{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:59:22Z","timestamp":1781902762052,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.mehy.2007.08.015","type":"journal-article","created":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T18:21:22Z","timestamp":1191608482000},"page":"1024-1028","source":"Crossref","is-referenced-by-count":24,"title":["Proposing a causal link between thyroid hormone resistance and primary autoimmune hypothyroidism"],"prefix":"10.1016","volume":"70","author":[{"given":"Claire","family":"Gavin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Meggison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teik Chye","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mehy.2007.08.015_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1067\/S0022-3476(03)00184-7","article-title":"Follow-up of newborns with elevated screening T4 concentrations","volume":"143","author":"Lafranchi","year":"2003","journal-title":"J Pediatr"},{"issue":"3","key":"10.1016\/j.mehy.2007.08.015_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1507\/endocrj.K05-182","article-title":"A family showing resistance to thyroid hormone associated with chronic thyroiditis and its clinical features: a case report","volume":"53","author":"Sato","year":"2006","journal-title":"Endocr J"},{"issue":"5","key":"10.1016\/j.mehy.2007.08.015_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM200502033520523","volume":"352","author":"Fukata","year":"2005","journal-title":"New Engl J Med"},{"issue":"12","key":"10.1016\/j.mehy.2007.08.015_bib4","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/00007611-199312000-00015","article-title":"Autoimmune hypothyroidism in a patient with generalized resistance to thyroid hormone","volume":"86","author":"Robinson","year":"1993","journal-title":"South Med J"},{"issue":"6","key":"10.1016\/j.mehy.2007.08.015_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/thy.1996.6.571","article-title":"A mutation in the thyroid hormone receptor (TR) beta gene (M313T) not previously reported in two unrelated families with resistance to thyroid hormone (RTH)","volume":"6","author":"Refetoff","year":"1996","journal-title":"Thyroid"},{"issue":"11","key":"10.1016\/j.mehy.2007.08.015_bib6","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1210\/jc.84.11.3919","article-title":"Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor \u03b2 gene","volume":"84","author":"Pohlenz","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.mehy.2007.08.015_bib7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1210\/jc.78.5.1253","article-title":"A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone","volume":"78","author":"Weiss","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.mehy.2007.08.015_bib8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4158\/EP.12.3.288","article-title":"Difficulties in diagnosing and managing coexisting primary hypothyroidism and resistance to thyroid hormone","volume":"12","author":"Tran","year":"2006","journal-title":"Endocr Pract"},{"issue":"4","key":"10.1016\/j.mehy.2007.08.015_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF03347207","article-title":"Resistance to thyroid hormone associated with autoimmune thyroid disease in a Turkish family","volume":"28","author":"Aksoy","year":"2005","journal-title":"J Endocrinol Invest"},{"issue":"7","key":"10.1016\/j.mehy.2007.08.015_bib10","first-page":"250","article-title":"Thyroid hormone resistance: variable clinical manifestations in five patients","volume":"36","author":"Reinhardt","year":"1997","journal-title":"Nuklearmedizin"},{"issue":"1","key":"10.1016\/j.mehy.2007.08.015_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1182\/blood-2002-02-0544","article-title":"An intrinsic thyrotropin-mediated pathway of TNF-\u03b1\u00b4 production by bone marrow cells","volume":"101","author":"Wang","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.mehy.2007.08.015_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/cimm.1998.1444","article-title":"Neuroendocrine-induced synthesis of bone marrow-derived cytokines with inflammatory immunomodulating properties","volume":"192","author":"Whetsell","year":"1999","journal-title":"Cell Immunol"},{"issue":"1","key":"10.1016\/j.mehy.2007.08.015_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.1365-2249.1996.d01-726.x","article-title":"Expression of tumour necrosis factor-alpha (TNF-alpha) mRNA and protein in pathological thyroid tissue and carcinoma cell lines","volume":"105","author":"Aust","year":"1996","journal-title":"Clin Exp Immunol"},{"issue":"Pt 1","key":"10.1016\/j.mehy.2007.08.015_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/jeb.00710","article-title":"Characterisation of a novel set of resident intrathyroidal bone-marrow-derived hematopoietic cells: potential for immune-endocrine interactions in thyroid homeostasis","volume":"207","author":"Klein","year":"2004","journal-title":"J Exp Biol"},{"issue":"3","key":"10.1016\/j.mehy.2007.08.015_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri750","article-title":"Autoimmune thyroid disease: new models of cell death in autoimmunity","volume":"2","author":"Stassi","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.mehy.2007.08.015_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/82725","article-title":"Control of target cells survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins","volume":"1","author":"Stassi","year":"2000","journal-title":"Nature Immunol"},{"issue":"2","key":"10.1016\/j.mehy.2007.08.015_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<138::AID-PATH810>3.0.CO;2-F","article-title":"Analysis of apoptosis in relation to tissue destruction associated with Hashimoto\u2019s autoimmune thyroiditis","volume":"182","author":"Hammond","year":"1997","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.mehy.2007.08.015_bib18","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1210\/jc.83.6.2199","article-title":"Fas\/Fas ligand up-regulation and Bcl-2 down-regulation may be significant in the pathogenesis of Hashimoto\u2019s thyroiditis","volume":"83","author":"Mitsiades","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.mehy.2007.08.015_bib19","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1084\/jem.166.3.786","article-title":"Effect of tumor necrosis factor alpha on mitogen-activated human B cells","volume":"166","author":"Kehrl","year":"1987","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.mehy.2007.08.015_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1084\/jem.20031104","article-title":"Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression","volume":"199","author":"Ueda","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.mehy.2007.08.015_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0140-6736(92)92171-B","article-title":"Antithyroid drugs and release of inflammatory mediators by complement-attacked thyroid cells","volume":"340","author":"Weetman","year":"1992","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.mehy.2007.08.015_bib22","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/labinvest.3780374","article-title":"Signaling from epithelial to dendritic cells of the thyroid gland: evidence for thyrocyte-derived factors controllin the survival, multiplication, and endocytic activity of dendritic cells","volume":"81","author":"Croizet","year":"2001","journal-title":"Lab Invest"},{"issue":"3","key":"10.1016\/j.mehy.2007.08.015_bib23","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.4049\/jimmunol.179.3.1449","article-title":"TNF-{alpha} drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses","volume":"179","author":"Iwamoto","year":"2007","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.mehy.2007.08.015_bib24","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1210\/jc.83.7.2486","article-title":"Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states","volume":"83","author":"Persani","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.mehy.2007.08.015_bib25","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1210\/jc.86.9.4543","article-title":"Thyroid resistance to TSH complicated by autoimmune thyroiditis","volume":"86","author":"Tonacchera","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.mehy.2007.08.015_bib26","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/01.SMJ.0000054784.64420.8B","article-title":"Thyrotropin-secreting pituitary tumour and Hashimoto\u2019s disease: a novel association","volume":"96","author":"Iskander","year":"2003","journal-title":"South Med J"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987707005452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987707005452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T16:53:47Z","timestamp":1546534427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987707005452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0306987707005452"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2007.08.015","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}