{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:00:11Z","timestamp":1762542011145},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.mehy.2011.06.016","type":"journal-article","created":{"date-parts":[[2011,9,11]],"date-time":"2011-09-11T14:03:38Z","timestamp":1315749818000},"page":"701-704","source":"Crossref","is-referenced-by-count":11,"title":["A potential therapeutic approach to overload-induced bone loss around implant: Parathyroid hormone (PTH)"],"prefix":"10.1016","volume":"77","author":[{"given":"Xiaohua","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2011.06.016_b0005","first-page":"125","article-title":"Mechanoperception of natural teeth versus endosseous implants revealed by magnitude estimation","volume":"4","author":"Muhlbradt","year":"1989","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.mehy.2011.06.016_b0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.id.0000165033.34294.db","article-title":"A positive correlation between occlusal trauma and peri-implant bone loss: literature support","volume":"14","author":"Misch","year":"2005","journal-title":"Implant Dent"},{"key":"10.1016\/j.mehy.2011.06.016_b0015","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-0501.1996.070208.x","article-title":"Loss of osseointegration caused by occlusal load of oral implants","volume":"7","author":"Isidor","year":"1996","journal-title":"A clinical and radiographical study in monkeys. Clin Oral Impl Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0020","first-page":"517","article-title":"Kurt B","volume":"8","author":"von Arx","year":"1997","journal-title":"Hardt N.Treatment of severe peri-implant bone loss using autogenous bone and a resorbable membrane. Case report and literature review. Clin Oral Implants Res"},{"issue":"5","key":"10.1016\/j.mehy.2011.06.016_b0025","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bjoms.2004.06.008","article-title":"Treatment of severe peri-implant bone loss using autogenous bone and a bioabsorbable polymer that delivered doxycycline (Atridox)","volume":"42","author":"B\u00fcchter","year":"2004","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.mehy.2011.06.016_b0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.prosdent.2004.04.016","article-title":"Management of peri-implant bone loss using guided bone regeneration: a clinical report","volume":"92","author":"Tomson","year":"2004","journal-title":"J Prosthet Dent"},{"key":"10.1016\/j.mehy.2011.06.016_b0035","doi-asserted-by":"crossref","unstructured":"Rotenberg SA, Tatakis DN. Recombinant Human Bone Morphogenetic Protein-2 for Peri-Implant Bone Regeneration. A Case Report. J Periodontol 2011 Jan 14. (Epub ahead of print).","DOI":"10.1902\/jop.2011.100626"},{"key":"10.1016\/j.mehy.2011.06.016_b0040","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1902\/jop.2001.72.11.1498","article-title":"Buchmann R.Surgical therapy of peri-implant disease: a 3-year follow-up study of cases treated with 3 different techniques of bone regeneration","volume":"72","author":"Khoury","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.mehy.2011.06.016_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0501.1997.tb00001.x","article-title":"Histological evaluation of peri-implant bone at implants subjected to occlusal overload or plaque accumulation","volume":"8","author":"Isidor","year":"1997","journal-title":"Clinical Oral Implants Research"},{"key":"10.1016\/j.mehy.2011.06.016_b0050","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1902\/jop.1998.69.2.178","article-title":"Histologic observations on 230 retrieved dental implants: 8 year\u2019s experience (1989\u20131996)","volume":"69","author":"Piattelli","year":"1998","journal-title":"Journal of Periodontology"},{"key":"10.1016\/j.mehy.2011.06.016_b0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1034\/j.1600-0501.1992.030302.x","article-title":"Fixture design and overload influence marginal bone loss and fixture success in the Branemark system","volume":"3","author":"Quirynen","year":"1992","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0060","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0022-3913(92)90557-Q","article-title":"A study of 589 consecutive implants supporting complete fixed prostheses","volume":"68","author":"Naert","year":"1992","journal-title":"Part II: prosthetic aspects. J Prosth Dent"},{"key":"10.1016\/j.mehy.2011.06.016_b0065","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00008505-199500440-00002","article-title":"Remodeling dynamics of bone supporting rigidly fixed titanium implanls: a histomorphomctric comparison in four species including humans","volume":"4","author":"Garetto","year":"1995","journal-title":"Implant Dent"},{"key":"10.1016\/j.mehy.2011.06.016_b0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S8756-3282(99)00151-9","article-title":"Microdamage adjacent to endosseous implants","volume":"25","author":"Huja","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2011.06.016_b0075","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1902\/jop.2000.72.9.1276","article-title":"A bioengineered implant for a predetermined bone cellular response to loading forces. A literature review and case reports","volume":"72","author":"Misch","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.mehy.2011.06.016_b0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S8756-3282(01)00642-1","article-title":"Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression","volume":"30","author":"Parfitt","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2011.06.016_b0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S8756-3282(01)00619-6","article-title":"Targeted