{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:49:05Z","timestamp":1692816545315},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The Youth Foundation of Gansu Province, China","award":["1007RJYA009"],"award-info":[{"award-number":["1007RJYA009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.mehy.2012.04.030","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T19:00:29Z","timestamp":1337108429000},"page":"186-188","source":"Crossref","is-referenced-by-count":5,"title":["Slit-Robo: A potential way to treat periodontitis"],"prefix":"10.1016","volume":"79","author":[{"given":"Yuan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mehy.2012.04.030_b0005","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0959-437X(02)00343-X","article-title":"Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes","volume":"12","author":"Wong","year":"2002","journal-title":"Curr Opin Genet Dev"},{"issue":"6831","key":"10.1016\/j.mehy.2012.04.030_b0010","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/35073616","article-title":"The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors","volume":"410","author":"Wu","year":"2001","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0015","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0092-8674(00)80590-5","article-title":"Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance","volume":"96","author":"Brose","year":"1999","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(00)80915-0","article-title":"Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors","volume":"92","author":"Kidd","year":"1998","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2012.04.030_b0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0925-4773(01)00454-3","article-title":"Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation","volume":"107","author":"Loes","year":"2001","journal-title":"Mech Dev"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0030","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0092-8674(00)80591-7","article-title":"Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons","volume":"96","author":"Li","year":"1999","journal-title":"Cell"},{"issue":"6742","key":"10.1016\/j.mehy.2012.04.030_b0035","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/22477","article-title":"Directional guidance of neuronal migration in the olfactory system by the protein Slit","volume":"400","author":"Wu","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0040","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1189\/jlb.1106678","article-title":"Slit-2\/Robo-1 modulates the CXCL12\/CXCR4-induced chemotaxis of T cells","volume":"82","author":"Prasad","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.mehy.2012.04.030_b0045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0002-9440(10)63301-9","article-title":"Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis","volume":"165","author":"Kanellis","year":"2004","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1016\/j.mehy.2012.04.030_b0050","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.4049\/jimmunol.171.12.6519","article-title":"Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses","volume":"171","author":"Guan","year":"2003","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.expneurol.2007.06.028","article-title":"Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia","volume":"207","author":"Altay","year":"2007","journal-title":"Exp Neurol"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0060","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1189\/jlb.0609391","article-title":"The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils","volume":"86","author":"Tole","year":"2009","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.mehy.2012.04.030_b0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1535-6108(03)00164-8","article-title":"Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity","volume":"4","author":"Wang","year":"2003","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0070","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1349-7006.2007.00721.x","article-title":"Targeting Slit-round about signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis","volume":"99","author":"Wang","year":"2008","journal-title":"Cancer Sci"},{"issue":"22","key":"10.1016\/j.mehy.2012.04.030_b0075","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1182\/blood-2009-01-196485","article-title":"HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells","volume":"113","author":"Urbich","year":"2009","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.mehy.2012.04.030_b0080","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1182\/blood-2008-12-193326","article-title":"Repulsive axon guidance molecule Slit3 is a novel angiogenic factor","volume":"114","author":"Zhang","year":"2009","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0085","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/10454411950060030501","article-title":"The pathophysiology of angiogenesis","volume":"6","author":"Polverini","year":"1995","journal-title":"Crit Rev Oral Biol Med"},{"issue":"1\u20134","key":"10.1016\/j.mehy.2012.04.030_b0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/biof.5520250126","article-title":"Antioxidant status (CoQ10 and Vit. E levels) and immunohistochemical analysis of soft tissues in periodontal diseases","volume":"25","author":"Battino","year":"2005","journal-title":"Biofactors"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2334\/josnusd.49.201","article-title":"Effects of egg yolk antibody against porphyromonas gingivalis gingipains in periodontitis patients","volume":"49","author":"Yokoyama","year":"2007","journal-title":"J Oral Sci"},{"issue":"Suppl. 7","key":"10.1016\/j.mehy.2012.04.030_b0100","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case definitions for use in population-based surveillance of periodontitis","volume":"78","author":"Page","year":"2007","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0105","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1902\/jop.2011.100638","article-title":"Underestimation of periodontitis in NHANES surveys","volume":"82","author":"Albandar","year":"2011","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF00918681","article-title":"Rheumatoid factor (RF) distribution in periodontal disease","volume":"11","author":"The","year":"1991","journal-title":"J Clin Immunol"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0029-7844(02)02314-1","article-title":"Maternal periodontal disease is associated with an increased risk for preeclampsia","volume":"101","author":"Boggess","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.mehy.2012.04.030_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/01.AOG.0000190212.87012.96","article-title":"Progressive periodontal disease and risk of very preterm delivery","volume":"107","author":"Offenbacher","year":"2006","journal-title":"Obstet Gynecol"},{"issue":"Suppl. 