{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:32:53Z","timestamp":1792758773977,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.mehy.2015.09.028","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T22:29:40Z","timestamp":1443738580000},"page":"842-845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early disruption of neurovascular units and microcirculatory dysfunction in the spinal cord in spinal muscular atrophy type I"],"prefix":"10.1016","volume":"85","author":[{"given":"Tatsuro","family":"Nobutoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2015.09.028_b0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2015.09.028_b0010","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1086\/302369","article-title":"Quantitative analysis of survival motor neuron copies: identification of subtle SMN1 mutations in patients with spinal muscular atrophy, genotype-phenotype correlation, and implications for genetic counseling","volume":"64","author":"Wirth","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.mehy.2015.09.028_b0015","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/hmg\/6.8.1205","article-title":"The survival motor neuron protein in spinal muscular atrophy","volume":"6","author":"Coovert","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2015.09.028_b0020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","article-title":"Correlation between severity and SMN protein level in spinal muscular atrophy","volume":"16","author":"Lefebvre","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2015.09.028_b0025","series-title":"Swaiman\u2019s Pediatric Neurology","first-page":"1482","article-title":"Anterior horn cell and cranial motor neuron disease","volume":"vol. 2","author":"Wang","year":"2012"},{"key":"10.1016\/j.mehy.2015.09.028_b0030","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/mus.21654","article-title":"Digital necroses and vascular thrombosis in severe spinal muscular atrophy","volume":"42","author":"Rudnik-Schoneborn","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.mehy.2015.09.028_b0035","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jpeds.2009.01.071","article-title":"Vascular perfusion abnormalities in infants with spinal muscular atrophy","volume":"155","author":"Araujo","year":"2009","journal-title":"J Pediatr"},{"key":"10.1016\/j.mehy.2015.09.028_b0040","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.nmd.2011.10.021","article-title":"Density, calibre and ramification of muscle capillaries are altered in a mouse model of severe spinal muscular atrophy","volume":"22","author":"Somers","year":"2012","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.mehy.2015.09.028_b0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mehy.2015.09.028_b0050","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jnr.22594","article-title":"Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis","volume":"89","author":"Miyazaki","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.mehy.2015.09.028_b0055","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2015.09.028_b0060","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuron.2011.08.009","article-title":"Role of astrocytes in neurovascular coupling","volume":"71","author":"Petzold","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2015.09.028_b0065","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/jcbfm.2012.5","article-title":"Control of brain capillary blood flow","volume":"32","author":"Itoh","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mehy.2015.09.028_b0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature13165","article-title":"Capillary pericytes regulate cerebral blood flow in health and disease","volume":"508","author":"Hall","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2015.09.028_b0075","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/jcbfm.2012.113","article-title":"Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability","volume":"32","author":"Winkler","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mehy.2015.09.028_b0080","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2015.09.028_b0085","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/stem.1977","article-title":"Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells","volume":"33","author":"Nakagomi","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.mehy.2015.09.028_b0090","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/glia.22522","article-title":"Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production","volume":"61","author":"McGivern","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.mehy.2015.09.028_b0095","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/hmg\/ddv148","article-title":"Astrocytes influence the severity of spinal muscular atrophy","volume":"24","author":"Rindt","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2015.09.028_b0100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.embor.7400941","article-title":"Chaperoning ribonucleoprotein biogenesis in health and disease","volume":"8","author":"Pellizzoni","year":"2007","journal-title":"EMBO Rep"},{"key":"10.1016\/j.mehy.2015.09.028_b0105","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(00)81632-3","article-title":"A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing","volume":"95","author":"Pellizzoni","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2015.09.028_b0110","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/hmg\/dds474","article-title":"A novel function for the survival motoneuron protein as a translational regulator","volume":"22","author":"Sanchez","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2015.09.028_b0115","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/med.21327","article-title":"Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications","volume":"35","author":"Wang","year":"2015","journal-title":"Med Res Rev"},{"key":"10.1016\/j.mehy.2015.09.028_b0120","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2015.09.028_b0125","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2010.09.026","article-title":"Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress","volume":"40","author":"Sengupta","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.mehy.2015.09.028_b0130","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1128\/MCB.00306-14","article-title":"Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways","volume":"35","author":"Wang","year":"2015","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.mehy.2015.09.028_b0135","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1093\/hmg\/ddu350","article-title":"SMN regulates axonal local translation via miR-183\/mTOR pathway","volume":"23","author":"Kye","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mehy.2015.09.028_b0140","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.braindev.2005.02.009","article-title":"Autonomic dysfunction in cases of spinal muscular atrophy type 1 with long survival","volume":"27","author":"Hachiya","year":"2005","journal-title":"Brain Dev"},{"key":"10.1016\/j.mehy.2015.09.028_b0145","first-page":"371","article-title":"Role of nitric oxide in the regulation of spinal arteriolar tone","volume":"50","author":"Ishikawa","year":"2002","journal-title":"Neurosurgery"},{"key":"10.1016\/j.mehy.2015.09.028_b0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.sc.3100348","article-title":"Regulation of vasomotion of arterioles and capillaries in the cat spinal cord: role of alpha actin and endothelin-1","volume":"35","author":"Toribatake","year":"1997","journal-title":"Spinal Cord"},{"key":"10.1016\/j.mehy.2015.09.028_b0155","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nn2073","article-title":"ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration","volume":"11","author":"Zhong","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.mehy.2015.09.028_b0160","first-page":"2","article-title":"The differences of the cerebral and spinal vessels in sensitivity to PaCO2 and vasoconstrictors","volume":"46","author":"Iida","year":"1997","journal-title":"Masui"},{"key":"10.1016\/j.mehy.2015.09.028_b0165","first-page":"492","article-title":"Hemodilution impairs hypocapnia-induced vasoconstrictor responses in the brain and spinal cord in dogs","volume":"80","author":"Czinn","year":"1995","journal-title":"Anesth Analg"},{"key":"10.1016\/j.mehy.2015.09.028_b0170","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1213\/00000539-199808000-00033","article-title":"Hyper- and hypoventilation affects spinal motor neuron excitability during isoflurane anesthesia","volume":"87","author":"Zhou","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1016\/j.mehy.2015.09.028_b0175","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3940(99)00358-4","article-title":"Roles of nitric oxide in the spinal cord in cardiovascular regulation in rats","volume":"267","author":"Koga","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.mehy.2015.09.028_b0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.braindev.2012.03.009","article-title":"Peripheral nerve abnormalities in pediatric patients with spinal muscular atrophy","volume":"35","author":"Yonekawa","year":"2013","journal-title":"Brain Dev"},{"key":"10.1016\/j.mehy.2015.09.028_b0185","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/jcbfm.2011.187","article-title":"Stem cell therapy for cerebral ischemia: from basic science to clinical applications","volume":"32","author":"Abe","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mehy.2015.09.028_b0190","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ana.23995","article-title":"Spinal muscular atrophy: development and implementation of potential treatments","volume":"74","author":"Arnold","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2015.09.028_b0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ana.24332","article-title":"A large animal model of spinal muscular atrophy and correction of phenotype","volume":"77","author":"Duque","year":"2015","journal-title":"Ann Neurol"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987715003710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987715003710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:19:24Z","timestamp":1759691964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987715003710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0306987715003710"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2015.09.028","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early disruption of neurovascular units and microcirculatory dysfunction in the spinal cord in spinal muscular atrophy type I","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2015.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}