{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:27:10Z","timestamp":1781080030998,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infection, Genetics and Evolution"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.meegid.2020.104615","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T20:17:30Z","timestamp":1604348250000},"page":"104615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The association between SNPs and hepatitis B virus related acute-on-chronic liver failure"],"prefix":"10.1016","volume":"86","author":[{"given":"Congchen","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0005","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/hep.28896","article-title":"Polymorphisms in the IL-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure","volume":"65","author":"Alcaraz-Quiles","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.meegid.2020.104615_bb0010","first-page":"20(6)","article-title":"TM6SF2 and MBOAT7 gene variants in liver fibrosis and cirrhosis","author":"Basyte-Bacevice","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/exd.12853","article-title":"Ixodes tick saliva suppresses the keratinocyte cytokine response to TLR2\/TLR3 ligands during early exposure to Lyme borreliosis","volume":"25","author":"Bernard","year":"2016","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0020","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.4049\/jimmunol.1002402","article-title":"The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1","volume":"186","author":"Carrol","year":"2011","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0025","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jiph.2019.01.061","article-title":"Validity of hepatitis B and hepatitis C case definitions","volume":"12","author":"Dakic","year":"2019","journal-title":"J. Infect. Public Health"},{"issue":"7","key":"10.1016\/j.meegid.2020.104615_bb0030","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.1007\/s13277-014-1863-7","article-title":"Susceptibility to hepatocellular carcinoma in the Chinese population\u2014associations with interleukin-6 receptor polymorphism","volume":"35","author":"Deng","year":"2014","journal-title":"Tumour Biol."},{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0035","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1038\/s41598-017-04991-0","article-title":"MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals","volume":"7","author":"Donati","year":"2017","journal-title":"Sci. Rep."},{"issue":"6\u20137","key":"10.1016\/j.meegid.2020.104615_bb0040","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ejcb.2011.09.003","article-title":"The role of ADAM-mediated shedding in vascular biology","volume":"91","author":"Dreymueller","year":"2012","journal-title":"Eur. J. Cell Biol."},{"issue":"10","key":"10.1016\/j.meegid.2020.104615_bb0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1471-4906(01)02034-8","article-title":"Annotating genes with potential roles in the immune system: six new members of the IL-1 family","volume":"22","author":"Dunn","year":"2001","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.meegid.2020.104615_bb0050","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/cvr\/cvq139","article-title":"The NO cascade, eNOS location, and microvascular permeability","volume":"87","author":"Duran","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0055","doi-asserted-by":"crossref","first-page":"12247","DOI":"10.1038\/s41598-018-30824-9","article-title":"Effect of MBOAT7 variant on hepatitis B and C infections in Moroccan patients","volume":"8","author":"Ezzikouri","year":"2018","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.meegid.2020.104615_bb0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/vim.2009.0102","article-title":"Persistent effect of IFNAR-1 genetic polymorphism on the long-term pathogenesis of chronic HBV infection","volume":"23","author":"He","year":"2010","journal-title":"Viral Immunol."},{"key":"10.1016\/j.meegid.2020.104615_bb0065","first-page":"2033","article-title":"Research on viral factors of mother-to-child transmission of hepatitis B","volume":"13","author":"Huanhuan","year":"2018","journal-title":"Modern Med. Health"},{"key":"10.1016\/j.meegid.2020.104615_bb0070","first-page":"495","article-title":"Host factors influencing the clinical outcome of chronic hepatitis B virus infection","volume":"7","author":"HuiChun","year":"2017","journal-title":"Chin. J. Hepatol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00251-012-0675-4","article-title":"Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure","volume":"65","author":"Jiang","year":"2013","journal-title":"Immunogenetics"},{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11894-011-0228-2","article-title":"Acute-on-chronic liver failure: what are the implications?","volume":"14","author":"Olson","year":"2012","journal-title":"Curr. Gastroenterol. Rep."},{"issue":"6","key":"10.1016\/j.meegid.2020.104615_bb0085","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/jmv.25394","article-title":"Association between miRNA-146a rs2910164 (G\/C) polymorphism with the susceptibility to chronic HBV infection and spontaneous viral clearance in an Iranian population","volume":"91","author":"Khanizadeh","year":"2019","journal-title":"J. Med. Virol."