{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:04:50Z","timestamp":1792166690502,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.mehy.2010.10.006","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T08:27:05Z","timestamp":1288686425000},"page":"237-238","source":"Crossref","is-referenced-by-count":12,"title":["Could local deliver of bisphosphonates be a new therapeutic choice for Gorham\u2013Stout syndrome?"],"prefix":"10.1016","volume":"76","author":[{"given":"Siguo","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mehy.2010.10.006_b0005","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.tripleo.2009.08.043","article-title":"Gorham\u2013Stout syndrome: a rare clinical entity and review of literature","volume":"109","author":"Gondivkar","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"9094","key":"10.1016\/j.mehy.2010.10.006_b0010","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/S0140-6736(05)63639-2","article-title":"Alpha-2b interferon and oral clodronate for Gorham\u2019s disease","volume":"350","author":"Hagberg","year":"1997","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.mehy.2010.10.006_b0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bjoms.2004.09.008","article-title":"Total mandibular reconstruction for massive osteolysis of the mandible (Gorham\u2013Stout syndrome)","volume":"43","author":"Paley","year":"2005","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.mehy.2010.10.006_b0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0360-3016(93)90968-2","article-title":"Gorham\u2019s massive osteolysis: the role of radiation therapy and a review of the literature","volume":"26","author":"Dunbar","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.mehy.2010.10.006_b0025","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/thx.51.12.1275","article-title":"Gorham\u2019s syndrome: a usually fatal cause of pleural effusion treated successfully with radiotherapy","volume":"51","author":"McNeil","year":"1996","journal-title":"Thorax"},{"key":"10.1016\/j.mehy.2010.10.006_b0030","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1054\/ijom.2002.0306","article-title":"Vanishing bone disease in a five year old: report of a case and review of the literature","volume":"32","author":"Ricalde","year":"2003","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.mehy.2010.10.006_b0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijporl.2009.12.007","article-title":"Use of zoledronic acid in the treatment of Gorham\u2019s disease","volume":"74","author":"Avelar","year":"2010","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"10.1016\/j.mehy.2010.10.006_b0040","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.tripleo.2009.08.045","article-title":"Conservative treatment of a pathologic fracture in a patient with Gorham\u2013Stout disease","volume":"109","author":"Pedroletti","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"7","key":"10.1016\/j.mehy.2010.10.006_b0045","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00402-008-0742-3","article-title":"Benefit of a 17-year long-term bisphosphonate therapy in a patient with Gorham\u2013Stout syndrome","volume":"129","author":"Lehmann","year":"2009","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"10.1016\/j.mehy.2010.10.006_b0050","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1359\/JBMR.041113","article-title":"Gorham\u2013Stout disease \u2013 stabilization during bisphosphonate treatment","volume":"20","author":"Hammer","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2010.10.006_b0055","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2106\/00004623-195537050-00008","article-title":"Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): its relation to hemangiomatosis","volume":"37-A","author":"Gorham","year":"1955","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.mehy.2010.10.006_b0060","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-2008-1033321","article-title":"The malignant degeneration of Gorham Stout disease?","volume":"155","author":"Fretz","year":"1991","journal-title":"Rofo-Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr"},{"key":"10.1016\/j.mehy.2010.10.006_b0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF00182645","article-title":"Massive pelvic osteolysis in the Gorham\u2013Stout syndrome","volume":"14","author":"Kulenkampff","year":"1990","journal-title":"Int Orthop"},{"key":"10.1016\/j.mehy.2010.10.006_b0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0221-8747(83)90001-2","article-title":"Progressive vertebral collapse in diffuse angiomatosis","volume":"5","author":"Young","year":"1983","journal-title":"Metab Bone Dis Relat Res"},{"key":"10.1016\/j.mehy.2010.10.006_b0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2106\/00004623-197759010-00009","article-title":"Disappearing bone disease: a clinical and histological study","volume":"59-A","author":"Heyden","year":"1977","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.mehy.2010.10.006_b0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/8756-3282(90)90215-K","article-title":"An investigation of vanishing bone disease","volume":"11","author":"Dickson","year":"1990","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2010.10.006_b0085","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/0030-4220(90)90003-B","article-title":"Massive osteolysis of the maxillofacial bones: report of two cases","volume":"70","author":"Ohya","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"2","key":"10.1016\/j.mehy.2010.10.006_b0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000313787","article-title":"Bisphosphonates induce apoptosis of circulating endothelial cells in multiple myeloma patients and in subjects with bisphosphonate-induced osteonecrosis of the jaws","volume":"124","author":"Allegra","year":"2010","journal-title":"Acta Haematol"},{"issue":"3","key":"10.1016\/j.mehy.2010.10.006_b0095","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/jpet.102.035295","article-title":"Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid","volume":"302","author":"Wood","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.mehy.2010.10.006_b0100","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ejca.2009.10.019","article-title":"Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma","volume":"46","author":"Moschetta","year":"2010","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.mehy.2010.10.006_b0105","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1210\/jc.2009-1947","article-title":"Long-term use of bisphosphonates in osteoporosis","volume":"95","author":"Watts","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.mehy.2010.10.006_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4012\/dmj.28.1","article-title":"Next generation calcium phosphate-based biomaterials","volume":"28","author":"Chow","year":"2009","journal-title":"Dent Mater J"},{"issue":"14","key":"10.1016\/j.mehy.2010.10.006_b0115","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.biomaterials.2004.05.019","article-title":"Novel biomaterials for bisphosphonate delivery","volume":"26","author":"Josse","year":"2005","journal-title":"Biomaterials"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987710004172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987710004172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T03:20:31Z","timestamp":1544152831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987710004172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0306987710004172"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2010.10.006","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}