{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:21:36Z","timestamp":1777587696949,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007073","name":"University of Mohaghegh Ardabili","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007073","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.meegid.2020.104431","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T21:55:58Z","timestamp":1592517358000},"page":"104431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Which genotype of Helicobacter pylori\u2014cagA or cagE\u2014Is better associated with gastric Cancer risk? Lessons from an extremely high-risk area in Iran"],"prefix":"10.1016","volume":"85","author":[{"given":"Seyedeh Zahra","family":"Bakhti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Latifi-Navid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shokufe","family":"Gholizade Tobnagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiana","family":"Yazdanbod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Yazdanbod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2020.104431_bb0005","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1002\/cam4.2497","article-title":"Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives","volume":"8","author":"Abdi","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.meegid.2020.104431_bb0010","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.3748\/wjg.v11.i43.6815","article-title":"Association between cag-pathogenicity island in helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and non-ulcer dyspepsia subjects with histological changes","volume":"11","author":"Ali","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.meegid.2020.104431_bb0015","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.dld.2009.01.010","article-title":"Determination of helicobacter pylori virulence by analysis of the cag pathogenicity island isolated from Iranian patients","volume":"41","author":"Baghaei","year":"2009","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.meegid.2020.104431_bb0020","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3906\/sag-1606-116","article-title":"Comparative analysis of selected cagPAI genes and different vacA genotypes in Iranian and Turkish H. pylori-positive patients suffering from gastric adenocarcinoma and active chronic gastritis","volume":"47","author":"Bahadori","year":"2017","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.meegid.2020.104431_bb0025","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/hel.12284","article-title":"Relevance of helicobacter pylori vacA 3\u2032-end region polymorphism to gastric Cancer","volume":"21","author":"Bakhti","year":"2016","journal-title":"Helicobacter"},{"key":"10.1016\/j.meegid.2020.104431_bb0030","doi-asserted-by":"crossref","first-page":"104167","DOI":"10.1016\/j.meegid.2019.104167","article-title":"Unique constellations of five polymorphic sites of helicobacter pylori vacA and cagA status associated with risk of gastric cancer","volume":"79","author":"Bakhti","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2020.104431_bb0035","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/hel.12220","article-title":"Helicobacter pylori might induce TGF-beta1-mediated EMT by means of cagE","volume":"20","author":"Chang","year":"2015","journal-title":"Helicobacter"},{"key":"10.1016\/j.meegid.2020.104431_bb0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijid.2007.03.012","article-title":"Prevalence of helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients","volume":"12","author":"Chomvarin","year":"2008","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.meegid.2020.104431_bb0045","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/j.1440-1746.2009.05876.x","article-title":"Distribution of helicobacter pylori cagA, cagE, oipA and vacA in different major ethnic groups in Tehran, Iran","volume":"24","author":"Dabiri","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.meegid.2020.104431_bb0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.micpath.2017.02.018","article-title":"Prevalence of helicobacter pylori vacA, cagA, cagE, oipA, iceA, babA2 and babB genotypes in Iranian dyspeptic patients","volume":"105","author":"Dabiri","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104431_bb0055","doi-asserted-by":"crossref","first-page":"7942489","DOI":"10.1155\/2017\/7942489","article-title":"Helicobacter pylori pathogenicity factors related to gastric Cancer","volume":"2017","author":"Dadashzadeh","year":"2017","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.meegid.2020.104431_bb0060","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1523-5378.2006.00461.x","article-title":"Prevalence of helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia","volume":"11","author":"Erzin","year":"2006","journal-title":"Helicobacter"},{"key":"10.1016\/j.meegid.2020.104431_bb0065","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.3923\/pjbs.2008.2579.2583","article-title":"The prevalence of cagA and cagE genes in helicobacter pylori strains isolated from different patient groups by polymerase chain reaction","volume":"11","author":"Ghasemi","year":"2008","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.meegid.2020.104431_bb0070","first-page":"43","article-title":"Role of plasticity region genes and cagE gene of cagPAI of helicobacter pylori in development of gastrointestinal (GI) diseases","volume":"18","author":"GholizadeTobnagh","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.meegid.2020.104431_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12665","article-title":"Helicobacter pylori inhibits GKN1 expression via the CagA\/p-ERK\/AUF1 pathway","volume":"25","author":"Guo","year":"2020","journal-title":"Helicobacter"},{"key":"10.1016\/j.meegid.2020.104431_bb0080","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/j.gastro.2003.08.033","article-title":"Meta-analysis of the relationship between cagA seropositivity and gastric cancer","volume":"125","author":"Huang","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.meegid.2020.104431_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/09674845.2017.1278887","article-title":"Association of heterogenicity of helicobacter pylori cag pathogenicity island with peptic ulcer diseases and gastric cancer","volume":"74","author":"Khatoon","year":"2017","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.meegid.2020.104431_bb0090","doi-asserted-by":"crossref","first-page":"356217","DOI":"10.1155\/2013\/356217","article-title":"Association