},{"issue":"5","key":"10.1016\/j.meegid.2020.104615_bb0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11882-011-0207-6","article-title":"The emerging role of interleukin-1beta in autoinflammatory diseases","volume":"11","author":"Lane","year":"2011","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00004872-199816010-00006","article-title":"Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects","volume":"16","author":"Lacolley","year":"1998","journal-title":"J. Hypertens."},{"issue":"6","key":"10.1016\/j.meegid.2020.104615_bb0100","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3892\/etm.2017.4361","article-title":"Interleukin-1 receptor antagonist expression is inversely associated with outcomes of hepatitis B-related acute-on-chronic liver failure","volume":"13","author":"Lai","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.meegid.2020.104615_bb0105","first-page":"103","article-title":"Immunopathogenesis of acute-on-chronic hepatitis B liver failure","volume":"03","author":"Li Xiaodong","year":"2015","journal-title":"J. Pract. Hepatol."},{"key":"10.1016\/j.meegid.2020.104615_bb0110","doi-asserted-by":"crossref","first-page":"205752","DOI":"10.1155\/2012\/205752","article-title":"Association of polymorphisms in mitofusin-2 gene with type 2 diabetes in Han Chinese","volume":"2012","author":"Li","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"issue":"3","key":"10.1016\/j.meegid.2020.104615_bb0115","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11596-014-1281-5","article-title":"SOCS3 expression correlates with severity of inflammation in mouse hepatitis virus strain 3-induced acute liver failure and HBV-ACLF","volume":"34","author":"Li","year":"2014","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"8","key":"10.1016\/j.meegid.2020.104615_bb0120","doi-asserted-by":"crossref","first-page":"878","DOI":"10.5551\/jat.22400","article-title":"Association between ADAM17 promoter polymorphisms and ischemic stroke in a Chinese population","volume":"21","author":"Li","year":"2014","journal-title":"J. Atheroscler. Thromb."},{"issue":"5","key":"10.1016\/j.meegid.2020.104615_bb0125","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1159\/000358708","article-title":"Analysis of ADAM17 polymorphisms and susceptibility to sporadic abdominal aortic aneurysm","volume":"33","author":"Li","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.meegid.2020.104615_bb0130","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1111\/jcmm.12320","article-title":"Tumour necrosis factor-alpha promotes liver ischaemia-reperfusion injury through the PGC-1alpha\/Mfn2 pathway","volume":"18","author":"Li","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.meegid.2020.104615_bb0135","first-page":"9","article-title":"Study on the analysis of HBV genotype and gene variation characteristics","volume":"5","author":"Liu","year":"2015","journal-title":"Chin. J. Birth Health Hered."},{"key":"10.1016\/j.meegid.2020.104615_bb0140","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.gene.2018.03.071","article-title":"The association between donor genetic variations in one-carbon metabolism pathway genes and hepatitis B recurrence after liver transplantation","volume":"663","author":"Lu","year":"2018","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.meegid.2020.104615_bb0145","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent","volume":"150","author":"Mancina","year":"2016","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.0954-6820.1986.tb02767.x","article-title":"Interleukin 1 and the pathogenesis of inflammatory diseases","volume":"220","author":"Maury","year":"1986","journal-title":"Acta Med. Scand."},{"issue":"24","key":"10.1016\/j.meegid.2020.104615_bb0155","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJM199106133242404","article-title":"Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis","volume":"324","author":"Omata","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"6\u20137","key":"10.1016\/j.meegid.2020.104615_bb0160","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejcb.2010.11.005","article-title":"The \u201cA Disintegrin and metalloproteases\u201d ADAM10 and ADAM17: novel drug targets with therapeutic potential?","volume":"90","author":"Saftig","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.meegid.2020.104615_bb0165","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3389\/fimmu.2014.00578","article-title":"MicroRNA-146a: a dominant, negative regulator of the innate immune response","volume":"5","author":"Saba","year":"2014","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0170","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1159\/000447830","article-title":"Association study between promoter polymorphisms of ADAM17 and progression of