{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:24:05Z","timestamp":1772706245282,"version":"3.50.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.mehy.2013.07.013","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T21:33:37Z","timestamp":1375824817000},"page":"607-610","source":"Crossref","is-referenced-by-count":35,"title":["Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues \u2013 A rationale for the versatile health protection associated with elevated plasma bilirubin"],"prefix":"10.1016","volume":"81","author":[{"given":"Mark F.","family":"McCarty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2008.01.001","article-title":"Gilbert syndrome, UGT1A1\u221728 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin","volume":"198","author":"Schwertner","year":"2008","journal-title":"Atherosclerosis"},{"issue":"22","key":"10.1016\/j.mehy.2013.07.013_b0010","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1161\/CIRCULATIONAHA.112.114066","article-title":"Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort","volume":"126","author":"Horsfall","year":"2012","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.mehy.2013.07.013_b0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/jama.2011.124","article-title":"Serum bilirubin and risk of respiratory disease and death","volume":"305","author":"Horsfall","year":"2011","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.mehy.2013.07.013_b0020","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1001\/jama.298.12.1398-b","article-title":"Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes","volume":"298","author":"Inoguchi","year":"2007","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.mehy.2013.07.013_b0025","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.mehy.2006.12.069","article-title":"\u201cIatrogenic Gilbert syndrome\u201d\u2013a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin","volume":"69","author":"McCarty","year":"2007","journal-title":"Med Hypotheses"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0030","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00125-012-2818-4","article-title":"Plasma total bilirubin levels predict amputation events in type 2 diabetes mellitus: the fenofibrate intervention and event lowering in diabetes (FIELD) study","volume":"56","author":"Chan","year":"2013","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.mehy.2013.07.013_b0035","first-page":"201","article-title":"High total bilirubin as a protective factor for diabetes mellitus: an analysis of NHANES data from 1","volume":"2","author":"Cheriyath","year":"2010","journal-title":"J Clin Med Res"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0040","first-page":"256","article-title":"Bilirubin as a protective factor for rheumatoid arthritis: an NHANES study of 2","volume":"2","author":"Fischman","year":"2010","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.mehy.2013.07.013_b0045","doi-asserted-by":"crossref","DOI":"10.1111\/jgh.12279","article-title":"Gilbert\u2019s syndrome and the risk of death: a population-based cohort study","author":"Horsfall","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5414\/CPP40233","article-title":"Predicting the risk of sporadic elevated bilirubin levels and diagnosing Gilbert\u2019s syndrome by genotyping UGT1A1\u221728 promoter polymorphism","volume":"40","author":"Rauchschwalbe","year":"2002","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2217\/bmm.12.4","article-title":"Gilbert syndrome: the UGT1A1\u221728 promoter polymorphism as a biomarker of multifactorial diseases and drug metabolism","volume":"6","author":"Gil","year":"2012","journal-title":"Biomark Med"},{"issue":"16","key":"10.1016\/j.mehy.2013.07.013_b0060","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","article-title":"Antioxidant activity of albumin-bound bilirubin","volume":"84","author":"Stocker","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0065","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.atherosclerosis.2007.11.022","article-title":"Improved resistance to serum oxidation in Gilbert\u2019s syndrome: a mechanism for cardiovascular protection","volume":"199","author":"Bulmer","year":"2008","journal-title":"Atherosclerosis"},{"issue":"25","key":"10.1016\/j.mehy.2013.07.013_b0070","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.2174\/138161209789058237","article-title":"Bilirubin chemistry and metabolism; harmful and protective aspects","volume":"15","author":"Vitek","year":"2009","journal-title":"Curr Pharm Des"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0075","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1542\/peds.113.6.1776","article-title":"Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle","volume":"113","author":"Sedlak","year":"2004","journal-title":"Pediatrics"},{"issue":"43","key":"10.1016\/j.mehy.2013.07.013_b0080","doi-asserted-by":"crossref","first-page":"29251","DOI":"10.1074\/jbc.M109.037119","article-title":"Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase","volume":"284","author":"Maghzal","year":"2009","journal-title":"J Biol Chem"},{"issue":"13","key":"10.1016\/j.mehy.2013.07.013_b0085","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1096\/fj.04-2368fje","article-title":"Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats","volume":"19","author":"Lanone","year":"2005","journal-title":"FASEB