{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:55:01Z","timestamp":1776444901833,"version":"3.51.2"},"reference-count":172,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.mehy.2010.07.047","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T10:00:23Z","timestamp":1282903223000},"page":"613-619","source":"Crossref","is-referenced-by-count":15,"title":["Chronic immune stimulation as a contributing cause of chronic disease in opiate addiction including multi-system ageing"],"prefix":"10.1016","volume":"75","author":[{"given":"Albert Stuart","family":"Reece","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2010.07.047_b0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0193-953X(05)70081-2","article-title":"Medical consequences of substance abuse","volume":"22","author":"Stein","year":"1999","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.mehy.2010.07.047_b0875","first-page":"1","article-title":"Drug abuse deaths in nine cities: A survey report","volume":"vol. 29","author":"Gottshcalk","year":"1979"},{"key":"10.1016\/j.mehy.2010.07.047_b0015","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/j.1360-0443.2009.02633.x","article-title":"Opioid agonist pharmacotherapy in New South Wales from 1985 to 2006: patient characteristics and patterns and predictors of treatment retention","volume":"104","author":"Burns","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.mehy.2010.07.047_b0020","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1360-0443.2006.01495.x","article-title":"Systemic disease among cases of fatal opioid toxicity","volume":"101","author":"Darke","year":"2006","journal-title":"Addiction"},{"key":"10.1016\/j.mehy.2010.07.047_b0025","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMra023160","article-title":"Drug addiction","volume":"349","author":"Cami","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0030","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0002-9343(53)90371-4","article-title":"Clinical characteristics of addictions","volume":"14","author":"Isbell","year":"1953","journal-title":"Am J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0035","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1360-0443.2006.01521.x","article-title":"Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis","volume":"101","author":"Andresz","year":"2006","journal-title":"Addiction"},{"key":"10.1016\/j.mehy.2010.07.047_b0865","series-title":"Goodman and gilman\u2019s the pharmacologic basis of therapeutics","year":"2006"},{"key":"10.1016\/j.mehy.2010.07.047_b0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-4933-4-6","article-title":"Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers","volume":"4","author":"Reece","year":"2007","journal-title":"Immun Ageing"},{"key":"10.1016\/j.mehy.2010.07.047_b0050","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1111\/j.1360-0443.1997.tb02866.x","article-title":"Patterns of symptom complaints in methadone maintenance patients","volume":"92","author":"Dyer","year":"1997","journal-title":"Addiction"},{"key":"10.1016\/j.mehy.2010.07.047_b0055","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.drugalcdep.2008.07.017","article-title":"Benzodiazepine use among opiate-dependent subjects in buprenorphine maintenance treatment: correlates of use, abuse and dependence","volume":"99","author":"Lavie","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.mehy.2010.07.047_b0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0376-8716(92)90005-W","article-title":"Benzodiazepine use and HIV risk-taking behaviour among injecting drug users","volume":"31","author":"Darke","year":"1992","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.mehy.2010.07.047_b0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jad.2006.09.017","article-title":"Depression in methadone maintenance treatment patients: rate and risk factors","volume":"99","author":"Peles","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.mehy.2010.07.047_b0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1300\/J069v24n04_02","article-title":"Co-consumption of benzodiazepines in heroin users, methadone-substituted and codeine-substituted patients","volume":"24","author":"Backmund","year":"2005","journal-title":"J Addict Dis"},{"key":"10.1016\/j.mehy.2010.07.047_b0075","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1046\/j.1440-1614.2003.01211.x","article-title":"Treatment of benzodiazepine dependence in methadone maintenance treatment patients: a comparison of two therapeutic modalities and the role of psychiatric comorbidity","volume":"37","author":"Weizman","year":"2003","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.mehy.2010.07.047_b0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/da.20564","article-title":"Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder","volume":"26","author":"Hoge","year":"2009","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.mehy.2010.07.047_b0085","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbi.2009.04.013","article-title":"Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress","volume":"23","author":"Blandino","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.mehy.2010.07.047_b0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbi.2006.12.004","article-title":"Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll\/Mr. Hyde duality of the innate immune system","volume":"21","author":"Gosselin","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.mehy.2010.07.047_b0095","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbi.2009.04.011","article-title":"A prospective evaluation of the directionality of the depression-inflammation