{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:07:06Z","timestamp":1761577626089,"version":"build-2065373602"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007064","name":"Universidad de Ja\u00e9n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.meegid.2019.05.014","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T12:15:41Z","timestamp":1558008941000},"page":"276-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Genetic associations of the vitamin D and antiviral pathways with natural resistance to HIV-1 infection are influenced by interpopulation variability"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-055X","authenticated-orcid":false,"given":"Wbeimar","family":"Aguilar-Jimenez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wildeman","family":"Zapata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rivero-Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Laplana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia A.","family":"Taborda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-4235","authenticated-orcid":false,"given":"Mara","family":"Biasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-7840","authenticated-orcid":false,"given":"Antonio","family":"Caruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-2227","authenticated-orcid":false,"given":"Joan","family":"Fibla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"Rugeles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.meegid.2019.05.014_bb0005","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1210\/en.2012-2245","article-title":"Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells","volume":"154","author":"Abboud","year":"2013","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.meegid.2019.05.014_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082717","article-title":"High transcript levels of vitamin D receptor are correlated with higher mRNA expression of human beta defensins and IL-10 in mucosa of HIV-1-exposed seronegative individuals","volume":"8","author":"Aguilar-Jim\u00e9nez","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.meegid.2019.05.014_bb0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0123-9392(13)70721-5","article-title":"Vitamin D involvement in the pathogenesis of human immunodeficiency virus type 1","volume":"17","author":"Aguilar-Jimenez","year":"2013","journal-title":"Infectio"},{"issue":"5","key":"10.1016\/j.meegid.2019.05.014_bb0020","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/QAI.0000000000001150","article-title":"Precursor forms of Vitamin D reduce HIV-1 infection in vitro","volume":"73","author":"Aguilar-Jimenez","year":"2016","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"7\u20138","key":"10.1016\/j.meegid.2019.05.014_bb0025","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.micinf.2016.03.015","article-title":"Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection","volume":"18","author":"Aguilar-Jimenez","year":"2016","journal-title":"Microbes Infect."},{"issue":"13","key":"10.1016\/j.meegid.2019.05.014_bb0030","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/hmg\/ddq155","article-title":"Genome-wide association study of circulating vitamin D levels","volume":"19","author":"Ahn","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.meegid.2019.05.014_bb0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/jmedgenet-2012-101085","article-title":"Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis","volume":"50","author":"Alcina","year":"2013","journal-title":"J. Med. Genet."},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0040","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/01.aids.0000218543.46963.6d","article-title":"Risk of HIV-1 transmission for parenteral exposure and blood transfusion: a systematic review and meta-analysis","volume":"20","author":"Baggaley","year":"2006","journal-title":"AIDS"},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098815","article-title":"Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort","volume":"9","author":"Bank","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.meegid.2019.05.014_bb0050","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1089\/aid.2006.22.897","article-title":"Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression","volume":"22","author":"Bedoya","year":"2006","journal-title":"AIDS Res. Hum. Retrovir."},{"issue":"4","key":"10.1016\/j.meegid.2019.05.014_bb0055","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2174\/157016208785132536","article-title":"Fetal-maternal HLA-A and -B discordance is associated with placental RNase expression and anti-HIV-1 activity","volume":"6","author":"Bedoya","year":"2008","journal-title":"Curr. HIV Res."},{"issue":"15","key":"10.1016\/j.meegid.2019.05.014_bb0060","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1097\/QAD.0b013e3283629117","article-title":"Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level","volume":"27","author":"Beima-Sofie","year":"2013","journal-title":"AIDS"},{"issue":"5","key":"10.1016\/j.meegid.2019.05.014_bb0065","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.4049\/jimmunol.0902463","article-title":"TLR activation pathways in HIV-1-exposed seronegative individuals","volume":"184","author":"Biasin","year":"2010","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0070","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00439-011-0962-4","article-title":"Genetic variants in TLR2 and TLR4 are associated with markers of monocyte activation: the atherosclerosis risk in communities MRI study","volume":"129","author":"Bielinski","year":"2011","journal-title":"Hum. Genet."