{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:42:04Z","timestamp":1759693324455,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2006]]},"DOI":"10.1016\/j.mehy.2006.04.063","type":"journal-article","created":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T10:21:22Z","timestamp":1152267682000},"page":"1095-1098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functional duality of merlin: A conundrum of proteome complexity"],"prefix":"10.1016","volume":"67","author":[{"given":"Z.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fadiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2006.04.063_bib1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90406-G","article-title":"A novel moesin, ezrin, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor","volume":"72","author":"Trofatter","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2006.04.063_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/363515a0","article-title":"Alteration in a new gene encoding a putative membrane organizing protein causes neuromatosis type 2","volume":"363","author":"Rouleau","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2006.04.063_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/ng0294-185","article-title":"Mutations in transcripts isoforms of the neurofibromatosis 2 gene in SCH gene in multi human tumor types","volume":"6","author":"Bianchi","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2006.04.063_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.cellbio.16.1.113","article-title":"ERM-merlin and EBP50 protein families in plasma membrane organization and function","volume":"16","author":"Bretscher","year":"2000","journal-title":"Ann Rev Cell Biol"},{"key":"10.1016\/j.mehy.2006.04.063_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0955-0674(01)00300-3","article-title":"ERM proteins and NF2 tumor suppressor: the yin and yang of cortical actin organization and cell growth signaling","volume":"14","author":"Gautreau","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.mehy.2006.04.063_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1040-8428(02)00172-5","article-title":"The role of the CD44\/ezrin complex in cancer metastasis","volume":"46","author":"Martin","year":"2003","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.mehy.2006.04.063_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.cellbio.16.1.113","article-title":"ERM-merlin and EBP50 protein families in plasma membrane organization and function","volume":"16","author":"Bretcher","year":"2000","journal-title":"Ann Rev Cell Dev Biol"},{"key":"10.1016\/j.mehy.2006.04.063_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj3560377","article-title":"The neurofibromatsis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association","volume":"356","author":"James","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.mehy.2006.04.063_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1534-5807(01)00009-0","article-title":"The NF2 tumor suppressor, merlin, function in Rac-dependent signaling","volume":"1","author":"Shaw","year":"2001","journal-title":"Dev Cell"},{"key":"10.1016\/j.mehy.2006.04.063_bib10","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1242\/jcs.112.6.895","article-title":"Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrin","volume":"112","author":"Gronholm","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mehy.2006.04.063_bib11","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1074\/jbc.M006708200","article-title":"Hierarchy of merlin and ezrin N-and C-terminal domain interactions in homo-and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3kARP","volume":"276","author":"Nguyen","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2006.04.063_bib12","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1002\/1097-0142(20011215)92:12<3068::AID-CNCR10149>3.0.CO;2-5","article-title":"Overian cancer proliferation, ezrin translocation and tyrosine phosphorylation are stimulated by interleukin 1 and epidermal growth factor","volume":"92","author":"Chen","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.mehy.2006.04.063_bib13","first-page":"1231","article-title":"A highly expressed 81kDa proteins in immortalized mouse fibroblasts: its proliferative function and identity with ezrin","volume":"13","author":"Kaul","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.mehy.2006.04.063_bib14","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1242\/jcs.114.10.1901","article-title":"Normal membrane localization and actin association of NF2 tumor suppressor protein are dependent on folding of its N-terminal domain","volume":"114","author":"Brault","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.mehy.2006.04.063_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0304-3835(99)00272-4","article-title":"Ezrin, a membrane cytoskeletal linking protein is involved in the process of invasion and metastasis of human endometrial cancer","volume":"147","author":"Ohtani","year":"1999","journal-title":"Cancer Lett"},{"key":"10.1016\/j.mehy.2006.04.063_bib16","doi-asserted-by":"crossref","first-page":"R365","DOI":"10.1186\/bcr1006","article-title":"The membrane crosslinker ezrin is required for metastasis of breast cancer cells","volume":"2","author":"Elliott","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.mehy.2006.04.063_bib17","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1128\/MCB.25.6.2384-2394.2005","article-title":"The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation by repressing cyclin D1 repression","volume":"25","author":"Xiao","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.mehy.2006.04.063_bib18","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1101\/gad.13.8.978","article-title":"Schwanoma cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein","volume":"13","author":"Giovannini","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.mehy.2006.04.063_bib19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/carcin\/bgh148","article-title":"P63: molecular complexity in development and cancer","volume":"24","author":"Westfall","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mehy.2006.04.063_bib20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: a double edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nature Rev Cancer"},{"key":"10.1016\/j.mehy.2006.04.063_bib21","doi-asserted-by":"crossref","first-page":"16208","DOI":"10.1074\/jbc.M408055200","article-title":"Oxygen-sensitive delta-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection","volume":"280","author":"Ma","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2006.04.063_bib22","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/01.STR.0000206444.29930.18","article-title":"Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor","volume":"37","author":"Zhang","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.mehy.2006.04.063_bib23","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.neuropharm.2005.06.016","article-title":"Effects of opioid antagonists and morphine in a hippocampal hypoxia\/hypoglycemia model","volume":"49","author":"Ammon-Treiber","year":"2005","journal-title":"Neuropharmacology"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987706003689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987706003689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:14:31Z","timestamp":1759691671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987706003689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006]]}},"alternative-id":["S0306987706003689"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2006.04.063","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2006]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional duality of merlin: A conundrum of proteome complexity","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2006.04.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}