{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:18:36Z","timestamp":1789373916620,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["medical-hypotheses.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.mehy.2013.09.015","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T02:31:07Z","timestamp":1379385067000},"page":"963-965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aquagenic wrinkling of the palms is due to vasoconstriction of palmar skin vasculature"],"prefix":"10.1016","volume":"81","author":[{"given":"E.P.","family":"Wilder-Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7893","key":"10.1016\/j.mehy.2013.09.015_b0005","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0140-6736(74)92249-1","article-title":"Letter: skin wrinkling in cystic fibrosis","volume":"2","author":"Elliott","year":"1974","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.mehy.2013.09.015_b0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archneur.1979.00500380083013","article-title":"Skin wrinkling on immersion of hands: a test of sympathetic function","volume":"36","author":"Braham","year":"1979","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.mehy.2013.09.015_b0015","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1525-1470.2002.00103.x","article-title":"Rofecoxib-induced instant aquagenic wrinkling of the palms","volume":"19","author":"Carder","year":"2002","journal-title":"Pediatr Dermatol"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.015_b0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1440-0960.2000.00424.x","article-title":"Transient reactive papulotranslucent acrokeratoderma associated with cystic fibrosis","volume":"41","author":"Lowes","year":"2000","journal-title":"Australas J Dermatol"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.015_b0025","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1001\/archderm.141.5.621","article-title":"Aquagenic wrinkling of the palms in patients with cystic fibrosis homozygous for the delta F508 CFTR mutation","volume":"141","author":"Katz","year":"2005","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.015_b0030","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1525-1470.2011.01708.x","article-title":"High prevalence of aquagenic wrinkling of the palms in patients with cystic fibrosis and association with measurable increases in transepidermal water loss","volume":"29","author":"Arkin","year":"2012","journal-title":"Pediatr Dermatol"},{"issue":"11","key":"10.1016\/j.mehy.2013.09.015_b0035","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/archdermatol.2009.260","article-title":"Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations","volume":"145","author":"Berk","year":"2009","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.mehy.2013.09.015_b0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ppul.21345","article-title":"Aquagenic wrinkling of palms on exposure to alcohol gel","volume":"46","author":"Bhojani","year":"2011","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.015_b0045","first-page":"232","article-title":"Aquagenic wrinkling of the palms in a patient with cystic fibrosis heterozygous for the DeltaF 508 mutation","volume":"135","author":"Garcon","year":"2008","journal-title":"Ann Dermatol Venereol"},{"issue":"1","key":"10.1016\/j.mehy.2013.09.015_b0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1440-0960.2007.00412.x","article-title":"Aquagenic wrinkling of the palms in a cystic fibrosis carrier","volume":"49","author":"Gild","year":"2008","journal-title":"Australas J Dermatol"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.015_b0055","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1365-2133.2010.09914.x","article-title":"Aquagenic wrinkling of the palms in cystic fibrosis and the cystic fibrosis carrier state: a case-control study","volume":"163","author":"Gild","year":"2010","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.015_b0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1525-1470.2011.01609.x","article-title":"Aquagenic wrinkling of the palms and the potential role for genetic testing","volume":"29","author":"Park","year":"2012","journal-title":"Pediatr Dermatol"},{"issue":"7","key":"10.1016\/j.mehy.2013.09.015_b0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5070\/D35D57W5ZZ","article-title":"Aquagenic wrinkling of the palms: a case report and literature review","volume":"16","author":"Syed","year":"2010","journal-title":"Dermatol Online J"},{"issue":"4","key":"10.1016\/j.mehy.2013.09.015_b0070","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1159\/000319754","article-title":"Aquagenic wrinkling of the palms in an adult cystic fibrosis population","volume":"221","author":"Tolland","year":"2010","journal-title":"Dermatology"},{"issue":"21","key":"10.1016\/j.mehy.2013.09.015_b0075","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1056\/NEJMicm1103833","article-title":"Images