},{"key":"10.1016\/j.meegid.2019.05.014_bb0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1465-9921-10-98","article-title":"Asthma and genes encoding components of the vitamin D pathway","volume":"10","author":"Bosse","year":"2009","journal-title":"Respir. Res."},{"issue":"30","key":"10.1016\/j.meegid.2019.05.014_bb0080","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1002\/sim.3431","article-title":"Improving strategies for detecting genetic patterns of disease susceptibility in association studies","volume":"27","author":"Calle","year":"2008","journal-title":"Stat. Med."},{"issue":"17","key":"10.1016\/j.meegid.2019.05.014_bb0085","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/bioinformatics\/btq352","article-title":"mbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits","volume":"26","author":"Calle","year":"2010","journal-title":"Bioinformatics"},{"issue":"21","key":"10.1016\/j.meegid.2019.05.014_bb0090","doi-asserted-by":"crossref","first-page":"18890","DOI":"10.1074\/jbc.M110.206110","article-title":"Hormonally active vitamin D3 (1\u03b1,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection","volume":"286","author":"Campbell","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.meegid.2019.05.014_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003017","article-title":"Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1","volume":"8","author":"Campbell","year":"2012","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.meegid.2019.05.014_bb0100","first-page":"3485","article-title":"A genomic perspective on vitamin D signaling","volume":"29","author":"Carlberg","year":"2009","journal-title":"Anticancer Res."},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0105","first-page":"546","article-title":"CFTR allelic heterogeneity in Mexican patients with cystic fibrosis: implications for molecular screening","volume":"62","author":"Chavez-Saldana","year":"2010","journal-title":"Rev. Investig. Clin."},{"issue":"9","key":"10.1016\/j.meegid.2019.05.014_bb0110","article-title":"An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use","volume":"7","author":"Che","year":"2014","journal-title":"BioData Min"},{"issue":"14","key":"10.1016\/j.meegid.2019.05.014_bb0115","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1073\/pnas.1202240109","article-title":"Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of beta chemokines and RNases","volume":"109","author":"Cocchi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9226","key":"10.1016\/j.meegid.2019.05.014_bb0120","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0140-6736(00)02500-9","article-title":"Limits on oral transmission of HIV-1","volume":"356","author":"Cohen","year":"2000","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.meegid.2019.05.014_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067735","article-title":"Dectin-1\/TLR2 and NOD2 agonists render dendritic cells susceptible to infection by X4-using HIV-1 and promote cis-infection of CD4(+) T cells","volume":"8","author":"Cote","year":"2013","journal-title":"PLoS One"},{"issue":"26","key":"10.1016\/j.meegid.2019.05.014_bb0130","doi-asserted-by":"crossref","first-page":"8052","DOI":"10.1073\/pnas.1500909112","article-title":"High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans","volume":"112","author":"Coussens","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.meegid.2019.05.014_bb0135","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/QAD.0b013e328354622a","article-title":"The evolving epidemiology of HIV\/AIDS","volume":"26","author":"De Cock","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.meegid.2019.05.014_bb0140","first-page":"111","article-title":"Vitamin D and HIV Infection","author":"Fibla","year":"2010"},{"issue":"5","key":"10.1016\/j.meegid.2019.05.014_bb0145","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/hep.24575","article-title":"Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes","volume":"54","author":"Gal-Tanamy","year":"2011","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131139","article-title":"High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus","volume":"10","author":"Gonzalez","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.meegid.2019.05.014_bb0155","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1086\/302879","article-title":"Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus","volume":"66","author":"Hamblin","year":"2000","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.meegid.2019.05.014_bb0160","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4049\/jimmunol.0902840","article-title":"Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state","volume":"184","author":"Hansdottir","year":"2010","journal-title":"J. Immunol."