{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:12:52Z","timestamp":1775614372404,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["medical-hypotheses.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.mehy.2013.12.003","type":"journal-article","created":{"date-parts":[[2013,12,15]],"date-time":"2013-12-15T13:47:53Z","timestamp":1387115273000},"page":"231-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anorexia nervosa: A rogue hibernation?"],"prefix":"10.1016","volume":"82","author":[{"given":"Barbara","family":"Scolnick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Mostofsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2013.12.003_b0280","series-title":"Chronicles of Narnia","author":"Lewis","year":"1950"},{"issue":"4","key":"10.1016\/j.mehy.2013.12.003_b0010","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1037\/0033-295X.110.4.745","article-title":"Adapted to flee famine: adding an evolutionary perspective on anorexia nervosa","volume":"110","author":"Guisinger","year":"2003","journal-title":"Psychol Rev"},{"issue":"10","key":"10.1016\/j.mehy.2013.12.003_b0015","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tem.2009.09.005","article-title":"Torpor induction in mammals; recent discoveries fueling new ideas","volume":"20","author":"Melvin","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.mehy.2013.12.003_b0020","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2307\/1313595","article-title":"Molecular and metabolic aspects of hibernation","volume":"29","author":"Boyer","year":"1999","journal-title":"Bioscience"},{"key":"10.1016\/j.mehy.2013.12.003_b0285","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00442-002-1014-5","article-title":"The energetics of autumn hoarding in eastern chipmunks","volume":"133","author":"Humphries","year":"2002","journal-title":"Oecologia"},{"key":"10.1016\/j.mehy.2013.12.003_b0030","doi-asserted-by":"crossref","first-page":"R255","DOI":"10.1152\/ajpregu.2000.279.1.R255","article-title":"Effects of ambient temperature on metabolic rate, respiratory quotient, and torpor in an arctic hibernator","volume":"279","author":"Buck","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.mehy.2013.12.003_b0290","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/physrev.00008.2003","article-title":"Mammalan hibernaton: cellular responses to depressed metabolism and low temperature","volume":"83","author":"Carey","year":"2003","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.mehy.2013.12.003_b0040","doi-asserted-by":"crossref","first-page":"R1044","DOI":"10.1152\/ajpregu.00688.2007","article-title":"Effects of polyunsaturated fatty acids on hibernation and torpor: a review and hypothesis","volume":"294","author":"Ruf","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"10.1016\/j.mehy.2013.12.003_b0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4067\/S0716-97602004000200013","article-title":"Omega-3 fatty acids and antioxidants in edible wild plants","volume":"37","author":"Simopoulos","year":"2004","journal-title":"Biol Res"},{"issue":"4","key":"10.1016\/j.mehy.2013.12.003_b0050","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0031-9384(99)00177-8","article-title":"The effects of a linseed oil diet on hibernation in yellow-bellied marmots","volume":"68","author":"Hill","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2013.12.003_b0055","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/B978-0-12-396968-2.00009-9","article-title":"Circannual transitions in gene expression","volume":"105","author":"Schwartz","year":"2013","journal-title":"Curr Top Dev Biol"},{"issue":"Pt. 6","key":"10.1016\/j.mehy.2013.12.003_b0060","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1042\/BST0321021","article-title":"Genes controlling the metabolic switch in hibernating mammals","volume":"32","author":"Andrews","year":"2004","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"10.1016\/j.mehy.2013.12.003_b0295","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.06.026","article-title":"Clocks, metabolism and the epigenome","volume":"47","author":"Feng","year":"2012","journal-title":"Mol Cell"},{"issue":"9","key":"10.1016\/j.mehy.2013.12.003_b0070","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nrm1980","article-title":"Metabolic cycles as underlying basis of biological oscillations","volume":"7","author":"Tu","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.mehy.2013.12.003_b0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1098-108X(199801)23:1<57::AID-EAT7>3.0.CO;2-0","article-title":"Prevalence of eating disorders in Norwegian general hospitals 1990\u20131994: admissions per year and seasonality","volume":"23","author":"Gotestam","year":"1998","journal-title":"Int J Eat Disord"},{"issue":"5","key":"10.1016\/j.mehy.2013.12.003_b0080","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.amepre.2013.01.012","article-title":"Seasonality in seeking mental health information on goggle","volume":"44","author":"Ayers","year":"2013","journal-title":"Am J Prev Med"},{"issue":"Suppl.","key":"10.1016\/j.mehy.2013.12.003_b0300","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.fertnstert.2008.04.055","article-title":"Seasonality and the prediction of weight at resumption of menses in anorexia nervosa","volume":"91","author":"Favaro","year":"2009","journal-title":"Fertil Steril"},{"issue":"7","key":"10.1016\/j.mehy.2013.12.003_b0090","doi-asserted-by":"crossref","first-page":"e41851","DOI":"10.1371\/journal.pone.0041851","article-title":"Hyperactivity in anorexia