{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:30:56Z","timestamp":1776069056298,"version":"3.50.1"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.meegid.2020.104517","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T16:52:34Z","timestamp":1598979154000},"page":"104517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Genome based evolutionary lineage of SARS-CoV-2 towards the development of novel chimeric vaccine"],"prefix":"10.1016","volume":"85","author":[{"given":"Mst Rubaiat Nazneen","family":"Akhand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazi Faizul","family":"Azim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda Farjana","family":"Hoque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmuda Akther","family":"Moli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijit Das","family":"Joy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Akter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Khalil","family":"Afif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadim","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmudul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"28","key":"10.1016\/j.meegid.2020.104517_bb0005","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.2174\/138161210793292447","article-title":"Epitope discovery and their use in peptide based vaccines","volume":"16","author":"Dudek","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.meegid.2020.104517_bb0010","series-title":"When Will A Coronavirus Vaccine Be Ready?","author":"Spinney","year":"2020"},{"key":"10.1016\/j.meegid.2020.104517_bb0015","series-title":"Infection Prevention and Control During Health Care When COVID-19 Is Suspected: Interim Guidance","first-page":"2020","author":"World Health Organization (WHO)","year":"2020"},{"key":"10.1016\/j.meegid.2020.104517_bb0020","series-title":"Biotech Company Moderna Says Its Coronavirus Vaccine is Ready For First Tests","author":"Ziady","year":"2020"},{"issue":"6","key":"10.1016\/j.meegid.2020.104517_bb0025","first-page":"S4","article-title":"AllerTOP v.2 - a server for in silico prediction of allergens","volume":"14","author":"Dimitrov","year":"2014","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.meegid.2020.104517_bb0030","author":"NIH News Event"},{"key":"10.1016\/j.meegid.2020.104517_bb0035","author":"World Health Organization (WHO)"},{"issue":"2","key":"10.1016\/j.meegid.2020.104517_bb0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1096-987X(19970130)18:2<169::AID-JCC3>3.0.CO;2-T","article-title":"A comparison of techniques for calculating protein essential dynamics","volume":"18","author":"Aalten","year":"1997","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.meegid.2020.104517_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2683286","article-title":"Design of a multiepitope-based peptide vaccine against the E protein of human COVID-19: an immunoinformatics approach","volume":"2020","author":"Abdelmageed","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/ijms18010139","article-title":"Mutation-structure function relationship 893 based integrated strategy reveals the potential impact of deleterious missense mutations in 894 autophagy related proteins on hepatocellular carcinoma (HCC): a comprehensive 895 informatics approach","volume":"18","author":"Awan","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.meegid.2020.104517_bb0055","article-title":"Conglomeration of highly antigenic nucleoproteins to inaugurate a heterosubtypic next generation vaccine candidate against Arenaviridae family","author":"Azim","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.meegid.2020.104517_bb0060","doi-asserted-by":"crossref","first-page":"103936","DOI":"10.1016\/j.meegid.2019.103936","article-title":"Immunoinformatics approaches for designing a novel multi epitope peptide vaccine against human norovirus (Norwalk virus)","volume":"74","author":"Azim","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2020.104517_bb0065","doi-asserted-by":"crossref","first-page":"100367","DOI":"10.1016\/j.imu.2020.100367","article-title":"Screening and druggability analysis of some plant metabolites against SARS-CoV-2: an integrative computational approach","volume":"20","author":"Azim","year":"2020","journal-title":"Inform. Med. Unlocked"},{"key":"10.1016\/j.meegid.2020.104517_bb0070","series-title":"In Silico Design of Novel Multi-Epitope Recombinant Vaccine Based on Coronavirus Spike Glycoprotein","author":"Behbahani","year":"2020"},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0075","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/jmv.25700","article-title":"Genomic variance of the 2019-nCoV coronavirus","volume":"92","author":"Ceraolo","year":"2020","journal-title":"J. Med. Virol."},{"issue":"10223","key":"10.1016\/j.meegid.2020.104517_bb0085","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"issue":"1 Suppl","key":"10.1016\/j.meegid.2020.104517_bb0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/jid.1984.33","article-title":"The role of antibody and complement in the control of viral infections","volume":"83","author":"Cooper","year":"1984","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0095","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/1471-2105-14-346","article-title":"Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteins","volume":"14","author":"Craig","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0100","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/bib\/bbm010","article-title":"Normal mode analysis theoretical and applications to biological and chemical systems","volume":"8","author":"Cui","year":"2007","journal-title":"Brief. Bioinform."