{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:48:37Z","timestamp":1774493317535,"version":"3.50.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.mehy.2007.02.046","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T07:38:50Z","timestamp":1186645130000},"page":"1183-1189","source":"Crossref","is-referenced-by-count":19,"title":["A Darwinian approach to Huntington\u2019s disease: Subtle health benefits of a neurological disorder"],"prefix":"10.1016","volume":"69","author":[{"given":"Benjamin R.","family":"Eskenazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah S.","family":"Wilson-Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip T.","family":"Starks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2007.02.046_bib1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/jnnp.74.7.968","article-title":"Genetically confirmed clinical Huntington\u2019s disease with no observable cell loss","volume":"74","author":"Caramins","year":"2003","journal-title":"J Neurol Neurosur Psychiat"},{"issue":"1","key":"10.1016\/j.mehy.2007.02.046_bib2","first-page":"39","article-title":"The neostriatum beyond the motor function: experimental and clinical evidence","volume":"78","author":"Calabresi","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2007.02.046_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0010-9452(87)80037-0","article-title":"Memory impairment associated with progression of Huntington\u2019s disease","volume":"23","author":"Huber","year":"1987","journal-title":"Cortex"},{"key":"10.1016\/j.mehy.2007.02.046_bib4","series-title":"Huntington\u2019s disease","year":"1996"},{"issue":"Suppl. 23","key":"10.1016\/j.mehy.2007.02.046_bib5","first-page":"1","article-title":"A clinico-genetic study of psychiatric disorder in Huntington\u2019s chorea","author":"Watt","year":"1993","journal-title":"Psychol Med"},{"key":"10.1016\/j.mehy.2007.02.046_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/jmg.33.2.128","article-title":"Familial psychiatric presentation of Huntington\u2019s disease","volume":"33","author":"Lovestone","year":"1996","journal-title":"J Med Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib7","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1212\/01.WNL.0000086373.32347.16","article-title":"Huntington\u2019s disease: clinical correlates of disability and progression","volume":"61","author":"Mahant","year":"2003","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.mehy.2007.02.046_bib8","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1176\/appi.ajp.162.4.725","article-title":"Critical periods of suicide risk in Huntington\u2019s disease","volume":"162","author":"Paulsen","year":"2005","journal-title":"Am J Psychol"},{"key":"10.1016\/j.mehy.2007.02.046_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/hmg\/4.2.207","article-title":"Ancestral differences in the distribution of the delta 2642 glutamic acid polymorphism is associated with varying CAG repeat lengths on normal chromosomes: insights into the genetic evolution of Huntington disease","volume":"4","author":"Almqvist","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1034\/j.1399-0004.2001.600305.x","article-title":"High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia","volume":"60","author":"Almqvist","year":"2001","journal-title":"Clin Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000472303","article-title":"Linkage disequilibrium between the expanded (CAG)n repeat and an allele of the adjacent (CCG)n repeat in Huntington\u2019s disease patients of Greek origin","volume":"3","author":"Yapijakis","year":"1995","journal-title":"J Hum Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib12","first-page":"1202","article-title":"The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size","volume":"60","author":"Brinkman","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jmg.31.5.377","article-title":"Instability of CAG repeats in Huntington\u2019s disease: relation to parental transmission and age of onset","volume":"31","author":"Trottier","year":"1994","journal-title":"J Med Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/hmg\/8.2.173","article-title":"Analysis of germline mutation spectra at the Huntington\u2019s disease locus supports a mitotic mutation mechanism","volume":"8","author":"Leeflang","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib15","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/jmg.30.12.996","article-title":"Dynamic mutation in Dutch Huntington\u2019s disease patients: increased paternal repeat instability extending to within the normal size range","volume":"30","author":"De Rooij","year":"1993","journal-title":"J Med Genet"},{"issue":"5","key":"10.1016\/j.mehy.2007.02.046_bib16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1086\/301846","article-title":"Laboratory guidelines for Huntington disease genetic testing","volume":"62","author":"Huntington Disease Genetic Testing Working Group","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng0894-525","article-title":"Mutational bias provides a model for the evolution of Huntington\u2019s disease and predicts a general increase in disease prevalence","volume":"7","author":"Rubinsztein","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib18","series-title":"Why we get sick: the new science of Darwinian medicine","author":"Nesse","year":"1994"},{"key":"10.1016\/j.mehy.2007.02.046_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/ng1093-174","article-title":"Molecular analysis of new mutations causing Huntington disease: intermediate alleles and sex of origin effects","volume":"5","author":"Goldberg","year":"1993","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.mehy.2007.02.046_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/jnnp.2004.036806","article-title":"Incidence and mutation rates of Huntington\u2019s disease in Spain: experience of 9 years of direct genetic testing","volume":"76","author":"Ramos-Arroyo","year":"2005","journal-title":"J Neurol Neurosur Psychiat"},{"key":"10.1016\/j.mehy.2007.02.046_bib21","first-page":"237","article-title":"Huntington\u2019s chorea in Minnesota","volume":"1","author":"Marx","year":"1973","journal-title":"Adv Neurol"},{"key":"10.1016\/j.mehy.2007.02.046_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1399-0004.1975.tb00341.x","article-title":"Investigation on Huntington\u2019s disease in the Canadian Prairies. II. Fecundity and fitness","volume":"7","author":"Shokeir","year":"1975","journal-title":"Clin Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib23","unstructured":"Stevens DL. Huntington\u2019s chorea: a demographic, genetic, and clinical study. MD Thesis, University of London; 1976."