},{"issue":"13","key":"10.1016\/j.meegid.2019.05.014_bb0165","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1097\/QAD.0b013e32832ea643","article-title":"Elevated elafin\/trappin-2 in the female genital tract is associated with protection against HIV acquisition","volume":"23","author":"Iqbal","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.meegid.2019.05.014_bb0170","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fimmu.2018.00458","article-title":"Vitamin D in human immunodeficiency virus infection: influence on immunity and disease","volume":"9","author":"Jimenez-Sousa","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.meegid.2019.05.014_bb0175","doi-asserted-by":"crossref","DOI":"10.1534\/g3.116.033274","article-title":"Transcriptome profiling in rat inbred strains and experimental cross reveals discrepant genetic architecture of genome-wide gene expression","author":"Kaisaki","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.meegid.2019.05.014_bb0180","first-page":"30","article-title":"Clinical and immunological characteristics of hiv-infection in patients with Asp299glly polymorphism of the toll-like receptor 4 gene","volume":"224","author":"Kirichenko","year":"2013","journal-title":"Georgian Med. News"},{"key":"10.1016\/j.meegid.2019.05.014_bb0185","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1471-2148-11-173","article-title":"Natural selection among Eurasians at genomic regions associated with HIV-1 control","volume":"11","author":"Klimentidis","year":"2011","journal-title":"BMC Evol. Biol."},{"issue":"12","key":"10.1016\/j.meegid.2019.05.014_bb0190","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.imbio.2012.07.018","article-title":"1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism","volume":"217","author":"Korf","year":"2012","journal-title":"Immunobiology"},{"issue":"9","key":"10.1016\/j.meegid.2019.05.014_bb0195","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/hmg\/ddt033","article-title":"A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A","volume":"22","author":"Lane","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.meegid.2019.05.014_bb0200","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10456-012-9322-9","article-title":"Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress","volume":"16","author":"Li","year":"2013","journal-title":"Angiogenesis"},{"issue":"7","key":"10.1016\/j.meegid.2019.05.014_bb0205","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/infdis\/jis028","article-title":"Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition","volume":"205","author":"Limou","year":"2012","journal-title":"J. Infect. Dis."},{"issue":"5768","key":"10.1016\/j.meegid.2019.05.014_bb0210","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.meegid.2019.05.014_bb0215","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1093\/infdis\/jit807","article-title":"Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans","volume":"209","author":"Mackelprang","year":"2014","journal-title":"J. Infect. Dis."},{"issue":"24","key":"10.1016\/j.meegid.2019.05.014_bb0220","doi-asserted-by":"crossref","first-page":"14053","DOI":"10.1128\/JVI.78.24.14053-14056.2004","article-title":"Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection","volume":"78","author":"Martin","year":"2004","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.meegid.2019.05.014_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003515","article-title":"Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls","volume":"9","author":"McLaren","year":"2013","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0230","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1128\/IAI.00099-11","article-title":"Vitamin D-mediated induction of innate immunity in gingival epithelial cells","volume":"79","author":"McMahon","year":"2011","journal-title":"Infect. Immun."},{"issue":"1\u20135","key":"10.1016\/j.meegid.2019.05.014_bb0235","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jsbmb.2004.03.086","article-title":"Association between AIDS disease progression rates and the Fok-I polymorphism of the VDR gene in a cohort of HIV-1 seropositive patients","volume":"89\u201390","author":"Nieto","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"9","key":"10.1016\/j.meegid.2019.05.014_bb0240","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1086\/597616","article-title":"A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers","volume":"199","author":"Oyugi","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0245","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1086\/302148","article-title":"Estimating African American admixture proportions by use of population-specific alleles","volume":"63","author":"Parra","year":"1998","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.meegid.2019.05.014_bb0250","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/QAD.0b013e328343817b","article-title":"Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population","volume":"25","author":"Petrovski","year":"2011","journal-title":"AIDS"},{"issue":"8","key":"10.1016\/j.meegid.2019.05.014_bb0255","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1101\/gr.113886.110","article-title":"Genetic analysis in the collaborative cross breeding population","volume":"21","author":"Philip","year":"2011","journal-title":"Genome Res."