{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:14:01Z","timestamp":1791756841780,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["12200"],"award-info":[{"award-number":["12200"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.meegid.2019.05.013","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T23:19:11Z","timestamp":1557962351000},"page":"255-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Molecular analysis of accessory gene regulator functionality and virulence genes in Staphylococcus aureus derived from pediatric wound infections"],"prefix":"10.1016","volume":"73","author":[{"given":"Donya Taghizadeh","family":"Maleki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Ghalavand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisem","family":"Laabei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Nikmanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Houri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor","family":"Kodori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-5541","authenticated-orcid":false,"given":"Ali","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiva","family":"Kadkhoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Eslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2019.05.013_bb0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.patbio.2006.07.010","article-title":"Prevalence of agr specificity groups among methicilin resistant Staphylococcus aureus circulating at Charles Nicolle Hospital of Tunis","volume":"54","author":"Ben Ayed","year":"2006","journal-title":"Pathol. Biol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3855\/jidc.9360","article-title":"Toxin production and drug resistance profiles of pediatric methicillin-resistant Staphylococcus aureus isolates in Tehran","volume":"11","author":"Benvidi","year":"2017","journal-title":"J. Infect. Dev. Ctries."},{"key":"10.1016\/j.meegid.2019.05.013_bb0015","first-page":"DC07","article-title":"Accessory gene regulator types of Staphylococcus aureus isolated in Gorgan, North of Iran","volume":"8","author":"Bibalan","year":"2014","journal-title":"IJCDR: JCDR"},{"key":"10.1016\/j.meegid.2019.05.013_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.femsre.2003.09.003","article-title":"Regulation of virulence determinants in Staphylococcus aureus: complexity and applications","volume":"28","author":"Bronner","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.meegid.2019.05.013_bb0025","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1128\/JCM.44.5.1881-1883.2006","article-title":"Occurrence of the enterotoxin gene cluster and the toxic shock syndrome toxin 1 gene among clinical isolates of methicillin-resistant staphylococcus aureus is related to clonal type and Agr group","volume":"44","author":"Chini","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0030","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1128\/JCM.44.5.1892-1895.2006","article-title":"Rapid Staphylococcus aureus Agr type determination by a novel multiplex real-time quantitative PCR assay","volume":"44","author":"Francois","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0035","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1099\/mic.0.030304-0","article-title":"Epidemiology, variable genetic organization and regulation of the EDIN-B toxin in Staphylococcus aureus from bacteraemic patients","volume":"156","author":"Franke","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.meegid.2019.05.013_bb0040","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/AAC.49.1.366-379.2005","article-title":"Analysis of the genetic variability of virulence-related loci in epidemic clones of methicillin-resistant Staphylococcus aureus","volume":"49","author":"Gomes","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.05.013_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175552","article-title":"Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections","volume":"12","author":"Gomes-Fernandes","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.meegid.2019.05.013_bb0050","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01653-17","article-title":"Evaluation of Oxacillin and Cefoxitin Disk Diffusion and MIC Breakpoints Established by the Clinical and Laboratory Standards Institute for Detection of mecA-Mediated Oxacillin Resistance in Staphylococcus schleiferi","volume":"56","author":"Huse","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0055","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1128\/JB.182.22.6517-6522.2000","article-title":"Exfoliatin-producing strains define a fourth Agr specificity group in Staphylococcus aureus","volume":"182","author":"Jarraud","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0060","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/IAI.70.2.631-641.2002","article-title":"Relationships between Staphylococcus aureus genetic background, virulence factors, Agr groups (alleles), and human disease","volume":"70","author":"Jarraud","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2019.05.013_bb0065","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1186\/s13104-017-3092-9","article-title":"Spectrum and antibiogram of bacteria isolated from patients presenting with infected wounds in a tertiary hospital, northern Tanzania","volume":"10","author":"Kassam","year":"2017","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.meegid.2019.05.013_bb0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/microorganisms6020040","article-title":"Pediatric methicillin-resistant Staphylococcus aureus osteoarticular infections","volume":"6","author":"Kaushik","year":"2018","journal-title":"Microorganisms"},{"key":"10.1016\/j.meegid.2019.05.013_bb0075","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/039139880903200909","article-title":"OpuC\u2013an ABC transporter that is associated with Staphylococcus aureus pathogenesis","volume":"32","author":"Kiran","year":"2009","journal-title":"Int. J. Artif. Organs."