{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:06:57Z","timestamp":1777525617519,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.meegid.2020.104468","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T12:07:30Z","timestamp":1595419650000},"page":"104468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Sequence-based detection of first-line and second-line drugs resistance-associated mutations in Mycobacterium tuberculosis isolates in Isfahan, Iran"],"prefix":"10.1016","volume":"85","author":[{"given":"Marzieh","family":"Safari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharareh","family":"Moghim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahshid","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-1235","authenticated-orcid":false,"given":"Rasool","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Nasr Esfahani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meegid.2020.104468_bb0005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.micpath.2017.05.002","article-title":"Analysis of rrs gene mutations in amikacin resistant clinical isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan","volume":"108","author":"Ahmad","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104468_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/167954","article-title":"Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland","volume":"2013","author":"Bakula","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.meegid.2020.104468_bb0015","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jmii.2015.04.003","article-title":"Second-line anti-tuberculosis drug resistance and its genetic determinants in multidrug-resistant Mycobacterium tuberculosis clinical isolates","volume":"49","author":"Bakula","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.meegid.2020.104468_bb0020","doi-asserted-by":"crossref","first-page":"11919","DOI":"10.1073\/pnas.93.21.11919","article-title":"The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol","volume":"93","author":"Belanger","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2020.104468_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.6061\/clinics\/2013(02)OA10","article-title":"Incidence of tuberculous and non-tuberculous mycobacteria, differentiated by multiplex PCR, in clinical specimens of a large general hospital","volume":"68","author":"Bensi","year":"2013","journal-title":"Clin. (Sao Paulo, Brazil)"},{"key":"10.1016\/j.meegid.2020.104468_bb0030","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1128\/JCM.01947-09","article-title":"Detection by GenoType MTBDRsl test of complex mechanisms of resistance to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates","volume":"48","author":"Brossier","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0035","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01299-16","article-title":"Molecular investigation of resistance to second-line injectable drugs in multidrug-resistant clinical isolates of Mycobacterium tuberculosis in France","volume":"61","author":"Brossier","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0040","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1128\/AAC.01550-10","article-title":"Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis","volume":"55","author":"Campbell","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0045","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1128\/AAC.01049-15","article-title":"Mutations in gyrA and gyrB among fluoroquinolone- and multidrug-resistant Mycobacterium tuberculosis isolates","volume":"60","author":"Chien","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0050","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1128\/JCM.41.3.1010-1015.2003","article-title":"Conventional methods versus 16S ribosomal DNA sequencing for identification of nontuberculous mycobacteria: cost analysis","volume":"41","author":"Cook","year":"2003","journal-title":"J. Clin. Microbiol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104468_bb0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S2213-2600(17)30079-6","article-title":"The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis","volume":"5","author":"Dheda","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.meegid.2020.104468_bb0060","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/jac\/dkx506","article-title":"Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care","volume":"73","author":"Dookie","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0065","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.diagmicrobio.2013.06.031","article-title":"Mycobacterium tuberculosis rrs A1401G mutation correlates with high-level resistance to kanamycin, amikacin, and capreomycin in clinical isolates from mainland China","volume":"77","author":"Du","year":"2013","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.meegid.2020.104468_bb0070","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jac\/dkr109","article-title":"Comparison of clinical isolates and in vitro selected mutants reveals that tlyA is not a sensitive genetic marker for capreomycin resistance in Mycobacterium tuberculosis","volume":"66","author":"Engstrom","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0075","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1128\/AAC.00050-09","article-title":"Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment","volume":"53","author":"Feuerriegel","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0080","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(06)69573-1","article-title":"Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa","volume":"368","author":"Gandhi","year":"2006","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.meegid.2020.104468_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033275","article-title":"Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review","volume":"7","author":"Georghiou","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104468_bb0090","first-page":"1","article-title":"Gene mutations related to rifampin resistance of tuberculosis in northwest of Iran","volume":"19","author":"Gholizadeh","year":"2020","journal-title":"Gene Rep."},{"key":"10.1016\/j.meegid.2020.104468_bb0095","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/jac\/dks178","article-title":"The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region","volume":"67","author":"Gikalo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/1120009X.2020.1716479","article-title":"Molecular identification of mutations conferring resistance to rifampin, isoniazid and pyrazinamide among Mycobacterium tuberculosis isolates from Iran","volume":"32","author":"Haratiasl","year":"2020","journal-title":"J. Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0105","first-page":"3214","article-title":"Mutation profiling for detection of isoniazid resistance in Mycobacterium tuberculosis clinical isolates","volume":"70","author":"Jagielski","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0110","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1128\/JCM.00691-14","article-title":"Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis","volume":"52","author":"Jamieson","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0115","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1128\/AAC.00851-09","article-title":"High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene","volume":"53","author":"Jugheli","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0120","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2147\/IDR.S196800","article-title":"Characterization of the most common embCAB gene mutations associated with ethambutol resistance in Mycobacterium tuberculosis isolates from Iran","volume":"12","author":"Khosravi","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.meegid.2020.104468_bb0125","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3201\/eid1205.050200","article-title":"Mycobacterium bovis isolates with M. tuberculosis specific characteristics","volume":"12","author":"Kubica","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2020.104468_bb0130","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.meegid.2020.104468_bb0135","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/j.1365-2672.2010.04840.x","article-title":"Usefulness of resistant gene markers for predicting treatment outcome on second-line anti-tuberculosis drugs","volume":"109","author":"Leung","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0140","doi-asserted-by":"crossref","first-page":"8949","DOI":"10.1016\/S0021-9258(17)34269-2","article-title":"On the mechanism of rifampicin inhibition of RNA synthesis","volume":"253","author":"McClure","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.meegid.2020.104468_bb0145","first-page":"117","article-title":"The relationship between embb306 and embb406 mutations and ethambutol resistant in Mycobacterium tuberculosis isolated from patiens in west of Iran","volume":"32","author":"Mohammadi","year":"2018","journal-title":"Med. J. Islam Repub. Iran"},{"key":"10.1016\/j.meegid.2020.104468_bb0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1995-7645(14)60019-5","article-title":"Drug resistance pattern of Mycobacterium tuberculosis isolates from patients of five provinces of Iran","volume":"7","author":"Nasiri","year":"2014","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.meegid.2020.104468_bb0155","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/jac\/dkp452","article-title":"Genetic analysis of extensively drug-resistant Mycobacterium tuberculosis strains in Lisbon, Portugal","volume":"65","author":"Perdigao","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-016-0575-9","article-title":"Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance","volume":"14","author":"Phelan","year":"2016","journal-title":"BMC Med."},{"key":"10.1016\/j.meegid.2020.104468_bb0165","first-page":"1","article-title":"Second line injectable drug resistance and associated genetic mutations in newly diagnosed cases of multidrug-resistant tuberculosis","volume":"00","author":"Ramakrishna","year":"2020","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.meegid.2020.104468_bb0170","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/AAC.04438-14","article-title":"Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium tuberculosis","volume":"59","author":"Reeves","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.meegid.2020.104468_bb0175","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00284-016-1145-2","article-title":"Genetic lineages of Mycobacterium tuberculosis isolates in Isfahan, Iran","volume":"74","author":"Riyahi Zaniani","year":"2017","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0180","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/JCM.02701-13","article-title":"Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations","volume":"52","author":"Rodwell","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biologicals.2017.07.003","article-title":"A comparative study of phenotypic and genotypic first- and second-line drug resistance testing of Mycobacterium tuberculosis","volume":"49","author":"Sakhaee","year":"2017","journal-title":"Biologicals"},{"key":"10.1016\/j.meegid.2020.104468_bb0190","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.micpath.2018.02.047","article-title":"Review on emergence of drug-resistant tuberculosis (MDR & XDR-TB) and its molecular diagnosis in Ethiopia","volume":"117","author":"Saravanan","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104468_bb0195","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/mdr.2011.0063","article-title":"Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis","volume":"18","author":"Sirgel","year":"2012","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.meegid.2020.104468_bb0200","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.2147\/IDR.S178831","article-title":"Molecular detection of rifampin, isoniazid, and ofloxacin resistance in Iranian isolates of Mycobacterium tuberculosis by high-resolution melting analysis","volume":"11","author":"Sirous","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.meegid.2020.104468_bb0205","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4314\/ejhs.v28i3.7","article-title":"Mutations of rpob gene associated with Rifampin resistance among Mycobacterium tuberculosis isolated in tuberculosis regional reference Laboratory in Northeast of Iran during 2015\u20132016","volume":"28","author":"Tavanaee Sani","year":"2018","journal-title":"Ethiop. J. Health Sci."},{"key":"10.1016\/j.meegid.2020.104468_bb0210","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm0597-567","article-title":"The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol","volume":"3","author":"Telenti","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.meegid.2020.104468_bb0215","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01477-18","article-title":"Genetic diversity of multi- and extensively drug-resistant Mycobacterium tuberculosis isolates in the Capital of Iran, revealed by whole-genome sequencing","volume":"57","author":"Vaziri","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0220","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1378\/chest.08-2427","article-title":"Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran","volume":"136","author":"Velayati","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.meegid.2020.104468_bb0225","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/JCM.01476-09","article-title":"Polymorphisms associated with resistance and cross-resistance to aminoglycosides and capreomycin in Mycobacterium tuberculosis isolates from South Korean Patients with drug-resistant tuberculosis","volume":"48","author":"Via","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104468_bb0230","series-title":"Multidrug and Extensively Drug-Resistant TB (M\/XDR-TB): 2010 Global Report on Surveillance and Response","author":"WHO","year":"2010"},{"key":"10.1016\/j.meegid.2020.104468_bb0235","series-title":"World Health Organization. Companion Handbook to the WHO Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis","author":"WHO","year":"2014"},{"key":"10.1016\/j.meegid.2020.104468_bb0240","series-title":"Global Tuberculosis Report 2018","author":"WHO","year":"2018"},{"key":"10.1016\/j.meegid.2020.104468_bb0245","doi-asserted-by":"crossref","first-page":"20004","DOI":"10.1073\/pnas.0907925106","article-title":"Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis","volume":"106","author":"Zaunbrecher","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.meegid.2020.104468_bb0250","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.5588\/ijtld.15.0389","article-title":"Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015","volume":"19","author":"Zhang","year":"2015","journal-title":"Int. J. Tuberc. Lung Dis."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820302999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820302999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:55:33Z","timestamp":1761576933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134820302999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":50,"alternative-id":["S1567134820302999"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104468","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sequence-based detection of first-line and second-line drugs resistance-associated mutations in Mycobacterium tuberculosis isolates in Isfahan, Iran","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104468"}}