},{"issue":"6","key":"10.1016\/j.meegid.2020.104517_bb0105","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/bioinformatics\/btt619","article-title":"AllergenFP: allergenicity prediction by descriptor fingerprints","volume":"30","author":"Dimitrov","year":"2014","journal-title":"Bioinformatics."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0110","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.vaccine.2006.09.032","article-title":"Identifying candidate subunit vaccines using an alignment-independent method based on principal amino acid properties","volume":"25","author":"Doytchinova","year":"2007","journal-title":"Vaccine."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0115","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinformatics"},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0120","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrmicro2090","article-title":"The spike protein of SARS-CoV\u2014a target for vaccine and therapeutic development","volume":"7","author":"Du","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0130","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/jvi.55.3.836-839.1985","article-title":"Induction of hepatitis a virus-neutralizing antibody by a virus-specific synthetic peptide","volume":"55","author":"Emini","year":"1985","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0135","article-title":"Engineering a replication-competent, propagation defective middle east respiratory syndrome coronavirus as a vaccine candidate","volume":"4","author":"Fernando","year":"2013","journal-title":"mBio."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tim.2016.09.001","article-title":"Molecular evolution of human coronavirus genomes","volume":"25","author":"Forni","year":"2017","journal-title":"Trends Microbiol."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0145","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.immunol.17.1.369","article-title":"Structural basis of T cell recognition","volume":"17","author":"Garcia","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.meegid.2020.104517_bb0150","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy server","author":"Gasteiger","year":"2005"},{"issue":"11","key":"10.1016\/j.meegid.2020.104517_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142563","article-title":"Improving multi-epitope long peptide vaccine potency by using a strategy that enhances CD4+ T help in BALB\/c mice","volume":"10","author":"Ghaffari-Nazari","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/0022-1317-83-1-1","article-title":"Adverse effects of feline IL-12 during DNA vaccination against feline infectious peritonitis virus","volume":"83","author":"Glansbeek","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.meegid.2020.104517_bb0165","series-title":"Reference Module in Biomedical Sciences","article-title":"Phylogeny of viruses","author":"Gorbalenya","year":"2017"},{"issue":"12","key":"10.1016\/j.meegid.2020.104517_bb0170","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrmicro3143","article-title":"A decade after SARS: strategies for controlling emerging coronaviruses","volume":"11","author":"Graham","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"issue":"Suppl. 2","key":"10.1016\/j.meegid.2020.104517_bb0175","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.meegid.2020.104517_bb0180","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.meegid.2020.104517_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.meegid.2020.104517_bb0190","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.meegid.2019.03.003","article-title":"Vaccinomics strategy for developing a unique multi-epitope monovalent vaccine against Marburg marburg virus","volume":"70","author":"Hasan","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.meegid.2020.104517_bb0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.micpath.2019.02.023","article-title":"Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus","volume":"130","author":"Hasan","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.meegid.2020.104517_bb0200","first-page":"1","article-title":"Contriving a chimeric polyvalent vaccine to prevent infections caused by herpes simplex virus (Type-1 and Type-2): an exploratory immunoinformatic approach","volume":"9","author":"Hasan","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41426-018-0155-5","article-title":"Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats","volume":"7","author":"Hu","year":"2018","journal-title":"Emerg. Microbes Infect."},{"issue":"10223","key":"10.1016\/j.meegid.2020.104517_bb0210","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2020.104517_bb0215","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijid.2020.01.009","article-title":"The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China","volume":"91","author":"Hui","year":"2020","journal-title":"Int. J. Infect. Dis."},{"issue":"06196","key":"10.1016\/j.meegid.2020.104517_bb0220","article-title":"Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses","volume":"2002","author":"Jaimes","year":"2020","journal-title":"ArXiv"},{"issue":"W1","key":"10.1016\/j.meegid.2020.104517_bb0225","doi-asserted-by":"crossref","first-page":"W24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.meegid.2020.104517_bb0230","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-1119(96)00847-5","article-title":"Sequence analysis of gene 3, gene 4 and gene 5 of avian infectious bronchitis virus strain CU-T2","volume":"189","author":"Jia","year":"1997","journal-title":"Gene."