{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:35:54Z","timestamp":1762623354777,"version":"3.38.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.mehy.2011.07.011","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T05:58:33Z","timestamp":1312264713000},"page":"668-670","source":"Crossref","is-referenced-by-count":9,"title":["Propofol\u2019s derivative: A potential drug for erectile dysfunction?"],"prefix":"10.1016","volume":"77","author":[{"given":"Shah","family":"Sweni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran","family":"Meenakshisundaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Senthilkumaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponniah","family":"Thirumalaikolundusubramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2011.07.011_b0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2165\/00003495-198835040-00002","article-title":"Propofol: a review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthetic","volume":"35","author":"Langley","year":"1988","journal-title":"Drugs"},{"key":"10.1016\/j.mehy.2011.07.011_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2009.01.007","article-title":"Propofol: a review of its non-anaesthetic effects","volume":"605","author":"Vasileiou","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.mehy.2011.07.011_b0015","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1745-7262.2008.00314.x","article-title":"Insights of priapism mechanism and rationale treatment for recurrent priapism","volume":"10","author":"Yuan","year":"2008","journal-title":"Asian J Androl"},{"key":"10.1016\/j.mehy.2011.07.011_b0020","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/0253-7613.68430","article-title":"Propofol and priapism","volume":"42","author":"Senthilkumaran","year":"2010","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.mehy.2011.07.011_b0025","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1345\/aph.1G555","article-title":"Propofol-induced priapism, a case confirmed with rechallenge","volume":"40","author":"Vesta","year":"2006","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.mehy.2011.07.011_b0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.urology.2008.12.066","article-title":"Successful treatment of propofol-induced priapism with distal glans to corporal cavernosal shunt","volume":"74","author":"Fuentes","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.mehy.2011.07.011_b0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0031-6997(24)01503-5","article-title":"Pharmacology of penile erection","volume":"53","author":"Andersson","year":"2001","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.mehy.2011.07.011_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(97)01115-1","article-title":"Functional characteristics of heterologously expressed 5-HT receptors","volume":"334","author":"Gerhardt","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.mehy.2011.07.011_b0045","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0149-7634(87)80008-8","article-title":"Pharmacological analysis of male rat sexual behavior","volume":"11","author":"Bitran","year":"1987","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.mehy.2011.07.011_b0050","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2826.1993.tb00532.x","article-title":"P-chlorophenylalanine facilitates copulatory behavior in septal lesioned but not in preoptic lesioned male rats","volume":"5","author":"Kondo","year":"1993","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.mehy.2011.07.011_b0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(84)90245-2","article-title":"Spinal monoaminergic modulation of masculine copulatory behavior in the rat","volume":"302","author":"Svensson","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2011.07.011_b0060","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02259106","article-title":"A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes","volume":"88","author":"Marson","year":"1992","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.mehy.2011.07.011_b0065","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/0024-3205(88)90584-X","article-title":"Effects of fenfluramine, M-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates","volume":"43","author":"Szele","year":"1988","journal-title":"Life Sci"},{"key":"10.1016\/j.mehy.2011.07.011_b0070","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1139\/y99-122","article-title":"Plasma and cerebrospinal fluid concentrations of neuropeptide Y, serotonin, and catecholamines in patients under propofol or isoflurane anesthesia","volume":"78","author":"Grouzmann","year":"2000","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.mehy.2011.07.011_b0075","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1097\/00001756-199709290-00016","article-title":"Propofol produces anticonflict action by inhibiting 5-HT release in rat dorsal hippocampus","volume":"8","author":"Matsuo","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.mehy.2011.07.011_b0080","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0091-3057(86)90456-9","article-title":"GABAergic control of masculine sexual behavior","volume":"24","author":"Fern\u00e1ndez-Guasti","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.mehy.2011.07.011_b0085","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1007\/BF01950011","article-title":"Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior","volume":"41","author":"Fern\u00e1ndez-Guasti","year":"1985","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.mehy.2011.07.011_b0090","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0022-3565(24)36907-1","article-title":"Antinociceptive properties of propofol: involvement of spinal cord \u03b3-aminobutyric acid