{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:03:55Z","timestamp":1789967035114,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.mehy.2004.10.021","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T11:38:16Z","timestamp":1123846696000},"page":"1038-1042","source":"Crossref","is-referenced-by-count":42,"title":["Optic neuropathies \u2013 Importance of spatial distribution of mitochondria as well as function"],"prefix":"10.1016","volume":"65","author":[{"given":"C.Y.","family":"Yu Wai Man","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.F.","family":"Chinnery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mehy.2004.10.021_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000267739","article-title":"Evidence of constriction of optic nerve axons at the lamina cribrosa in the normotensive eye in humans and other mammals","volume":"27","author":"Hollander","year":"1995","journal-title":"Ophthalmic Res"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0002-9394(76)90416-5","article-title":"Distribution of axonal and glial elements in the rhesus optic nerve head studied by electron microscopy","volume":"82","author":"Minckler","year":"1976","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.mehy.2004.10.021_bib3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/archopht.120.6.791","article-title":"The distribution of mitochondrial activity in relation to optic nerve structure","volume":"120","author":"Bristow","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/bjo.83.2.231","article-title":"Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina","volume":"83","author":"Andrews","year":"1999","journal-title":"Brit J Ophthalmol"},{"key":"10.1016\/j.mehy.2004.10.021_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1022690030664","article-title":"Leber hereditary optic neuropathy: how do mitochondrial DNA mutations cause degeneration of the optic nerve","volume":"29","author":"Howell","year":"1997","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.mehy.2004.10.021_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/brain\/118.2.319","article-title":"The clinical features of Leber\u2019s hereditary optic neuropathy defined by the presence of a pathogenic mitochondrial DNA mutation","volume":"118","author":"Riordan-Eva","year":"1995","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.mehy.2004.10.021_bib7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0002-9394(14)73478-6","article-title":"Optic disk risk factors for nonarteritic anterior ischemic optic neuropathy","volume":"116","author":"Burde","year":"1993","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/bjo.2003.027664","article-title":"The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head","volume":"88","author":"Barron","year":"2004","journal-title":"Brit J Ophthalmol"},{"issue":"9","key":"10.1016\/j.mehy.2004.10.021_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1212\/WNL.28.9_Part_2.27","article-title":"Prerequisites for conduction in demyelinated fibers","volume":"28","author":"Waxman","year":"1978","journal-title":"Neurology"},{"key":"10.1016\/j.mehy.2004.10.021_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2741\/A118","article-title":"The pattern and mechanism of mitochondrial transport in axons","author":"Hollenbeck","year":"1996","journal-title":"Front Biosci"},{"issue":"1","key":"10.1016\/j.mehy.2004.10.021_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1471-4159.1971.tb00172.x","article-title":"Dependence of fast axoplasmic transport in nerve on oxidative metabolism","volume":"18","author":"Ochs","year":"1971","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.mehy.2004.10.021_bib12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1242\/jcs.104.3.917","article-title":"The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth","volume":"104","author":"Morris","year":"1993","journal-title":"J Cell Sci"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0306-4522(91)90143-C","article-title":"Cytoplasmic architecture of the axon terminal: filamentous strands specifically associated with synaptic vesicles","volume":"40","author":"Gotow","year":"1991","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.mehy.2004.10.021_bib14","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/BF01218352","article-title":"Axoplasmic organelles at nodes of Ranvier. II. Occurrence and distribution in large myelinated spinal cord axons of the adult cat","volume":"22","author":"Fabricius","year":"1993","journal-title":"J Neurocytol"},{"key":"10.1016\/j.mehy.2004.10.021_bib15","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0021-9258(18)65313-X","article-title":"The quantitative histochemistry of the retina","volume":"220","author":"Lowry","year":"1956","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.143.2.351","article-title":"A human dynamin-related protein controls the distribution of mitochondria","volume":"143","author":"Smirnova","year":"1998","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1172\/JCI200420138","article-title":"Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport","volume":"113","author":"Ferreirinha","year":"2004","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.mehy.2004.10.021_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2004.10.021_bib19","unstructured":"Smith CH. Nuclear and infranuclear ocular motility disorders. In: Newman NJ, editor. Walst & Hoyt\u2019s clinical neuro-ophthalmology. 5th ed. USA; 1998. p. 1264."},{"issue":"5407","key":"10.1016\/j.mehy.2004.10.021_bib20","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1126\/science.283.5407.1482","article-title":"Mitochondrial diseases in man and mouse","volume":"283","author":"Wallace","year":"1999","journal-title":"Science"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987705003257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987705003257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T12:54:07Z","timestamp":1626353647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987705003257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0306987705003257"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2004.10.021","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}