{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:57:05Z","timestamp":1792144625974,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.mehy.2011.03.033","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T16:52:34Z","timestamp":1303145554000},"page":"87-90","source":"Crossref","is-referenced-by-count":11,"title":["A new view of the roles of blood flow dynamics and Kupffer cell in intra-hepatic metastasis of hepatocellular carcinoma"],"prefix":"10.1016","volume":"77","author":[{"given":"Qiaofei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mehy.2011.03.033_b0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"issue":"175","key":"10.1016\/j.mehy.2011.03.033_b0010","first-page":"75","article-title":"Anatomical base of routes of intra-hepatic metastasis of primary liver cancer","volume":"6","author":"Yang","year":"2006","journal-title":"Chin J Min Inv Surg"},{"issue":"Suppl. 3","key":"10.1016\/j.mehy.2011.03.033_b0015","doi-asserted-by":"crossref","first-page":"S249","DOI":"10.1016\/S1590-8658(10)60513-0","article-title":"Treatment of early hepatocellular carcinoma: how to predict and prevent recurrence","volume":"42","author":"Andreana","year":"2010","journal-title":"Dig Liver Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.mehy.2011.03.033_b0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000086628","article-title":"The molecular signature of metastases of human hepatocellular carcinoma","volume":"69","author":"Budhu","year":"2005","journal-title":"Oncology"},{"key":"10.1016\/j.mehy.2011.03.033_b0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00432-003-0511-1","article-title":"A decade\u2019s studies on metastasis of hepatocellular carcinoma","volume":"130","author":"Tang","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.033_b0030","first-page":"142","article-title":"Study of the route of intra-hepatic metastasis of primary hepatic carcinoma","volume":"23","author":"Dong","year":"2001","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"issue":"6","key":"10.1016\/j.mehy.2011.03.033_b0035","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/BF00115112","article-title":"Intrahepatic metastases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel","volume":"14","author":"Mitsunobu","year":"1996","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.mehy.2011.03.033_b0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2009.02.011","article-title":"Role of macrophages in tumour progression","volume":"123","author":"Siveen","year":"2009","journal-title":"Immunol Lett"},{"key":"10.1016\/j.mehy.2011.03.033_b0045","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/hep.1840060430","article-title":"Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver","volume":"6","author":"Bouwens","year":"1986","journal-title":"Hepatology"},{"key":"10.1016\/j.mehy.2011.03.033_b0050","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0002-9440(10)62038-X","article-title":"Macrophage responses to hypoixc: implications for tumor progression and anti-cancer therapies","volume":"167","author":"Lewis","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.mehy.2011.03.033_b0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2006.01.007","article-title":"Macrophages: obligate partners for tumor cell migration, invasion, and metastasis","volume":"124","author":"Condeelis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2011.03.033_b0060","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1189\/jlb.70.4.478","article-title":"Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors","volume":"70","author":"Crowther","year":"2001","journal-title":"J Leukoc Biol"},{"issue":"46","key":"10.1016\/j.mehy.2011.03.033_b0065","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of Kupffer cells in the pathogenesis of liver disease","volume":"12","author":"Kolios","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.mehy.2011.03.033_b0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/jsre.2001.6253","article-title":"Induction of Fas and Fas ligand expression on malignant glioma cells by Kupffer cells, a potential pathway of antiliver metastases","volume":"101","author":"Lau","year":"2001","journal-title":"J Surg Res"},{"key":"10.1016\/j.mehy.2011.03.033_b0075","first-page":"2732","article-title":"Role of carcinoembryonic antigen in the progression of colon cancer cells that express carbohydrate antigen","volume":"61","author":"Minami","year":"2001","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.033_b0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/toxsci\/kfl173","article-title":"Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis","volume":"96","author":"Roberts","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.mehy.2011.03.033_b0085","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/exmp.2001.2399","article-title":"Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats","volume":"71","author":"Luckey","year":"2001","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.mehy.2011.03.033_b0090","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mehy.2011.03.033_b0095","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1189\/jlb.1105633","article-title":"Hemokines, chemokine receptors, and cancer