32","author":"Qureshi","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.meegid.2019.01.003_bb0190","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1651-2227.1993.tb12577.x","article-title":"Concentrations of nucleotides, nucleosides, purine bases and urate in cerebrospinal fluid of children with meningitis","volume":"82","author":"Rodr\u00edguez-N\u00fa\u00f1ez","year":"1993","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.meegid.2019.01.003_bb0200","first-page":"125","article-title":"Diagnostic usefulness of Xpert MTB\/RIF assay for detection of tuberculous meningitis using cerebrospinal fluid","volume":"75","author":"Rufai","year":"2017","journal-title":"J. Inf. Secur."},{"key":"10.1016\/j.meegid.2019.01.003_bb0205","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007637","article-title":"Diagnostic value of lactate, procalcitonin, ferritin, serum-C-reactive protein, and other biomarkers in bacterial and viral meningitis: a cross-sectional study","volume":"96","author":"Sanaei Dashti","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.meegid.2019.01.003_bb0210","first-page":"153","article-title":"L-methionine production","volume":"159","author":"Shim","year":"2017","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.meegid.2019.01.003_bb0215","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s11064-017-2261-5","article-title":"Branched-chain amino acids and brain metabolism","volume":"42","author":"Sperringer","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.meegid.2019.01.003_bb0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/2213235X02666140301002510","article-title":"Recent advances in metabolic profiling and imaging of prostate cancer","volume":"2","author":"Thapar","year":"2014","journal-title":"Curr. Metabolomics"},{"key":"10.1016\/j.meegid.2019.01.003_bb0225","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1086\/378642","article-title":"Pathophysiology and prognosis in Vietnamese adults with tuberculous meningitis","volume":"188","author":"Thwaites","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0230","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/bmb\/ldv003","article-title":"Tuberculous meningitis: advances in diagnosis and treatment","volume":"113","author":"T\u00f6r\u00f6k","year":"2015","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.meegid.2019.01.003_bb0235","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0240","first-page":"857","article-title":"1H NMR-based metabolomics study on urine form Haematitum-treated rats","volume":"44","author":"Wei","year":"2016","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.meegid.2019.01.003_bb0245","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrneurol.2017.120","article-title":"Tuberculous meningitis","volume":"13","author":"Wilkinson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.meegid.2019.01.003_bb0250","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkq329","article-title":"MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data","volume":"38","author":"Xia","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2019.01.003_bb0255","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0-making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2019.01.003_bb0260","doi-asserted-by":"crossref","first-page":"494","DOI":"10.5588\/ijtld.15.0600","article-title":"Diagnostic accuracy of interferon-gamma release assays for tuberculous meningitis: a meta-analysis","volume":"20","author":"Yu","year":"2016","journal-title":"Int. J. Tuberc. Lung. Dis."},{"key":"10.1016\/j.meegid.2019.01.003_bb0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cbpa.2016.12.006","article-title":"Frontiers of high-throughput metabolomics","volume":"36","author":"Zampieri","year":"2017","journal-title":"Curr. Opin. Chem. Biol."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134818307457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134818307457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:37:47Z","timestamp":1761575867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134818307457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":51,"alternative-id":["S1567134818307457"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2019.01.003","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1H nuclear magnetic resonance-based metabolic profiling of cerebrospinal fluid to identify metabolic features and markers for tuberculosis meningitis","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2019.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}