nervosa: warming up not just burning off calories","volume":"7","author":"Carrera","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mehy.2013.12.003_b0095","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.eatbeh.2013.05.006","article-title":"Climate might be considered as a risk factor for anorexia nervosa? A hypothesis worth another look","volume":"14","author":"Gutierrez","year":"2013","journal-title":"Eat Behav"},{"key":"10.1016\/j.mehy.2013.12.003_b0100","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1192\/bjp.180.6.509","article-title":"Eating behaviours and attitudes following prolonged exposure to television among ethnic Fijian adolescent girls","volume":"180","author":"Becker","year":"2002","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.mehy.2013.12.003_b0105","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1176\/appi.ajp.162.4.748","article-title":"The incidence of anorexia nervosa on Curacao","volume":"162","author":"Hoek","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.mehy.2013.12.003_b0110","series-title":"The biology of human starvation","author":"Keys","year":"1950"},{"key":"10.1016\/j.mehy.2013.12.003_b0115","first-page":"1495","article-title":"Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentration","volume":"1","author":"Polito","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2013.12.003_b0305","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/1098-108X(198605)5:4<713::AID-EAT2260050410>3.0.CO;2-S","article-title":"Hypothermia and abnormalities in thermoregulation in patients with anorexia nervosa","volume":"Vol. 5 No 4","author":"Nishita","year":"1986","journal-title":"Int J Eat Dis"},{"issue":"5","key":"10.1016\/j.mehy.2013.12.003_b0125","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archinte.165.5.561","article-title":"Medical findings in outpatients with anorexia nervosa","volume":"165","author":"Miller","year":"2005","journal-title":"Arch Int Med"},{"key":"10.1016\/j.mehy.2013.12.003_b0130","unstructured":"Paper presentation at the University of Minnesota celebration of the Semi-Starvation study in 2004 celebrating the 100 birth day of Ancel Keys found in Tucker, Todd, The Great Starvation Experiment. New York: Simon & Schuster; 2006."},{"key":"10.1016\/j.mehy.2013.12.003_b0135","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/ajcn\/32.7.1396","article-title":"Caloric requirements for weight gain in anorexia nervosa","volume":"32","author":"Walker","year":"1979","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.mehy.2013.12.003_b0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0306-4530(00)00036-6","article-title":"Altered energy metabolism in anorexia nervosa","volume":"26","author":"Russell","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mehy.2013.12.003_b0145","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1210\/jc.2006-1319","article-title":"Hormonal and psychological factors linked to the increased thermic effect of food in malnourished fasting anorexia. nervosa","volume":"92","author":"Rigaud","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.mehy.2013.12.003_b0150","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/jn\/135.6.1347","article-title":"They starved so that others might be better fed: remembering Ancel Keys and the Minnesota experiment","volume":"135","author":"Kalm","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.mehy.2013.12.003_b0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0031-9384(03)00102-1","article-title":"Hyperactivity in patients with anorexia nervosa and rats: evidence for a pivotal role of hypoliptenemia","volume":"79","author":"Hebebrand","year":"2003","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2013.12.003_b0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.diabet.2008.08.004","article-title":"Hypercholesterolaemia in anorexia nervosa: frequency and changes during refeeding","volume":"35","author":"Rigaud","year":"2009","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.mehy.2013.12.003_b0165","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1079\/BJN20041151","article-title":"Lipoprotein metabolism in patients with anorexia nervosa: a case\u2013control study investigating the mechanisms leading to hypercholesterolaemia","volume":"91","author":"Weinbrenner","year":"2004","journal-title":"Br J Nutr"},{"key":"10.1016\/j.mehy.2013.12.003_b0170","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/01.psy.0000127873.31062.80","article-title":"Total serum cholesterol and suicidality in anorexia nervosa","volume":"66","author":"Favaro","year":"2004","journal-title":"Psychosom Med"},{"key":"10.1016\/j.mehy.2013.12.003_b0310","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/clc.4960200307","article-title":"Heart rate variability as a measure of autonomic nervous system function in anorexia nervosa","volume":"20","author":"Petretta","year":"1977","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.mehy.2013.12.003_b0315","article-title":"Baroreflex sensitivity and heart rate variability are enhanced in patients with anorexia nervosa","author":"Jocoangeli","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.mehy.2013.12.003_b0320","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability standards of measurement, physiological interpretation","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.mehy.2013.12.003_b0190","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.CIR.98.6.547","article-title":"Mechanisms underlying very-low-frequency RR-interval oscillations in