relationship","volume":"23","author":"Stewart","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.mehy.2010.07.047_b0100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1017\/S0033291708003723","article-title":"Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study","volume":"39","author":"Gimeno","year":"2009","journal-title":"Psychol Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.51.1.29","article-title":"The pain of being sick: implications of immune-to-brain communication for understanding pain","volume":"51","author":"Watkins","year":"2000","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.mehy.2010.07.047_b0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/japplphysiol.01151.2001","article-title":"Elevated IL-1beta contributes to antibody suppression produced by stress","volume":"93","author":"Moraska","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1100\/tsw.2007.230","article-title":"Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward","volume":"7","author":"Hutchinson","year":"2007","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.mehy.2010.07.047_b0125","doi-asserted-by":"crossref","unstructured":"Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ et al. Evidence for a role of heat shock protein-90 (HSP90) in TLR4 mediated pain enhancement in rats, Neuroscience 2009.","DOI":"10.1016\/j.neuroscience.2009.09.046"},{"key":"10.1016\/j.mehy.2010.07.047_b0130","doi-asserted-by":"crossref","unstructured":"Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects, Brain Behav Immun 2009.","DOI":"10.1016\/j.bbi.2009.08.004"},{"key":"10.1016\/j.mehy.2010.07.047_b0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mehy.2010.07.047_b0140","doi-asserted-by":"crossref","unstructured":"Watkins LR, Hutchinson MR, Rice KC, Maier SF. The \u201cToll\u201d of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia, Trends Pharmacol Sci 2009.","DOI":"10.1016\/j.tips.2009.08.002"},{"key":"10.1016\/j.mehy.2010.07.047_b0145","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/HJR.0b013e328045c4e9","article-title":"The association of opium with coronary artery disease","volume":"14","author":"Sadeghian","year":"2007","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.mehy.2010.07.047_b0150","series-title":"Harrison\u2019s principles of internal medicine","author":"Fauci","year":"2008"},{"key":"10.1016\/j.mehy.2010.07.047_b0155","doi-asserted-by":"crossref","first-page":"33A","DOI":"10.1016\/j.amjcard.2005.11.014","article-title":"Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) \u2013 can C-reactive protein be used to target statin therapy in primary prevention?","volume":"97","author":"Mora","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1056\/NEJMoa042000","article-title":"Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease","volume":"352","author":"Nissen","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0165","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.jacc.2005.08.024","article-title":"Relationship between uncontrolled risk factors and C-reactive protein levels in patients receiving standard or intensive statin therapy for acute coronary syndromes in the PROVE IT-TIMI 22 trial","volume":"46","author":"Ray","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0170","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa042378","article-title":"C-reactive protein levels and outcomes after statin therapy","volume":"352","author":"Ridker","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0175","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJM200106283442601","article-title":"Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events","volume":"344","author":"Ridker","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0180","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa021993","article-title":"Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events","volume":"347","author":"Ridker","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0185","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1373\/clinchem.2008.112334","article-title":"Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors","volume":"55","author":"Ruckerl","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.mehy.2010.07.047_b0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.286.1.64","article-title":"Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation\/CRP evaluation (PRINCE): a randomized trial and cohort study","volume":"286","author":"Albert","year":"2001","journal-title":"JAMA"},{"issue":"Suppl 1","key":"10.1016\/j.mehy.2010.07.047_b0195","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.archger.2009.09.028","article-title":"Is there a relationship between high C-reactive protein (CRP) levels and dementia?","volume":"49","author":"Mancinella","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.mehy.2010.07.047_b0200","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0891988709351832","article-title":"Decreased C-reactive protein levels in Alzheimer disease","volume":"23","author":"O\u2019Bryant","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.1016\/j.mehy.2010.07.047_b0205","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jalz.2009.01.025","article-title":"Association of C-reactive protein with mild cognitive impairment","volume":"5","author":"Roberts","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mehy.2010.07.047_b0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/WAD.0b013e3181a4485c","article-title":"Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: a population-based study","volume":"24","author":"Roberts","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.mehy.2010.07.047_b0215","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jalz.2009.04.1230","article-title":"Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old","volume":"5","author":"Kravitz","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mehy.2010.07.047_b0220","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2009.09.035","article-title":"Sialic