in clinical medicine. Aquagenic wrinkling of palms in cystic fibrosis","volume":"366","author":"Weibel","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.mehy.2013.09.015_b0080","first-page":"203","article-title":"Aquagenic wrinkling of the palms","volume":"10","author":"Gild","year":"2012","journal-title":"Skinmed"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.015_b0085","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1111\/j.1365-2230.2009.03223.x","article-title":"Tobramycin-induced aquagenic wrinkling of the palms in a patient with cystic fibrosis","volume":"34","author":"Ludgate","year":"2009","journal-title":"Clin Exp Dermatol"},{"issue":"Pt 11","key":"10.1016\/j.mehy.2013.09.015_b0090","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.02372","article-title":"TRPV4 exhibits a functional role in cell-volume regulation","volume":"118","author":"Becker","year":"2005","journal-title":"J Cell Sci"},{"issue":"52","key":"10.1016\/j.mehy.2013.09.015_b0095","doi-asserted-by":"crossref","first-page":"54062","DOI":"10.1074\/jbc.M409708200","article-title":"Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia","volume":"279","author":"Arniges","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.015_b0100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1684\/ejd.2012.1792","article-title":"Unilateral aquagenic wrinkling of the palms with a peculiar clinical course","volume":"22","author":"Ibusuki","year":"2012","journal-title":"Eur J Dermatol"},{"issue":"12","key":"10.1016\/j.mehy.2013.09.015_b0105","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1001\/archderm.142.12.1661","article-title":"Unilateral aquagenic wrinkling of the palms associated with aspirin intake","volume":"142","author":"Khuu","year":"2006","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.mehy.2013.09.015_b0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10286-004-0172-4","article-title":"Water immersion wrinkling-physiology and use as an indicator of sympathetic function","volume":"14","author":"Wilder-Smith","year":"2004","journal-title":"Clin Auton Res"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.015_b0115","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jhsb.2004.12.010","article-title":"Fingertip skin wrinkling \u2013 the effect of varying tonicity","volume":"30","author":"Tsai","year":"2005","journal-title":"J Hand Surg Br"},{"issue":"7872","key":"10.1016\/j.mehy.2013.09.015_b0120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0140-6736(74)91675-4","article-title":"Letter: Wrinkling of skin in cystic fibrosis","volume":"2","author":"Elliott","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2013.09.015_b0125","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1152\/physrev.1971.51.4.702","article-title":"Permeability of the skin","author":"Scheuplein","year":"1971","journal-title":"Physiol Rev"},{"key":"10.1016\/j.mehy.2013.09.015_b0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00318346","article-title":"The fine structure of human digital arterio-venous anastomosis (Hoyer\u2013Grosser\u2019s organs)","volume":"150","author":"Karin","year":"1977","journal-title":"Anat Embryol"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.015_b0135","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mus.10323","article-title":"Water-immersion wrinkling is due to vasoconstriction","volume":"27","author":"Wilder-Smith","year":"2003","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.mehy.2013.09.015_b0140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0026-2862(03)00020-7","article-title":"Water immersion and EMLA cause similar digit skin wrinkling and vasoconstriction","volume":"66","author":"Wilder-Smith","year":"2003","journal-title":"Microvasc Res"},{"issue":"4","key":"10.1016\/j.mehy.2013.09.015_b0145","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.mehy.2005.10.022","article-title":"A capillary hemostasis mechanism regulated by sympathetic tone and activity via factor VIII or von Willebrand\u2019s factor may function as a \u201ccapillary gate\u201d and may explain angiodysplasia, angioneurotic edema, and variations in systemic vascular resistance","volume":"66","author":"Coleman","year":"2006","journal-title":"Med Hypotheses"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713004532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713004532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T08:14:45Z","timestamp":1646554485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987713004532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0306987713004532"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2013.09.015","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aquagenic wrinkling of the palms is due to vasoconstriction of palmar skin vasculature","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2013.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}