{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:39:38Z","timestamp":1777606778044,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.mehy.2006.04.047","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T07:44:37Z","timestamp":1150962277000},"page":"1223-1225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Magnesium supplementation in the treatment of dementia patients"],"prefix":"10.1016","volume":"67","author":[{"given":"Serefnur","family":"Ozturk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asl\u0131 Ece","family":"Cilliler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2006.04.047_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1749-6632.2002.tb02109.x","article-title":"Alzheimer\u2019s disease: role of aging in pathogenesis","volume":"959","author":"Harman","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.mehy.2006.04.047_bib2","first-page":"231","article-title":"Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer\u2019s disease","volume":"4","author":"Basun","year":"1991","journal-title":"J Neural Transm Park Dis Dement Sect"},{"key":"10.1016\/j.mehy.2006.04.047_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0197-4580(02)00078-7","article-title":"A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes","volume":"23","author":"Esposito","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.mehy.2006.04.047_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/oxfordjournals.aje.a008922","article-title":"Dietary antioxidants and cognitive function in a population based sample of older persons. The Rotterdam study","volume":"144","author":"Jama","year":"1996","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mehy.2006.04.047_bib5","first-page":"257","article-title":"Magnesium metabolism: a review","volume":"18","author":"Ebel","year":"1980","journal-title":"J Clin Chem Clin Biochem"},{"key":"10.1016\/j.mehy.2006.04.047_bib6","first-page":"217","article-title":"Magnesium depletion and the pathogenesis of Alzheimer\u2019s disease","volume":"3","author":"Durlach","year":"1990","journal-title":"Magnesium Res"},{"key":"10.1016\/j.mehy.2006.04.047_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0306-9877(90)90095-V","article-title":"Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer\u2019s disease","volume":"31","author":"Glick","year":"1990","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2006.04.047_bib8","first-page":"831","article-title":"Use of magnesium in the management of dementias","volume":"18","author":"Glick","year":"1990","journal-title":"Med Sci Res"},{"key":"10.1016\/j.mehy.2006.04.047_bib9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/307462a0","article-title":"Magnesium gates glutamate activated channels in mouse central neurons","volume":"307","author":"Nowak","year":"1984","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mehy.2006.04.047_bib10","first-page":"283","article-title":"Magnesium and potassium status in elderly subjects with and without dementia of the Alzheimer type","volume":"3","author":"Borella","year":"1990","journal-title":"Magnes Res"},{"issue":"3","key":"10.1016\/j.mehy.2006.04.047_bib11","first-page":"189","article-title":"Disturbances of magnesium concentrations in various brain areas in Alzheimer\u2019s disease","volume":"13","author":"Andrasi","year":"2000","journal-title":"Magnes Res"},{"key":"10.1016\/j.mehy.2006.04.047_bib12","series-title":"Ionotropic glutamate receptors as therapeutic targets","article-title":"Introduction to glutamate receptors, their function and pharmacology","author":"Parsons","year":"2002"},{"key":"10.1016\/j.mehy.2006.04.047_bib13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1358\/dnp.1998.11.9.863689","article-title":"Glutamate in CNS disorders as a target for drug development. An update","volume":"11","author":"Parsons","year":"1998","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.mehy.2006.04.047_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1099-1166(199901)14:1<3::AID-GPS897>3.0.CO;2-7","article-title":"The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer\u2019s disease","volume":"14","author":"Cacabelos","year":"1999","journal-title":"Int J Geriatr Psychiatr"},{"key":"10.1016\/j.mehy.2006.04.047_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF03033787","article-title":"Neuroprotective and symptomatological action of memantine relevant for Alzheimer\u2019s disease-A unified glutamatergic hypothesis on the mechanism of action","volume":"2","author":"Danysz","year":"2000","journal-title":"Neurotoxicity Res"},{"issue":"1","key":"10.1016\/j.mehy.2006.04.047_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(84)91199-5","article-title":"Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats","volume":"322","author":"Landfield","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2006.04.047_bib17","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer\u2019s disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.mehy.2006.04.047_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2005.12.002","article-title":"Glutamate based therapeutic approaches: clinical trials with NMDA antagonists","volume":"6","author":"Muir","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.mehy.2006.04.047_bib19","first-page":"CD003154","article-title":"Memantine for dementia","author":"Areosa","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.mehy.2006.04.047_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1567205053585846","article-title":"The molecular basis of memantine action in Alzheimer\u2019s disease and other neurological disorders: low-affinity, uncompetitive antagonism","volume":"2","author":"Lipton","year":"2005","journal-title":"Curr Alzheimer Res"},{"issue":"3","key":"10.1016\/j.mehy.2006.04.047_bib21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1124\/jpet.105.085142","article-title":"Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-d-aspartate-gated channels","volume":"314","author":"Chen","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"10.1016\/j.mehy.2006.04.047_bib22","first-page":"76","article-title":"Role of magnesium ions on the regulation of NMDA receptor \u2013 a pharmacopathology of memantine","volume":"14","author":"Kato","year":"2004","journal-title":"Clin Calcium"},{"issue":"3","key":"10.1016\/j.mehy.2006.04.047_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1254\/fpj.124.145","article-title":"Memantine: a therapeutic drug for Alzheimer\u2019s disease and the comparison with MK-801","volume":"124","author":"Kato","year":"2004","journal-title":"Nippon Yakurigaku Zasshi"},{"issue":"2","key":"10.1016\/j.mehy.2006.04.047_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrd1958","article-title":"Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer\u2019s disease and other neurologic disorders","volume":"5","author":"Lipton","year":"2006","journal-title":"Nat Rev Drug Discov"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987706003173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987706003173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:15:08Z","timestamp":1759691708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987706003173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006]]}},"alternative-id":["S0306987706003173"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2006.04.047","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnesium supplementation in the treatment of dementia patients","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2006.04.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}