acid, homocysteine and CRP: potential markers for dementia","volume":"465","author":"Davis","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.mehy.2010.07.047_b0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3233\/JAD-2009-1126","article-title":"Systemic inflammation and the risk of Alzheimer\u2019s disease and dementia: a prospective population-based study","volume":"18","author":"Sundelof","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.mehy.2010.07.047_b0230","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glq030","article-title":"Plasma Pentraxin 3, but not high-sensitivity C-reactive protein, is a useful inflammatory biomarker for predicting cognitive impairment in elderly hypertensive patients","volume":"65","author":"Yano","year":"2010","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.mehy.2010.07.047_b0235","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/jama.291.5.585","article-title":"C-reactive protein and the risk of incident colorectal cancer","volume":"291","author":"Erlinger","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.mehy.2010.07.047_b0880","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2009.27.0454","article-title":"C-reactive protein and risk of lung cancer","author":"Chaturvedi","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.mehy.2010.07.047_b0885","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyq012","article-title":"Circulating levels of coagulation and inflammation markers and cancer risks: individual participant analysis of data from three long-term cohorts","author":"Dos Santos Silva","year":"2010","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0890","article-title":"Interaction of gonadal status with systemic inflammation and opioid use in determining nutritional status and prognosis in advanced pancreatic cancer","author":"Skipworth","year":"2010","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.mehy.2010.07.047_b0255","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1523\/JNEUROSCI.22-22-09980.2002","article-title":"The role of spinal neuroimmune activation in morphine tolerance\/hyperalgesia in neuropathic and sham-operated rats","volume":"22","author":"Raghavendra","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2010.07.047_b0260","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/sj.npp.1300315","article-title":"Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats","volume":"29","author":"Raghavendra","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mehy.2010.07.047_b0265","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1100\/tsw.2007.248","article-title":"Glial cells and the neurobiology of addiction","volume":"7","author":"Lawrence","year":"2007","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.mehy.2010.07.047_b0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1100\/tsw.2007.195","article-title":"Astrocytes control neuronal excitability in the nucleus accumbens","volume":"7","author":"Fellin","year":"2007","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.mehy.2010.07.047_b0275","doi-asserted-by":"crossref","first-page":"E865","DOI":"10.1208\/aapsj070484","article-title":"Viewing chemokines as a third major system of communication in the brain","volume":"7","author":"Adler","year":"2005","journal-title":"AAPS J"},{"key":"10.1016\/j.mehy.2010.07.047_b0280","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1189\/jlb.0405222","article-title":"Are chemokines the third major system in the brain?","volume":"78","author":"Adler","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.mehy.2010.07.047_b0285","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuropharm.2009.07.012","article-title":"Opiate-induced hypernociception and chemokine receptors","volume":"58","author":"White","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mehy.2010.07.047_b0290","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.cell.2007.09.008","article-title":"Crystal structure of the TLR1\u2013TLR2 heterodimer induced by binding of a tri-acylated lipopeptide","volume":"130","author":"Jin","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0295","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2007.08.002","article-title":"Crystal structure of the TLR4\u2013MD-2 complex with bound endotoxin antagonist Eritoran","volume":"130","author":"Kim","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0300","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/prot.21504","article-title":"Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface","volume":"69","author":"Lee","year":"2007","journal-title":"Proteins"},{"key":"10.1016\/j.mehy.2010.07.047_b0305","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.1139111","article-title":"Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa","volume":"316","author":"Ohto","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mehy.2010.07.047_b0895","doi-asserted-by":"crossref","first-page":"8230","DOI":"10.1002\/anie.200702324","article-title":"Crystal structure and guest uptake of a mesoporous metal-organic framework containing cages of 3.9 and 4.7 nm in diameter","volume":"46","author":"Park","year":"2007","journal-title":"Angewandte Chemie (International ed.)"