and nontargeted remodeling","volume":"30","author":"Burr","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2011.06.016_b0090","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2006.10.027","article-title":"Effect of mechanical stimuli on skeletal regeneration around implants","volume":"40","author":"Leucht","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2011.06.016_b0095","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.0909-8836..t01-6-.x","article-title":"Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis","volume":"106","author":"Esposito","year":"1998","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.mehy.2011.06.016_b0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/08959374990130012301","article-title":"In vivo bone response to biomechanical loading at the bone\/dental-implant interface","volume":"13","author":"Brunski","year":"1999","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.0909-8836..t01-2-.x","article-title":"Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology","volume":"106","author":"Esposito","year":"1998","journal-title":"Eur J Oral Sci"},{"issue":"6","key":"10.1016\/j.mehy.2011.06.016_b0110","first-page":"829","article-title":"Microbiota around root-form endosseous implants: a review of the literature","volume":"17","author":"Heydenrijk","year":"2002","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"3","key":"10.1016\/j.mehy.2011.06.016_b0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1902\/jop.2003.74.3.385","article-title":"Clinical and histologic aspects of dental implants removed due to mobility","volume":"74","author":"Piattelli","year":"2003","journal-title":"J Periodontol"},{"key":"10.1016\/j.mehy.2011.06.016_b0120","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1053\/j.sodo.2004.01.004","article-title":"Mechanism of osseointegration: characterization of supporting bone with indentation testing and backscattered imaging","volume":"10","author":"Huja","year":"2004","journal-title":"Semin Orthod"},{"key":"10.1016\/j.mehy.2011.06.016_b0125","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2174\/092986730611220401164817","article-title":"Design and applications of parathyroid hormone analogues","volume":"6","author":"Morley","year":"1999","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.mehy.2011.06.016_b0130","first-page":"73","article-title":"Parathyroid hormone and its analogues - molecular mechanisms of action and efficacy in osteoporosis therapy","volume":"62","author":"Misiorowski","year":"2011","journal-title":"Endokrynol Pol"},{"key":"10.1016\/j.mehy.2011.06.016_b0135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1359\/JBMR.041114","article-title":"Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling","volume":"20","author":"Riggs","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0140","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2011.06.016_b0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1359\/jbmr.2003.18.1.9","article-title":"The effect of teriparatide [human parathyroid hormone (1\u201334)] therapy on bone density in men with osteoporosis","volume":"18","author":"Orwoll","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0150","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1210\/jc.85.9.3069","article-title":"Parathyroid Hormone as a therapy for idiopathic osteoporosis in men: Effects on bone nineral density and bone markers","volume":"85","author":"Kurland","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2011.06.016_b0155","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa035725","article-title":"The effects of parathyroid hormone, alendronate, or both in men with osteoporosis","volume":"349","author":"Finkelstein","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2011.06.016_b0160","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1359\/jbmr.2000.15.5.944","article-title":"Bone mass continues to increase at the hip after parathyroid hormone treatment is discontinued in glucocorticoid-induced osteoporosis: results of a randomized controlled clinical trial","volume":"15","author":"Lane","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0165","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2106\/JBJS.D.02115","article-title":"Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1\u201334)","volume":"87","author":"Alkhiary","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.mehy.2011.06.016_b0170","first-page":"293","article-title":"Teriparatide and fracture healing in cortical bone","volume":"10","author":"Knecht","year":"2004","journal-title":"Endocr Pract"},{"key":"10.1016\/j.mehy.2011.06.016_b0175","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.5435\/00124635-200600001-00033","article-title":"Accelerated fracture healing","volume":"14","author":"Puzas","year":"2006","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.mehy.2011.06.016_b0180","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1359\/jbmr.090731","article-title":"Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures","volume":"25","author":"Aspenberg","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0185","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0501.2007.01342.x","article-title":"The effect of matrix bound parathyroid hormone on bone regeneration","volume":"18","author":"Jung","year":"2007","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0190","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1902\/jop.2010.090562","article-title":"Evaluation of parathyroid hormone bound to a synthetic matrix for guided bone regeneration around dental