{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:08:15Z","timestamp":1792807695282,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.mehy.2003.12.036","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T17:09:07Z","timestamp":1079802547000},"page":"958-965","source":"Crossref","is-referenced-by-count":20,"title":["Experimentally gained insight \u2013 based proposal apropos the treatment of osteonecrosis of the femoral head"],"prefix":"10.1016","volume":"62","author":[{"given":"J.H","family":"Boss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Misselevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bejar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zinman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.N","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2003.12.036_BIB1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","article-title":"Pathogenesis and natural history of osteonecrosis","volume":"32","author":"Assouline-Dayan","year":"2002","journal-title":"Semin. Arthritis. Rheum."},{"key":"10.1016\/j.mehy.2003.12.036_BIB2","first-page":"337","article-title":"Osteonecrosis of the hip: management in the 21st century","volume":"52","author":"Lieberman","year":"2003","journal-title":"Instr. Course Lect."},{"key":"10.1016\/j.mehy.2003.12.036_BIB3","first-page":"348","article-title":"Abnormalities in the replicative capacity of osteoblastic cells in the proximal femur of patients with osteonecrosis of the femoral head","volume":"30","author":"Gangji","year":"2003","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.mehy.2003.12.036_BIB4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1302\/0301-620X.85B3.13237","article-title":"Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head","volume":"85","author":"Reis","year":"2003","journal-title":"J. Bone Joint Surg. B"},{"key":"10.1016\/j.mehy.2003.12.036_BIB5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00003086-199603000-00020","article-title":"Core decompression versus nonoperative management for osteonecrosis of the hip","volume":"324","author":"Mont","year":"1996","journal-title":"Clin. Orthop."},{"key":"10.1016\/j.mehy.2003.12.036_BIB6","first-page":"169","article-title":"Understanding and treating osteonecrosis of the femoral head","volume":"49","author":"Mont","year":"2000","journal-title":"Instr. Course Lect."},{"key":"10.1016\/j.mehy.2003.12.036_BIB7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Non-traumatic avascular necrosis of the femoral head","volume":"77","author":"Mont","year":"1995","journal-title":"J. Bone Joint Surg. A"},{"key":"10.1016\/j.mehy.2003.12.036_BIB8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5435\/00124635-199801000-00005","article-title":"Revascularization of the femoral head in osteonecrosis","volume":"6","author":"Urbaniak","year":"1998","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.mehy.2003.12.036_BIB9","doi-asserted-by":"crossref","unstructured":"Norman D, Misselevich I, Peled E, Salman S, Boss JH, Zinman C. Intraosseous conduit-induced enhancement of ingrowth of blood vessels into the necrotic femoral head of rats. J Orthop Traumatol, in press","DOI":"10.1007\/s10195-004-0036-7"},{"key":"10.1016\/j.mehy.2003.12.036_BIB10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1354\/vp.40-4-345","article-title":"Osteonecrosis of the femoral head of laboratory animals: the lessons learned from a comparative study of osteonecrosis in man and experimental animals","volume":"40","author":"Boss","year":"2003","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.mehy.2003.12.036_BIB11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003086-200105000-00006","article-title":"Magnetic resonance imaging and histology of repair in femoral head osteonecrosis","volume":"386","author":"Plenk","year":"2001","journal-title":"Clin. Orthop."},{"key":"10.1016\/j.mehy.2003.12.036_BIB12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1063-4584(03)00075-X","article-title":"Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement","volume":"11","author":"Wagner","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mehy.2003.12.036_BIB13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1297-319X(01)00346-3","article-title":"Can ischemic hip disease cause rapidly destructive hip osteoarthritis? A case report","volume":"69","author":"Laroche","year":"2002","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.mehy.2003.12.036_BIB14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1365-2613.1998.00063.x","article-title":"Vascular deprivation-induced necrosis of the femoral head of the rat. An experimental model of avascular necrosis in the skeletally immature individual or Legg-Perthes disease","volume":"79","author":"Norman","year":"1998","journal-title":"Int. J. Exp. Path."},{"key":"10.1016\/j.mehy.2003.12.036_BIB15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01202412-199907000-00005","article-title":"Long-term prognosis of Legg-Calve-Perthes disease: a meta-analysis","volume":"8B","author":"Yrjonen","year":"1999","journal-title":"J. Pediatr. Orthop."},{"key":"10.1016\/j.mehy.2003.12.036_BIB16","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2106\/00004623-200208000-00006","article-title":"Development of flattening and apparent fragmentation following ischemic necrosis of the capital femoral epiphysis in a piglet model","volume":"84","author":"Kim","year":"2002","journal-title":"J. Bone Joint Surg. A"},{"key":"10.1016\/j.mehy.2003.12.036_BIB17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0344-0338(99)80129-0","article-title":"Osteoarthritis-like disorder in rats with vascular deprivation-induced necrosis of the femoral head","volume":"195","author":"Levin","year":"1999","journal-title":"Pathol. Res. Prac."