{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:31:24Z","timestamp":1779103884449,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470434"],"award-info":[{"award-number":["81470434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270420"],"award-info":[{"award-number":["81270420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M560647"],"award-info":[{"award-number":["2014M560647"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M560647"],"award-info":[{"award-number":["2014M560647"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province Cooperative innovation Center for Molecular Target New Drug Study"},{"DOI":"10.13039\/501100005225","name":"Construct Program of the Key Discipline in Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["14JJ3102"],"award-info":[{"award-number":["14JJ3102"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015T80875"],"award-info":[{"award-number":["2015T80875"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Science and Technology","award":["2015RS4040"],"award-info":[{"award-number":["2015RS4040"]}]},{"name":"Administration of Traditional Chinese Medicine of Hunan Province","award":["201578"],"award-info":[{"award-number":["201578"]}]},{"DOI":"10.13039\/501100010451","name":"Health and Family Planning Commission of Hunan Province","doi-asserted-by":"crossref","award":["B2015-48"],"award-info":[{"award-number":["B2015-48"]}],"id":[{"id":"10.13039\/501100010451","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.mehy.2016.02.017","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T13:43:52Z","timestamp":1456667032000},"page":"6-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["The mechanosensitive APJ internalization via clathrin-mediated endocytosis: A new molecular mechanism of cardiac hypertrophy"],"prefix":"10.1016","volume":"90","author":[{"given":"Lu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2016.02.017_b0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1536\/jhj.41.117","article-title":"Molecular mechanism of mechanical stress-induced cardiac hypertrophy","volume":"41","author":"Komuro","year":"2000","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.mehy.2016.02.017_b0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00041552-199301000-00004","article-title":"The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes","volume":"2","author":"Dzau","year":"1993","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.mehy.2016.02.017_b0015","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0378-1119(93)90495-O","article-title":"A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11","volume":"136","author":"O\u2019Dowd","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.mehy.2016.02.017_b0020","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mehy.2016.02.017_b0025","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.bcp.2007.12.015","article-title":"The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential","volume":"75","author":"Japp","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.mehy.2016.02.017_b0030","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cca.2015.09.029","article-title":"Apelin\/APJ signaling in hypoxia-related diseases","volume":"451","author":"He","year":"2015","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.mehy.2016.02.017_b0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2174\/1389450115666141128120053","article-title":"Targeting drugs to APJ receptor: the prospect of treatment of hypertension and other cardiovascular diseases","volume":"16","author":"Cao","year":"2015","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.mehy.2016.02.017_b0040","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1007\/s11033-014-3552-4","article-title":"Apelin\/APJ system: a promising therapy target for hypertension","volume":"41","author":"Wu","year":"2014","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.mehy.2016.02.017_b0045","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/abbs\/gmt040","article-title":"Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis","volume":"45","author":"Lv","year":"2013","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.mehy.2016.02.017_b0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/abbs\/gmt140","article-title":"ERK1\/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13","volume":"46","author":"Yang","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.mehy.2016.02.017_b0055","doi-asserted-by":"crossref","first-page":"1248636","DOI":"10.1126\/science.1248636","article-title":"Toddler: an embryonic signal that promotes cell movement via Apelin receptors","volume":"343","author":"Pauli","year":"2014","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.mehy.2016.02.017_b0060","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1038\/srep08170","article-title":"Elabela\u2013apelin receptor signaling pathway is functional in mammalian systems","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.mehy.2016.02.017_b0065","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cardiores.2004.08.018","article-title":"The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo","volume":"65","author":"Ashley","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.mehy.2016.02.017_b0070","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature11263","article-title":"APJ acts as a dual receptor in cardiac hypertrophy","volume":"488","author":"Scimia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2016.02.017_b0075","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/abbs\/gmu046","article-title":"A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway","volume":"46","author":"Xie","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.mehy.2016.02.017_b0080","first-page":"1660","article-title":"Additional