{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:31Z","timestamp":1787169991184,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.mehy.2015.08.024","type":"journal-article","created":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T07:01:57Z","timestamp":1441522917000},"page":"972-975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vascular restoration: Is there a window of opportunity?"],"prefix":"10.1016","volume":"85","author":[{"given":"Jianhua","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2015.08.024_b0005","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMoa035071","article-title":"Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery","volume":"349","author":"Moses","year":"2003","journal-title":"New Engl J Med"},{"key":"10.1016\/j.mehy.2015.08.024_b0010","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMp068305","article-title":"Unanswered questions\u2013drug-eluting stents and the risk of late thrombosis","volume":"356","author":"Maisel","year":"2007","journal-title":"New Engl J Med"},{"key":"10.1016\/j.mehy.2015.08.024_b0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jcin.2008.11.015","article-title":"Durability of antirestenotic efficacy in drug-eluting stents with and without permanent polymer","volume":"2","author":"Byrne","year":"2009","journal-title":"JACC Cardiovasc Interven"},{"key":"10.1016\/j.mehy.2015.08.024_b0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","article-title":"Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk","volume":"48","author":"Joner","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.mehy.2015.08.024_b0025","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.107.693739","article-title":"Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization","volume":"115","author":"Finn","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.mehy.2015.08.024_b0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1541-9215.2004.03632.x","article-title":"Drug-eluting stents: are they really safe?","volume":"2","author":"Virmani","year":"2004","journal-title":"Am Heart Hospital J"},{"key":"10.1016\/j.mehy.2015.08.024_b0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/CIRCINTERVENTIONS.108.831800.108.831800","article-title":"Two-year clinical, angiographic, and intravascular ultrasound follow-up of the xience v everolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions: the spirit ii trial","volume":"2","author":"Claessen","year":"2009","journal-title":"Circul Cardiovasc Interven"},{"key":"10.1016\/j.mehy.2015.08.024_b0040","article-title":"Coronary drug-eluting stents: from design optimization to newer strategies","author":"Sun","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.mehy.2015.08.024_b0045","unstructured":"Serruys PW. Four-year outcomes from the randomized comparison of a zotarolimus-eluting and an everolimus-eluting stent in the resolute all comers trial. EUROPCR; 2013."},{"key":"10.1016\/j.mehy.2015.08.024_b0050","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jcin.2013.04.011","volume":"6","author":"Serruys","year":"2013","journal-title":"JACC Cardiovasc Interven"},{"key":"10.1016\/j.mehy.2015.08.024_b0055","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1540-8183.2007.00307.x","article-title":"Bioabsorbable stents","volume":"20","author":"Kahn","year":"2007","journal-title":"J Interven Cardiol"},{"key":"10.1016\/j.mehy.2015.08.024_b0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijcard.2012.05.093","article-title":"Bioresorbable scaffolds: current knowledge, potentialities and limitations experienced during their first clinical applications","volume":"167","author":"Bourantas","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.mehy.2015.08.024_b0065","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1540-8183.2004.04081.x","article-title":"Drug-eluting bioabsorbable magnesium stent","volume":"17","author":"Di Mario","year":"2004","journal-title":"J Interven Cardiol"},{"key":"10.1016\/j.mehy.2015.08.024_b0070","doi-asserted-by":"crossref","unstructured":"Oberhauser JP, Hossainy S, Rapoza RJ. Design principles and performance of bioresorbable polymeric vascular scaffolds. EuroIntervention: Journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2009; 5(Suppl F): F15\u201322.","DOI":"10.4244\/EIJV5IFA3"},{"key":"10.1016\/j.mehy.2015.08.024_b0075","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1161\/CIRCULATIONAHA.110.970772","article-title":"Evaluation of the second generation of a bioresorbable everolimus drug-eluting vascular scaffold for treatment of de novo coronary artery stenosis: six-month clinical and imaging outcomes","volume":"122","author":"Serruys","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.mehy.2015.08.024_b0080","doi-asserted-by":"crossref","unstructured":"Capodanno D, Gori T, Nef H, Latib A, Mehilli J, Lesiak M, et al. Percutaneous coronary intervention with everolimus-eluting bioresorbable vascular scaffolds in routine clinical practice: early and midterm outcomes from the european multicentre ghost-eu registry. EuroIntervention: Journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology; 2014.","DOI":"10.4244\/EIJY14M07_11"},{"key":"10.1016\/j.mehy.2015.08.024_b0085","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/01.HYP.25.4.748","article-title":"Influence of endothelium on cultured vascular smooth muscle cell proliferation","volume":"25","author":"Peiro","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.mehy.2015.08.024_b0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00441-008-0694-5","article-title":"Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees","volume":"335","author":"Dejana","year":"2009","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.mehy.2015.08.024_b0095","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/physrev.00035.2003","article-title":"Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis","volume":"84","author":"Bazzoni","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.mehy.2015.08.024_b0100","doi-asserted-by":"crossref","unstructured":"Simionescu M, Antohe F. Functional ultrastructure of the vascular endothelium: changes in various pathologies. Handbook of experimental pharmacology; 2006. p. 41\u201369.","DOI":"10.1007\/3-540-32967-6_2"},{"key":"10.1016\/j.mehy.2015.08.024_b0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12013-011-9179-3","article-title":"Nitric oxide inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia by increasing the ubiquitination and degradation of UbcH10","volume":"60","author":"Tsihlis","year":"2011","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.mehy.2015.08.024_b0110","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0735-1097(10)80196-2","article-title":"A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies","volume":"17","author":"Forrester","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.mehy.2015.08.024_b0115","first-page":"439","article-title":"The importance of the endothelium in atherothrombosis and coronary stenting. Nature reviews","volume":"9","author":"Otsuka","year":"2012","journal-title":"Cardiology"},{"key":"10.1016\/j.mehy.2015.08.024_b0120","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.mehy.2015.08.024_b0125","unstructured":"Hou J. A prospective randomised controlled 3- and 12-month oct study to evaluate the endotelial healing between a novel sirolimus-eluting stent buma and an everolimus-eluting stent xience v. EUROPCR; 2013."},{"key":"10.1016\/j.mehy.2015.08.024_b0130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1755-5922.2010.00144.x","article-title":"Current status of drug-eluting stents","volume":"29","author":"Raber","year":"2011","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.mehy.2015.08.024_b0135","unstructured":"Qian J, Zhang YJ, Xu B, Yang YJ, Yan HB, Sun ZW, et al. Optical coherence tomography assessment of a plga-polymer with electro-grafting base layer versus a pla-polymer sirolimus-eluting stent at three-month follow-up: The buma-oct randomised trial. EuroIntervention: Journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology; 2014."},{"key":"10.1016\/j.mehy.2015.08.024_b0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2005.09.042","article-title":"Drug-eluting stents: sirolimus and paclitaxel differentially affect cultured cells and injured arteries","volume":"524","author":"Parry","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.mehy.2015.08.024_b0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1615\/JLongTermEffMedImplants.v10.i12.120","article-title":"Influence of topography on endothelialization of stents: clues for new designs","volume":"10","author":"Simon","year":"2000","journal-title":"J Long Term Eff Med Implants"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771500331X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771500331X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:16:05Z","timestamp":1759691765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030698771500331X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S030698771500331X"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2015.08.024","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular restoration: Is there a window of opportunity?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2015.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}