Sepsis","volume":"39","author":"Shao","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"33","key":"10.1016\/j.meegid.2020.104615_bb0175","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0180","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/gutjnl-2016-313035","article-title":"Genome-wide association study identi fi es HLA-DR variants conferring risk of HBV-related acute-on-chronic liver failure","volume":"67","author":"Tan","year":"2018","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.meegid.2020.104615_bb0185","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.97.6.2832","article-title":"Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298","volume":"97","author":"Tesauro","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.meegid.2020.104615_bb0190","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/hep.29064","article-title":"The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B","volume":"65","author":"Thabet","year":"2017","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.meegid.2020.104615_bb0195","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00439-012-1253-4","article-title":"A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations","volume":"132","author":"Wang","year":"2013","journal-title":"Hum. Genet."},{"issue":"6","key":"10.1016\/j.meegid.2020.104615_bb0200","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20175758","article-title":"Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population","volume":"50","author":"Wei","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.meegid.2020.104615_bb0205","first-page":"245","article-title":"Research progress on prognostic evaluation models for liver failure","volume":"2","author":"Wei-qiang","year":"2019","journal-title":"Hainan Med. J."},{"key":"10.1016\/j.meegid.2020.104615_bb0210","first-page":"839","article-title":"Association of IL-12A, IL-1B and IL-17A polymorphisms with HBeAg seroconver- sion in chronic hepatitis B patients who received entecavir treatment","volume":"9","author":"Wu Junqiu","year":"2015","journal-title":"Acta Acad. Med. Militaris Tertiae"},{"issue":"6","key":"10.1016\/j.meegid.2020.104615_bb0215","first-page":"669","article-title":"Production of nitric oxide and nitric oxide synthase in mice with acute hepatic failure","author":"Xia Qin","year":"2002","journal-title":"J. Huazhong Univ. Sci. Technol. (Health Sciences)"},{"key":"10.1016\/j.meegid.2020.104615_bb0220","first-page":"890","article-title":"Polymorphism of blood IFN-\u03b3gene in patients with hepatitis B induced acute-on-chronic liver failure","volume":"6","author":"Xiaofang","year":"2018","journal-title":"J. Pract. Hepatol."},{"issue":"4","key":"10.1016\/j.meegid.2020.104615_bb0225","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1440-1746.2006.04306.x","article-title":"Protective role of supplement with foreign Bifidobacterium and Lactobacillus in experimental hepatic ischemia-reperfusion injury","volume":"21","author":"Xing","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"03","key":"10.1016\/j.meegid.2020.104615_bb0230","first-page":"270","article-title":"Research progress on virological factors affecting chronic hepatitis B virus","volume":"15","author":"Xu Chunli","year":"2012","journal-title":"J. Pract. Hepatol."},{"issue":"3","key":"10.1016\/j.meegid.2020.104615_bb0235","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00535-010-0315-4","article-title":"Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure","volume":"46","author":"Xu","year":"2011","journal-title":"J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.meegid.2020.104615_bb0240","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/iji.12263","article-title":"Association between interleukin-21 gene polymorphisms (rs12508721) and HBV-related hepatocellular carcinoma","volume":"43","author":"Zhang","year":"2016","journal-title":"Int. J. Immunogenet."},{"issue":"10","key":"10.1016\/j.meegid.2020.104615_bb0245","doi-asserted-by":"crossref","first-page":"17538","DOI":"10.1002\/jcp.28377","article-title":"PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.meegid.2020.104615_bb0250","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1142\/S0192415X76000032","article-title":"Management of hepatitis B in China","volume":"122","author":"Lu","year":"2009","journal-title":"Chin. Med. J."}],"container-title":["Infection, Genetics and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820304469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567134820304469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T14:45:19Z","timestamp":1761576319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567134820304469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":50,"alternative-id":["S1567134820304469"],"URL":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104615","relation":{},"ISSN":["1567-1348"],"issn-type":[{"value":"1567-1348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between SNPs and hepatitis B virus related acute-on-chronic liver failure","name":"articletitle","label":"Article Title"},{"value":"Infection, Genetics and Evolution","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meegid.2020.104615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104615"}}