humans","volume":"98","author":"Taylor","year":"1998","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.mehy.2013.12.003_b0325","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1182\/blood.V91.2.691","article-title":"Fetal hemoglobin in starvation ketosis of young women","volume":"91","author":"Peters","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.mehy.2013.12.003_b0330","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1086\/339250","article-title":"Evidence for a susceptibility gene for anorexia nervosa on chromosome 1","volume":"70","author":"Grice","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.mehy.2013.12.003_b0335","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/sj.mp.4001318","article-title":"Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa","volume":"8","author":"Bergen","year":"2003","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.mehy.2013.12.003_b0210","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.1038\/mp.2010.107","article-title":"A genome-wide associate study on common SNPs and rare CNVs in anorexia nervosa","volume":"16","author":"Wang","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.mehy.2013.12.003_b0215","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/0024-3205(88)90406-7","article-title":"Further studies on opioids and hibernation: delta opioid receptor ligand selectively induced hibernation in summer-active ground squirrels","volume":"43","author":"Oeltgen","year":"1988","journal-title":"Life Sci"},{"key":"10.1016\/j.mehy.2013.12.003_b0340","article-title":"Hibernation and plasma from hibernating animals modulate the cardioprotective delta opiod system","volume":"23","author":"Gerene","year":"2009","journal-title":"FASEB"},{"issue":"6","key":"10.1016\/j.mehy.2013.12.003_b0225","doi-asserted-by":"crossref","first-page":"e66119","DOI":"10.1371\/journal.pone.0066119","article-title":"Serum immune-related proteins are differentially expressed during hibernation in the American black bear","volume":"8","author":"Chow","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mehy.2013.12.003_b0230","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.plefa.2004.03.007","article-title":"A pilot open case series of Ethyl-EPA supplementation in the treatment of anorexia nervosa","volume":"71","author":"Ayton","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"14","key":"10.1016\/j.mehy.2013.12.003_b0235","doi-asserted-by":"crossref","first-page":"9486","DOI":"10.1073\/pnas.142284799","article-title":"Randomized controlled trial of a treatment for anorexia and bulimia nervosa","volume":"99","author":"Bergh","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2013.12.003_b0240","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jad.2010.10.014","article-title":"Bright light treatment of depressive symptoms in patients with restrictive type of anorexia nervosa","volume":"130","author":"Janas-Kozik","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.mehy.2013.12.003_b0245","first-page":"290","article-title":"Reducing symptoms in women with chronic anorexia nervosa. A pilot study on the effects of bright light therapy","volume":"31","author":"Daansen","year":"2013","journal-title":"Neuro Endocrinol Lett"},{"issue":"4","key":"10.1016\/j.mehy.2013.12.003_b0250","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/BF03339975","article-title":"Circadian neuroendocrine functions in disorders of eating behavior","volume":"2","author":"Ferrari","year":"1997","journal-title":"Eat Weight Disord"},{"issue":"3","key":"10.1016\/j.mehy.2013.12.003_b0255","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/1098-108X(199411)16:3<257::AID-EAT2260160306>3.0.CO;2-3","article-title":"Melatonin disturbances in anorexia nervosa and bulimia nervosa","volume":"16","author":"Kennedy","year":"1994","journal-title":"Int J Eat Disord"},{"issue":"6","key":"10.1016\/j.mehy.2013.12.003_b0260","first-page":"1540","article-title":"Melatonin rhythms in women with anorexia nervosa and bulimia nervosa","volume":"77","author":"Mortola","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2013.12.003_b0265","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1009554825745","article-title":"Resonant frequency biofeedback training to increase cardiac variability: rationale and manual for training","volume":"25","author":"Lehrer","year":"2000","journal-title":"Appl Psychophysiol Biofeed"},{"issue":"2","key":"10.1016\/j.mehy.2013.12.003_b0270","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1528-1167.2006.00438.x","article-title":"A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy","volume":"47","author":"Kossoff","year":"2006","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.mehy.2013.12.003_b0275","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-7075-1-2","article-title":"Ketogenic diets and physical performance","volume":"17","author":"Phinney","year":"2004","journal-title":"Nutr Metab"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713005872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987713005872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T04:12:09Z","timestamp":1597205529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987713005872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0306987713005872"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2013.12.003","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anorexia nervosa: A rogue hibernation?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2013.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}