J"},{"issue":"5","key":"10.1016\/j.mehy.2013.07.013_b0090","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.HYP.0000242336.58387.1f","article-title":"NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells","volume":"48","author":"Jiang","year":"2006","journal-title":"Hypertension"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2013.07.013_b0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11010-006-9190-y","article-title":"Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction","volume":"291","author":"Matsumoto","year":"2006","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0100","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1161\/HYPERTENSIONAHA.107.092296","article-title":"Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress","volume":"50","author":"Datla","year":"2007","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.mehy.2013.07.013_b0105","doi-asserted-by":"crossref","first-page":"C422","DOI":"10.1152\/ajpcell.00381.2008","article-title":"Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells","volume":"296","author":"Basuroy","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0110","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1210\/en.2005-0632","article-title":"Bilirubin can induce tolerance to islet allografts","volume":"147","author":"Wang","year":"2006","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3727\/096368909X484680","article-title":"Bilirubin promotes de novo generation of T regulatory cells","volume":"19","author":"Rocuts","year":"2010","journal-title":"Cell Transplant"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0120","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.mehy.2011.08.041","article-title":"Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders","volume":"77","author":"McCarty","year":"2011","journal-title":"Med Hypotheses"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2796.2012.02576.x","article-title":"Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis","volume":"273","author":"Stender","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.mehy.2013.07.013_b0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2261-12-16","article-title":"Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference","volume":"12","author":"McArdle","year":"2012","journal-title":"BMC Cardiovasc Disord"},{"issue":"Suppl. 4","key":"10.1016\/j.mehy.2013.07.013_b0135","first-page":"1","article-title":"Heme oxygenase-1 as a protective gene","volume":"114","author":"Bach","year":"2002","journal-title":"Wien Klin Wochenschr"},{"issue":"21","key":"10.1016\/j.mehy.2013.07.013_b0140","doi-asserted-by":"crossref","first-page":"7942","DOI":"10.1128\/MCB.00700-06","article-title":"BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress","volume":"26","author":"Zhang","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.mehy.2013.07.013_b0145","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.freeradbiomed.2004.07.008","article-title":"The role of heme oxygenase-1 promoter polymorphisms in human disease","volume":"37","author":"Exner","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"10.1016\/j.mehy.2013.07.013_b0150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/152660280100800501","article-title":"Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty","volume":"8","author":"Exner","year":"2001","journal-title":"J Endovasc Ther"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-002-0769-4","article-title":"Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients","volume":"111","author":"Chen","year":"2002","journal-title":"Hum Genet"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0160","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0049-3848(02)00100-7","article-title":"Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm","volume":"106","author":"Schillinger","year":"2002","journal-title":"Thromb Res"},{"issue":"10","key":"10.1016\/j.mehy.2013.07.013_b0165","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.ATV.0000033515.96747.6F","article-title":"Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors","volume":"22","author":"Kaneda","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0170","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ehj.2003.10.009","article-title":"Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting","volume":"25","author":"Chen","year":"2004","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0175","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jacc.2003.09.058","article-title":"Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor","volume":"43","author":"Schillinger","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"3\u20134","key":"10.1016\/j.mehy.2013.07.013_b0180","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.thromres.2004.03.003","article-title":"The effect of a promoter polymorphism in the heme oxygenase-1 gene on the risk of ischaemic cerebrovascular events: the influence of other vascular risk factors","volume":"113","author":"Funk","year":"2004","journal-title":"Thromb Res"},{"issue":"9","key":"10.1016\/j.mehy.2013.07.013_b0185","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1373\/clinchem.2005.051581","article-title":"Clinical