{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:23:45Z","timestamp":1781504625419,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.mehy.2011.07.007","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T19:26:57Z","timestamp":1312313217000},"page":"658-661","source":"Crossref","is-referenced-by-count":26,"title":["Symptomatic myositis-myalgia in hypercholesterolemic statin-treated patients with concurrent vitamin D deficiency leading to statin intolerance may reflect a reversible interaction between vitamin D deficiency and statins on skeletal muscle"],"prefix":"10.1016","volume":"77","author":[{"given":"Charles J.","family":"Glueck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Abuchaibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2011.07.007_b0005","doi-asserted-by":"crossref","unstructured":"[1]. Ghatak A, Faheem O, Thompson PD. The genetics of statin-induced myopathy. Atherosclerosis, 2009.","DOI":"10.1016\/j.atherosclerosis.2009.11.033"},{"key":"10.1016\/j.mehy.2011.07.007_b0010","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.clinthera.2007.08.022","article-title":"Does statin therapy initiation increase the risk for myopathy? An observational study of 32, 225 diabetic and nondiabetic patients","volume":"29","author":"Nichols","year":"2007","journal-title":"Clin Ther"},{"key":"10.1016\/j.mehy.2011.07.007_b0015","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.clinthera.2006.06.004","article-title":"Rosuvastatin 5 and 10 mg\/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies","volume":"28","author":"Glueck","year":"2006","journal-title":"Clin Ther"},{"key":"10.1016\/j.mehy.2011.07.007_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11883-009-0002-1","article-title":"How do you treat patients with myalgia who take statins?","volume":"11","author":"Siddiqi","year":"2009","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.mehy.2011.07.007_b0025","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2265.2008.03448.x","article-title":"Vitamin D insufficiency\u2013a novel mechanism of statin-induced myalgia?","volume":"71","author":"Lee","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.mehy.2011.07.007_b0030","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jclinepi.2006.11.006","article-title":"Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population","volume":"60","author":"McClure","year":"2007","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.mehy.2011.07.007_b0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.trsl.2008.11.002","article-title":"Low serum 25 (OH) vitamin D levels (<32 ng\/mL) are associated with reversible myositis-myalgia in statin-treated patients","volume":"153","author":"Ahmed","year":"2009","journal-title":"Transl Res"},{"key":"10.1016\/j.mehy.2011.07.007_b0040","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1001\/jama.289.13.1681","article-title":"Statin-associated myopathy","volume":"289","author":"Thompson","year":"2003","journal-title":"Jama"},{"key":"10.1016\/j.mehy.2011.07.007_b0045","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/SMJ.0b013e3181e21088","article-title":"Resolution of statin-induced myalgias by correcting vitamin D deficiency","volume":"103","author":"Bell","year":"2010","journal-title":"South Med J"},{"key":"10.1016\/j.mehy.2011.07.007_b0050","doi-asserted-by":"crossref","unstructured":"Duell PB CW. Vitamin D deficiency is associated with myalgias in hyperlipidemic subjects taking statins (Abstract). Circulation 2008;118:Suppl S470.","DOI":"10.1161\/circ.118.suppl_18.S_470"},{"key":"10.1016\/j.mehy.2011.07.007_b0055","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11883-010-0120-9","article-title":"Evidence-based management of statin myopathy","volume":"12","author":"Harper","year":"2010","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.mehy.2011.07.007_b0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.atherosclerosis.2010.11.039","article-title":"The relationship of vitamin D deficiency to statin myopathy","volume":"215","author":"Gupta","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mehy.2011.07.007_b0065","doi-asserted-by":"crossref","first-page":"1080S","DOI":"10.1093\/ajcn\/87.4.1080S","article-title":"Vitamin D deficiency: a worldwide problem with health consequences","volume":"87","author":"Holick","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2011.07.007_b0070","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1373\/clinchem.2008.104158","article-title":"Low vitamin D status in a representative sample of youth from Quebec, Canada","volume":"54","author":"Mark","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.mehy.2011.07.007_b0075","first-page":"229","article-title":"Prevalence and potential significance of vitamin D deficiency in Asian Indians","volume":"127","author":"Goswami","year":"2008","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.mehy.2011.07.007_b0080","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/MAJ.0b013e318167b0bd","article-title":"Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure","volume":"335","author":"Alsafwah","year":"2008","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.mehy.2011.07.007_b0085","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1210\/jc.2009-1773","article-title":"Update in vitamin D","volume":"95","author":"Adams","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2011.07.007_b0090","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2265.2006.02633.x","article-title":"Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients","volume":"65","author":"Targher","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.mehy.2011.07.007_b0095","doi-asserted-by":"crossref","unstructured":"Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004. Pediatrics, 2009.","DOI":"10.1542\/peds.2009-0051"},{"key":"10.1016\/j.mehy.2011.07.007_b0100","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/aje\/kwq005","article-title":"Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study","volume":"171","author":"Jorde","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mehy.2011.07.007_b0105","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00198-006-0069-2","article-title":"High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors","volume":"17","author":"Erkal","year":"2006","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.mehy.2011.07.007_b0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1079\/BJN2003837","article-title":"Vitamin D in preventive medicine: are we ignoring the evidence?","volume":"89","author":"Zittermann","year":"2003","journal-title":"Br J Nutr"},{"key":"10.1016\/j.mehy.2011.07.007_b0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s001980200012","article-title":"Vitamin D and muscle function","volume":"13","author":"Pfeifer","year":"2002","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.mehy.2011.07.007_b0120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/0115426507022003297","article-title":"Vitamin D and rehabilitation: improving functional outcomes","volume":"22","author":"Shinchuk","year":"2007","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.mehy.2011.07.007_b0125","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/ajcn\/80.3.752","article-title":"Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y","volume":"80","author":"Bischoff-Ferrari","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2011.07.007_b0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","article-title":"Vitamin D physiology","volume":"92","author":"Lips","year":"2006","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.mehy.2011.07.007_b0135","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.exger.2006.05.001","article-title":"Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects","volume":"41","author":"Bunout","year":"2006","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.mehy.2011.07.007_b0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ajcn\/84.1.18","article-title":"Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes","volume":"84","author":"Bischoff-Ferrari","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2011.07.007_b0145","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0009-8981(96)06376-0","article-title":"Myopathy associated with lipid lowering therapy in patients with previously undiagnosed or undertreated hypothyroidism","volume":"254","author":"Lang","year":"1996","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.mehy.2011.07.007_b0150","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1592\/phco.27.4.603","article-title":"Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients","volume":"27","author":"Molden","year":"2007","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.mehy.2011.07.007_b0155","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1093\/ndt\/gfp416","article-title":"Incidence, predictors and associated outcomes of rhabdomyolysis after kidney transplantation","volume":"24","author":"Hurst","year":"2009","journal-title":"Nephrol Dial Transp"},{"key":"10.1016\/j.mehy.2011.07.007_b0160","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1021\/ac048249c","article-title":"Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography\u2013tandem mass spectrometry","volume":"77","author":"Tsugawa","year":"2005","journal-title":"Anal Chem"},{"key":"10.1016\/j.mehy.2011.07.007_b0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711003240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711003240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T11:49:46Z","timestamp":1638186586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987711003240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0306987711003240"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2011.07.007","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}