},{"issue":"4","key":"10.1016\/j.meegid.2020.104517_bb0235","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0240","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/sji.12302","article-title":"Epitope-based peptide vaccine design and target site depiction against Ebola viruses: an immunoinformatics study","volume":"82","author":"Khan","year":"2015","journal-title":"Scand. J. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.meegid.2020.104517_bb0245","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"Kolaskar","year":"1990","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0250","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"issue":"1314","key":"10.1016\/j.meegid.2020.104517_bb0255","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2020.20235","article-title":"COVID-19 pandemic: palliative care for elderly and frail patients at home and in residential and nursing homes","volume":"150","author":"Kunz","year":"2020","journal-title":"Swiss Med. Wkly."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0260","first-page":"772","article-title":"Partitionfinder 2: new methods for selecting partitioned models of evolution for molecular and morphological phylogenetic analyses","volume":"34","author":"Lanfear","year":"2016","journal-title":"Mol. Biol. Evol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104517_bb0265","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1128\/JVI.02615-14","article-title":"Receptor recognition mechanisms of coronaviruses: a decade of structural studies","volume":"89","author":"Li","year":"2015","journal-title":"J. Virol."},{"issue":"6965","key":"10.1016\/j.meegid.2020.104517_bb0270","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0275","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/vaccines2030515","article-title":"Peptide vaccine: progress and challenges","volume":"2","author":"Li","year":"2014","journal-title":"Vaccines."},{"issue":"8","key":"10.1016\/j.meegid.2020.104517_bb0280","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1086\/656315","article-title":"The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes","volume":"202","author":"Liu","year":"2010","journal-title":"J. Infect. Dis."},{"issue":"W1","key":"10.1016\/j.meegid.2020.104517_bb0285","doi-asserted-by":"crossref","first-page":"W271","DOI":"10.1093\/nar\/gku339","article-title":"iMODS: internal coordinates normal mode analysis server","volume":"42","author":"L\u00f3pez-Blanco","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.meegid.2020.104517_bb0290","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jmv.25678","article-title":"Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle","volume":"92","author":"Lu","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.meegid.2020.104517_bb0295","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.3389\/fimmu.2019.02776","article-title":"Editorial: reverse vaccinology","author":"Moxon","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0300","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jsb.2010.11.021","article-title":"A structural analysis of M protein in coronavirus assembly and morphology","volume":"174","author":"Neuman","year":"2011","journal-title":"J. Struct. Biol."},{"issue":"2","key":"10.1016\/j.meegid.2020.104517_bb0305","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.virol.2011.03.029","article-title":"Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein","volume":"415","author":"Nieto-Torres","year":"2011","journal-title":"Virology."},{"key":"10.1016\/j.meegid.2020.104517_bb0310","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2147\/DDDT.S67861","article-title":"Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach","volume":"8","author":"Oany","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"issue":"17","key":"10.1016\/j.meegid.2020.104517_bb0315","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.vaccine.2018.03.042","article-title":"Immunoinformatics approaches to design a novel multi-epitope subunit vaccine against HIV infection","volume":"36","author":"Pandey","year":"2018","journal-title":"Vaccine."},{"issue":"10","key":"10.1016\/j.meegid.2020.104517_bb0320","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1099\/vir.0.80111-0","article-title":"Protective humoral responses to severe acute respiratory syndrome-associated coronavirus: implications for the design of an effective protein-based vaccine","volume":"85","author":"Pang","year":"2004","journal-title":"J. Gen. Virol."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0325","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/jcm9030623","article-title":"Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-nCoV): a systematic review","volume":"9","author":"Pang","year":"2020","journal-title":"J. Clin. Med."