restenosis after coronary stent implantation is associated with the heme oxygenase-1 gene promoter polymorphism and the heme oxygenase-1 +99G\/C variant","volume":"51","author":"Gulesserian","year":"2005","journal-title":"Clin Chem"},{"issue":"12","key":"10.1016\/j.mehy.2013.07.013_b0190","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1365-2362.2005.01580.x","article-title":"Haem oxygenase-1 genotype and cardiovascular adverse events in patients with peripheral artery disease","volume":"35","author":"Dick","year":"2005","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0195","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/02688690500305456","article-title":"Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms","volume":"19","author":"Morgan","year":"2005","journal-title":"Br J Neurosurg"},{"issue":"8","key":"10.1016\/j.mehy.2013.07.013_b0200","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/dc07-2126","article-title":"Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients","volume":"31","author":"Chen","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mehy.2013.07.013_b0205","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1423-0127-17-12","article-title":"Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients","volume":"17","author":"Bai","year":"2010","journal-title":"J Biomed Sci"},{"issue":"3","key":"10.1016\/j.mehy.2013.07.013_b0210","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.taap.2010.08.005","article-title":"GT-repeat polymorphism in the heme oxygenase-1 gene promoter is associated with cardiovascular mortality risk in an arsenic-exposed population in northeastern Taiwan","volume":"248","author":"Wu","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.mehy.2013.07.013_b0215","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1423-0127-17-70","article-title":"GT-repeat polymorphism in the heme oxygenase-1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure","volume":"17","author":"Wu","year":"2010","journal-title":"J Biomed Sci"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0220","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.atherosclerosis.2011.08.047","article-title":"Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: an observation based on arsenic-exposed individuals","volume":"219","author":"Wu","year":"2011","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.mehy.2013.07.013_b0225","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12192-011-0309-z","article-title":"Short (GT) (n) repeats in heme oxygenase-1 gene promoter are associated with lower risk of coronary heart disease in subjects with high levels of oxidative stress","volume":"17","author":"Chen","year":"2012","journal-title":"Cell Stress Chaperones"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0230","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/gtmb.2010.0132","article-title":"Association of (GT)n repeats promoter polymorphism of heme oxygenase-1 gene with serum bilirubin levels in healthy Indian adults","volume":"15","author":"D\u2019Silva","year":"2011","journal-title":"Genet Test Mol Biomarkers"},{"issue":"9","key":"10.1016\/j.mehy.2013.07.013_b0235","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/15216540310001620968","article-title":"Evidence for heme oxygenase-1 association with caveolin-1 and -2 in mouse mesangial cells","volume":"55","author":"Jung","year":"2003","journal-title":"IUBMB Life"},{"issue":"10","key":"10.1016\/j.mehy.2013.07.013_b0240","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1096\/fj.03-1391com","article-title":"Caveolae compartmentalization of heme oxygenase-1 in endothelial cells","volume":"18","author":"Kim","year":"2004","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0245","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.4049\/jimmunol.0712437","article-title":"The heme oxygenase-1\/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1","volume":"182","author":"Wang","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0250","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jnutbio.2010.12.002","article-title":"Epigallocatechin-gallate stimulates NF-E2-related factor and heme oxygenase-1 via caveolin-1 displacement","volume":"23","author":"Zheng","year":"2012","journal-title":"J Nutr Biochem"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0255","doi-asserted-by":"crossref","first-page":"H954","DOI":"10.1152\/ajpheart.00758.2006","article-title":"TNF-alpha potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells","volume":"292","author":"Yang","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.mehy.2013.07.013_b0260","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1089\/ars.2008.2333","article-title":"Compartmentalization of redox signaling through NADPH oxidase-derived ROS","volume":"11","author":"Ushio-Fukai","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"10.1016\/j.mehy.2013.07.013_b0265","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1089\/ars.2009.2908","article-title":"Mechanical strain-induced RhoA activation requires NADPH oxidase-mediated ROS generation in