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Preferential localisation of effector memory cells in nonlymphoid tissue. www.sciencexpress.org\/1March2001\/Page1\/10.1126\/science.1058867."},{"key":"10.1016\/j.mehy.2009.03.040_bib77","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.166.3.1813","article-title":"Activated antigen-specific CD8+ T-cells persist in the lungs following recovery from respiratory virus infections","volume":"166","author":"Hogan","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.mehy.2009.03.040_bib78","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.4049\/jimmunol.159.11.5715","article-title":"A single monomer from the Yersinia 60kDa heat shock protein is the target of HLA B27-restricted CTL response in Yersinai-induced reactive arthritis","volume":"159","author":"Ugrinovic","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.mehy.2009.03.040_bib79","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0140-6736(95)91089-1","article-title":"HLA B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies","volume":"345","author":"Schofield","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.mehy.2009.03.040_bib80","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2567.2005.02303.x","article-title":"Luminal bacterial antigen-specific CD4+ T-cell responses in HLA B27 transgenic rats with chronic colitis are mediated by both major histocompatibility class II and HLA B27 molecules","volume":"117","author":"Qian","year":"2006","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.mehy.2009.03.040_bib81","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/ard.43.2.181","article-title":"Enhanced neutrophil migration in vivo HLA B27 positive subjects","volume":"43","author":"Koivuranta-Varra","year":"1984","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.mehy.2009.03.040_bib82","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S1357-4310(00)01699-3","article-title":"HLA B27 misfolding: a solution to the spondyloarthropathy conundrum?","volume":"6","author":"Colbert","year":"2000","journal-title":"Mol Med Today"},{"issue":"11","key":"10.1016\/j.mehy.2009.03.040_bib83","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1002\/art.10605","article-title":"Cell-surface expression and immune receptor recognition of HLA B27 homodimers","volume":"46","author":"Kollnberger","year":"2002","journal-title":"Arthritis Rheum"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987709002394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987709002394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T05:32:32Z","timestamp":1684992752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987709002394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0306987709002394"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2009.03.040","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}