},{"key":"10.1016\/j.mehy.2010.07.047_b0315","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.immuni.2008.07.007","article-title":"Structures of the toll-like receptor family and its ligand complexes","volume":"29","author":"Jin","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.mehy.2010.07.047_b0320","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.immuni.2009.09.018","article-title":"Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer","volume":"31","author":"Kang","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.mehy.2010.07.047_b0325","series-title":"Molecular biology of the cell","author":"Alberts","year":"2008"},{"key":"10.1016\/j.mehy.2010.07.047_b0330","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbi.2009.08.004","article-title":"Evidence that opioids may have toll-like receptor 4 and MD-2 effects","volume":"24","author":"Hutchinson","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.mehy.2010.07.047_b0335","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbi.2008.09.012","article-title":"Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)","volume":"23","author":"Hutchinson","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.mehy.2010.07.047_b0900","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2009.01.014","article-title":"The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release","author":"Bland","year":"2009","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.mehy.2010.07.047_b0345","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00281-007-0079-y","article-title":"NALP inflammasomes: a central role in innate immunity","volume":"29","author":"Martinon","year":"2007","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.mehy.2010.07.047_b0350","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mehy.2010.07.047_b0355","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2004.05.004","article-title":"Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases","volume":"117","author":"Martinon","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0360","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (\u2217)","volume":"27","author":"Masters","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mehy.2010.07.047_b0365","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.mehy.2010.07.047_b0370","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1056\/NEJMe0910690","article-title":"A common genetic fingerprint in leprosy and Crohn\u2019s disease?","volume":"361","author":"Schurr","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0375","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.1184004","article-title":"How the noninflammasome NLRs function in the innate immune system","volume":"327","author":"Ting","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.mehy.2010.07.047_b0380","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","article-title":"Caspase activation precedes and leads to tangles","volume":"464","author":"de Calignon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2010.07.047_b0385","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s00213-005-2239-x","article-title":"Randomized clinical trial to compare the effects of methadone and buprenorphine on the immune system in drug abusers","volume":"179","author":"Neri","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.mehy.2010.07.047_b0390","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1902\/jop.2000.71.10.1535","article-title":"Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment","volume":"71","author":"Gamonal","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.mehy.2010.07.047_b0395","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10865-004-0005-x","article-title":"Health conditions among aging narcotics addicts: medical examination results","volume":"27","author":"Hser","year":"2004","journal-title":"J Behav Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0400","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/JGP.0b013e31816ff35a","article-title":"The prevalence of mental and physical health disorders among older methadone patients","volume":"16","author":"Rosen","year":"2008","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.mehy.2010.07.047_b0405","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/QAD.0b013e3280148c05","article-title":"Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection","volume":"21","author":"Arnsten","year":"2007","journal-title":"AIDS (London, England)"},{"key":"10.1016\/j.mehy.2010.07.047_b0410","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2796.2006.01667.x","article-title":"Fracture risk associated with the use of morphine and opiates","volume":"260","author":"Vestergaard","year":"2006","journal-title":"J Intern Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0415","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1086\/501015","article-title":"HIV infection and bone mineral density in middle-aged women","volume":"42","author":"Arnsten","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mehy.2010.07.047_b0420","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.drugalcdep.2006.05.027","article-title":"Low bone density in patients receiving methadone maintenance treatment","volume":"85","author":"Kim","year":"2006","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.mehy.2010.07.047_b0425","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1834-7819.2009.01116_7.x","article-title":"Dental health in addiction","volume":"54","author":"Reece","year":"2009","journal-title":"Aust Dent J"},{"key":"10.1016\/j.mehy.2010.07.047_b0430","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1834-7819.2007.tb00480.x","article-title":"Dentition of addiction in Queensland: poor dental status and major contributing drugs","volume":"52","author":"Reece","year":"2007","journal-title":"Aust Dent J"},{"key":"10.1016\/j.mehy.2010.07.047_b0435","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1834-7819.1978.tb03528.x","article-title":"Dental implications of narcotic addiction","volume":"23","author":"Carter","year":"1978","journal-title":"Aust Dent J"},{"key":"10.1016\/j.mehy.2010.07.047_b0905","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1834-7819.2003.tb00006.x","article-title":"Oral