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Dis."},{"issue":"6522","key":"10.1016\/j.meegid.2019.104094_bb0345","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","article-title":"CpG motifs in bacterial DNA trigger direct B-cell activation","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.meegid.2019.104094_bb0350","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2013.11.002","article-title":"The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells","volume":"39","author":"Lahaye","year":"2013","journal-title":"Immunity"},{"issue":"6260","key":"10.1016\/j.meegid.2019.104094_bb0355","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.aab3291","article-title":"DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway","volume":"350","author":"Lau","year":"2015","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.meegid.2019.104094_bb0360","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1186\/ar3317","article-title":"Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis research & therapy"},{"issue":"9","key":"10.1016\/j.meegid.2019.104094_bb0365","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat. 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A."},{"issue":"6","key":"10.1016\/j.meegid.2019.104094_bb0375","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.immuni.2013.10.019","article-title":"Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization","volume":"39","author":"Li","year":"2013","journal-title":"Immunity"},{"issue":"6152","key":"10.1016\/j.meegid.2019.104094_bb0380","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1244040","article-title":"Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects","volume":"341","author":"Li","year":"2013","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.meegid.2019.104094_bb0385","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/j.celrep.2018.11.097","article-title":"The Cyclopeptide Astin C specifically inhibits the innate immune CDN sensor STING","volume":"25","author":"Li","year":"2018","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.meegid.2019.104094_bb0390","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMoa1312625","article-title":"Activated STING in a vascular and pulmonary syndrome","volume":"371","author":"Liu","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"31","key":"10.1016\/j.meegid.2019.104094_bb0395","doi-asserted-by":"crossref","first-page":"E4306","DOI":"10.1073\/pnas.1503831112","article-title":"Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses","volume":"112","author":"Ma","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.meegid.2019.104094_bb0400","doi-asserted-by":"crossref","first-page":"831","DOI":"10.15252\/embj.201593339","article-title":"Ribonuclease H2 mutations induce a cGAS\/STING-dependent innate immune response","volume":"35","author":"Mackenzie","year":"2016","journal-title":"EMBO J."},{"issue":"7668","key":"10.1016\/j.meegid.2019.104094_bb0405","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature23449","article-title":"cGAS surveillance of micronuclei links genome instability to innate immunity","volume":"548","author":"Mackenzie","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.meegid.2019.104094_bb0410","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.celrep.2016.07.002","article-title":"Restriction by SAMHD1 limits cGAS\/STING-dependent innate and adaptive immune responses to HIV-1","volume":"16","author":"Maelfait","year":"2016","journal-title":"Cell Rep."},{"issue":"24","key":"10.1016\/j.meegid.2019.104094_bb0415","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.15252\/embj.201488726","article-title":"DNA hybrids activate the cGAS-STING axis","volume":"33","author":"Mankan","year":"2014","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.meegid.2019.104094_bb0420","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cytogfr.2014.08.004","article-title":"Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection","volume":"25","author":"Maringer","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"issue":"28","key":"10.1016\/j.meegid.2019.104094_bb0425","doi-asserted-by":"crossref","first-page":"19655","DOI":"10.1074\/jbc.274.28.19655","article-title":"Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3\u2032\u21925\u2032 exonucleases","volume":"274","author":"Mazur","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.meegid.2019.104094_bb0430","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jaci.2016.10.031","article-title":"Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling","volume":"140","author":"Melki","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.meegid.2019.104094_bb0435","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrrheum.2010.63","article-title":"Genetics of SLE: evidence from mouse models","volume":"6","author":"Morel","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"issue":"15","key":"10.1016\/j.meegid.2019.104094_bb0440","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1128\/MCB.24.15.6719-6727.2004","article-title":"Gene-targeted mice lacking the Trex1 (DNase III) 3\u2032-->5\u2019 DNA exonuclease develop inflammatory myocarditis","volume":"24","author":"Morita","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.meegid.2019.104094_bb0445","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11932","article-title":"Activation of STING requires palmitoylation at the Golgi","volume":"7","author":"Mukai","year":"2016","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.meegid.2019.104094_bb0450","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.immuni.2013.05.004","article-title":"Immune sensing of DNA","volume":"38","author":"Paludan","year":"2013","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.meegid.2019.104094_bb0455","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.chest.2016.02.682","article-title":"Severe pulmonary fibrosis as the first manifestation of Interferonopathy (TMEM173 mutation)","volume":"150","author":"Picard","year":"2016","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.meegid.2019.104094_bb0460","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/eji.201343921","article-title":"Circulating mitochondrial DNA increases with age and is a familiar trait: implications for \u201cinflamm-aging\u201d","volume":"44","author":"Pinti","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.meegid.2019.104094_bb0465","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.20151464","article-title":"RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice","volume":"213","author":"Pokatayev","year":"2016","journal-title":"J. Exp. Med."