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Dis."},{"key":"10.1016\/j.meegid.2019.104020_bb0330","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1292\/jvms.09-0538","article-title":"Molecular analysis of antimicrobial resistance in gram-negative bacteria isolated from fish farms in Egypt","volume":"72","author":"Ishida","year":"2010","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.meegid.2019.104020_bb0335","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1128\/AAC.50.4.1178-1182.2006","article-title":"qnrB, another plasmid-mediated gene for quinolone resistance","volume":"50","author":"Jacoby","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0340","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1128\/AAC.00147-08","article-title":"qnr gene nomenclature","volume":"52","author":"Jacoby","year":"2008","journal-title":"Antimicrob. 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Microbiol."},{"key":"10.1016\/j.meegid.2019.104020_bb0355","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1179\/joc.2010.22.5.318","article-title":"Detection of unrelated Escherichia coli strains harboring genes of CTX-M-15, OXA-1, and AAC(6\u2032)-Ib-cr enzymes in a Tunisian hospital and characterization of their integrons and virulence factors","volume":"22","author":"Jouini","year":"2010","journal-title":"J. Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0360","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1469-0691.2008.01964.x","article-title":"Molecular characterisation of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. isolates at a tertiary-care centre in Lebanon","volume":"14","author":"Kanj","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.meegid.2019.104020_bb0365","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.323","article-title":"Self\u2010medication misuse in the Middle East: a systematic literature review","volume":"5","author":"Khalifeh","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.meegid.2019.104020_bb0370","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.diagmicrobio.2008.11.016","article-title":"Prevalence and characteristics of aac(6\u2032)-Ib-cr in AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens: a multicenter study from Korea","volume":"63","author":"Kim","year":"2009","journal-title":"Diagn. Microbiol. Infect. 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Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0390","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1128\/AAC.49.6.2343-2351.2005","article-title":"Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections","volume":"49","author":"Komp Lindgren","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0395","doi-asserted-by":"crossref","first-page":"7524","DOI":"10.1128\/AAC.01447-16","article-title":"Updated multiplex PCR for detection of all six plasmid-mediated qnr gene families","volume":"60","author":"Kraychete","year":"2016","journal-title":"Antimicrob. 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Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0420","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1128\/AEM.03409-12","article-title":"Real-Time PCR assays for quantification of qnr genes in environmental water samples and chicken feces","volume":"79","author":"Marti","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.meegid.2019.104020_bb0425","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(97)07322-4","article-title":"Quinolone resistance from a transferable plasmid","volume":"351","author":"Mart\u00ednez-Mart\u00ednez","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2019.104020_bb0430","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jac\/dks386","article-title":"Nosocomial dissemination of Providencia stuartii isolates carrying bla OXA-48, bla PER-1, bla CMY-4 and qnrA6 in a Tunisian hospital","volume":"68","author":"Mnif","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0435","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/AAC.33.2.254","article-title":"gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli","volume":"33","author":"Nakamura","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0440","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.plasmid.2008.03.003","article-title":"Nucleotide sequence of pOLA52: a conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux","volume":"60","author":"Norman","year":"2008","journal-title":"Plasmid"},{"key":"10.1016\/j.meegid.2019.104020_bb0445","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1128\/AAC.39.8.1667","article-title":"Detection of gyrA and gyrB mutations in quinolone-resistant clinical isolates of Escherichia coli by single-strand conformational polymorphism analysis and determination of levels of resistance conferred by two different single gyrA mutations","volume":"39","author":"Ouabdesselam","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0450","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1093\/jac\/dkx218","article-title":"Quantitative and automated MALDI-TOF MS-based detection of the plasmid-mediated quinolone resistance determinant AAC(6\u2032)-Ib-cr in Enterobacteriaceae","volume":"72","author":"Ovia\u00f1o","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0455","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/jac\/dkx218","article-title":"Rapid detection of the plasmid-mediated quinolone resistance determinant AAC(6\u2032)-Ib-cr in Enterobacteriaceae by MALDI-TOF MS analysis","volume":"72","author":"Ovia\u00f1o","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0460","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1007\/s10096-016-2762-1","article-title":"Rapid detection of AAC(6\u2032)-Ib-cr production using a MALDI-TOF MS strategy","volume":"35","author":"Pardo","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.meegid.2019.104020_bb0465","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1128\/AAC.00915-06","article-title":"Prevalence in the United States of aac(6\u2032)-Ib-cr encoding a ciprofloxacin-modifying enzyme","volume":"50","author":"Park","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0470","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro1464","article-title":"Multidrug-resistance efflux pumps - not just for resistance","volume":"4","author":"Piddock","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.meegid.2019.104020_bb0475","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/jac\/dkn068","article-title":"Surveillance for plasmid-mediated quinolone resistance determinants in Enterobacteriaceae within the Calgary Health Region, Canada: the emergence of aac(6\u2032)-Ib-cr","volume":"61","author":"Pitout","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0480","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/AAC.44.9.2233-2241.2000","article-title":"Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria","volume":"44","author":"Poole","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0485","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tim.2014.04.007","article-title":"Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success","volume":"22","author":"Redgrave","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.meegid.2019.104020_bb0490","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1473-3099(06)70599-0","article-title":"The worldwide emergence of plasmid-mediated quinolone resistance","volume":"6","author":"Robicsek","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.meegid.2019.104020_bb0495","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm1347","article-title":"Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase","volume":"12","author":"Robicsek","year":"2006","journal-title":"Nat. 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Updat."},{"key":"10.1016\/j.meegid.2019.104020_bb0515","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/mdr.2015.0298","article-title":"Assessment of chromosomal DNA fragmentation by quinolones in an isogenic collection of Escherichia coli with defined resistance mechanisms","volume":"22","author":"Rodr\u00edguez-Mart\u00ednez","year":"2016","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.meegid.2019.104020_bb0520","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijantimicag.2012.02.011","article-title":"Transferable mechanisms of quinolone resistance","volume":"40","author":"Ruiz","year":"2012","journal-title":"Int. J. Antimicrob. 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Drug Resist."},{"key":"10.1016\/j.meegid.2019.104020_bb0585","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2217\/fmb-2017-0171","article-title":"Genomic attributes of extended-spectrum \u03b2-lactamase-producing Escherichia coli isolated from patients in Lebanon","volume":"12","author":"Tokajian","year":"2017","journal-title":"Future Microbiol."},{"key":"10.1016\/j.meegid.2019.104020_bb0590","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40199-015-0116-7","article-title":"The emergence of plasmid mediated quinolone resistance qnrA2 in extended spectrum \u03b2-lactamase producing Klebsiella pneumoniae in the Middle East","volume":"23","author":"Vali","year":"2015","journal-title":"Daru"},{"key":"10.1016\/j.meegid.2019.104020_bb0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/bi052130w","article-title":"Pentapeptide repeat proteins","volume":"45","author":"Vetting","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.meegid.2019.104020_bb0600","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1128\/AAC.38.10.2477","article-title":"Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs","volume":"38","author":"Vila","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0605","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1128\/AAC.02167-15","article-title":"Mutations that enhance the ciprofloxacin resistance of Escherichia coli with qnrA1","volume":"60","author":"Vinu\u00e9","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2019.104020_bb0610","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijantimicag.2018.01.012","article-title":"Chromosomal mutations that accompany qnr in clinical isolates of Escherichia coli","volume":"51","author":"Vinu\u00e9","year":"2018","journal-title":"Int. J. Antimicrob. 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