health status of prison inmates \u2013 New South Wales, Australia","volume":"48","author":"Butler","year":"2003","journal-title":"Aust Dental J"},{"key":"10.1016\/j.mehy.2010.07.047_b0445","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1300\/J465v27n01_04","article-title":"Tooth retention, tooth loss and use of dental care among long-term narcotics abusers","volume":"27","author":"Fan","year":"2006","journal-title":"Subst Abus"},{"key":"10.1016\/j.mehy.2010.07.047_b0450","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.physbeh.2009.06.013","article-title":"Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells","volume":"98","author":"Bailey","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2010.07.047_b0455","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1016\/j.lfs.2005.10.033","article-title":"Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD14 and TLR-4 receptor activation in human gingival fibroblasts","volume":"78","author":"Gutierrez-Venegas","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.mehy.2010.07.047_b0460","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1034\/j.1600-0765.2000.035003172.x","article-title":"Effect of the interleukin-1 genotype on monocyte IL-1beta expression in subjects with adult periodontitis","volume":"35","author":"Mark","year":"2000","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.mehy.2010.07.047_b0465","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1902\/jop.2009.097001","article-title":"The American Journal of Cardiology and Journal of Periodontology editors\u2019 consensus: periodontitis and atherosclerotic cardiovascular disease (diamond)","volume":"80","author":"Friedewald","year":"2009","journal-title":"J Periodontol"},{"key":"10.1016\/j.mehy.2010.07.047_b0470","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1902\/jop.2000.71.10.1554","article-title":"Identification of periodontal pathogens in atheromatous plaques","volume":"71","author":"Haraszthy","year":"2000","journal-title":"J Periodontol"},{"issue":"Suppl K","key":"10.1016\/j.mehy.2010.07.047_b0910","first-page":"51","article-title":"Dental infections as a risk factor for acute myocardial infarction","volume":"14","author":"Mattila","year":"1993","journal-title":"Eur Heart J"},{"key":"10.1016\/j.mehy.2010.07.047_b0480","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/oxfordjournals.aje.a009570","article-title":"Infections and atherosclerosis: new clues from an old hypothesis?","volume":"148","author":"Nieto","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0485","doi-asserted-by":"crossref","first-page":"e1000378","DOI":"10.1371\/journal.pgen.1000378","article-title":"Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis","volume":"5","author":"Schaefer","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.mehy.2010.07.047_b0490","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1001\/archinte.160.18.2749","article-title":"Periodontal disease and risk of cerebrovascular disease: the first national health and nutrition examination survey and its follow-up study","volume":"160","author":"Wu","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0495","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/oxfordjournals.aje.a010203","article-title":"Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen","volume":"151","author":"Wu","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0915","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1161\/01.STR.0000085086.50957.22","article-title":"Relationship between periodontal disease, tooth loss, and carotid artery plaque: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)","volume":"34","author":"Desvarieux","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.mehy.2010.07.047_b0505","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-0765.2008.01090.x","article-title":"Porphyromonas gingivalis lipopolysaccharide induces tumor necrosis factor-alpha and interleukin-6 secretion, and CCL25 gene expression, in mouse primary gingival cell lines: interleukin-6-driven activation of CCL2","volume":"43","author":"Ekhlassi","year":"2008","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.mehy.2010.07.047_b0510","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/039463200702000107","article-title":"Nuclear factor kappaB activity is increased in peripheral blood mononuclear cells of children affected by atopic and non-atopic eczema","volume":"20","author":"Angelini","year":"2007","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.mehy.2010.07.047_b0515","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1136\/thx.2007.082677","article-title":"Reducing inflammation in COPD: the evidence builds","volume":"62","author":"Barnes","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.mehy.2010.07.047_b0520","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1164\/ajrccm.160.supplement_1.7","article-title":"Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma","volume":"160","author":"Cosio","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0525","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/15412550802237531","article-title":"COPD as a lung disease with systemic consequences \u2013 clinical impact, mechanisms, and potential for early intervention","volume":"5","author":"Decramer","year":"2008","journal-title":"COPD"},{"key":"10.1016\/j.mehy.2010.07.047_b0530","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.mehy.2006.07.028","article-title":"Exercise and the inflammatory response in chronic obstructive pulmonary disease (COPD) \u2013 does training confer anti-inflammatory properties in COPD?","volume":"68","author":"Garrod","year":"2007","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2010.07.047_b0535","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cell.2005.03.021","article-title":"Melanocyte