},{"issue":"7476","key":"10.1016\/j.meegid.2019.104094_bb0470","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature12769","article-title":"HIV-1 evades innate immune recognition through specific cofactor recruitment","volume":"503","author":"Rasaiyaah","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.meegid.2019.104094_bb0475","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.cell.2012.04.011","article-title":"Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development","volume":"149","author":"Reijns","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.meegid.2019.104094_bb0480","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10875-015-0147-3","article-title":"Human disease phenotypes associated with mutations in TREX1","volume":"35","author":"Rice","year":"2015","journal-title":"J. Clin. Immunol."},{"issue":"7","key":"10.1016\/j.meegid.2019.104094_bb0485","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cell.2014.11.037","article-title":"Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA","volume":"159","author":"Rongvaux","year":"2014","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.meegid.2019.104094_bb0490","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00647-17","article-title":"High levels of cyclic Di-GMP in Klebsiella pneumoniae attenuate virulence in the lung","volume":"86","author":"Rosen","year":"2018","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.meegid.2019.104094_bb0495","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI108132","article-title":"The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein","volume":"56","author":"Roth","year":"1975","journal-title":"J. Clin. Invest."},{"issue":"49","key":"10.1016\/j.meegid.2019.104094_bb0500","doi-asserted-by":"crossref","first-page":"20842","DOI":"10.1073\/pnas.0911267106","article-title":"Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response","volume":"106","author":"Saitoh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.meegid.2019.104094_bb0505","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1128\/JVI.72.4.3307-3320.1998","article-title":"Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins","volume":"72","author":"Samaniego","year":"1998","journal-title":"J. Virol."},{"issue":"7485","key":"10.1016\/j.meegid.2019.104094_bb0510","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nature12862","article-title":"Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity","volume":"505","author":"Schoggins","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.meegid.2019.104094_bb0515","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.jaci.2016.10.030","article-title":"Tofacitinib relieves symptoms of stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173","volume":"139","author":"Seo","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"10.1016\/j.meegid.2019.104094_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.11.047","article-title":"Magnitude of therapeutic STING activation determines CD8(+) T cell-mediated anti-tumor immunity","volume":"25","author":"Sivick","year":"2018","journal-title":"Cell Reports"},{"issue":"6121","key":"10.1016\/j.meegid.2019.104094_bb0525","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.meegid.2019.104094_bb0530","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/ard.41.4.388","article-title":"Prognostic value of anti-dsDNA in SLE","volume":"41","author":"Swaak","year":"1982","journal-title":"Ann. Rheum. Dis."},{"issue":"7152","key":"10.1016\/j.meegid.2019.104094_bb0535","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature06013","article-title":"DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response","volume":"448","author":"Takaoka","year":"2007","journal-title":"Nature"},{"issue":"214","key":"10.1016\/j.meegid.2019.104094_bb0540","doi-asserted-by":"crossref","first-page":"ra20","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.meegid.2019.104094_bb0545","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1006\/bbrc.1998.8876","article-title":"Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines","volume":"247","author":"Tokutake","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.meegid.2019.104094_bb0550","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni.1932","article-title":"IFI16 is an innate immune sensor for intracellular DNA","volume":"11","author":"Unterholzner","year":"2010","journal-title":"Nat. Immunol."},{"issue":"5\u20136","key":"10.1016\/j.meegid.2019.104094_bb0555","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0049-3848(03)00379-7","article-title":"The mechanism of action of aspirin","volume":"110","author":"Vane","year":"2003","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.meegid.2019.104094_bb0560","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41467-017-00833-9","article-title":"Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice","volume":"8","author":"Vincent","year":"2017","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.meegid.2019.104094_bb0565","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrc3365","article-title":"Mitochondria and cancer","volume":"12","author":"Wallace","year":"2012","journal-title":"Nat. Rev. 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Rev. Immunol."},{"issue":"6121","key":"10.1016\/j.meegid.2019.104094_bb0600","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.meegid.2019.104094_bb0605","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.celrep.2015.12.029","article-title":"Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis","volume":"14","author":"Xia","year":"2016","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.meegid.2019.104094_bb0610","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molcel.2013.07.004","article-title":"The cGAS-STING pathway for DNA sensing","volume":"51","author":"Xiao","year":"2013","journal-title":"Mol. Cell"},{"issue":"24","key":"10.1016\/j.meegid.2019.104094_bb0615","doi-asserted-by":"crossref","first-page":"11946","DOI":"10.1073\/pnas.1905013116","article-title":"Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation","volume":"116","author":"Xie","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.meegid.2019.104094_bb0620","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ni.1941","article-title":"The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1","volume":"11","author":"Yan","year":"2010","journal-title":"Nat. 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A."},{"issue":"4","key":"10.1016\/j.meegid.2019.104094_bb0635","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/eji.201445133","article-title":"Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG","volume":"45","author":"Yildiz","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.meegid.2019.104094_bb0640","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. 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