{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:35:27Z","timestamp":1773768927856,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["medical-hypotheses.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.mehy.2013.09.018","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T05:34:22Z","timestamp":1379396062000},"page":"1012-1014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Insulin analogues may accelerate progression of diabetic retinopathy after impairment of inner blood-retinal barrier"],"prefix":"10.1016","volume":"81","author":[{"given":"Abdullah","family":"Kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Kar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakup","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veysel","family":"\u00d6zalper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbaros","family":"Ba\u015fbu\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mehy.2013.09.018_b0005","doi-asserted-by":"crossref","first-page":"995","DOI":"10.2337\/db07-1618","article-title":"DCCT\/EDIC Research Group. Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial-revisited","volume":"57","author":"Lachin","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.mehy.2013.09.018_b0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2337\/diab.2.1.7","article-title":"The houssay phenomenon in man: recovery from retinopathy in a case of diabetes with Simmond\u2019s disease","volume":"2","author":"Poulsen","year":"1953","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.mehy.2013.09.018_b0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/archopht.1990.01070040067032","article-title":"The relationship of puberty to diabetic retinopathy","volume":"108","author":"Murphy","year":"1990","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"10.1016\/j.mehy.2013.09.018_b0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-8227(87)80006-2","article-title":"The effect of puberty on the development of early diabetic microvascular disease in insulin-dependent diabetes","volume":"3","author":"Rogers","year":"1987","journal-title":"Diabetes Res Clin Pract"},{"issue":"22","key":"10.1016\/j.mehy.2013.09.018_b0025","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJM197806012982202","article-title":"A follow-up study of vascular disease in growth-hormone-deficient dwarfs with diabetes","volume":"298","author":"Merimee","year":"1978","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.mehy.2013.09.018_b0030","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2337\/diab.23.8.698","article-title":"Hypophysectomy in diabetic retinopathy. The relationship between the degree of pituitary ablation and ocular response","volume":"23","author":"Adams","year":"1974","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mehy.2013.09.018_b0035","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2337\/diacare.23.4.504","article-title":"The efficacy of octreotide in the therapy of severe non-proliferative and early proliferative diabetic retinopathy: a randomized controlled study","volume":"23","author":"Grant","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mehy.2013.09.018_b0040","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-12-0026","article-title":"Insulin and its analogs and their affinities to the IGF-1 receptor","author":"Varewijck","year":"2012","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"10.1016\/j.mehy.2013.09.018_b0045","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2337\/diabetes.49.6.999","article-title":"Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use","volume":"49","author":"Kurtzhals","year":"2000","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.mehy.2013.09.018_b0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/13813450801900553","article-title":"Insulin, insulin analogues and diabetic retinopathy","volume":"114","author":"Chantelau","year":"2008","journal-title":"Arch Physiol Biochem"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.018_b0055","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mehy.2008.10.014","article-title":"Insulin may cause deterioration of proliferative diabetic retinopathy","volume":"72","author":"Zhang","year":"2009","journal-title":"Med Hypotheses"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.018_b0060","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2337\/diacare.22.5.874","article-title":"Insulin lispro and the development of proliferative diabetic retinopathy during pregnancy","volume":"22","author":"Kitzmiller","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mehy.2013.09.018_b0065","unstructured":"Kubo Y., Hosoya K. Inner blood-retinal barrier transporters. In: Relevance to diabetic retinopathy. Diabetic Retinopathy. ISBN: 978-953-51-0044-7."},{"issue":"6","key":"10.1016\/j.mehy.2013.09.018_b0070","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0161-6420(89)32817-X","article-title":"Immunostaining of pre-retinal membranes for actin, fibronectin, and glial fibrillary acidic protein","volume":"96","author":"Sramek","year":"1989","journal-title":"Ophthalmol"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.018_b0075","first-page":"387","article-title":"Idiopathic proliferative vitreoretinopathy: activation of microglial cells as the deciding factor","volume":"89","author":"Weller","year":"1992","journal-title":"Ophthalmol"},{"issue":"11","key":"10.1016\/j.mehy.2013.09.018_b0080","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/bjo.77.11.731","article-title":"Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy: differentiation of subpopulations","volume":"77","author":"Esser","year":"1993","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"10.1016\/j.mehy.2013.09.018_b0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000267327","article-title":"Epiretinal membrane of proliferative diabetic retinopathy: an immunohistochemical study","volume":"25","author":"Hosoda","year":"1993","journal-title":"Ophthal Res"},{"issue":"3","key":"10.1016\/j.mehy.2013.09.018_b0090","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2337\/diabetes.47.3.445","article-title":"Muller cell changes in human diabetic retinopathy","volume":"47","author":"Mizutani","year":"1998","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.mehy.2013.09.018_b0095","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/glia.20950","article-title":"A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and M\u00fcller glia","volume":"58","author":"Fischer","year":"2010","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.mehy.2013.09.018_b0100","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1167\/iovs.06-1095","article-title":"The insulin-like growth factor system modulates retinal pigment epithelial cell tractional force generation","volume":"48","author":"Mukherjee","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.mehy.2013.09.018_b0105","first-page":"2053","article-title":"Tractional force generation by porcine M\u00fcller cells: stimulation by growth factors in human vitreous","volume":"38","author":"Hardwick","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713004568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713004568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T21:53:08Z","timestamp":1539381188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987713004568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0306987713004568"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2013.09.018","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin analogues may accelerate progression of diabetic retinopathy after impairment of inner blood-retinal barrier","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2013.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}