{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:13:01Z","timestamp":1778821981723,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2017\/ SKK11 \/AIMST\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2017\/ SKK11 \/AIMST\/02\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.meegid.2020.104439","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T03:47:34Z","timestamp":1592884054000},"page":"104439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Bioinformatics analysis reveals four major hexon variants of human adenovirus type-3 (HAdV-3) as the potential strains for development of vaccine and siRNA-based therapeutics against HAdV-3 respiratory infections"],"prefix":"10.1016","volume":"85","author":[{"given":"Somnath","family":"Panda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urmila","family":"Banik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun K.","family":"Adhikary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2020.104439_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary Transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.meegid.2020.104439_bb0010","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1099\/jmm.0.000625","article-title":"Genomic diversity of human adenovirus type 3 isolated in Fukui, Japan over a 24-year period","volume":"66","author":"Adhikary","year":"2017","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.meegid.2020.104439_bb0015","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.bbrc.2004.02.157","article-title":"An algorithm for selection of functional siRNA sequences","volume":"316","author":"Amarzguioui","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.meegid.2020.104439_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4149\/av_2013_02_97","article-title":"Role and application of RNA interference in replication of influenza viruses","volume":"57","author":"Bet\u00e1kov\u00e1","year":"2013","journal-title":"Acta Virol."},{"key":"10.1016\/j.meegid.2020.104439_bb0025","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1128\/JCM.42.4.1686-1693.2004","article-title":"Molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults","volume":"42","author":"Blasiole","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104439_bb0030","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1128\/jvi.70.3.1836-1844.1996","article-title":"Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residues","volume":"70","author":"Crawford-Miksza","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2020.104439_bb0035","doi-asserted-by":"crossref","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr: robust phylogenetic analysis for the non-specialist","volume":"36","author":"Dereeper","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2020.104439_bb0040","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.antiviral.2010.08.002","article-title":"Inhibition of adenovirus infections by siRNA-mediated silencing of early and late adenoviral gene functions","volume":"88","author":"Eckstein","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.meegid.2020.104439_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159211","article-title":"In Silico design and experimental validation of siRNAs targeting conserved regions of multiple hepatitis C virus genotypes","volume":"11","author":"ElHefnawi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104439_bb0050","article-title":"Novel computational approaches to developing potential STAT4 silencing siRNAs for immunomodulation of atherosclerosis","author":"Fookolaee","year":"2019","journal-title":"Curr Comput Aided Drug Des"},{"key":"10.1016\/j.meegid.2020.104439_bb0055","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1073\/pnas.0437841100","article-title":"RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription","volume":"100","author":"Ge","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2020.104439_bb0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.virusres.2004.01.013","article-title":"Use of siRNAs to prevent and treat influenza virus infection","volume":"102","author":"Ge","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.meegid.2020.104439_bb0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-5793(03)00400-9","article-title":"Short interfering RNA-directed inhibition of hepatitis B virus replication","volume":"543","author":"Hamasaki","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.meegid.2020.104439_bb0070","article-title":"Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon","volume":"13","author":"Haque","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104439_bb0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature00896","article-title":"Modulation of HIV-1 replication by RNA interference","volume":"418","author":"Jacque","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.meegid.2020.104439_bb0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jmv.1890300116","article-title":"A new genome type of adenovirus 3 associated with severe lower acute respiratory infection in children","volume":"30","author":"Kajon","year":"1990","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2020.104439_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-018-1064-x","article-title":"Molecular characterization of human adenovirus associated with acute respiratory infections in Cameroon from 2011 to 2014","volume":"15","author":"Kenmoe","year":"2018","journal-title":"Virol. J."},{"key":"10.1016\/j.meegid.2020.104439_bb0090","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1128\/JCM.41.10.4594-4599.2003","article-title":"Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in children","volume":"41","author":"Kim","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104439_bb0095","series-title":"Fields Virology - NLM Catalog - NCBI","author":"Knipe and Howley F","year":"2013"},{"key":"10.1016\/j.meegid.2020.104439_bb0100","article-title":"Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010\u20132011","volume":"8","author":"Lai","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104439_bb0105","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jmii.2018.07.005","article-title":"Molecular epidemiology and clinical features of adenovirus infection in Taiwanese children, 2014","volume":"52","author":"Lin","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.meegid.2020.104439_bb0110","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.meegid.2020.104439_bb0115","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0036-1584923","article-title":"Adenovirus: epidemiology, global spread of novel serotypes, and advances in treatment and prevention","volume":"37","author":"Lynch","year":"2016","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.meegid.2020.104439_bb0120","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1586\/14787210.2013.836964","article-title":"Diagnosis and treatment of adenovirus infection in immunocompromised patients","volume":"11","author":"Matthes-Martin","year":"2013","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"10.1016\/j.meegid.2020.104439_bb0125","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/jgm.739","article-title":"Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors","volume":"7","author":"Moore","year":"2005","journal-title":"J Gene Med"},{"key":"10.1016\/j.meegid.2020.104439_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025642","article-title":"MysiRNA-designer: a workflow for efficient siRNA design","volume":"6","author":"Mysara","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104439_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-392","article-title":"siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect","volume":"10","author":"Naito","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.meegid.2020.104439_bb0140","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1101\/gr.2129504","article-title":"zPicture: dynamic alignment and visualization tool for analyzing conservation profiles","volume":"14","author":"Ovcharenko","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.meegid.2020.104439_bb0145","unstructured":"Pichla-Gollon SL. Structure-based Identification of a Major Neutralizing Site in an Adenovirus Hexon - PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/17108028\/?from_single_result=Structure-based+identification+of+a+major+neutralizing+site+in+an+adenovirus+hexon ((accessed March 19, 2020)."},{"key":"10.1016\/j.meegid.2020.104439_bb0150","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nbt936","article-title":"Rational siRNA design for RNA interference","volume":"22","author":"Reynolds","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.meegid.2020.104439_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.003087-0","article-title":"Adenoviruses: update on structure and function","volume":"90","author":"Russell","year":"2009","journal-title":"J Gen Virol"},{"key":"10.1016\/j.meegid.2020.104439_bb0160","doi-asserted-by":"crossref","first-page":"8682","DOI":"10.1073\/pnas.0402630101","article-title":"Protection against lethal influenza virus challenge by RNA interference in vivo","volume":"101","author":"Tompkins","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2020.104439_bb0165","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/nar\/gkh247","article-title":"Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference","volume":"32","author":"Ui-Tei","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2020.104439_bb0170","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/femsre\/fuz008","article-title":"Drug development against human adenoviruses and its advancement by Syrian hamster models","volume":"43","author":"Wold","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.meegid.2020.104439_bb0175","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.1330920100","article-title":"Caspase 8 small interfering RNA prevents acute liver failure in mice","volume":"100","author":"Zender","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2020.104439_bb0180","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1600-0463.2012.02890.x","article-title":"Human adenovirus infection in children with acute respiratory tract disease in Guangzhou, China","volume":"120","author":"Zou","year":"2012","journal-title":"APMIS"}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820302707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820302707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:41:49Z","timestamp":1778820109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134820302707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":36,"alternative-id":["S1567134820302707"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104439","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioinformatics analysis reveals four major hexon variants of human adenovirus type-3 (HAdV-3) as the potential strains for development of vaccine and siRNA-based therapeutics against HAdV-3 respiratory infections","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104439"}}