caveolae","volume":"13","author":"Zhang","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.mehy.2013.07.013_b0270","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1161\/ATVBAHA.111.230623","article-title":"Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells","volume":"31","author":"Lobysheva","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0275","doi-asserted-by":"crossref","first-page":"F159","DOI":"10.1152\/ajprenal.00749.2010","article-title":"High glucose-induced RhoA activation requires caveolae and PKCbeta1-mediated ROS generation","volume":"302","author":"Zhang","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"10.1016\/j.mehy.2013.07.013_b0280","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/CIRCULATIONAHA.104.528802","article-title":"Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation","volume":"112","author":"Ollinger","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0285","doi-asserted-by":"crossref","first-page":"H333","DOI":"10.1152\/ajpheart.00870.2006","article-title":"An analysis of the DOCA-salt model of hypertension in HO-1\u2212\/\u2212 mice and the Gunn rat","volume":"293","author":"Nath","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.mehy.2013.07.013_b0290","doi-asserted-by":"crossref","first-page":"F552","DOI":"10.1152\/ajprenal.00278.2004","article-title":"The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II","volume":"288","author":"Pflueger","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"issue":"9","key":"10.1016\/j.mehy.2013.07.013_b0295","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ki.2010.265","article-title":"Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase","volume":"78","author":"Fujii","year":"2010","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0300","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/ATVBAHA.110.211789","article-title":"The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus","volume":"31","author":"Dekker","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"10.1016\/j.mehy.2013.07.013_b0305","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.metabol.2009.04.003","article-title":"Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the sibutramine cardiovascular outcome trial","volume":"58","author":"Andersson","year":"2009","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0310","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3961\/jpmph.2012.45.2.105","article-title":"Cigarette smoking and serum bilirubin subtypes in healthy Korean men: the Korea Medical Institute study","volume":"45","author":"Jo","year":"2012","journal-title":"J Prev Med Public Health"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0315","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-6143.2004.00695.x","article-title":"Protection against ischemia\/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both","volume":"5","author":"Nakao","year":"2005","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0320","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/01.MIB.0000164017.06538.8a","article-title":"Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis","volume":"11","author":"Berberat","year":"2005","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0325","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4161\/cc.6.1.3700","article-title":"Bilirubin and biliverdin treatment of atherosclerotic diseases","volume":"6","author":"Ollinger","year":"2007","journal-title":"Cell Cycle"},{"issue":"12","key":"10.1016\/j.mehy.2013.07.013_b0330","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1089\/ars.2007.1807","article-title":"Therapeutic applications of bilirubin and biliverdin in transplantation","volume":"9","author":"Ollinger","year":"2007","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.mehy.2013.07.013_b0335","first-page":"73","article-title":"Heme oxygenase-1 end-products carbon monoxide and biliverdin ameliorate murine collagen induced arthritis","volume":"30","author":"Bonelli","year":"2012","journal-title":"Clin Exp Rheumatol"},{"issue":"8","key":"10.1016\/j.mehy.2013.07.013_b0340","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s00125-011-2197-2","article-title":"Biliverdin protects against the deterioration of glucose tolerance in db\/db mice","volume":"54","author":"Ikeda","year":"2011","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.mehy.2013.07.013_b0345","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1152\/ajpregu.00648.2011","article-title":"Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress","volume":"304","author":"Zheng","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1016\/j.mehy.2013.07.013_b0350","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1089\/jmf.2007.621","article-title":"Clinical potential of Spirulina as a source of phycocyanobilin","volume":"10","author":"McCarty","year":"2007","journal-title":"J Med Food"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713003356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713003356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T13:25:30Z","timestamp":1563629130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987713003356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0306987713003356"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2013.07.013","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}