},{"key":"10.1016\/j.mehy.2007.02.046_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/jmg.20.1.12","article-title":"Huntington\u2019s chorea in South Wales: mutation, fertility, and genetic fitness","volume":"20","author":"Walker","year":"1983","journal-title":"J Med Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/00048679109077743","article-title":"The fertility of HD\u2212 affected individuals in Tasmania","volume":"25","author":"Pridmore","year":"1991","journal-title":"Aust NZ J Psychiat"},{"key":"10.1016\/j.mehy.2007.02.046_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1192\/bjp.116.532.255","article-title":"Socio-psychiatric consequences of Huntington\u2019s disease","volume":"116","author":"Dewhurst","year":"1970","journal-title":"Brit J Psychiat"},{"key":"10.1016\/j.mehy.2007.02.046_bib27","first-page":"746","article-title":"Juvenile Huntington chorea with persistent sexual deviance: a case report","volume":"41","author":"Postrach","year":"1989","journal-title":"Psychiat Neurol Med Psychol"},{"key":"10.1016\/j.mehy.2007.02.046_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/mds.870090317","article-title":"Leuprolide acetate for exhibitionism in Huntington\u2019s disease","volume":"9","author":"Rich","year":"1994","journal-title":"Movement Disord"},{"issue":"7","key":"10.1016\/j.mehy.2007.02.046_bib29","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","article-title":"Evidence for specific cognitive deficits in preclinical Huntington\u2019s disease","volume":"121","author":"Lawrence","year":"1998","journal-title":"Brain"},{"key":"10.1016\/j.mehy.2007.02.046_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1442-2018.2004.00183.x","article-title":"Living with Huntington\u2019s disease: need for supportive care","volume":"6","author":"Dawson","year":"2004","journal-title":"Nurs Health Sci"},{"key":"10.1016\/j.mehy.2007.02.046_bib31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00415-004-0461-9","article-title":"Cognitive changes in patients with Huntington\u2019s disease (HD) and asymptomatic carriers of the HD mutation","volume":"251","author":"Lemiere","year":"2004","journal-title":"J Neurol"},{"key":"10.1016\/j.mehy.2007.02.046_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tree.2003.12.009","article-title":"Promiscuous females protect their offspring","volume":"19","author":"Wolff","year":"2004","journal-title":"Trends Ecol Evol"},{"key":"10.1016\/j.mehy.2007.02.046_bib33","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/(SICI)1097-0142(19991001)86:7<1342::AID-CNCR33>3.0.CO;2-3","article-title":"Significantly lower incidence of cancer among patients with Huntington disease: an apoptotic effect of an expanded polyglutamine tract?","volume":"86","author":"Sorensen","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.mehy.2007.02.046_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0162-3095(88)90009-X","article-title":"Human fertility and fitness optimization","volume":"9","author":"Lopreato","year":"1988","journal-title":"Ethol Sociobiol"},{"key":"10.1016\/j.mehy.2007.02.046_bib35","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1600-0447.1995.tb09767.x","article-title":"Reproductive rates in families of schizophrenic patients in a case-control study","volume":"91","author":"Fananas","year":"1995","journal-title":"Acta Psychiat Scand"},{"key":"10.1016\/j.mehy.2007.02.046_bib36","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1600-0447.1999.tb00990.x","article-title":"The fertility and fecundity of patients with psychoses","volume":"99","author":"McGrath","year":"1999","journal-title":"Acta Psychiat Scand"},{"key":"10.1016\/j.mehy.2007.02.046_bib37","first-page":"260","volume":"2","year":"1994","journal-title":"Social stratification and socioeconomic inequality"},{"key":"10.1016\/j.mehy.2007.02.046_bib38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1749-6632.2000.tb05602.x","article-title":"Evolution of functions within the p53\/p63\/p73 family","volume":"926","author":"De Laurenzi","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.mehy.2007.02.046_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2007.02.046_bib40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0378-4274(98)00238-0","article-title":"Mechanisms of p53-induced apoptosis: in search of genes which are regulated during p53-mediated cell death","volume":"102\u2013103","author":"Choisy-Rossi","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.mehy.2007.02.046_bib41","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01850","article-title":"Integration of interferon-alpha\/beta signalling to p53 responses in tumour suppression and antiviral defence","volume":"424","author":"Takaoka","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2007.02.046_bib42","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1189\/jlb.1202607","article-title":"p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest","volume":"73","author":"Baek","year":"2003","journal-title":"J Leukocyte Biol"},{"key":"10.1016\/j.mehy.2007.02.046_bib43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00384-003-0553-5","article-title":"Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy","volume":"19","author":"Lechpammer","year":"2004","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.mehy.2007.02.046_bib44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1055\/s-2008-1040853","article-title":"Recent insights into the molecular pathogenesis of Huntington disease","volume":"19","author":"Leavitt","year":"1999","journal-title":"Semin Neurol"},{"key":"10.1016\/j.mehy.2007.02.046_bib45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin\u2013protein interactions and the pathogenesis of Huntington\u2019s disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib46","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0968-0004(03)00168-3","article-title":"The hunt for Huntingtin function: interaction partners tell many different