},{"issue":"3","key":"10.1016\/j.meegid.2019.05.014_bb0260","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"15","key":"10.1016\/j.meegid.2019.05.014_bb0265","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1056\/NEJM199704103361507","article-title":"Sexual transmission of HIV","volume":"336","author":"Royce","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.meegid.2019.05.014_bb0270","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00002030-200303070-00002","article-title":"Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition","volume":"17","author":"Rugeles","year":"2003","journal-title":"AIDS"},{"issue":"2","key":"10.1016\/j.meegid.2019.05.014_bb0275","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/aid.2015.0019","article-title":"Short communication: immune activation is present in HIV-1-exposed seronegative individuals and is independent of microbial translocation","volume":"32","author":"Saulle","year":"2016","journal-title":"AIDS Res. Hum. Retrovir."},{"issue":"17","key":"10.1016\/j.meegid.2019.05.014_bb0280","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1128\/JVI.01053-14","article-title":"Triggering TLR2, \u22123, \u22124, \u22125, and \u22128 reinforces the restrictive nature of M1- and M2-polarized macrophages to HIV","volume":"88","author":"Schlaepfer","year":"2014","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.meegid.2019.05.014_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030048","article-title":"Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state","volume":"7","author":"Songok","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.meegid.2019.05.014_bb0290","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1097\/INF.0000000000000483","article-title":"High-dose vitamin D3 supplementation in children and young adults with HIV: a randomized, placebo-controlled trial","volume":"34","author":"Stallings","year":"2015","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"3","key":"10.1016\/j.meegid.2019.05.014_bb0295","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1086\/525043","article-title":"Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users","volume":"197","author":"de la Torre","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.meegid.2019.05.014_bb0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2004.05.014","article-title":"Genetics and biology of vitamin D receptor polymorphisms","volume":"338","author":"Uitterlinden","year":"2004","journal-title":"Gene"},{"year":"2017","series-title":"2017 GLOBAL HIV STATISTICS","author":"UNAIDS","key":"10.1016\/j.meegid.2019.05.014_bb0305"},{"issue":"5 Pt 1","key":"10.1016\/j.meegid.2019.05.014_bb0310","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1753-4887.2006.tb00205.x","article-title":"A potential role for vitamin D on HIV infection?","volume":"64","author":"Villamor","year":"2006","journal-title":"Nutr. Rev."},{"issue":"5","key":"10.1016\/j.meegid.2019.05.014_bb0315","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.4049\/jimmunol.173.5.2909","article-title":"Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression","volume":"173","author":"Wang","year":"2004","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.meegid.2019.05.014_bb0320","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/gepi.21754","article-title":"EINVis: a visualization tool for analyzing and exploring genetic interactions in large-scale association studies","volume":"37","author":"Wu","year":"2013","journal-title":"Genet. Epidemiol."},{"issue":"2","key":"10.1016\/j.meegid.2019.05.014_bb0325","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/pcmr.12437","article-title":"Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival","volume":"29","author":"Yin","year":"2016","journal-title":"Pigment Cell Melanoma Res"},{"issue":"6","key":"10.1016\/j.meegid.2019.05.014_bb0330","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/157016208786501463","article-title":"Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals","volume":"6","author":"Zapata","year":"2008","journal-title":"Curr. HIV Res."},{"issue":"12","key":"10.1016\/j.meegid.2019.05.014_bb0335","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1089\/aid.2012.0299","article-title":"Influence of CCR5 and CCR2 genetic variants in the resistance\/susceptibility to HIV in serodiscordant couples from Colombia","volume":"29","author":"Zapata","year":"2013","journal-title":"AIDS Res. Hum. Retrovir."},{"issue":"3","key":"10.1016\/j.meegid.2019.05.014_bb0340","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.micinf.2015.10.009","article-title":"Identification of innate immune antiretroviral factors during in vivo and in vitro exposure to HIV-1","volume":"18","author":"Zapata","year":"2016","journal-title":"Microbes Infect."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134819300929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134819300929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:38:30Z","timestamp":1761575910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134819300929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":68,"alternative-id":["S1567134819300929"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2019.05.014","relation":{},"ISSN":["1567-1348"],"issn-type":[{"type":"print","value":"1567-1348"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic associations of the vitamin D and antiviral pathways with natural resistance to HIV-1 infection are influenced by interpopulation variability","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2019.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}