role for APJ in cardiac hypertrophy","volume":"4","author":"Sklan","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.mehy.2016.02.017_b0085","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1172\/JCI112359","article-title":"Receptor-mediated endocytosis","volume":"77","author":"Stahl","year":"1986","journal-title":"J Clin Investig"},{"key":"10.1016\/j.mehy.2016.02.017_b0090","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1517\/17425247.2015.992778","article-title":"Receptor-mediated endocytosis of macromolecules and strategy to enhance their transport in alveolar epithelial cells","volume":"12","author":"Takano","year":"2015","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.mehy.2016.02.017_b0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jcp.1041210202","article-title":"Platelet-derived growth factor: morphologic and biochemical studies of binding, internalization, and degradation","volume":"121","author":"Rosenfeld","year":"1984","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.mehy.2016.02.017_b0100","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1600-0854.2007.00551.x","article-title":"Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis","volume":"8","author":"Wolfe","year":"2007","journal-title":"Traffic (Copenhagen, Denmark)"},{"key":"10.1016\/j.mehy.2016.02.017_b0105","doi-asserted-by":"crossref","first-page":"H585","DOI":"10.1152\/ajpheart.00821.2013","article-title":"Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3","volume":"306","author":"Zeng","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.mehy.2016.02.017_b0110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12967-015-0635-5","article-title":"Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients","volume":"13","author":"Ye","year":"2015","journal-title":"J Transl Med"},{"key":"10.1016\/j.mehy.2016.02.017_b0115","doi-asserted-by":"crossref","first-page":"e71041","DOI":"10.1371\/journal.pone.0071041","article-title":"Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction","volume":"8","author":"Li","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mehy.2016.02.017_b0120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.yjmcc.2013.07.002","article-title":"Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction","volume":"63","author":"Ceylan-Isik","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.mehy.2016.02.017_b0125","doi-asserted-by":"crossref","first-page":"H605","DOI":"10.1152\/ajpheart.00366.2012","article-title":"Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction","volume":"303","author":"Li","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.mehy.2016.02.017_b0130","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1093\/eurheartj\/ehr389","article-title":"Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1","volume":"33","author":"Pchejetski","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.mehy.2016.02.017_b0135","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.febslet.2010.04.025","article-title":"Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy","volume":"584","author":"Foussal","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.mehy.2016.02.017_b0140","doi-asserted-by":"crossref","first-page":"H2007","DOI":"10.1152\/ajpheart.00089.2009","article-title":"Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension","volume":"296","author":"Falcao-Pires","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.mehy.2016.02.017_b0145","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/abbs\/gmu046","article-title":"A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway","volume":"46","author":"Xie","year":"2014","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.mehy.2016.02.017_b0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1247\/csf.27.469","article-title":"Endocytic pathway in mouse cardiac cells","volume":"27","author":"Soeiro Mde","year":"2002","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.mehy.2016.02.017_b0155","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/hh2401.100427","article-title":"Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy","volume":"89","author":"Wu","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.mehy.2016.02.017_b0160","doi-asserted-by":"crossref","first-page":"42214","DOI":"10.1074\/jbc.M303428200","article-title":"RGD-containing peptides activate S6K1 through beta3 integrin in adult cardiac muscle cells","volume":"278","author":"Balasubramanian","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2016.02.017_b0165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/cvr\/cvn008","article-title":"Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes","volume":"78","author":"Morisco","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.mehy.2016.02.017_b0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2006.01.018","article-title":"Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure","volume":"45","author":"Perrino","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.mehy.2016.02.017_b0175","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ejps.2013.05.028","article-title":"Transmembrane transport of the Galphaq protein carboxyl terminus imitation polypeptide GCIP-27","volume":"49","author":"Yang","year":"2013","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.mehy.2016.02.017_b0180","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvq014","article-title":"Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload","volume":"86","author":"Gilsbach","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.mehy.2016.02.017_b0185","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.2741\/1681","article-title":"Ouabain-induced