stem cell maintenance and hair graying","volume":"121","author":"Steingrimsson","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0540","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1747-597X-2-19","article-title":"Deficit of circulating stem \u2013 progenitor cells in opiate addiction: a pilot study","volume":"2","author":"Reece","year":"2007","journal-title":"Subst Abus Treat Prev Policy"},{"key":"10.1016\/j.mehy.2010.07.047_b0545","first-page":"142","article-title":"Positive association of opium addiction and cancer of the bladder. Results of urine cytology in 3,500 opium addicts","volume":"25","author":"Behmard","year":"1981","journal-title":"Acta Cytol"},{"key":"10.1016\/j.mehy.2010.07.047_b0550","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0528.1983.tb01354.x","article-title":"Epidemiologic study of oral cancer in Fars Province, Iran","volume":"11","author":"Fahmy","year":"1983","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0555","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0093-7754(01)90086-7","article-title":"Esophageal cancer in Iran","volume":"28","author":"Ghavamzadeh","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1016\/j.mehy.2010.07.047_b0560","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1097\/00005537-200311000-00016","article-title":"Opium and risk of laryngeal cancer","volume":"113","author":"Mousavi","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mehy.2010.07.047_b0565","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/1097-0142(197807)42:1<353::AID-CNCR2820420153>3.0.CO;2-W","article-title":"Cancer of the bladder in Southern Iran","volume":"42","author":"Sadeghi","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.mehy.2010.07.047_b0570","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/1097-0142(197708)40:2<841::AID-CNCR2820400237>3.0.CO;2-K","article-title":"Cancer of the esophagus in southern Iran","volume":"40","author":"Sadeghi","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.mehy.2010.07.047_b0575","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/1097-0142(197906)43:6<2315::AID-CNCR2820430622>3.0.CO;2-J","article-title":"Opium: a potential urinary bladder carcinogen in man","volume":"43","author":"Sadeghi","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.mehy.2010.07.047_b0870","first-page":"154","article-title":"Narcotic addiction and cervical carcinoma","volume":"10","author":"Weaver","year":"1966","journal-title":"Acta Cytol"},{"key":"10.1016\/j.mehy.2010.07.047_b0585","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1479-828X.2007.00769.x","article-title":"Lifetime prevalence of cervical neoplasia in addicted and medical patients","volume":"47","author":"Reece","year":"2007","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.mehy.2010.07.047_b0590","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0595","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1056\/NEJMoa012673","article-title":"Toll-like receptor 4 polymorphisms and atherogenesis","volume":"347","author":"Kiechl","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0600","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJM200507283530425","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"353","author":"Kriszbacher","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2010.07.047_b0605","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1161\/01.CIR.0000075572.40158.77","volume":"107","author":"Thompson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.mehy.2010.07.047_b0610","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrn2054","article-title":"The neuropoietic cytokine family in development, plasticity, disease and injury","volume":"8","author":"Bauer","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mehy.2010.07.047_b0615","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuron.2009.09.015","article-title":"Innate and adaptive autoimmunity directed to the central nervous system","volume":"64","author":"Bhat","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2010.07.047_b0620","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuron.2009.09.001","article-title":"Immune proteins in brain development and synaptic plasticity","volume":"64","author":"Boulanger","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2010.07.047_b0625","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.4049\/jimmunol.0802907","article-title":"TLR activation induces TNF-alpha production from adult neural stem\/progenitor cells","volume":"182","author":"Covacu","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.mehy.2010.07.047_b0630","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2009.09.002","article-title":"Cytokines and CNS development","volume":"64","author":"Deverman","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2010.07.047_b0635","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2010.07.047_b0640","doi-asserted-by":"crossref","first-page":"C1605","DOI":"10.1152\/ajpcell.00010.2004","article-title":"Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways","volume":"287","author":"Frost","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.mehy.2010.07.047_b0645","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1534-5807(01)00064-8","article-title":"Signaling pathways in mammary gland development","volume":"1","author":"Hennighausen","year":"2001","journal-title":"Dev Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0650","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.immunol.16.1.293","article-title":"Jaks and STATs: biological implications","volume":"16","author":"Leonard","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.mehy.2010.07.047_b0655","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/ncb1629","article-title":"Toll-like