{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:15:03Z","timestamp":1786994103260,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.mehy.2011.03.006","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T17:55:50Z","timestamp":1302803750000},"page":"908-910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Spinal balance failure: A potential cause of spinal ligament ossification"],"prefix":"10.1016","volume":"76","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.mehy.2011.03.006_b0005","doi-asserted-by":"crossref","first-page":"E861","DOI":"10.1097\/BRS.0b013e3181bb89fc","article-title":"Cervical cord injury in patients with ankylosed spines: progressive paraplegia in two patients after posterior fusion without decompression","volume":"34","author":"Sugimoto","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.006_b0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00002517-199504000-00009","article-title":"Surgical treatment for ossification of the posterior longitudinal ligament of the cervical spine","volume":"8","author":"Kawano","year":"1995","journal-title":"J Spinal Disord"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.006_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s100380170117","article-title":"Gender-specific haplotype association of collagen alpha2 (XI) gene in ossification of the posterior longitudinal ligament of the spine","volume":"46","author":"Maeda","year":"2001","journal-title":"J Hum Genet"},{"issue":"6","key":"10.1016\/j.mehy.2011.03.006_b0020","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s004390050993","article-title":"Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"104","author":"Nakamura","year":"1999","journal-title":"Hum Genet"},{"issue":"10","key":"10.1016\/j.mehy.2011.03.006_b0025","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/00007632-199905150-00002","article-title":"Genetic analysis of ossification of the posterior longitudinal ligament","volume":"24","author":"Matsunaga","year":"1999","journal-title":"Spine (Phila Pa 1976)"},{"issue":"8","key":"10.1016\/j.mehy.2011.03.006_b0030","first-page":"527","article-title":"Genetic study on OPLL in the cervical spine with HLA haplotype","volume":"65","author":"Yamaguchi","year":"1991","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"issue":"11","key":"10.1016\/j.mehy.2011.03.006_b0035","first-page":"1059","article-title":"Etiological study of spinal ligament ossification with special reference to dietary habits and serum sex hormones","volume":"64","author":"Musha","year":"1990","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.006_b0040","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00007632-199901150-00010","article-title":"Ossification of the posterior longitudinal ligament of the spine. A case-control risk factor study","volume":"24","author":"Wang","year":"1999","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"10.1016\/j.mehy.2011.03.006_b0045","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00774-004-0531-1","article-title":"Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case-control study in Japan","volume":"22","author":"Okamoto","year":"2004","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.006_b0050","first-page":"49","article-title":"Cervical myelopathy from ossification of the posterior longitudinal vertebral ligament. Report of 2 cases","volume":"45","author":"Okais","year":"1999","journal-title":"Neurochirurgie"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0055","first-page":"139","article-title":"Ossification of the ligamentum flavum of the cervical spine","volume":"51","author":"Miyazawa","year":"2007","journal-title":"J Neurosurg Sci"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0060","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1254\/jphs.FMJ05004X4","article-title":"Current topics in pharmacological research on bone metabolism: molecular basis of ectopic bone formation induced by mechanical stress","volume":"100","author":"Furukawa","year":"2006","journal-title":"J Pharmacol Sci"},{"issue":"9","key":"10.1016\/j.mehy.2011.03.006_b0065","first-page":"725","article-title":"A radiographic study of the progression of ossification of the cervical posterior longitudinal ligament: the correlation between the ossification of the posterior longitudinal ligament and that of the anterior longitudinal ligament","volume":"68","author":"Nakamura","year":"1994","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s002239900231","article-title":"Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament","volume":"60","author":"Kon","year":"1997","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.mehy.2011.03.006_b0075","first-page":"445","article-title":"Effect of transforming growth factor-beta on fibroblasts in ossification of the posterior longitudinal ligament","volume":"10","author":"Inaba","year":"1996","journal-title":"In Vivo"},{"issue":"17","key":"10.1016\/j.mehy.2011.03.006_b0080","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1097\/00007632-200209010-00009","article-title":"Possible roles of CTGF\/Hcs24 in the initiation and development of ossification of the posterior longitudinal ligament","volume":"27","author":"Yamamoto","year":"2002","journal-title":"Spine (Phila Pa 1976)"},{"issue":"5","key":"10.1016\/j.mehy.2011.03.006_b0085","first-page":"461","article-title":"Comparative roentgenographical study on the incidence of ossification of the posterior longitudinal ligament and other degenerative changes of the cervical spine among Japanese, Koreans, Americans and Germans (author\u2019s transl)","volume":"54","author":"Izawa","year":"1980","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.006_b0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3171\/SPI-07\/07\/013","article-title":"Results of surgical treatment