},{"issue":"S10","key":"10.1016\/j.meegid.2020.104517_bb0330","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/prot.23175","article-title":"Raptorx: exploiting structure information for protein alignment by statistical inference","volume":"79","author":"Peng","year":"2011","journal-title":"Proteins"},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0335","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.0818-9641.2004.01272.x","article-title":"Vaccine adjuvants: current state and future trends","volume":"82","author":"Petrovsky","year":"2004","journal-title":"Immunol. Cell Biol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104517_bb0340","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/07391102.2015.1054430","article-title":"Monomerization alters the dynamics 897 of the lid region in campylobacter jejuni CstII: an MD simulation study","volume":"34","author":"Prabhakar","year":"2016","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0345","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrd2224","article-title":"More than one reason to rethink the use of peptides in vaccine design","volume":"6","author":"Purcell","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7440","key":"10.1016\/j.meegid.2020.104517_bb0350","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature12005","article-title":"Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC","volume":"495","author":"Raj","year":"2013","journal-title":"Nature."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0355","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1369-5274(00)00119-3","article-title":"Reverse vaccinology","volume":"3","author":"Rappuoli","year":"2000","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.meegid.2020.104517_bb0360","article-title":"In silico identification of novel B cell and T cell epitopes of Wuhan coronavirus (2019-nCoV) for effective multi epitope-based peptide vaccine production","author":"Rasheed","year":"2020","journal-title":"Preprints"},{"issue":"W1","key":"10.1016\/j.meegid.2020.104517_bb0365","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"Robert","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0370","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sysbio\/sys029","article-title":"MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space","volume":"61","author":"Ronquist","year":"2012","journal-title":"Syst. Biol."},{"issue":"6","key":"10.1016\/j.meegid.2020.104517_bb0375","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.apjtm.2017.06.016","article-title":"In silico identification and characterization of common epitope-based peptide vaccine for Nipah and Hendra viruses","volume":"10","author":"Saha","year":"2017","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-019-1182-0","article-title":"Coronavirus envelope protein: current knowledge","volume":"16","author":"Schoeman","year":"2019","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0385","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-15-161","article-title":"A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design","volume":"15","author":"Sharmin","year":"2014","journal-title":"BMC Bioinformatics."},{"issue":"15","key":"10.1016\/j.meegid.2020.104517_bb0390","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1128\/JVI.78.15.8312-8321.2004","article-title":"Role of CD8+ T cells in control of West Nile virus infection","volume":"78","author":"Shrestha","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.meegid.2020.104517_bb0395","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-62703-646-7_6","article-title":"Clustal omega, accurate alignment of very large numbers of sequences","volume":"1079","author":"Sievers","year":"2014","journal-title":"Methods Mol. Biol."},{"issue":"19","key":"10.1016\/j.meegid.2020.104517_bb0400","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/bioinformatics\/btl623","article-title":"Protein solubility: sequence based prediction and experimental verification","volume":"23","author":"Smialowski","year":"2007","journal-title":"Bioinformatics."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0405","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/bioinformatics\/btm619","article-title":"Phyutility: a phyloinformatics tool for trees, alignments and molecular data","volume":"24","author":"Smith","year":"2008","journal-title":"Bioinformatics."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-26689-7","article-title":"Subtractive proteomics to identify novel drug targets and reverse vaccinology for the development of chimeric vaccine against Acinetobacter baumannii","volume":"8","author":"Solanki","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.meegid.2020.104517_bb0415","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics."},{"key":"10.1016\/j.meegid.2020.104517_bb0420","series-title":"Immunization Safety Review: Vaccinations And Sudden Unexpected Death In Infancy, Institute of Medicine (US)","author":"Stratton","year":"2003"},{"issue":"7","key":"10.1016\/j.meegid.2020.104517_bb0425","first-page":"995","article-title":"Platform strategies for rapid response against emerging coronaviruses: MERS-CoV serologic and antigenic relationships in vaccine design","volume":"209","author":"Sudhakar","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.meegid.2020.104517_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmed.2020.02.008","article-title":"COVID-19: epidemiology, evolution, and cross-disciplinary perspectives","author":"Sun","year":"2020","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0435","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3390\/ijerph17051633","article-title":"Potential factors influencing repeated SARS outbreaks in China","volume":"17","author":"Sun","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.meegid.2020.104517_bb0440","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.virusres.2015.02.023","article-title":"MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels","volume":"201","author":"Surya","year":"2015","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0445","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.biophys.35.040405.102010","article-title":"Symmetry, form, and shape: guiding principles for robustness in macromolecular machines","volume":"35","author":"Tama","year":"2006","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"issue":"12","key":"10.1016\/j.meegid.2020.104517_bb0450","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3201\/eid0812.020229","article-title":"Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model","volume":"8","author":"Tesh","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.meegid.2020.104517_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/289597","article-title":"Cytokines: the future of intranasal vaccine adjuvants","volume":"2011","author":"Thompson","year":"2011","journal-title":"Clin. Dev. Immunol."