receptors","volume":"282","author":"Nadeson","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mehy.2011.07.011_b0095","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1213\/00000539-200210000-00021","article-title":"The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat","volume":"95","author":"Dong","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1016\/j.mehy.2011.07.011_b0100","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4161\/chan.5044","article-title":"Polymodal regulation of NMDA receptor channels","volume":"1","author":"Kloda","year":"2007","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.mehy.2011.07.011_b0105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(97)83037-3","article-title":"N-Methyl-aspartic acid-induced penile erection and yawning: role of hypothalamic paraventricular nitric oxide","volume":"328","author":"Melis","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.mehy.2011.07.011_b0110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0959-4388(92)90123-3","article-title":"Nitric oxide and neurons","volume":"2","author":"Snyder","year":"1992","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.mehy.2011.07.011_b0115","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/00003246-200104000-00026","article-title":"Intravenous anesthetics differentially reduce neurotransmission damage caused by oxygen\u2013glucose deprivation in rat hippocampal slices in correlation with N-methyl-d-aspartate receptor inhibition","volume":"29","author":"Zhan","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.mehy.2011.07.011_b0120","first-page":"241","article-title":"Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats","volume":"242","author":"Benassi-Benelli","year":"1979","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.mehy.2011.07.011_b0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0006-8993(88)91599-5","article-title":"Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats","volume":"443","author":"Pehek","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2011.07.011_b0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00000542-199101000-00005","article-title":"Propofol and spontaneous movements: an EEG study","volume":"74","author":"Borgeat","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1016\/j.mehy.2011.07.011_b0135","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1210\/en.136.12.5709","article-title":"Reduction of penile nitric oxide synthase in diabetic BB\/WORdp (type I) and BBZ\/WORdp (type II) rats with erectile dysfunction","volume":"136","author":"Vernet","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.mehy.2011.07.011_b0140","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0090-4295(97)00512-8","article-title":"Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through inos or enos","volume":"50","author":"Seftel","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.mehy.2011.07.011_b0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00210-007-0220-4","article-title":"Effects of propofol on the leukocyte nitric oxide pathway: in vitro and ex vivo studies in surgical patients","volume":"376","author":"Gonz\u00e1lez-Correa","year":"2008","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.mehy.2011.07.011_b0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1054\/plef.1999.0021","article-title":"The role of prostaglandins in the aetiology and treatment of erectile dysfunction","volume":"60","author":"Khan","year":"1999","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.mehy.2011.07.011_b0155","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/S0022-5347(05)68160-8","article-title":"Repeated PGE1 treatment enhances nitric oxide and erection responses to nerve stimulation in the rat penis by upregulating constitutive NOS isoforms","volume":"162","author":"Escrig","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.mehy.2011.07.011_b0160","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00000542-199802000-00015","article-title":"In vivo and in vitro studies of the inhibitory effect of propofol on human platelet aggregation","volume":"88","author":"Aoki","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.mehy.2011.07.011_b0165","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1097\/00000542-199911000-00028","article-title":"Propofol has both enhancing and suppressing effects on human platelet aggregation in vitro","volume":"91","author":"Hirakata","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.mehy.2011.07.011_b0170","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1152\/physrev.1995.75.1.191","article-title":"Physiology of penile erection","volume":"75","author":"Andersson","year":"1995","journal-title":"Physiol Rev"},{"key":"10.1016\/j.mehy.2011.07.011_b0175","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/00000542-200403000-00035","article-title":"Mechanisms of cardioprotection by volatile anesthetics","volume":"100","author":"Tanaka","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.mehy.2011.07.011_b0180","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1097\/00000542-200006000-00033","article-title":"Sarcolemmal and mitochondrial adenosine triphosphate\u2013dependent potassium channels: mechanism of desflurane-induced cardioprotection","volume":"92","author":"Toller","year":"2000","journal-title":"Anesthesiology"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711003288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987711003288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T01:06:21Z","timestamp":1741395981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987711003288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0306987711003288"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2011.07.011","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}