for thoracic myelopathy: minimum 2-year follow-up study in 132 patients","volume":"7","author":"Aizawa","year":"2007","journal-title":"J Neurosurg Spine"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.006_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1620\/tjem.184.1","article-title":"Thoracic myelopathy in the Japanese: epidemiological and clinical observations on the cases in Miyagi Prefecture","volume":"184","author":"Sato","year":"1998","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.mehy.2011.03.006_b0100","doi-asserted-by":"crossref","DOI":"10.1227\/NEU.0b013e3181ef2806","article-title":"Ossification of the posterior longitudinal ligament of the lumbar spine: a case series","author":"Okada","year":"2010","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.006_b0105","first-page":"53","article-title":"Prevalence, morphology, and pathologic implications of ossification of lumbar ligamenta flava: a large prospective CT study","volume":"82","author":"Coulier","year":"1999","journal-title":"JBR-BTR"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.006_b0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/BRS.0b013e3181b3f779","article-title":"Prevalence, distribution, and morphology of ossification of the ligamentum flavum: a population study of one thousand seven hundred thirty-six magnetic resonance imaging scans","volume":"35","author":"Guo","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"issue":"25","key":"10.1016\/j.mehy.2011.03.006_b0115","doi-asserted-by":"crossref","first-page":"E959","DOI":"10.1097\/01.brs.0000248126.96737.0f","article-title":"Gravity line analysis in adult volunteers: age-related correlation with spinal parameters, pelvic parameters, and foot position","volume":"31","author":"Schwab","year":"2006","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.mehy.2011.03.006_b0120","article-title":"Rotational stress: role in development of ossification of posterior longitudinal ligament and ligamentum flavum","author":"Chen","year":"2010","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2011.03.006_b0125","series-title":"Clinical Biomechanics of the Spine","author":"White","year":"1990"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.006_b0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00267756","article-title":"Ossification of the ligamentum flavum of the thoracic spine in adult kyphosis","volume":"10","author":"Otani","year":"1986","journal-title":"Int Orthop"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jocn.2009.06.023","article-title":"Static versus dynamic factors for the development of myelopathy in patients with cervical ossification of the posterior longitudinal ligament","volume":"17","author":"Fujiyoshi","year":"2010","journal-title":"J Clin Neurosci"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0140","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/BSD.0b013e31819e9066","article-title":"Etiology of cervical myelopathy induced by ossification of the posterior longitudinal ligament: determining the responsible level of OPLL myelopathy by correlating static compression and dynamic factors","volume":"23","author":"Azuma","year":"2010","journal-title":"J Spinal Disord Tech"},{"issue":"7","key":"10.1016\/j.mehy.2011.03.006_b0145","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00007632-198310000-00003","article-title":"Expansive open-door laminoplasty for cervical spinal stenotic myelopathy","volume":"8","author":"Hirabayashi","year":"1983","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"10.1016\/j.mehy.2011.03.006_b0150","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00007632-198107000-00005","article-title":"Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament","volume":"6","author":"Hirabayashi","year":"1981","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0155","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3171\/spi.2006.4.3.191","article-title":"Surgical treatment of 40 patients with thoracic ossification of the ligamentum flavum","volume":"4","author":"Li","year":"2006","journal-title":"J Neurosurg Spine"},{"issue":"4","key":"10.1016\/j.mehy.2011.03.006_b0160","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S8756-3282(03)00204-7","article-title":"Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments","volume":"33","author":"Tanno","year":"2003","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.mehy.2011.03.006_b0165","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00223-002-0021-1","article-title":"Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament","volume":"74","author":"Iwasaki","year":"2004","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.006_b0170","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1124\/jpet.102.047142","article-title":"Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament","volume":"305","author":"Ohishi","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"issue":"Suppl.","key":"10.1016\/j.mehy.2011.03.006_b0175","first-page":"71P","article-title":"Role of PGI2 in ectopic bone formation of spinal ligaments","volume":"122","author":"Furukawa","year":"2003","journal-title":"Nippon Yakurigaku Zasshi"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711001083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711001083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:16:27Z","timestamp":1759691787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987711001083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0306987711001083"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2011.03.006","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spinal balance failure: A potential cause of spinal ligament ossification","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2011.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}