implants: a histomorphometric study in dogs","volume":"81","author":"Valderrama","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.mehy.2011.06.016_b0195","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00223-010-9458-9","article-title":"Parathyroid hormone treatment increases fixation of orthopedic implants with gap healing: a biomechanical and histomorphometric canine study of porous coated titanium alloy implants in cancellous bone","volume":"88","author":"Daugaard","year":"2011","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.mehy.2011.06.016_b0200","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1056\/NEJMoa1005361","article-title":"Teriparatide and osseous regeneration in the oral cavity","volume":"363","author":"Bashutski","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2011.06.016_b0205","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00198-009-1061-4","article-title":"Successful treatment of sternal fracture nonunion with teriparatide","volume":"21","author":"Chintamaneni","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.mehy.2011.06.016_b0210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/BSD.0b013e31819a8b7a","article-title":"Teriparatide may accelerate healing in delayed unions of type III odontoid fractures: A report of 3 cases","volume":"23","author":"Rubery","year":"2010","journal-title":"J Spinal Disord Tech"},{"key":"10.1016\/j.mehy.2011.06.016_b0215","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1016\/j.jse.2010.05.005","article-title":"Atrophic humeral shaft nonunion treated with teriparatide: a case report","volume":"19","author":"Oteo-Alvaro","year":"2010","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.mehy.2011.06.016_b0220","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1359\/jbmr.1999.14.3.439","article-title":"Parathyroid hormone and mechanical usage have a synergistic effect in rat tibial diaphyseal cortical bone","volume":"14","author":"Ma","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0225","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s007740170027","article-title":"Effect of parathyroid hormone on cortical bone response to in vivo external loading of the rat tibia","volume":"19","author":"Hagino","year":"2001","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.mehy.2011.06.016_b0230","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1210\/en.2002-220821","article-title":"Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels","volume":"144","author":"Li","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mehy.2011.06.016_b0235","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1359\/jbmr.2003.18.12.2116","article-title":"Trabecular bone response to mechanical and parathyroid hormone stimulation: the role of mechanical microenvironment","volume":"18","author":"Kim","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2011.06.016_b0240","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.jbiomech.2009.08.030","article-title":"Local bone formation due to combined mechanical loading and intermittent hPTH-(1\u201334) treatment and its correlation to mechanical signal distributions","volume":"42","author":"Roberts","year":"2009","journal-title":"J Biomech"},{"key":"10.1016\/j.mehy.2011.06.016_b0245","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bone.2008.04.012","article-title":"Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1\u201334) on trabecular and cortical bone in mice","volume":"43","author":"Sugiyama","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2011.06.016_b0250","first-page":"35","article-title":"Jovanovic, Miomri LJ","volume":"11","author":"Janko","year":"2004","journal-title":"Biomechanical model of vertebra based on bone remodeling. Medicine and Biology"},{"key":"10.1016\/j.mehy.2011.06.016_b0255","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.jbiomech.2009.08.030","article-title":"Ocal bone formation due to combined mechanical loading and intermittent hPTH-(1\u201334) treatment and its correlation to mechanical signal distributions","volume":"42","author":"Roberts","year":"2009","journal-title":"J Biomech"},{"key":"10.1016\/j.mehy.2011.06.016_b0260","series-title":"Mesenchymal Stem Cells and Osteoblast Differentiation. Principles of bone biology","author":"Aubin","year":"2002"},{"key":"10.1016\/j.mehy.2011.06.016_b0265","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI6610","article-title":"Increased bone formation by prevention of osteoblast apoptosis with PTH","volume":"104","author":"Jilka","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2011.06.016_b0270","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1210\/en.2003-0350","article-title":"Parallel phosphatidylinositol-3 kinase and p42\/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like growth factor I in osteoblastic cells","volume":"144","author":"Grey","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mehy.2011.06.016_b0275","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1210\/en.136.8.3632","article-title":"Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells","volume":"136","author":"Dobnig","year":"1995","journal-title":"Endocrinology"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771100274X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771100274X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:22:59Z","timestamp":1686309779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030698771100274X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S030698771100274X"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2011.06.016","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}