{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:47:13Z","timestamp":1789865233299,"version":"4.0.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.mehy.2011.02.009","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T14:19:15Z","timestamp":1298557155000},"page":"729-732","source":"Crossref","is-referenced-by-count":3,"title":["Macular degeneration: A possible biochemical mechanism"],"prefix":"10.1016","volume":"76","author":[{"given":"Albert H.","family":"Soloway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert W.","family":"Curley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Soloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2011.02.009_b0005","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/tx700210j","article-title":"Oxidative stress and neurotoxicity","volume":"21","author":"Sayre","year":"2008","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.mehy.2011.02.009_b0010","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1172\/JCI5017","article-title":"Large neutral amino acids block phenylalanine transport into brain tissue in patients with phenylketonuria","volume":"103","author":"Peitz","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2011.02.009_b0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/humu.20637","article-title":"Molecular genetics of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency","volume":"29","author":"Zurfluh","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/j.mehy.2011.02.009_b0020","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1039\/b004314l","article-title":"Isolation of a stable benzene oxide from a fungal biotransformation and evidence for an \u2018NIH shift\u2019 of the carbomethoxy group during hydroxylation of methyl benzoates","author":"Boyd","year":"2000","journal-title":"Chem Commun"},{"key":"10.1016\/j.mehy.2011.02.009_b0025","series-title":"The Biology of Cancer","first-page":"488","article-title":"Aflatoxin B 1\u20138,9 oxide","author":"Weinberg","year":"2007"},{"key":"10.1016\/j.mehy.2011.02.009_b0030","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.mehy.2007.04.023","article-title":"Potential endogenous epoxides of steroid hormones: initiators of breast and other malignancies?","volume":"69","author":"Soloway","year":"2007","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2011.02.009_b0035","first-page":"19","article-title":"Potential endogenous epoxides of tyrosine: causative agents in initiating idiopathic Parkinson disease?","volume":"5","author":"Soloway","year":"2009","journal-title":"Med Hypotheses Res"},{"key":"10.1016\/j.mehy.2011.02.009_b0040","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1056\/NEJMra062326","article-title":"Age-related macular degeneration","volume":"355","author":"de Jong","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2011.02.009_b0045","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/bj1860475","article-title":"5,6-Epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat","volume":"186","author":"McCormick","year":"1980","journal-title":"Biochem J"},{"key":"10.1016\/j.mehy.2011.02.009_b0050","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0002-9394(14)71036-0","article-title":"Familial aggregation of age-related maculopathy","volume":"123","author":"Seddon","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.mehy.2011.02.009_b0055","series-title":"The Language of Life-DNA and the Revolution in Personalized Medicine","first-page":"67","article-title":"The first success story: Macular degeneration","author":"Collins","year":"2010"},{"key":"10.1016\/j.mehy.2011.02.009_b0060","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1167\/iovs.07-1470","article-title":"Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following vitamin A supplementation","volume":"49","author":"Radu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.mehy.2011.02.009_b0065","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1074\/jbc.M708989200","article-title":"A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor","volume":"283","author":"Iriyama","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2011.02.009_b0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1194\/jlr.R000687","article-title":"Phospholipid meets all-trans-retinal: the making of RPE","volume":"51","author":"Sparrow","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1016\/j.mehy.2011.02.009_b0075","doi-asserted-by":"crossref","first-page":"18207","DOI":"10.1074\/jbc.M300457200","article-title":"A2E-epoxides damage DNA in retinal pigment epithelial cells","volume":"278","author":"Sparrow","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2011.02.009_b0080","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1074\/jbc.M708982200","article-title":"Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina","volume":"283","author":"Golczak","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2011.02.009_b0085","first-page":"49","article-title":"Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at the level of protein and mRNA","volume":"88","author":"Thomas","year":"1990","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.mehy.2011.02.009_b0090","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/jmg.38.4.234","article-title":"A polymorphism in the gene for microsomal epoxide hydrolases is associated with pre-eclampsia","volume":"38","author":"Zusterzeel","year":"2001","journal-title":"J Med Genet"},{"key":"10.1016\/j.mehy.2011.02.009_b0095","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.pharmtox.45.120403.095920","article-title":"Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles","volume":"45","author":"Morisseau","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.mehy.2011.02.009_b0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00204-009-0416-0","article-title":"Mammalian epoxide hydrolases in xenobiotic metabolism and signaling","volume":"83","author":"Decker","year":"2009","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.mehy.2011.02.009_b0105","first-page":"22","article-title":"Detoxification strategy of epoxide hydrolases. The basis for a threshold in chemical carcinogenesis","volume":"2","author":"Arand","year":"2003","journal-title":"EXCLI J"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711000600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711000600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T15:20:48Z","timestamp":1543936848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987711000600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0306987711000600"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2011.02.009","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}