{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:34:28Z","timestamp":1789965268859,"version":"4.0.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["medical-hypotheses.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.mehy.2015.02.013","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T18:20:36Z","timestamp":1425320436000},"page":"555-556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Periodontitis as a risk factor for systemic disease: Are microparticles the missing link?"],"prefix":"10.1016","volume":"84","author":[{"given":"Zahi","family":"Badran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Struillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Verner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Clee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Rakic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assem","family":"Soueidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"58","key":"10.1016\/j.mehy.2015.02.013_b0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0757.2011.00414.x","article-title":"Causal theory and the etiology of periodontal diseases","volume":"2000","author":"Heaton","year":"2012","journal-title":"Periodontology"},{"key":"10.1016\/j.mehy.2015.02.013_b0010","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s11926-014-0408-9","article-title":"The link between periodontal disease and rheumatoid arthritis: an updated review","volume":"16","author":"Koziel","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.mehy.2015.02.013_b0015","first-page":"63","article-title":"Diabetes and periodontal disease. Review of the literature","volume":"27","author":"Bascones-Martinez","year":"2014","journal-title":"Am J Dent"},{"key":"10.1016\/j.mehy.2015.02.013_b0020","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/0022034513483142","article-title":"Periodontal disease and rheumatoid arthritis: a systematic review","volume":"92","author":"Kaur","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.mehy.2015.02.013_b0025","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/JPN.0b013e31821072e4","article-title":"Periodontal disease in pregnancy: review of the evidence and prevention strategies","volume":"25","author":"Lachat","year":"2011","journal-title":"J Perinat Neonatal Nurs"},{"key":"10.1016\/j.mehy.2015.02.013_b0030","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1600-051X.2010.01636.x","article-title":"Periodontal disease and pre-eclampsia: a systematic review","volume":"37","author":"Kunnen","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.mehy.2015.02.013_b0035","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1096\/fj.02-0574fje","article-title":"Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets","volume":"17","author":"M\u00fcller","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.mehy.2015.02.013_b0040","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.tips.2011.06.005","article-title":"Microparticles: targets and tools in cardiovascular disease","volume":"32","author":"Martinez","year":"2011","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.mehy.2015.02.013_b0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.blre.2014.04.002","article-title":"Platelet microparticles: detection and assessment of their paradoxical functional roles in disease and regenerative medicine","volume":"28","author":"Burnouf","year":"2014","journal-title":"Blood Rev"},{"key":"10.1016\/j.mehy.2015.02.013_b0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/CS20120309","article-title":"Microparticles: biomarkers and beyond","volume":"124","author":"Burger","year":"2013","journal-title":"Clin Sci"},{"key":"10.1016\/j.mehy.2015.02.013_b0055","doi-asserted-by":"crossref","first-page":"e73088","DOI":"10.1371\/journal.pone.0073088","article-title":"Circulating microparticles from Crohn\u2019s disease patients cause endothelial and vascular dysfunctions","volume":"8","author":"Leonetti","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mehy.2015.02.013_b0060","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.ejim.2011.02.010","article-title":"Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept-there could be light in the end of the tunnel","volume":"22","author":"Blum","year":"2011","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.mehy.2015.02.013_b0065","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ejim.2010.07.011","article-title":"Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept","volume":"21","author":"Pizzo","year":"2010","journal-title":"Eur J Intern Med"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987715000900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987715000900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T13:22:35Z","timestamp":1566393755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987715000900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0306987715000900"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2015.02.013","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periodontitis as a risk factor for systemic disease: Are microparticles the missing link?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2015.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}