receptors modulate adult hippocampal neurogenesis","volume":"9","author":"Rolls","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.mehy.2010.07.047_b0660","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0167-5699(95)80064-6","article-title":"The immunology of exceptional individuals: the lesson of centenarians","volume":"16","author":"Franceschi","year":"1995","journal-title":"Immunol Today"},{"key":"10.1016\/j.mehy.2010.07.047_b0665","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1182\/blood.V82.9.2767.2767","article-title":"Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians","volume":"82","author":"Sansoni","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.mehy.2010.07.047_b0670","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/gerona\/60.5.556","article-title":"An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans","volume":"60","author":"Wikby","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.mehy.2010.07.047_b0675","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cell.2005.02.006","article-title":"Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone","volume":"120","author":"Chien","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0680","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1126\/science.1122446","article-title":"Cellular senescence in aging primates","volume":"311","author":"Herbig","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mehy.2010.07.047_b0685","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.01.027","article-title":"Understanding the odd science of aging","volume":"120","author":"Kirkwood","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0690","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1176\/appi.ajp.161.3.426","article-title":"Drug dependence and addiction. II: Adult neurogenesis and drug abuse","volume":"161","author":"Eisch","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.mehy.2010.07.047_b0695","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0091-3057(77)90147-2","article-title":"Effect of maternally administered heroin on the motor activity of rat offspring","volume":"7","author":"Lasky","year":"1977","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.mehy.2010.07.047_b0700","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1007\/BF01918824","article-title":"Methadone and brain development","volume":"33","author":"Zagon","year":"1977","journal-title":"Experientia"},{"key":"10.1016\/j.mehy.2010.07.047_b0705","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/0014-4886(77)90320-X","article-title":"The effects of different schedules of methadone treatment on rat brain development","volume":"56","author":"Zagon","year":"1977","journal-title":"Exp Neurol"},{"key":"10.1016\/j.mehy.2010.07.047_b0710","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000136703","article-title":"Effects of chronic morphine administration on pregnant rats and their offspring","volume":"15","author":"Zagon","year":"1977","journal-title":"Pharmacology"},{"key":"10.1016\/j.mehy.2010.07.047_b0715","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000136699","article-title":"Morphine and brain growth retardation in the rat","volume":"15","author":"Zagon","year":"1977","journal-title":"Pharmacology"},{"key":"10.1016\/j.mehy.2010.07.047_b0720","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0165-0173(01)00160-6","article-title":"The biology of the opioid growth factor receptor (OGFr)","volume":"38","author":"Zagon","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2010.07.047_b0725","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1091\/mbc.E08-07-0681","article-title":"The OGF-OGFr axis utilizes the p16INK4a and p21WAF1\/CIP1 pathways to restrict normal cell proliferation","volume":"20","author":"Cheng","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0730","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2009.08.038","article-title":"Immune influence on adult neural stem cell regulation and function","volume":"64","author":"Carpentier","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2010.07.047_b0735","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1073\/pnas.120552597","article-title":"Opiates inhibit neurogenesis in the adult rat hippocampus","volume":"97","author":"Eisch","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2010.07.047_b0740","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0079-6123(02)38085-3","article-title":"Adult neurogenesis: implications for psychiatry","volume":"138","author":"Eisch","year":"2002","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.mehy.2010.07.047_b0745","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2010.07.047_b0750","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1523\/JNEUROSCI.22-17-07650.2002","article-title":"Neuronal apoptosis associated with morphine tolerance. evidence for an opioid-induced neurotoxic mechanism","volume":"22","author":"Mao","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2010.07.047_b0755","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tips.2008.12.005","article-title":"Peroxynitrite: a strategic linchpin of opioid analgesic tolerance","volume":"30","author":"Salvemini","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.mehy.2010.07.047_b0760","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1073\/pnas.0802531105","article-title":"Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures","volume":"105","author":"Svensson","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2010.07.047_b0765","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","article-title":"Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors","volume":"120","author":"Campisi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0770","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2005.01.028","article-title":"DNA