},{"issue":"D1","key":"10.1016\/j.meegid.2020.104517_bb0460","doi-asserted-by":"crossref","first-page":"D405","DOI":"10.1093\/nar\/gku938","article-title":"The immune epitope database (IEDB) 3.0","volume":"43","author":"Vita","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"10223","key":"10.1016\/j.meegid.2020.104517_bb0465","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","article-title":"A novel coronavirus outbreak of global health concern","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.meegid.2020.104517_bb0470","series-title":"Corona And Related Viruses","first-page":"221","article-title":"Protection of cats from infectious peritonitis by vaccination with a recombinant raccoon poxvirus expressing the nucleocapsid gene of feline infectious peritonitis virus","author":"Wasmoen","year":"1995"},{"issue":"9","key":"10.1016\/j.meegid.2020.104517_bb0475","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview version 2-a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics."},{"issue":"10","key":"10.1016\/j.meegid.2020.104517_bb0480","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1099\/0022-1317-74-10-2061","article-title":"Mouse hepatitis virus spike and nucleocapsid proteins expressed by adenovirus vectors protect mice against a lethal infection","volume":"74","author":"Wesseling","year":"1993","journal-title":"J. Gen. Virol."},{"issue":"6483","key":"10.1016\/j.meegid.2020.104517_bb0485","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science."},{"key":"10.1016\/j.meegid.2020.104517_bb0490","article-title":"Strong evolutionary convergence of receptor-binding protein spike between COVID-19 and SARS-related coronaviruses","author":"Wu","year":"2020","journal-title":"bioRxiv."},{"issue":"7798","key":"10.1016\/j.meegid.2020.104517_bb0495","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0500","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0006-3495(80)84989-7","article-title":"Correlations between internal mobility and stability of globular proteins","volume":"32","author":"W\u00fcthrich","year":"1980","journal-title":"Biophys. J."},{"issue":"3","key":"10.1016\/j.meegid.2020.104517_bb0515","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/21645515.2015.1012017","article-title":"In silico design of a DNA-based HIV-1 multi-epitope vaccine for Chinese populations","volume":"11","author":"Yang","year":"2015","journal-title":"Hum. Vaccin. Immunother."},{"issue":"10965","key":"10.1016\/j.meegid.2020.104517_bb0520","article-title":"Genotyping coronavirus SARS-CoV-2: methods and implications","volume":"2003","author":"Yin","year":"2020","journal-title":"ArXiv"},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0530","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.virol.2004.10.016","article-title":"Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine","volume":"331","author":"Zhao","year":"2005","journal-title":"Virology."},{"key":"10.1016\/j.meegid.2020.104517_bb0535","series-title":"Chinese Scientists Race To Develop Vaccine As Coronavirus Death Toll Jumps","author":"Jeong-ho","year":"2020"},{"issue":"8","key":"10.1016\/j.meegid.2020.104517_bb0540","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/14760584.2018.1506702","article-title":"Prospects for a MERS-CoV spike vaccine","volume":"17","author":"Zhou","year":"2018","journal-title":"Expert Rev. Vaccines"},{"issue":"1","key":"10.1016\/j.meegid.2020.104517_bb0545","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-020-0153-3","article-title":"Network-based drug repurposing for novel coronavirus 2019-nCoV\/SARS-CoV-2","volume":"6","author":"Zhou","year":"2020","journal-title":"Cell Discov."},{"issue":"7798","key":"10.1016\/j.meegid.2020.104517_bb0550","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature."},{"issue":"8","key":"10.1016\/j.meegid.2020.104517_bb0555","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.meegid.2020.104517_bb0560","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrd.2015.37","article-title":"Coronaviruses-drug discovery and therapeutic options","volume":"15","author":"Zumla","year":"2016","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820303488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820303488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:47:19Z","timestamp":1761576439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134820303488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":107,"alternative-id":["S1567134820303488"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104517","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.15.036285","asserted-by":"object"}]},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome based evolutionary lineage of SARS-CoV-2 towards the development of novel chimeric vaccine","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104517","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104517"}}