{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:41:24Z","timestamp":1792593684278,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.mehy.2010.03.001","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T06:19:44Z","timestamp":1269497984000},"page":"284-286","source":"Crossref","is-referenced-by-count":4,"title":["The \u201csoft collagen\u201d hypothesis in the pathogenesis of the inflammatory bowel disease and the seronegative spondylarthritides"],"prefix":"10.1016","volume":"75","author":[{"given":"Periklis","family":"Vounotrypidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kouklakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2010.03.001_bib1","doi-asserted-by":"crossref","first-page":"924138","DOI":"10.1155\/2009\/924138","article-title":"Prevalence of joint hypermobility and patterns of articular manifestations in patients with inflammatory bowel disease","volume":"2009","author":"Vounotrypidis","year":"2009","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.mehy.2010.03.001_bib2","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/0016-5085(95)90687-8","article-title":"Immunocytochemical evidence of Listeria, Escherichia coli and Streptococcus antigens in Crohn\u2019s disease","volume":"108","author":"Liu","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mehy.2010.03.001_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.gastro.2004.04.061","article-title":"High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn\u2019s disease","volume":"127","author":"Darfeuille-Michaud","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mehy.2010.03.001_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.autrev.2004.03.002","article-title":"Inflammatory bowel disease: the role of environmental factors","volume":"3","author":"Danese","year":"2004","journal-title":"Autoimmune Rev"},{"key":"10.1016\/j.mehy.2010.03.001_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/003655201753265082","article-title":"The bacterial flora in inflammatory bowel disease: current insights in the pathogenesis and the influence of antibiotics and probiotics","author":"Linskens","year":"2001","journal-title":"Scand J Gastroenterol Suppl"},{"key":"10.1016\/j.mehy.2010.03.001_bib6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1097\/00054725-200411000-00019","article-title":"Inflammatory bowel disease and smoking: a review of the epidemiology, pathophysiology and therapeutic implications","volume":"10","author":"Birrenbach","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.mehy.2010.03.001_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bpg.2003.12.003","article-title":"Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practice","volume":"18","author":"Cosnes","year":"2004","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.mehy.2010.03.001_bib8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/gut.40.5.619","article-title":"Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease","volume":"40","author":"Evans","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.mehy.2010.03.001_bib9","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2169\/internalmedicine.43.534","article-title":"The role of bacterial infection in the pathogenesis of inflammatory bowel disease","volume":"43","author":"Ohkusa","year":"2004","journal-title":"Intern Med"},{"key":"10.1016\/j.mehy.2010.03.001_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3748\/wjg.14.165","article-title":"Hygiene hypothesis in inflammatory bowel disease: a critical review of the literature","volume":"14","author":"Koloski","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.mehy.2010.03.001_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/ajcn\/22.2.214","article-title":"Whither bovine milk?","volume":"22","author":"Floch","year":"1969","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2010.03.001_bib12","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/bmj.298.6688.1617","article-title":"Role of infant feeding practices in development of Crohn\u2019s disease in childhood","volume":"298","author":"Koletzko","year":"1989","journal-title":"BMJ"},{"key":"10.1016\/j.mehy.2010.03.001_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/bmj.1.5220.154","article-title":"Ulcerative colitis provoked by milk","volume":"1","author":"Truelove","year":"1961","journal-title":"Br Med J"},{"key":"10.1016\/j.mehy.2010.03.001_bib14","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/ibd.20206","article-title":"Preterm birth but no mode of delivery is associated with an increased risk of developing inflammatory bowel disease later in life","volume":"13","author":"Sonntag","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.mehy.2010.03.001_bib15","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3109\/00365528708991950","article-title":"Chidhood factors in ulcerative colitis and Crohn\u2019s disease. An international cooperative study","volume":"22","author":"Gilat","year":"1987","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.mehy.2010.03.001_bib16","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.2460\/javma.1992.201.10.1603","article-title":"Idiopathic inflammatory bowel disease in dogs and cats: 84 case (1987\u20131990)","volume":"201","author":"Jergens","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.mehy.2010.03.001_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ibd.20240","article-title":"What is human inflammatory bowel disease (IBD) more like: Johne\u2019s disease in cattle or IBD in dogs and cats?","volume":"14","author":"Qin","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.mehy.2010.03.001_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/gut.28.4.394","article-title":"Histopathology of intestinal inflammation related to reactive arthritis","volume":"28","author":"Cuvelier","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.mehy.2010.03.001_bib19","first-page":"7","article-title":"The gut in the spondylarthropathies","volume":"17","author":"Mielants","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1016\/j.mehy.2010.03.001_bib20","first-page":"1491","article-title":"Macroscopic and microscopic gut lesions in seronegative spondylarthropathies","volume":"17","author":"Simenon","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1016\/j.mehy.2010.03.001_bib21","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gut.37.6.805","article-title":"Seromarkers of collagen I and III metabolism in active Crohn\u2019s disease. Relation to disease activity and response to therapy","volume":"37","author":"Kjeldsen","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.mehy.2010.03.001_bib22","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/0016-5085(95)90630-4","article-title":"Corticosteroids