repair, genome stability, and aging","volume":"120","author":"Lombard","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0775","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/s-2007-1011844","article-title":"Impaired glucose metabolism in heroin and methadone users","volume":"19","author":"Ceriello","year":"1987","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.mehy.2010.07.047_b0780","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2337\/diacare.11.5.443","article-title":"Opiate addict as diabetic patient?","volume":"11","author":"Ceriello","year":"1988","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mehy.2010.07.047_b0785","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF03346942","article-title":"Impaired insulin response to glucose but not to arginine in heroin addicts","volume":"9","author":"Passariello","year":"1986","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.mehy.2010.07.047_b0790","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/0026-0495(83)90065-3","article-title":"Glucose tolerance and hormonal responses in heroin addicts. A possible role for endogenous opiates in the pathogenesis of non-insulin-dependent diabetes","volume":"32","author":"Passariello","year":"1983","journal-title":"Metabolism"},{"issue":"Suppl. 2","key":"10.1016\/j.mehy.2010.07.047_b0920","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1038\/ijo.2009.73","article-title":"Reward systems and food intake: role of opioids","volume":"33","author":"Gosnell","year":"2009","journal-title":"Intl J Obes (2005)"},{"key":"10.1016\/j.mehy.2010.07.047_b0800","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1097\/00001756-200106130-00042","article-title":"Evidence of interactions between melanocortin and opioid systems in regulation of feeding","volume":"12","author":"Olszewski","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.mehy.2010.07.047_b0805","doi-asserted-by":"crossref","first-page":"11075","DOI":"10.1523\/JNEUROSCI.3542-07.2007","article-title":"Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens","volume":"27","author":"Zheng","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2010.07.047_b0810","first-page":"373","article-title":"Nutritional status of the opiate dependent persons after 4 years of methadone maintenance treatment","volume":"62","author":"Kolarzyk","year":"2005","journal-title":"Przegl Lek"},{"key":"10.1016\/j.mehy.2010.07.047_b0815","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.4049\/jimmunol.168.8.4025","article-title":"Role of p38 mitogen-activated protein kinase phosphorylation and Fas\u2013Fas ligand interaction in morphine-induced macrophage apoptosis","volume":"168","author":"Singhal","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.mehy.2010.07.047_b0925","series-title":"Neuroimmune Circuits","first-page":"127","article-title":"Opiates Promote T Cell Apoptosis through JNK and Caspase Pathway","volume":"vol. 1","author":"Singhal","year":"2001"},{"key":"10.1016\/j.mehy.2010.07.047_b0825","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jneuroim.2006.02.001","article-title":"Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD\/P53 and anti-apoptotic PI3K\/Akt\/NF-kappaB pathways","volume":"174","author":"Yin","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.mehy.2010.07.047_b0830","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-3565(25)10733-7","article-title":"Morphine potentiates transforming growth factor-beta release from human peripheral blood mononuclear cell cultures","volume":"262","author":"Chao","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mehy.2010.07.047_b0835","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2567.2000.00007.x","article-title":"Morphine-induced macrophage apoptosis: the role of transforming growth factor-beta","volume":"100","author":"Singhal","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.mehy.2010.07.047_b0840","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/138920309789630561","article-title":"Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function","volume":"10","author":"Dozio","year":"2009","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.mehy.2010.07.047_b0845","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1043-2760(97)00156-2","article-title":"Gp130-Related cytokines and their receptors in the pituitary","volume":"8","author":"Melmed","year":"1997","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.mehy.2010.07.047_b0850","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI119541","article-title":"Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion","volume":"100","author":"Shimon","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2010.07.047_b0855","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2007.07.003","article-title":"Cellular senescence in cancer and aging","volume":"130","author":"Collado","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2010.07.047_b0860","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1101\/gad.451008","article-title":"The longest telomeres: a general signature of adult stem cell compartments","volume":"22","author":"Flores","year":"2008","journal-title":"Genes Dev"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771000294X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771000294X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T04:01:16Z","timestamp":1740456076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030698771000294X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":172,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S030698771000294X"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2010.07.047","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}