10","key":"10.1016\/j.mehy.2012.04.030_b0125","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1902\/jop.1996.67.10s.1085","article-title":"Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus","volume":"67","author":"Taylor","year":"1996","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.mehy.2012.04.030_b0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.amjcard.2009.05.002","article-title":"The American journal of cardiology and journal of periodontology editors\u2019 consensus: periodontitis and atherosclerotic cardiovascular disease","volume":"104","author":"Friedewald","year":"2009","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0135","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.phrs.2010.12.003","article-title":"Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD)","volume":"63","author":"Caton","year":"2011","journal-title":"Pharmacol Res"},{"issue":"9","key":"10.1016\/j.mehy.2012.04.030_b0140","doi-asserted-by":"crossref","first-page":"e24422","DOI":"10.1371\/journal.pone.0024422","article-title":"Impaired phagocytosis in localized aggressive periodontitis: rescue by resolvin E1","volume":"6","author":"Fredman","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mehy.2012.04.030_b0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1902\/jop.1990.61.4.228","article-title":"Susceptibility and resistance of plaque bacteria to minocycline","volume":"61","author":"O\u2019Connor","year":"1990","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0150","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1902\/jop.1999.70.6.657","article-title":"A 15-month evaluation of the effects of repeated subgingival minocycline in chronic adult periodontitis","volume":"70","author":"van Steenberghe","year":"1999","journal-title":"J Periodontol"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phrs.2010.10.006","article-title":"Using tetracyclines to treat osteoporotic\/osteopenic bone loss: from the basic science laboratory to the clinic","volume":"63","author":"Payne","year":"2011","journal-title":"Pharmacol Res"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7883\/yoken.64.156","article-title":"Impact of minocycline ointment for periodontal treatment of oral bacteria","volume":"64","author":"Nakao","year":"2011","journal-title":"Jpn J Infect Dis"},{"issue":"5","key":"10.1016\/j.mehy.2012.04.030_b0165","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1902\/jop.2010.090524","article-title":"Immunoexpression of angiogenesis, nitric oxide synthase, and proliferation markers in gingival samples of patients with aggressive and chronic periodontitis","volume":"81","author":"Artese","year":"2010","journal-title":"J Periodontol"},{"issue":"11","key":"10.1016\/j.mehy.2012.04.030_b0170","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1902\/jop.2009.090239","article-title":"Vascular endothelial growth factor and microvessel density in periodontitis patients with and without diabetes","volume":"80","author":"Aspriello","year":"2009","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0175","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1902\/jop.2007.060397","article-title":"The expression of vascular endothelial growth factor in a rat model at destruction and healing stages of periodontal disease","volume":"78","author":"Cetinkaya","year":"2007","journal-title":"J Periodontol"},{"issue":"10","key":"10.1016\/j.mehy.2012.04.030_b0180","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1034\/j.1600-0714.2000.291004.x","article-title":"Vascular remodelling in chronic inflammatory periodontal disease","volume":"29","author":"Chapple","year":"2000","journal-title":"J Oral Pathol Med"},{"issue":"9","key":"10.1016\/j.mehy.2012.04.030_b0185","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1902\/jop.2009.090160","article-title":"Clinical and histologic evaluation of non-surgical periodontal therapy with enamel matrix derivative: a report of four cases","volume":"80","author":"Mellonig","year":"2009","journal-title":"J Periodontol"},{"issue":"4","key":"10.1016\/j.mehy.2012.04.030_b0190","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1902\/jop.2010.100180","article-title":"Effects of enamel matrix derivative on vascular endothelial growth factor expression and microvessel density in gingival tissues of periodontal pocket: a comparative study","volume":"82","author":"Aspriello","year":"2011","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.mehy.2012.04.030_b0195","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/sj.bjp.0702328","article-title":"Leukocyte\u2013endothelial cell adhesion: avenues for therapeutic intervention","volume":"126","author":"Panes","year":"1999","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0200","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2012.04.030_b0205","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2261-11-62","article-title":"Novel toll-like receptor-4 deficiency attenuates trastuzumab (Herceptin) induced cardiac injury in mice","volume":"11","author":"Yousif","year":"2011","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"10.1016\/j.mehy.2012.04.030_b0210","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2249.2011.04409.x","article-title":"In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells","volume":"166","author":"Rossi","year":"2011","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1016\/j.mehy.2012.04.030_b0215","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987712001958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987712001958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T19:30:08Z","timestamp":1687462208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987712001958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0306987712001958"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2012.04.030","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}