metastasis","volume":"79","author":"Kakinuma","year":"2006","journal-title":"J Leukoc Biol"},{"issue":"7","key":"10.1016\/j.mehy.2011.03.033_b0100","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1593\/neo.09272","article-title":"CXCR4 regulates the early extravasation of metastatic tumor cells in vivo","volume":"11","author":"Gassmann","year":"2009","journal-title":"Neoplasia"},{"issue":"5","key":"10.1016\/j.mehy.2011.03.033_b0105","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1872-034X.2010.00635.x","article-title":"Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells","volume":"40","author":"Copple","year":"2010","journal-title":"Hepatol Res"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.033_b0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/hep.510260205","article-title":"Factors regulating tumor pressure in hepatocellular carcinoma and implications for tumor spread","volume":"26","author":"Tanaka","year":"1997","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.mehy.2011.03.033_b0115","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/ijc.23828","article-title":"Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress","volume":"123","author":"Tsuchiya","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.mehy.2011.03.033_b0120","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.mehy.2011.03.033_b0125","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1182\/blood-2005-01-0428","article-title":"A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3\/STAT1 activation)","volume":"107","author":"Biswas","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.mehy.2011.03.033_b0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrc1256","article-title":"Tumour-educated macrophages promote tumour progression and metastasis","volume":"4","author":"Pollard","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.mehy.2011.03.033_b0135","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1182\/blood-2004-03-1109","article-title":"Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues","volume":"104","author":"Murdock","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.mehy.2011.03.033_b0140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2011.03.033_b0145","doi-asserted-by":"crossref","unstructured":"Joyce1 JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009;9:239\u2013252.","DOI":"10.1038\/nrc2618"},{"issue":"9","key":"10.1016\/j.mehy.2011.03.033_b0150","first-page":"1391","article-title":"Hemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells","volume":"198","author":"Zheng","year":"2003","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.mehy.2011.03.033_b0155","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/sj.bjc.6603251","article-title":"Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4","volume":"95","author":"Schimanski","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.mehy.2011.03.033_b0160","first-page":"1","article-title":"Enhanced expression and clinical significance of chemokine receptor CXCR2 in hepatocellular carcinoma","author":"Liu","year":"2009","journal-title":"J Surg Res"},{"issue":"15","key":"10.1016\/j.mehy.2011.03.033_b0165","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.3748\/wjg.v16.i15.1832","article-title":"Chemokines and hepatocellular carcinoma","volume":"16","author":"Huang","year":"2010","journal-title":"World J Gastroenterol"},{"issue":"13","key":"10.1016\/j.mehy.2011.03.033_b0170","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1158\/0008-5472.CAN-08-4625","article-title":"The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression","volume":"69","author":"Ilkovitch","year":"2009","journal-title":"Cancer Res"},{"issue":"20","key":"10.1016\/j.mehy.2011.03.033_b0175","doi-asserted-by":"crossref","first-page":"8067","DOI":"10.1158\/0008-5472.CAN-09-0901","article-title":"Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7\u2013H1\/programmed death-1 interactions","volume":"69","author":"Wu","year":"2009","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.mehy.2011.03.033_b0180","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2353\/ajpath.2007.060886","article-title":"The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation","volume":"170","author":"Auguste","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.mehy.2011.03.033_b0185","first-page":"S144","article-title":"An unique Kupffer cell receptor system: involvement in colorectal cancer metastasis to the liver","volume":"56","author":"Thomas","year":"2007","journal-title":"Inflamm Res"},{"issue":"3","key":"10.1016\/j.mehy.2011.03.033_b0190","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.humpath.2008.08.011","article-title":"High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection","volume":"40","author":"Ding","year":"2009","journal-title":"Hum pathol"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711001356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711001356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T10:45:47Z","timestamp":1686048347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987711001356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0306987711001356"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2011.03.033","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}