of IS605 and cag-PAI of helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan","volume":"2013","author":"Lai","year":"2013","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.meegid.2020.104431_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020513","article-title":"Helicobacter pylori targets the EPHA2 receptor tyrosine kinase in gastric cells modulating key cellular functions","volume":"9","author":"Leite","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.meegid.2020.104431_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2015.14","article-title":"Somatic DNA hypomethylation in H. pylori-associated high-risk gastritis and gastric cancer: enhanced somatic hypomethylation associates with advanced stage cancer","volume":"6","author":"Leodolter","year":"2015","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.meegid.2020.104431_bb0105","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1016\/j.canep.2011.02.017","article-title":"Prevalence of helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian\u2019s patients: an association with histopathological parameters","volume":"35","author":"Lima","year":"2011","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.meegid.2020.104431_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-9378-5-1","article-title":"Association of LEC and tnpA helicobacter pylori genes with gastric cancer in a Brazilian population","volume":"5","author":"Mattar","year":"2010","journal-title":"Infect Agent Cancer"},{"key":"10.1016\/j.meegid.2020.104431_bb0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/S1413-86702007000100020","article-title":"Correlation between helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil","volume":"11","author":"Modena","year":"2007","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.meegid.2020.104431_bb0120","first-page":"891","article-title":"Genes inside the cagPAI of helicobacter pylori are not associated with gastric cancer in Japan","volume":"51","author":"Nishiya","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.meegid.2020.104431_bb0125","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.micpath.2018.03.004","article-title":"Risk of gastric cancer in association with helicobacter pylori different virulence factors: a systematic review and meta-analysis","volume":"118","author":"Pormohammad","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104431_bb0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ijc.11359","article-title":"Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran","volume":"107","author":"Sadjadi","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.meegid.2020.104431_bb0135","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.micpath.2018.04.018","article-title":"Multiplex serology of helicobacter pylori antigens in detection of current infection and atrophic gastritis - a simple and cost-efficient method","volume":"119","author":"Shafaie","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104431_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142606","article-title":"Biochemical analysis of CagE: a VirB4 homologue of helicobacter pylori Cag-T4SS","volume":"10","author":"Shariq","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104431_bb0145","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2217\/fmb.10.135","article-title":"Serum helicobacter pylori CagA antibody as a biomarker for gastric cancer in east-Asian countries","volume":"5","author":"Shiota","year":"2010","journal-title":"Future Microbiol"},{"key":"10.1016\/j.meegid.2020.104431_bb0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/febs.13592","article-title":"Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner","volume":"283","author":"Sougleri","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.meegid.2020.104431_bb0155","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.lab.2005.06.010","article-title":"Heterogeneity of cag genotypes and clinical outcome of helicobacter pylori infection","volume":"146","author":"Sozzi","year":"2005","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.meegid.2020.104431_bb0160","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41423-019-0339-5","article-title":"Molecular anatomy and pathogenic actions of helicobacter pylori CagA that underpin gastric carcinogenesis","volume":"17","author":"Takahashi-Kanemitsu","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.meegid.2020.104431_bb0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.micpath.2013.04.001","article-title":"Distribution of helicobacter pylori virulence markers in patients with gastroduodenal diseases in a region at high risk of gastric cancer","volume":"59\u201360","author":"Wang","year":"2013","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104431_bb0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/09674845.2009.11730260","article-title":"Low prevalence of the intact cag pathogenicity island in clinical isolates of helicobacter pylori in Karachi, Pakistan","volume":"66","author":"Yakoob","year":"2009","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.meegid.2020.104431_bb0175","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/1319-3767.118123","article-title":"Comparison of the virulence markers of helicobacter pylori and their associated diseases in patients from Pakistan and Afghanistan","volume":"19","author":"Yakoob","year":"2013","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.meegid.2020.104431_bb0180","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1099\/jmm.0.001088","article-title":"N-terminal region of helicobacter pylori CagA induces IL-8 production in gastric epithelial cells via the beta1 integrin receptor","volume":"69","author":"Zeng","year":"2020","journal-title":"J. Med. Microbiol."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820302628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820302628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:44:15Z","timestamp":1761576255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134820302628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":36,"alternative-id":["S1567134820302628"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104431","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Which genotype of Helicobacter pylori\u2014cagA or cagE\u2014Is better associated with gastric Cancer risk? Lessons from an extremely high-risk area in Iran","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104431","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104431"}}