},{"key":"10.1016\/j.meegid.2019.05.013_bb0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jiph.2013.11.003","article-title":"Prevalence of exfoliative toxin A and B genes in Staphylococcus aureus isolated from clinical specimens","volume":"7","author":"Koosha","year":"2014","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.meegid.2019.05.013_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087270","article-title":"Staphylococcus aureus interaction with phospholipid vesicles \u2013 a new method to accurately determine accessory gene regulator (Agr) activity","volume":"9","author":"Laabei","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2019.05.013_bb0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fmicb.2018.00055","article-title":"Therapeutic targeting of the Staphylococcus aureus accessory gene regulator (Agr) system","volume":"9","author":"Li","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018617","article-title":"Global changes in Staphylococcus aureus gene expression in human blood","volume":"6","author":"Malachowa","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2019.05.013_bb0100","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/IAI.69.2.885-896.2001","article-title":"Characterization of sarR, a modulator ofsar expression in Staphylococcus aureus","volume":"69","author":"Manna","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.meegid.2019.05.013_bb0105","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.genet.42.110807.091640","article-title":"Quorum sensing in staphylococci","volume":"42","author":"Novick","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.meegid.2019.05.013_bb0110","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1099\/jmm.0.010173-0","article-title":"Nationwide epidemiological study revealed the dissemination of meticillin-resistant Staphylococcus aureus carrying a specific set of virulence-associated genes in Japanese hospitals","volume":"58","author":"Ohkura","year":"2009","journal-title":"J. Med. Microbiol. Diagn."},{"key":"10.1016\/j.meegid.2019.05.013_bb0115","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tim.2014.09.002","article-title":"What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?","volume":"22","author":"Painter","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0120","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1086\/315342","article-title":"Molecular analysis of the accessory gene regulator (Agr) locus and balance of virulence factor expression in epidemic methicillin-resistant Staphylococcus aureus","volume":"181","author":"Papakyriacou","year":"2000","journal-title":"Infect. Dis. (Lond.)"},{"key":"10.1016\/j.meegid.2019.05.013_bb0125","first-page":"1","article-title":"Interfering with bacterial quorum sensing","volume":"8","author":"Reuter","year":"2016","journal-title":"Perspect. Med. Chem."},{"key":"10.1016\/j.meegid.2019.05.013_bb0130","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1086\/368128","article-title":"Staphylococcus aureus accessory gene regulator (Agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?","volume":"187","author":"Sakoulas","year":"2003","journal-title":"Infect. Dis. (Lond.)"},{"key":"10.1016\/j.meegid.2019.05.013_bb0135","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1086\/368128","article-title":"Staphylococcus aureus accessory gene regulator (Agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?","volume":"187","author":"Sakoulas","year":"2003","journal-title":"Infect. Dis. (Lond.)"},{"key":"10.1016\/j.meegid.2019.05.013_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066153","article-title":"Molecular characterization of Staphylococcus aureus from patients with surgical site infections at Mulago Hospital in Kampala, Uganda","volume":"8","author":"Seni","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2019.05.013_bb0145","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ja.2016.59","article-title":"Impact of Staphylococcus aureus accessory gene regulator (Agr) system on linezolid efficacy by profiling pharmacodynamics and RNAIII expression","volume":"70","author":"Soon","year":"2017","journal-title":"J. Antibiot."},{"key":"10.1016\/j.meegid.2019.05.013_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14110-8","article-title":"Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase","volume":"7","author":"Stevens","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.meegid.2019.05.013_bb0155","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/jcp.56.10.782","article-title":"Fast, simultaneous, and sensitive detection of staphylococci","volume":"56","author":"Stuhlmeier","year":"2003","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.meegid.2019.05.013_bb0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/jpids\/pis087","article-title":"Molecular characterization of invasive Staphylococcus aureus infection in Central New York children: importance of two clonal groups and inconsistent presence of selected virulence determinants","volume":"2","author":"Suryadevara","year":"2012","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"10.1016\/j.meegid.2019.05.013_bb0165","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1099\/mic.0.2007\/011874-0","article-title":"Agr function in clinical Staphylococcus aureus isolates","volume":"154","author":"Traber","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.meegid.2019.05.013_bb0170","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1128\/AAC.00671-06","article-title":"Evaluation of accessory gene regulator (Agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus","volume":"51","author":"Tsuji","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.05.013_bb0175","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1128\/AAC.05453-11","article-title":"Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus","volume":"56","author":"Tsuji","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.05.013_bb0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.diagmicrobio.2004.03.009","article-title":"Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus","volume":"49","author":"von Eiff","year":"2004","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.meegid.2019.05.013_bb0185","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbamem.2013.12.006","article-title":"New insight into transmembrane topology of Staphylococcus aureus histidine kinase AgrC","volume":"1838","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"10.1016\/j.meegid.2019.05.013_bb0190","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2334\/josnusd.55.145","article-title":"Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer","volume":"55","author":"Yamashita","year":"2013","journal-title":"J. Oral Sci."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134819300917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134819300917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:37:02Z","timestamp":1761575822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134819300917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":38,"alternative-id":["S1567134819300917"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2019.05.013","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular analysis of accessory gene regulator functionality and virulence genes in Staphylococcus aureus derived from pediatric wound infections","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2019.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}