endocytosis and signal transduction of the Na\/K-ATPase","volume":"10","author":"Liu","year":"2005","journal-title":"Front Biosci"},{"key":"10.1016\/j.mehy.2016.02.017_b0190","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.freeradbiomed.2006.08.018","article-title":"Involvement of Na+\/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes","volume":"41","author":"Liu","year":"2006","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.mehy.2016.02.017_b0195","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1096\/fj.09-140715","article-title":"Identification and pharmacological properties of E339\u20133D6, the first nonpeptidic apelin receptor agonist","volume":"24","author":"Iturrioz","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.mehy.2016.02.017_b0200","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1021\/jm401789v","article-title":"Structure-activity relationship studies toward the discovery of selective apelin receptor agonists","volume":"57","author":"Margathe","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.mehy.2016.02.017_b0205","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/HYPERTENSIONAHA.114.05099","article-title":"Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist","volume":"65","author":"Brame","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.mehy.2016.02.017_b0210","article-title":"Directed molecular evolution of an engineered gammaretroviral envelope protein with dual receptor use shows stable maintenance of both receptor specificities","author":"Friis","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.mehy.2016.02.017_b0215","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1471-4159.2001.00320.x","article-title":"Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain","volume":"77","author":"Reaux","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2016.02.017_b0220","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/j.1471-4159.2004.02591.x","article-title":"Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure","volume":"90","author":"El Messari","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2016.02.017_b0225","first-page":"704","article-title":"Functional dissociation between apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure","volume":"100","author":"Iturrioz","year":"2007","journal-title":"Arch Mal Coeur Vaiss"},{"key":"10.1016\/j.mehy.2016.02.017_b0230","first-page":"741","article-title":"Apelin, a neuropeptide that counteracts vasopressin secretion","volume":"21","author":"Llorens-Cortes","year":"2005","journal-title":"Med Sci"},{"key":"10.1016\/j.mehy.2016.02.017_b0235","doi-asserted-by":"crossref","first-page":"32627","DOI":"10.1074\/jbc.M110.127167","article-title":"By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization","volume":"285","author":"Iturrioz","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2016.02.017_b0240","doi-asserted-by":"crossref","first-page":"24599","DOI":"10.1074\/jbc.M113.541698","article-title":"Biased signaling favoring gi over beta-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine","volume":"289","author":"Ceraudo","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2016.02.017_b0245","doi-asserted-by":"crossref","first-page":"31173","DOI":"10.1074\/jbc.M114.574020","article-title":"Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling","volume":"289","author":"Chen","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2016.02.017_b0250","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1471-4159.2001.00269.x","article-title":"Visualizing differences in ligand-induced beta-arrestin-GFP interactions and trafficking between three recently characterized G protein-coupled receptors","volume":"77","author":"Evans","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2016.02.017_b0255","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0042-6822(02)00021-1","article-title":"Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ","volume":"307","author":"Zhou","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.mehy.2016.02.017_b0260","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbrc.2010.03.151","article-title":"The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin","volume":"395","author":"Lee","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mehy.2016.02.017_b0265","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/cvr\/cvn042","article-title":"Novel signalling cascade for cardiac hypertrophy activation by uncoupling and internalization of beta1-adrenoceptors","volume":"78","author":"Endoh","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.mehy.2016.02.017_b0270","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/01.RES.86.5.502","article-title":"Beta-adrenergic receptor signaling: an acute compensatory adjustment-inappropriate for the chronic stress of heart failure? Insights from Gsalpha overexpression and other genetically engineered animal models","volume":"86","author":"Vatner","year":"2000","journal-title":"Circ Res"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716000669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716000669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T10:33:51Z","timestamp":1589625231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716000669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":54,"alternative-id":["S0306987716000669"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.02.017","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanosensitive APJ internalization via clathrin-mediated endocytosis: A new molecular mechanism of cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}