{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:31:54Z","timestamp":1740126714738,"version":"3.37.3"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.mehy.2012.07.039","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T23:30:40Z","timestamp":1346801440000},"page":"630-634","source":"Crossref","is-referenced-by-count":5,"title":["Low dose, early mucosal exposure will minimize the risk of microbial disease"],"prefix":"10.1016","volume":"79","author":[{"given":"James A.","family":"Morris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Telford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Neary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2012.07.039_b0005","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.gtc.2005.05.006","article-title":"New perspectives of the gut microbiota: implications for future research","volume":"31","author":"Tannock","year":"2005","journal-title":"Gastroenterol Clin N Am"},{"year":"1994","series-title":"Essential immunology","author":"Roitt","key":"10.1016\/j.mehy.2012.07.039_b0010"},{"key":"10.1016\/j.mehy.2012.07.039_b0015","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/cmi.2010.67","article-title":"The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases","volume":"8","author":"Tlaskalova-Hogenova","year":"2011","journal-title":"Cell Mol Immunol"},{"year":"2008","series-title":"Genes IX","author":"Lewin","key":"10.1016\/j.mehy.2012.07.039_b0020"},{"key":"10.1016\/j.mehy.2012.07.039_b0025","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/jcp.40.2.210","article-title":"Autoimmunity: a decision theory model","volume":"40","author":"Morris","year":"1987","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.mehy.2012.07.039_b0030","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/oxfordjournals.aje.a112848","article-title":"The epidemiology of poliomyelitis: enigmas surrounding its appearance, epidimicity, and disappearance","volume":"110","author":"Nathanson","year":"1979","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mehy.2012.07.039_b0035","series-title":"The Epstein-Barr virus","first-page":"61","article-title":"Seroepidemiology of the virus","author":"Henle","year":"1979"},{"key":"10.1016\/j.mehy.2012.07.039_b0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/oxfordjournals.aje.a121369","article-title":"Infectious mononucleosis in a general population","volume":"95","author":"Heath","year":"1972","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.mehy.2012.07.039_b0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF02708977","article-title":"Information theory: a guide in the investigation of disease","volume":"26","author":"Morris","year":"2001","journal-title":"J Biosci"},{"key":"10.1016\/j.mehy.2012.07.039_b0050","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.molimm.2003.11.014","article-title":"Induction, acceleration or prevention of autoimmunity by molecular mimicry","volume":"40","author":"Christian","year":"2004","journal-title":"Mol Immunol"},{"key":"10.1016\/j.mehy.2012.07.039_b0055","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.nut.2007.12.006","article-title":"Autoantibodies against appetite-regulating peptide hormones and neuropeptides; putative modulation by gut microflora","volume":"24","author":"Fetissov","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.mehy.2012.07.039_b0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0306-9877(90)90036-E","article-title":"The age incidence of multiple sclerosis: a decision theory model","volume":"32","author":"Morris","year":"1990","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2012.07.039_b0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0306-9877(89)90103-5","article-title":"A possible role for bacteria in the pathogenesis of insulin dependent diabetes mellitus","volume":"29","author":"Morris","year":"1989","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2012.07.039_b0070","first-page":"6","article-title":"Childhood antecedents of allergic sensitization in young British adults","volume":"99","author":"Strachan","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.mehy.2012.07.039_b0075","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"Br Med J"},{"key":"10.1016\/j.mehy.2012.07.039_b0080","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1046\/j.1464-5491.2000.00220.x","article-title":"Early social mixing and childhood type 1 diabetes mellitus: a case control study in Yorkshire, UK","volume":"17","author":"McKinney","year":"2000","journal-title":"Diabetic Med"},{"key":"10.1016\/j.mehy.2012.07.039_b0085","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1464-5491.2004.01282.x","article-title":"Type 1 diabetes mellitus in childhood: a matched case control study in Lancashire and Cumbria","volume":"21","author":"Marshall","year":"2004","journal-title":"Diabetic Med"},{"key":"10.1016\/j.mehy.2012.07.039_b0090","doi-asserted-by":"crossref","unstructured":"Paulo AC, Correla-Neves M, Domingos T, Murta AG, Pedrosa J. Influenza infectious dose may explain the high mortality of the second and third wave of 1918\u201319 influenza pandemic. PLoS One 2010;5:e11655. http:\/\/dx.doi.org\/10.1371\/journal.pone.0011655 [accessed 13.05.11].","DOI":"10.1371\/journal.pone.0011655"},{"key":"10.1016\/j.mehy.2012.07.039_b0095","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.mehy.2008.08.027","article-title":"Hypothesis: increased male mortality caused by infection is due to a decrease in heterozygous loci as a result of a single X chromosome","volume":"72","author":"Morris","year":"2009","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2012.07.039_b0100","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1093\/infdis\/jir171","article-title":"Circulating influenza virus, climatic factors, and acute myocardial infarction: a time series study in England and Wales and Hong Kong","volume":"203","author":"Warren-Gash","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.mehy.2012.07.039_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711430103","article-title":"Oncogenes","volume":"143","author":"Paul","year":"1984","journal-title":"J Pathol"},{"key":"10.1016\/j.mehy.2012.07.039_b0110","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0140-6736(85)90404-0","article-title":"Anti-oncogenes: a sub-set of regulatory genes involved in carcinogenesis","volume":"2","author":"Green","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2012.07.039_b0115","first-page":"1725","article-title":"A mutational model of carcinogenesis","volume":"11","author":"Morris","year":"1991","journal-title":"Anticancer Res"},{"key":"10.1016\/j.mehy.2012.07.039_b0120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1136\/bmj.1.5231.981","article-title":"Leukaemia in childhood and young adult life. Trends in mortality in relation to aetiology","volume":"26","author":"Court-Brown","year":"1961","journal-title":"Br Med J"},{"key":"10.1016\/j.mehy.2012.07.039_b0125","first-page":"593","article-title":"Epidemiology of human leukaemia: recent observations","volume":"38","author":"Fraumeni","year":"1967","journal-title":"J Nat Cancer Inst"},{"key":"10.1016\/j.mehy.2012.07.039_b0130","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/S0140-6736(08)60774-6","article-title":"Sudden unexpected death in infancy: evidence of infection","volume":"371","author":"Morris","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2012.07.039_b0135","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.mehy.2007.02.039","article-title":"Transient bacteraemia; a possible cause of life threatening events","volume":"69","author":"Morris","year":"2007","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2012.07.039_b0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2217\/14796678.5.2.201","article-title":"Sudden infant death syndrome and cardiac arrhythmias","volume":"5","author":"Morris","year":"2009","journal-title":"Future Cardiol."},{"key":"10.1016\/j.mehy.2012.07.039_b0145","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1358\/dot.2009.045.004.1353924","article-title":"Potential microbial origins of schizophrenia and their treatments","volume":"45","author":"Fatemi","year":"2009","journal-title":"Drugs Today"},{"key":"10.1016\/j.mehy.2012.07.039_b0150","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.it.2008.01.002","article-title":"The hygiene hypothesis and psychiatric disorders","volume":"29","author":"Rook","year":"2008","journal-title":"Trends Immunol"},{"key":"10.1016\/j.mehy.2012.07.039_b0155","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.mehy.2012.03.002","article-title":"Anorexia nervosa, autoimmunity and the hygiene hypothesis","volume":"78","author":"Acres","year":"2012","journal-title":"Med Hypotheses"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987712003635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987712003635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:56:45Z","timestamp":1551920205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987712003635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0306987712003635"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2012.07.039","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}