},{"key":"10.1016\/j.mehy.2003.12.036_BIB18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/exmp.1999.2273","article-title":"Treatment of experimental avascular necrosis of the femoral head with hyperbaric oxygen in rats: Histological evaluation of the femoral heads during the early phase of the reparative process","volume":"67","author":"Levin","year":"1999","journal-title":"Exp. Molec. Path."},{"key":"10.1016\/j.mehy.2003.12.036_BIB19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01706656","article-title":"Chondrolysis in rats with vascular deprivation-induced osteonecrosis of the femoral head","volume":"11","author":"Peskin","year":"2001","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.mehy.2003.12.036_BIB20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00009957-200107000-00011","article-title":"Transphyseal osseous bridges in experimental osteonecrosis of the femoral head of the rat. Histologic study of the bony bridges connecting the epiphyseal with the metaphyseal bony trabeculae through gaps in the physeal cartilage","volume":"10","author":"Peskin","year":"2001","journal-title":"J. Pediatr. Orthop. B"},{"key":"10.1016\/j.mehy.2003.12.036_BIB21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1054\/cuor.2001.0140","article-title":"Experimental avascular osteonecrosis","volume":"15","author":"Boss","year":"2001","journal-title":"Curr. Orthop."},{"key":"10.1016\/j.mehy.2003.12.036_BIB22","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/exmp.2001.2394","article-title":"Computer-assisted image analysis of the rat postosteonecrotic remodeled femoral head","volume":"71","author":"Sabo","year":"2001","journal-title":"Exp. Molec. Path."},{"key":"10.1016\/j.mehy.2003.12.036_BIB23","first-page":"187","article-title":"Effects of non-weight bearing and hyperbaric oxygen therapy in vascular deprivation-induced osteonecrosis of the rat femoral head","volume":"28","author":"Peskin","year":"2001","journal-title":"Undersea Hyper. Med."},{"key":"10.1016\/j.mehy.2003.12.036_BIB24","first-page":"214","article-title":"Transphyseal osseous bridges in experimental osteonecrosis of the femoral head of the rat. Histologic study of the bony bridges connecting the epiphyseal with the metaphyseal bony trabeculae through gaps in the physeal cartilage","volume":"10","author":"Peskin","year":"2001","journal-title":"J. Pediatr. Orthop. B"},{"key":"10.1016\/j.mehy.2003.12.036_BIB25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/jor.1100080610","article-title":"Torsional strength reduction due to cortical defects in bone","volume":"8","author":"Edgerton","year":"1990","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.mehy.2003.12.036_BIB26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/17453679308994570","article-title":"The effect of fracture on femoral head blood flow. Osteonecrosis and revascularization studied in miniature swine","volume":"64","author":"Swiontkowski","year":"1993","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.mehy.2003.12.036_BIB27","first-page":"7","article-title":"Osteoarthritis as a remodeling process","volume":"14","author":"Sokoloff","year":"1987","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.mehy.2003.12.036_BIB28","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.168.1.450","article-title":"Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats","volume":"168","author":"Yamashita","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.mehy.2003.12.036_BIB29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s007740170006","article-title":"Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor\/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor","volume":"19","author":"Yano","year":"2001","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.mehy.2003.12.036_BIB30","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.2106\/00004623-198668090-00002","article-title":"Core decompression of the femoral head for osteonecrosis","volume":"68","author":"Camp","year":"1986","journal-title":"J. Bone Joint Surg. A"},{"key":"10.1016\/j.mehy.2003.12.036_BIB31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/00003086-199602000-00031","article-title":"Core decompression for osteonecrosis of the femoral head","volume":"323","author":"Markel","year":"1996","journal-title":"Clin. Orthop."},{"key":"10.1016\/j.mehy.2003.12.036_BIB32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1302\/0301-620X.70B1.3276703","article-title":"Joint-preserving operations for idiopathic avascular necrosis of the femoral head","volume":"70","author":"Saito","year":"1988","journal-title":"J. Bone Joint Surg. B"},{"key":"10.1016\/j.mehy.2003.12.036_BIB33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00003086-198105000-00035","article-title":"Mechanical characteristics of bone in femoral capital aseptic necrosis","volume":"156","author":"Brown","year":"1981","journal-title":"Clin. Orthop."},{"key":"10.1016\/j.mehy.2003.12.036_BIB34","doi-asserted-by":"crossref","unstructured":"Astrand J, Aspenberg P. Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats. BMC Musculoskelet. Disord. 2002;7 August 3(1):19","DOI":"10.1186\/1471-2474-3-19"},{"key":"10.1016\/j.mehy.2003.12.036_BIB35","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc. Natl. Assoc. Sci."},{"key":"10.1016\/j.mehy.2003.12.036_BIB36","first-page":"337","article-title":"Osteonecrosis of the hip: Management in the twenty-first century","volume":"52","author":"Lieberman","year":"2003","journal-title":"Instr. Course Lect."}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987704000672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987704000672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T04:46:22Z","timestamp":1682657182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987704000672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0306987704000672"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2003.12.036","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}