increase procollagen gene expression, synthesis and secretion by human intestinal smooth muscle cells","volume":"109","author":"Graham","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mehy.2010.03.001_bib23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/gut.53.1.85","article-title":"Reversal of abnormal collagen production in Crohn\u2019s disease intestinal biopsies treated with regenerating agents","volume":"53","author":"Alexakis","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.mehy.2010.03.001_bib24","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/ard.59.12.945","article-title":"Comparative study of the synovial histology in rheumatoid arthritis, spondylarthropathy, and osteoarthritis: influence of disease duration and activity","volume":"59","author":"Baeten","year":"2000","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.mehy.2010.03.001_bib25","first-page":"980","article-title":"Relative value of erythrocyte sedimentation rate and C-reactive protein in assessment of disease activity in ankylosing spondylitis","volume":"26","author":"Spoorenberg","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1016\/j.mehy.2010.03.001_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF01297104","article-title":"Predictors of acute relapse of Crohn\u2019s disease. A laboratory and clinical study","volume":"32","author":"Wright","year":"1987","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.mehy.2010.03.001_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00004836-198808000-00011","article-title":"The clinical significance of serum C reactive protein levels in Crohn\u2019s disease. Results of a prospective longitudinal study","volume":"10","author":"Boirivant","year":"1988","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.mehy.2010.03.001_bib28","unstructured":"Morgan JP, Bierry DN. Spondylosis deformans. In: Newton CD, Nunamaker DM, editors. Textbook of small animal orthopaedics. JB Lippincott Company; 1985 [Chapter 61] http:\/\/cal.vet.upenn.edu\/projects\/saortho\/chapter_61\/61mast.htm."},{"key":"10.1016\/j.mehy.2010.03.001_bib29","first-page":"48","article-title":"Urinary retention caused by ankylosing spondylitis in a 3-year-old dog","volume":"15","author":"Leblanc","year":"1974","journal-title":"Can Vet J"},{"key":"10.1016\/j.mehy.2010.03.001_bib30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.7589\/0090-3558-41.4.717","article-title":"Spondylitic changes in long-finned pilot whales (Globicephala Melas) stranded on Cape Cod, Massachusetts, USA, between 1982 and 2000","volume":"41","author":"Sweeny","year":"2005","journal-title":"J Wildl Dis"},{"key":"10.1016\/j.mehy.2010.03.001_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/vr.137.18.460","article-title":"Idiopathic infective arthritis of the coxofemoral joint in a mature horse","volume":"137","author":"Clegg","year":"1995","journal-title":"Vet Rec"},{"key":"10.1016\/j.mehy.2010.03.001_bib32","first-page":"531","article-title":"Benign joint hypermobility syndrome: evaluation, diagnosis, and management","volume":"106","author":"Simpson","year":"2006","journal-title":"J Am \u00d2steopath Assoc"},{"key":"10.1016\/j.mehy.2010.03.001_bib33","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/art.20376","article-title":"The genetic epidemiology of joint hypermobility: a population study of female twins","volume":"50","author":"Hakim","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.mehy.2010.03.001_bib34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/gut.30.5.618","article-title":"Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983; marginal fall in ulcerative colitis, three-fold rise in Crohn\u2019s disease","volume":"30","author":"Barton","year":"1989","journal-title":"Gut"},{"key":"10.1016\/j.mehy.2010.03.001_bib35","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/adc.74.5.460","article-title":"The epidemiology of paediatric inflammatory bowel disease","volume":"74","author":"Cosgrove","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.mehy.2010.03.001_bib36","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0140-6736(99)00333-5","article-title":"Incidence of juvenile-onset Crohn\u2019s disease in Scotland","volume":"353","author":"Armitage","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2010.03.001_bib37","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0140-6736(99)02625-2","article-title":"Incidence of paediatric Crohn\u2019s disease in Stockholm, Sweden","volume":"354","author":"Askling","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2010.03.001_bib38","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/art.1780401015","article-title":"Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment","volume":"40","author":"Brown","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.mehy.2010.03.001_bib39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/art.1780380313","article-title":"Occurrence of ankylosing spondylitis in a nationwide series of twins","volume":"38","author":"Jarvinen","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.mehy.2010.03.001_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000136834","article-title":"Effect of salicylic acid on articular cartilage in organ culture","volume":"17","author":"Lowther","year":"1978","journal-title":"Pharmacology"},{"key":"10.1016\/j.mehy.2010.03.001_bib41","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/ard.56.10.573","article-title":"Hypermobility","volume":"56","author":"Klemp","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.mehy.2010.03.001_bib42","first-page":"664","article-title":"The need to take a fresh look at criteria for hypermobility","volume":"34","author":"Grahame","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.mehy.2010.03.001_bib43","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/art.22812","article-title":"A common genetic background for inflammatory bowel disease and ankylosing spondylitis: a genealogic study in Iceland","volume":"56","author":"Thjodleifsson","year":"2007","journal-title":"Arthritis Rheum"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987710001131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987710001131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:22:54Z","timestamp":1711358574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987710001131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0306987710001131"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2010.03.001","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}