stories","volume":"28","author":"Harjes","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.mehy.2007.02.046_bib47","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1523\/JNEUROSCI.20-10-03705.2000","article-title":"Wild-type Huntingtin protects from apoptosis upstream of caspase-3","volume":"20","author":"Rigamonti","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2007.02.046_bib48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2007.02.046_bib49","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of Huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mehy.2007.02.046_bib50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/nbdi.1998.0168","article-title":"Intranuclear neuronal inclusions in Huntington\u2019s disease and dentatorubral and pallidoluysian atrophy \u2013 correlation between the density of inclusions and IT-15 CAG triplet repeat length","volume":"4","author":"Becher","year":"1998","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.mehy.2007.02.046_bib51","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/10.10.1049","article-title":"Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal Huntingtin induces apoptosis by capsase activation through mitochondrial cytochrome c release","volume":"10","author":"Jana","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib52","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1073\/pnas.97.6.2898","article-title":"Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington\u2019s disease","volume":"97","author":"Wyttenbach","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2007.02.046_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02257483","article-title":"Structure and expression of the Huntington\u2019s disease gene: evidence against simple inactivation due to an expanded CAG repeat","volume":"20","author":"Ambrose","year":"1994","journal-title":"Somat Cell Mol Gen"},{"issue":"8","key":"10.1016\/j.mehy.2007.02.046_bib54","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1074\/jbc.M110338200","article-title":"Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells","volume":"277","author":"Song","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2007.02.046_bib55","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1399-0004.1985.tb00185.x","article-title":"Diabetes mellitus in Huntington disease","volume":"27","author":"Farrer","year":"1984","journal-title":"Clin Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib56","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00109-004-0552-1","article-title":"Neurodegenerative disorders associated with diabetes mellitus","volume":"82","author":"Ristow","year":"2004","journal-title":"J Mol Med"},{"key":"10.1016\/j.mehy.2007.02.046_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1568-1637(02)00047-8","article-title":"Can teatime increase one\u2019s lifetime?","volume":"2","author":"Nakachi","year":"2003","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.mehy.2007.02.046_bib58","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells","volume":"9","author":"Trettel","year":"2000","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.mehy.2007.02.046_bib59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","article-title":"p53 mediates cellular dysfunction and behavioral abnormalities in Huntington\u2019s disease","volume":"47","author":"Bae","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2007.02.046_bib60","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","article-title":"The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription","volume":"97","author":"Steffan","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2007.02.046_bib61","doi-asserted-by":"crossref","first-page":"41299","DOI":"10.1074\/jbc.M008408200","article-title":"Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain","volume":"275","author":"Hackam","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2007.02.046_bib62","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1469-1809.1996.tb00440.x","article-title":"Genetic fitness in Huntington\u2019s disease and spinocerebellar ataxia 1: a population genetics model for CAG repeat expansions","volume":"60","author":"Frontali","year":"1996","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0169-5347(01)02428-4","article-title":"Pregnancy sickness and embryo quality","volume":"17","author":"Forbes","year":"2002","journal-title":"Trends Ecol Evol"},{"issue":"4","key":"10.1016\/j.mehy.2007.02.046_bib64","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1152\/japplphysiol.00288.2003","article-title":"Invited review: theories of aging","volume":"95","author":"Weinert","year":"2003","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.mehy.2007.02.046_bib65","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1399-0004.1979.tb02027.x","article-title":"Polymorphism of apolipoprotein E.II. Genetics of hyperlipoproteinemia type III","volume":"15","author":"Utermann","year":"1979","journal-title":"Clin Genet"},{"key":"10.1016\/j.mehy.2007.02.046_bib66","series-title":"Evolution of infectious disease","author":"Ewald","year":"1994"},{"key":"10.1016\/j.mehy.2007.02.046_bib67","series-title":"Evolution in health and disease","year":"1999"},{"key":"10.1016\/j.mehy.2007.02.046_bib68","series-title":"Evolutionary medicine","author":"Trevathan","year":"1999"},{"key":"10.1016\/j.mehy.2007.02.046_bib69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1086\/393377","article-title":"Morning sickness: a mechanism for protecting mother and embryo","volume":"75","author":"Flaxman","year":"2000","journal-title":"Q Rev Biol"},{"key":"10.1016\/j.mehy.2007.02.046_bib70","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1641\/0006-3568(2003)053[0585:EBITMS]2.0.CO;2","article-title":"Evolutionary biology in the medical school curriculum","volume":"53","author":"Nesse","year":"2003","journal-title":"Bioscience"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987707003532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987707003532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T17:40:54Z","timestamp":1556732454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987707003532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0306987707003532"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2007.02.046","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1089176.542374","asserted-by":"object"}]},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}